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Journal Articles

Large-Scale Alternative Polyadenylation-Wide Association Studies to Identify Putative Cancer Susceptibility Genes

Xingyi Guo, Jie Ping, Yaohua Yang, Xinwan Su, Xiao-Ou Shu, Wanqing Wen, Zhishan Chen, Yunjing Zhang, Ran Tao, Guochong Jia, Jingni He, Qiuyin Cai, Qingrun Zhang, Graham G. Giles, Rachel Pearlman, Gad Rennert, Pavel Vodicka, Amanda Phipps, Stephen B. Gruber, Graham Casey, Ulrike Peters, Jirong Long, Weiqiang Lin, Wei Zheng
Journal: Cancer Research
Cancer Res (2024) 84 (16): 2707–2719.
https://doi.org/10.1158/0008-5472.CAN-24-0521
Published: 15 August 2024
View article titled, Large-Scale Alternative Polyadenylation-Wide Association Studies to Identify Putative Cancer Susceptibility Genes
Open the PDF for Large-Scale Alternative Polyadenylation-Wide Association Studies to Identify Putative Cancer Susceptibility Genes in another window
Includes: Supplementary data
Journal Articles

Case-Case Genome-Wide Analyses Identify Subtype-Informative Variants That Confer Risk for Breast Cancer

Xiaohui Sun, Shiv P. Verma, Guochong Jia, Xinjun Wang, Jie Ping, Xingyi Guo, Xiao-Ou Shu, Jianhong Chen, Andriy Derkach, Qiuyin Cai, Xiaolin Liang, Jirong Long, Kenneth Offit, Jung H. Oh, Anne S. Reiner, Gordon P. Watt, Meghan Woods, Yaohua Yang, Christine B. Ambrosone, Stefan Ambs, Yu Chen, Patrick Concannon, Montserrat Garcia-Closas, Jian Gu, Christopher A. Haiman, Jennifer J. Hu, Dezheng Huo, Esther M. John, Julia A. Knight, Christopher I. Li, Charles F. Lynch, Lene Mellemkjær, Katherine L. Nathanson, Barbara Nemesure, Olufunmilayo I. Olopade, Andrew F. Olshan, Tuya Pal, Julie R. Palmer, Michael F. Press, Maureen Sanderson, Dale P. Sandler, Melissa A. Troester, Wei Zheng, Jonine L. Bernstein, Matthew F. Buas, Xiang Shu
Journal: Cancer Research
Cancer Res (2024) 84 (15): 2533–2548.
https://doi.org/10.1158/0008-5472.CAN-23-3854
Published: 01 August 2024
View article titled, Case-Case Genome-Wide Analyses Identify Subtype-Informative Variants That Confer Risk for Breast Cancer
Open the PDF for Case-Case Genome-Wide Analyses Identify Subtype-Informative Variants That Confer Risk for Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract PS10-09: Development of an absolute risk prediction model for premenopausal breast cancer in an international consortium

Kristen Brantley, Michael Jones, Minouk Schoemaker, Hazel Nichols, Anthony Swerdlow, Robert MacInnis, Roger Milne, Tess Clenenden, Yu Chen, Xiao-Ou Shu, Wei Zheng, Woon-Puay Koh, Jian-Min Yuan, Cari Kitahara, Martha Linet, Dale Sandler, Bernard A Rosner, Peter Kraft, A. Heather Eliassen
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PS10-09.
https://doi.org/10.1158/1538-7445.SABCS23-PS10-09
Published: 02 May 2024
View article titled, Abstract PS10-09: Development of an absolute risk prediction model for premenopausal breast cancer in an international consortium
Journal Articles

Abstract LB136: Global metabolomics identified promising biomarkers for lung cancer risk among former smokers

Thuraya Al-Sayegh, Wanqing Wen, Jie Wu, Wei Zheng, Xiao-Ou Shu, Qiuyin Cai
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB136.
https://doi.org/10.1158/1538-7445.AM2024-LB136
Published: 05 April 2024
View article titled, Abstract LB136: Global metabolomics identified promising biomarkers for lung cancer risk among former smokers
Journal Articles

Abstract LB146: Multi Omics analyses identified novel loci and genes for lung cancer risk among European Descendants

Shuai Xu, Yaohua Yang, Tianying Zhao, Jiajun Shi, Jie Ping, Wanqing Wen, Hui Cai, Xingyi Guo, Ran Tao, Xiao-Ou Shu, Wei Zheng, Jirong Long, Qiuyin Cai
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB146.
https://doi.org/10.1158/1538-7445.AM2024-LB146
Published: 05 April 2024
View article titled, Abstract LB146: Multi Omics analyses identified novel loci and genes for lung cancer risk among European Descendants
Journal Articles

Abstract 5819: An anti-TROP2-CPT113 ADC, exhibits potent targeted antitumor activity and favorable pharmacokinetic properties

Huihui Guo, Xiangfei Kong, Yong Du, Zhicang Ye, Yongxiang Chen, Zhixiang Guo, Lingli Zhang, Lu Bai, Junxiang Jia, Yunxia Zheng, Wei Zheng, Jun Zheng, Wenjun Li, Yuanyuan Huang, Zhongliang Fan, Mengmeng Liu, Binbin Chen, Meng Dai, Juan Wang, Miaomiao Chen, Qingliang Yang, Robert Y. Zhao
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5819.
https://doi.org/10.1158/1538-7445.AM2024-5819
Published: 22 March 2024
View article titled, Abstract 5819: An anti-TROP2-CPT113 ADC, exhibits potent targeted antitumor activity and favorable pharmacokinetic properties
Journal Articles

Abstract 3147: DXC025, a novel anti-MUC1/EGFR bispecific antibody-tubulysin conjugate with a function linker, exhibits potent anti-tumor efficacy

Xingyan Jiang, Junxiang Jia, Huihui Guo, Xiangfei Kong, Yongfang Xu, Sishi Ye, Yong Du, Zhicang Ye, Qikuang Cen, Lingli Zhang, Yongxiang Chen, Gaituo Chen, Lu Bai, Yunxia Zheng, Wei Zheng, Jun Zheng, Juan Wang, Wenjun Li, Yuanyuan Huang, Linyao Zhao, Yifang Xu, Mengmeng Liu, Binbin Chen, Meng Dai, Miaomiao Chen, Zhixiang Guo, Qingliang Yang, Robert Y. Zhao
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3147.
https://doi.org/10.1158/1538-7445.AM2024-3147
Published: 22 March 2024
View article titled, Abstract 3147: DXC025, a novel anti-MUC1/EGFR bispecific antibody-tubulysin conjugate with a function linker, exhibits potent anti-tumor efficacy
Journal Articles

Abstract 6614: Integrating single-cell RNA-seq and large genome-wide association study data to identify colorectal cancer cell-of-origin populations

Chao Li, Zhishan Chen, Qing Li, Jungyoon Choi, Quanhu Sheng, Wanqing Wen, Xiang Shu, Xiao-ou Shu, Jirong Long, Qiuyin Cai, Bhuminder Singh, Martha J. Shrubsole, Ken Lau, Wei Zheng, Xingyi Guo
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6614.
https://doi.org/10.1158/1538-7445.AM2024-6614
Published: 22 March 2024
View article titled, Abstract 6614: Integrating single-cell RNA-seq and large genome-wide association study data to identify colorectal cancer cell-of-origin populations
Journal Articles

Abstract 6581: DX126-262 combined with chemotherapy (Cisplatin and 5-Fu) demonstrates promising antitumor efficacy in HER2-positive gastric cancer

Xiaobo Cai, Min Cao, Huihui Guo, Qingliang Yang, Xiangfei Kong, Yong Du, Zhicang Ye, Zhixiang Guo, Lingli Zhang, Lu Bai, Junxiang Jia, Yunxia Zheng, Yongxiang Chen, Miaomiao Chen, Wei Zheng, Jun Zheng, Wenjun Li, Yuanyuan Huang, Mengmeng Liu, Zhongliang Fan, Hangbo Ye, Yifang Xu, Binbin Chen, Meng Dai, Robert Y. Zhao
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6581.
https://doi.org/10.1158/1538-7445.AM2024-6581
Published: 22 March 2024
View article titled, Abstract 6581: DX126-262 combined with chemotherapy (Cisplatin and 5-Fu) demonstrates promising antitumor efficacy in HER2-positive gastric cancer
Journal Articles

Abstract 2214: Impacts of habitual and recent alcohol intake on gut microbiome diversity and composition among Black Americans

Lili Liu, Sang Nguyen, Qiuyin Cai, Martha Shrubsole, Wei Zheng, Danxia Yu
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2214.
https://doi.org/10.1158/1538-7445.AM2024-2214
Published: 22 March 2024
View article titled, Abstract 2214: Impacts of habitual and recent alcohol intake on gut microbiome diversity and composition among Black Americans
Journal Articles

Abstract 4442: Associations between pre-diagnostic plasma metabolites and biliary tract cancer risk in the prospective UK Biobank cohort

Valerie Gunchick, Guochong Jia, Wei Zheng
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4442.
https://doi.org/10.1158/1538-7445.AM2024-4442
Published: 22 March 2024
View article titled, Abstract 4442: Associations between pre-diagnostic plasma metabolites and biliary tract cancer risk in the prospective UK Biobank cohort
Journal Articles

Abstract 3432: Blood metabolomic profile of glioma risk: A pooled, multi-cohort analysis in COMETS

Jiaqi Huang, Bin Zhao, Stephanie J. Weinstein, Marian L. Neuhouser, Steve C. Moore, Heather Eliassen, David J. Cote, Loic Le Marchand, Lorelei Mucci, Ying Yang, Victoria Stevens, Wei Zheng, Xiao-Ou Shu, Demetrius Albanes
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3432.
https://doi.org/10.1158/1538-7445.AM2024-3432
Published: 22 March 2024
View article titled, Abstract 3432: Blood metabolomic profile of glioma risk: A pooled, multi-cohort analysis in COMETS
Journal Articles

Abstract 3428: Association of adipokines and inflammation biomarkers with cancer risk in men

Douglas DeMoulin, Hui Cai, Qiuyin Cai, Wei Zheng, Xiao-Ou Shu
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3428.
https://doi.org/10.1158/1538-7445.AM2024-3428
Published: 22 March 2024
View article titled, Abstract 3428: Association of adipokines and inflammation biomarkers with cancer risk in men
Journal Articles

Abstract 1884: DXC006, Anti-CD56-CPT113 ADC displays favorable anti-tumor efficacy, pharmacokinetic and safety profiles in preclinical studies

Xiangfei Kong, Huihui Guo, Yong Du, Zhicang Ye, Yongxiang Chen, Zhixiang Guo, Lingli Zhang, Lu Bai, Junxiang Jia, Yunxia Zheng, Wei Zheng, Jun Zheng, Wenjun Li, Yuanyuan Huang, Zhongliang Fan, Mengmeng Liu, Binbin Chen, Meng Dai, Juan Wang, Fang Du, Miaomiao Chen, Qingliang Yang, Robert Y. Zhao
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1884.
https://doi.org/10.1158/1538-7445.AM2024-1884
Published: 22 March 2024
View article titled, Abstract 1884: DXC006, Anti-CD56-CPT113 ADC displays favorable anti-tumor efficacy, pharmacokinetic and safety profiles in preclinical studies
Journal Articles

Abstract 1883: A MUC1 antibody-conjugated with a tubulysin B analog, DXC005, demonstrates excellent synergistic effect in combination with gemcitabine for treatment of pancreatic tumors

Xiaobo Cai, Min Cao, Huihui Guo, Qingliang Yang, Yongxiang Chen, Xiangfei Kong, Yong Du, Zhicang Ye, Zhixiang Guo, Lingli Zhang, Lu Bai, Junxiang Jia, Yunxia Zheng, Wei Zheng, Jun Zheng, Wenjun Li, Yuanyuan Huang, Zhongliang Fan, Binbin Chen, Yanlei Yang, Meng Dai, Robert Y. Zhao
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1883.
https://doi.org/10.1158/1538-7445.AM2024-1883
Published: 22 March 2024
View article titled, Abstract 1883: A MUC1 antibody-conjugated with a tubulysin B analog, DXC005, demonstrates excellent synergistic effect in combination with gemcitabine for treatment of pancreatic tumors
Journal Articles

Abstract 1882: DXC024, a novel anti-TROP2/EGFR bispecific antibody and tubulysin conjugate, for targeted treatment of highly TROP2- or EGFR-expressing tumors

Jingjing Zhu, Junxiang Jia, Huihui Guo, Xiangfei Kong, Yong Du, Zhicang Ye, Lingli Zhang, Yongxiang Chen, Lu Bai, Yunxia Zheng, Wei Zheng, Jun Zheng, Juan Wang, Wenjun Li, Yuanyuan Huang, Zhongliang Fan, Mengmeng Liu, Binbin Chen, Meng Dai, Fang Du, Miaomiao Chen, Zhixiang Guo, Qingliang Yang, Robert Y. Zhao
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1882.
https://doi.org/10.1158/1538-7445.AM2024-1882
Published: 22 March 2024
View article titled, Abstract 1882: DXC024, a novel anti-TROP2/EGFR bispecific antibody and tubulysin conjugate, for targeted treatment of highly TROP2- or EGFR-expressing tumors
Journal Articles

Abstract 6149: Polygenic risk score and lung adenocarcinoma risk among never-smokers by EGFR mutation status

Batel Blechter, Chao Agnes Hsiung, Keitaro Matsuo, Kouya Shiraishi, Kevin Wang, Haoyu Zhang, Wei Jie Seow, Jianxin Shi, Nilanjan Chatterjee, Jason Y.Y. Wong, Juncheng Dai, H. Dean Hosgood, I-Shou Chang, Jiyeon Choi, Wei Hu, Wei Zheng, Young Tae Kim, Xiao-Ou Shu, Qiuyin Cai, Pan-Chyr Yang, Dongxin Lin, Kexin Chen, Yi-Long Wu, Hongbin Shen, Takashi Kohno, Stephen J. Chanock, Nathaniel Rothman, Qing Lan
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6149.
https://doi.org/10.1158/1538-7445.AM2024-6149
Published: 22 March 2024
View article titled, Abstract 6149: Polygenic risk score and lung adenocarcinoma risk among never-smokers by <em>EGFR</em> mutation status
Journal Articles

Abstract 1219: In vivo delivery of CRISPR-Cas9 using lipid nanoparticles enables ATAD3A gene depletion to enhance RAS-targeted therapy

Fanghui Chen, Liwei Lang, Yamin Li, Wei Zheng, Yong Teng
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1219.
https://doi.org/10.1158/1538-7445.AM2024-1219
Published: 22 March 2024
View article titled, Abstract 1219: In vivo delivery of CRISPR-Cas9 using lipid nanoparticles enables ATAD3A gene depletion to enhance RAS-targeted therapy
Journal Articles

Abstract 6466: Multi-omics analysis of molecular characteristics and transformation mechanisms of stage I-III micropapillary lung adenocarcinoma

Kang Shao, Shugeng Gao, Fengwei Tan, Anqi Shao, Xiaoli Feng, Qi Xue, Yang Qu, Bo Zheng, Wei Zheng, Hanlin Chen, Qiuxiang Ou, Haimeng Tang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6466.
https://doi.org/10.1158/1538-7445.AM2024-6466
Published: 22 March 2024
View article titled, Abstract 6466: Multi-omics analysis of molecular characteristics and transformation mechanisms of stage I-III micropapillary lung adenocarcinoma
Journal Articles

Abstract 4769: Phospho-YAP (Ser127) overexpression is associated with sporadic advanced adenomas: The Tennessee Colorectal Polyp Study

Lei Fan, Xingyi Guo, Mary Kay Washington, Jiajun Shi, Reid M. Ness, Qi Liu, Wanqing Wen, Xiao Liu, Qiuyin Cai, Wei Zheng, Robert J. Coffey, Martha J. Shrubsole, Timothy Su
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4769.
https://doi.org/10.1158/1538-7445.AM2024-4769
Published: 22 March 2024
View article titled, Abstract 4769: Phospho-YAP (Ser127) overexpression is associated with sporadic advanced adenomas: The Tennessee Colorectal Polyp Study