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Journal Articles

Abstract LB279: SDP01873, a novel HER3×c-Met bispecific antibody-drug conjugate (ADC) targeting EGFR tyrosine kinase inhibitor (TKI)-resistant non-small cell lung cancer (NSCLC), colorectal cancer (CRC) and beyond

Free
Limin Wang, Xing Sun, Changyong Yang, Dan Li, Yali Hu, Simeng Chen, Wei Zhang, Cheng Liao
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): LB279.
https://doi.org/10.1158/1538-7445.AM2025-LB279
Published: 25 April 2025
View articletitled, Abstract LB279: SDP01873, a novel HER3×c-Met bispecific antibody-drug conjugate (ADC) targeting EGFR tyrosine kinase inhibitor (TKI)-resistant non-small cell lung cancer (NSCLC), colorectal cancer (CRC) and beyond
Journal Articles

Abstract LB255: MCTarg: A plasma-based metabolic biomarker model for multi-cancer early detection

Free
Yan Li, Xinping Xu, Chunyan Zeng, Bei Qing, Yun He, Yanlong Liu, Guodong Song, Jianhua Hu, Tianqi Shao, Li Liu, Qingyan Wei, Shuqi Yu, He Wen, Junyuan Hu, Wei Zhang, Youxiang Chen, Zhenkun Xia
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): LB255.
https://doi.org/10.1158/1538-7445.AM2025-LB255
Published: 25 April 2025
View articletitled, Abstract LB255: MCTarg: A plasma-based metabolic biomarker model for multi-cancer early detection
Journal Articles

Abstract LB413: Analysis of multimodal real world data from 1,248 breast cancer patients reveals distinct, novel consensus molecular segments associated with CDK4/6 inhibitor resistance

Free
Sahil Seth, Ha Dang, Matthew Ware, Milad R. Vahid, Chunan Liu, William Ashworth, Brendan O’Brien, Ana Lako, Rachel Webster, Micaela Tatman, Kwok-Kin Wong, Jiehui Deng, Nancy Chan, Alfonso Lopez, Kai Wang, Neil Bence, Rupal Bhatt, Gonzalo Lopez, Wei Zhang, Vipin Yadav, Konstantinos J. Mavrakis, Jason R. Dobson
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): LB413.
https://doi.org/10.1158/1538-7445.AM2025-LB413
Published: 25 April 2025
View articletitled, Abstract LB413: Analysis of multimodal real world data from 1,248 breast cancer patients reveals distinct, novel consensus molecular segments associated with CDK4/6 inhibitor resistance
Journal Articles

Abstract CT185: Trispecific EGFR x cMET x VEGF antibody, TAVO412, has clinical responses in esophageal and lung cancers

Free
Mark Chiu, Wei Zhang, Yanjiao Yu, Helen Jiang, Chao Han
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): CT185.
https://doi.org/10.1158/1538-7445.AM2025-CT185
Published: 25 April 2025
View articletitled, Abstract CT185: Trispecific EGFR x cMET x VEGF antibody, TAVO412, has clinical responses in esophageal and lung cancers
Journal Articles

Abstract LB368: A first-in-class CTLA-4×TIGIT BsAb selectively targets tumor-associated Treg cells to improve the safety profile of CTLA-4 targeting therapy

Free
Hong Yan, Luyao Bao, Chenglong Liu, Simeng Chen, Wei Zhang, Xing Sun, Wenjing Cheng, Zeyun Xue, Wei Wang, Jimin Yuan, Cheng Liao
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): LB368.
https://doi.org/10.1158/1538-7445.AM2025-LB368
Published: 25 April 2025
View articletitled, Abstract LB368: A first-in-class CTLA-4×TIGIT BsAb selectively targets tumor-associated Treg cells to improve the safety profile of CTLA-4 targeting therapy
Journal Articles

Abstract 3064: The interaction of calcium-sensing receptor with KIF11 enhances cisplatin resistance in lung adenocarcinoma

Free
Fuhao Wang, Ming Chang, Xiao Zhang, Xiaoyi Li, Zhiying Chen, Wei Zhang, Jian Zhang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3064.
https://doi.org/10.1158/1538-7445.AM2025-3064
Published: 21 April 2025
View articletitled, Abstract 3064: The interaction of calcium-sensing receptor with KIF11 enhances cisplatin resistance in lung adenocarcinoma
Journal Articles

Abstract 5010: High-resolution multi-omic dissociation of brain tumors with deep multimodal autoencoder

Free
Jiao Sun, Yue Pan, Tong Lin, Kyle Smith, Arzu Onar-Thomas, Giles W. Robinson, Wei Zhang, Paul A. Northcott, Qian Li
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5010.
https://doi.org/10.1158/1538-7445.AM2025-5010
Published: 21 April 2025
View articletitled, Abstract 5010: High-resolution multi-omic dissociation of brain tumors with deep multimodal autoencoder
Journal Articles

Abstract 737: Androgen receptor-indifferent prostate cancer in radical prostatectomy cases detected by single-cell image analysis

Free
Beatrice S. Knudsen, Wei Zhang, Mason Hovinga, Erika Egal, Chance Walker, Yosep Chong, Galaxy Yang, Michael R. Freeman, Yi Qiao
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 737.
https://doi.org/10.1158/1538-7445.AM2025-737
Published: 21 April 2025
View articletitled, Abstract 737: Androgen receptor-indifferent prostate cancer in radical prostatectomy cases detected by single-cell image analysis
Journal Articles

Abstract 3068: The clonal nature of FGFR3-TACC3 in glioma: Mechanism discovery and preclinical study

Free
Yiming Li, Tao Li, Xiude Ren, Jianshen Liang, Jikang Fan, Xisen Wang, Shengping Yu, Wei Zhang, Xuejun Yang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3068.
https://doi.org/10.1158/1538-7445.AM2025-3068
Published: 21 April 2025
View articletitled, Abstract 3068: The clonal nature of FGFR3-TACC3 in glioma: Mechanism discovery and preclinical study
Journal Articles

Abstract 1253: Single-cell analysis reveals intricate subclonal heterogeneity and evolution in response to standard of care treatments in glioblastoma

Free
Yueshan Zhao, Xiaoyu Lu, Verah Nyarige, Junfei Zhao, Gonzalo Lopez, Ann Forslund, Maria Ortiz-Estevez, Jorge Benitez-Hernandez, Wei Zhang, Celia Fontanillo, Kai Wang, Ha Dang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 1253.
https://doi.org/10.1158/1538-7445.AM2025-1253
Published: 21 April 2025
View articletitled, Abstract 1253: Single-cell analysis reveals intricate subclonal heterogeneity and evolution in response to standard of care treatments in glioblastoma
Journal Articles

Abstract 2623: Targeted therapy with DFMO and immunotherapy equalizes survival in MYCN-amplified neuroblastoma: insights from genomic and network analyses

Free
Anderson O. Cox, Abhinav Nagulapally, Deha Ay, Qianqian Song, Liang Liu, Hong-Gang Wang, Abigail Moore, Valerie I. Brown, Wei Zhang, Giselle L. Saulnier Sholler
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2623.
https://doi.org/10.1158/1538-7445.AM2025-2623
Published: 21 April 2025
View articletitled, Abstract 2623: Targeted therapy with DFMO and immunotherapy equalizes survival in MYCN-amplified neuroblastoma: insights from genomic and network analyses
Journal Articles

HBV Remodels PP2A Complexes to Rewire Kinase Signaling in Hepatocellular Carcinoma

Available to Purchase
Rigney E. Turnham, Adriana Pitea, Gwendolyn M. Jang, Zhong Xu, Huat Chye Lim, Alex L. Choi, John Von Dollen, Rebecca S. Levin, James T. Webber, Elizabeth McCarthy, Junjie Hu, Xiaolei Li, Li Che, Ananya Singh, Alex Yoon, Gary K.L. Chan, Robin K. Kelley, Danielle L. Swaney, Wei Zhang, Sourav Bandyopadhyay, Fabian J. Theis, Manon Eckhardt, Xin Chen, Kevan M. Shokat, Trey Ideker, Nevan J. Krogan, John D. Gordan
Journal: Cancer Research
Cancer Res (2025) 85 (4): 660–674.
https://doi.org/10.1158/0008-5472.CAN-24-0456
Published: 17 February 2025
View articletitled, HBV Remodels PP2A Complexes to Rewire Kinase Signaling in Hepatocellular Carcinoma
Open the PDF for HBV Remodels PP2A Complexes to Rewire Kinase Signaling in Hepatocellular Carcinoma in another window
Includes: Supplementary data
Journal Articles

Mutant U2AF1-Induced Mis-Splicing of mRNA Translation Genes Confers Resistance to Chemotherapy in Acute Myeloid Leukemia

Available to Purchase
Peng Jin, Xiaoling Wang, Qiqi Jin, Yi Zhang, Jie Shen, Ge Jiang, Hongming Zhu, Ming Zhao, Dan Wang, Zeyi Li, Yan Zhou, Wenzhu Li, Wei Zhang, Yabin Liu, Siyang Wang, Wen Jin, Yuncan Cao, Guangying Sheng, Fangyi Dong, Shishuang Wu, Xiaoyang Li, Zhen Jin, Mengke He, Xiaxin Liu, Luonan Chen, Yunxiang Zhang, Kankan Wang, Junmin Li
Journal: Cancer Research
Cancer Res (2024) 84 (10): 1583–1596.
https://doi.org/10.1158/0008-5472.CAN-23-2543
Published: 15 May 2024
View articletitled, Mutant U2AF1-Induced Mis-Splicing of mRNA Translation Genes Confers Resistance to Chemotherapy in Acute Myeloid Leukemia
Open the PDF for Mutant U2AF1-Induced Mis-Splicing of mRNA Translation Genes Confers Resistance to Chemotherapy in Acute Myeloid Leukemia in another window
Includes: Supplementary data
Journal Articles

Abstract PO4-07-07: The construction and clinical research value of the prediction model of sentinel lymph node metastasis based on indocyanine green fluorescence quantification in breast cancer

Free
Yang Wu, Wei Zhang, Jinhai Tang
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO4-07-07.
https://doi.org/10.1158/1538-7445.SABCS23-PO4-07-07
Published: 02 May 2024
View articletitled, Abstract PO4-07-07: The construction and clinical research value of the prediction model of sentinel lymph node metastasis based on indocyanine green fluorescence quantification in breast cancer
Journal Articles

KDM5C-Mediated Recruitment of BRD4 to Chromatin Regulates Enhancer Activation and BET Inhibitor Sensitivity

Available to Purchase
Yulong Qiang, Jiachen Fan, Chuanshuai Xie, Leilei Yan, Xiaofei Song, Nan Zhang, Yan Lin, Jie Xiong, Wei Zhang, Yu Liu, Lei Wei, Yu Li, Shizhen Chen, Kaiwei Liang, Feng Li
Journal: Cancer Research
Cancer Res (2024) 84 (8): 1252–1269.
https://doi.org/10.1158/0008-5472.CAN-23-2888
Published: 15 April 2024
View articletitled, KDM5C-Mediated Recruitment of BRD4 to Chromatin Regulates Enhancer Activation and BET Inhibitor Sensitivity
Open the PDF for KDM5C-Mediated Recruitment of BRD4 to Chromatin Regulates Enhancer Activation and BET Inhibitor Sensitivity in another window
Includes: Supplementary data
Journal Articles

Abstract 5646: Altered intronic polyadenylation by mutant p53 impairs transcription of DNA repair genes in lung cancer

Free
Liang Liu, Elizabeth Forbes, Wei Zhang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5646.
https://doi.org/10.1158/1538-7445.AM2024-5646
Published: 22 March 2024
View articletitled, Abstract 5646: Altered intronic polyadenylation by mutant p53 impairs transcription of DNA repair genes in lung cancer
Journal Articles

Abstract 5940: JAB-30355: A highly potent, orally bioavailable p53-Y220C reactivator

Free
Qian Zheng, Peng Wang, Chen Liang, Yao Li, Xin Sun, Amin Li, Wei Zhang, Wei Long, Yanping Wang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5940.
https://doi.org/10.1158/1538-7445.AM2024-5940
Published: 22 March 2024
View articletitled, Abstract 5940: JAB-30355: A highly potent, orally bioavailable p53-Y220C reactivator
Journal Articles

Abstract 1835: Discovery of HSN003839, a highly potent inhibitor of ubiquitin-specific protease USP21 for cancer therapy

Free
Xiaohui Liu, Ying Wang, Dongliang Xia, Wei Zhang, Yan He, Shijie Tian, Xuerong Feng, Xia Yang, Qi Zhang, Fei Liu, Shiyi Jiang, Ran Hu, Ming Tang, Xuelin Tang, Yuqing Liu, Weijiao Yuan, Xuedan You
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1835.
https://doi.org/10.1158/1538-7445.AM2024-1835
Published: 22 March 2024
View articletitled, Abstract 1835: Discovery of HSN003839, a highly potent inhibitor of ubiquitin-specific protease USP21 for cancer therapy
Journal Articles

Abstract 6126: Understanding disparities in lung cancer using single cell RNA sequencing data transformed by the Gerchberg Saxton algorithm

Free
Seha Ay, Liang Liu, Elizabeth Forbes, Umit Topaloglu, Wei Zhang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6126.
https://doi.org/10.1158/1538-7445.AM2024-6126
Published: 22 March 2024
View articletitled, Abstract 6126: Understanding disparities in lung cancer using single cell RNA sequencing data transformed by the Gerchberg Saxton algorithm
Journal Articles

Abstract 5065: Integrating blood based liquid biopsies with TNM stage improves survival prediction model for non-small cell lung cancer

Free
Lauren Schmalz, Cetin Urtis, Liang Liu, Elizabeth Forbes, Fang-Chi Hsu, Nury Steuerwald, Alberto de Hoyos, Thomas Lycan, Jimmy Ruiz, William Petty, Wei Zhang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5065.
https://doi.org/10.1158/1538-7445.AM2024-5065
Published: 22 March 2024
View articletitled, Abstract 5065: Integrating blood based liquid biopsies with TNM stage improves survival prediction model for non-small cell lung cancer