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Journal Articles

DPP9 Stabilizes NRF2 to Suppress Ferroptosis and Induce Sorafenib Resistance in Clear Cell Renal Cell Carcinoma

Kun Chang, Yingji Chen, Xuanzhi Zhang, Wei Zhang, Ning Xu, Bohan Zeng, Yue Wang, Tao Feng, Bo Dai, Fujiang Xu, Dingwei Ye, Chenji Wang
Journal: Cancer Research
Cancer Res (2023)
https://doi.org/10.1158/0008-5472.CAN-22-4001
Published: 15 September 2023
View article titled, DPP9 Stabilizes NRF2 to Suppress Ferroptosis and Induce Sorafenib Resistance in Clear Cell Renal Cell Carcinoma
Open the PDF for DPP9 Stabilizes NRF2 to Suppress Ferroptosis and Induce Sorafenib Resistance in Clear Cell Renal Cell Carcinoma in another window
Includes: Supplementary data
Journal Articles

GTP cyclohydrolase drives breast cancer development and promotes EMT in an enzyme-independent manner

Zijing Wang, Nan Zhang, Miao Zhang, Yao Jiang, Aik Seng Ng, Esther Bridges, Wei Zhang, Xin Zeng, Qi Luo, Jiabien Liang, Balázs Gyorffy, Philip Hublitz, Zhu Liang, Roman Fischer, David Kerr, Adrian L. Harris, Shijie Cai
Journal: Cancer Research
Cancer Res CAN-22-3471.
https://doi.org/10.1158/0008-5472.CAN-22-3471
Published: 18 July 2023
View article titled, GTP cyclohydrolase drives breast cancer development and promotes EMT in an enzyme-independent manner
Open the PDF for GTP cyclohydrolase drives breast cancer development and promotes EMT in an enzyme-independent manner in another window
Includes: Supplementary data
Journal Articles

Abstract 1996: Prostate cancer androgen receptor signaling inhibition via romidepsin encapsulated lipid-polymer hybrid nanoparticle with PSMA617 targeting

Wendi Ma, Daiki Hara, Yu-Ping Yang, Olivia Yolande Bosquet, Wei Zhang, Emre Dikici, Huayang Feng, Tim Horton, Wensi Tao, Jessi Hersh, Junwei Shi, Sylvia Daunert, Sapna Deo, Alan Pollack
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1996.
https://doi.org/10.1158/1538-7445.AM2023-1996
Published: 04 April 2023
View article titled, Abstract 1996: Prostate cancer androgen receptor signaling inhibition via romidepsin encapsulated lipid-polymer hybrid nanoparticle with PSMA617 targeting
Journal Articles

Abstract 2918: In vivo delivery of CD3-directed CD19-CAR lentivectors leads to the generation of CAR T and NK-like (CAR-TaNK) cells capable of complete ablation of B cells in the blood, bone marrow, and tissue of NSG-SGM3 CD34+ humanized mice

Frederic Vigant, Ani Kundu, Ramya Yarlagadda, Cody Gowan, Michael Betts, Jonathan Kato, Renata Soares, Alan Ponce, Lintao Liu, Junyi Zhang, Ewa Jaruga-Killeen, Michelle Andraza, Suraj Kachgal, Gregory Schreiber, Wei Zhang, Gregory Wade, Gregory I. Frost, Sid P. Kerkar
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2918.
https://doi.org/10.1158/1538-7445.AM2023-2918
Published: 04 April 2023
View article titled, Abstract 2918: <em>In vivo</em> delivery of CD3-directed CD19-CAR lentivectors leads to the generation of CAR T and NK-like (CAR-TaNK) cells capable of complete ablation of B cells in the blood, bone marrow, and tissue of NSG-SGM3 CD34+ humanized mice
Journal Articles

Abstract 5809: Tracking cancer stem cell expression of pancreatic and ampullary cancer organoids in response to chemotherapy

Eleanor Riedl, Austin Stram, MD Shahadat Hossan, Ethan S. Lin, Luke Koeppel, Jamie Warner, Sam Lubner, Stephanie McGregor, Wei Zhang, Jeremy Kratz
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5809.
https://doi.org/10.1158/1538-7445.AM2023-5809
Published: 04 April 2023
View article titled, Abstract 5809: Tracking cancer stem cell expression of pancreatic and ampullary cancer organoids in response to chemotherapy
Journal Articles

Abstract 1660: Preclinical investigation of orally bioavailable, potent KRASMulti inhibitor JAB-23425

Peng Wang, Yanping Wang, Xin Sun, Dan Liu, Xiaoyu Liu, Wei Zhang, Xueting He, Rui Zhou, Cunbo Ma, Amin Li, Yiwei Lin, Wei Long
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1660.
https://doi.org/10.1158/1538-7445.AM2023-1660
Published: 04 April 2023
View article titled, Abstract 1660: Preclinical investigation of orally bioavailable, potent KRAS<sup>Multi</sup> inhibitor JAB-23425
Journal Articles

Abstract 925: NTRK gene fusion in adults and pediatrics with solid tumors: a record linkage study of expression frequency and patient characteristics using the Auria Biobank in Finland

Wei Zhang, Merja Perälä, Roosa E. Kallionpää, Niina Pitkänen, Korinna Jöhrens, Renate Schulze-Rath, Arndt A Schmitz, Helen Guo, Jihong Zong
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 925.
https://doi.org/10.1158/1538-7445.AM2023-925
Published: 04 April 2023
View article titled, Abstract 925: <em>NTRK</em> gene fusion in adults and pediatrics with solid tumors: a record linkage study of expression frequency and patient characteristics using the Auria Biobank in Finland
Journal Articles

Abstract 1878: Preclinical development of a novel bispecific mAb-Trap fusion protein, IMM2520, targeting both PD-L1 and CD47 as cancer immunotherapy

Wenzhi Tian, Song Li, Dianze Chen, Wenqi Zhu, Yanan Yang, Dandan Liu, Huiqin Guo, Chunmei Yang, Li Zhang, Wei Zhang, Xiaoping Tu, Liang Peng, Gui Zhao, Ruliang Zhang, Fan Zhang, Frank Gan
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1878.
https://doi.org/10.1158/1538-7445.AM2023-1878
Published: 04 April 2023
View article titled, Abstract 1878: Preclinical development of a novel bispecific mAb-Trap fusion protein, IMM2520, targeting both PD-L1 and CD47 as cancer immunotherapy
Journal Articles

Abstract 451: AICAR targets oncogenic signaling pathways of MUC1-CT

Fareesa Aftab, Alice Rodriguez-Fuguet, Luis Silva, Ikei S. Kobayashi, Jiao Sun, Katerina Politi, Elena Levantini, Wei Zhang, Susumu S. Kobayashi, Wen Cai Zhang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 451.
https://doi.org/10.1158/1538-7445.AM2023-451
Published: 04 April 2023
View article titled, Abstract 451: AICAR targets oncogenic signaling pathways of MUC1-CT
Journal Articles

Abstract 6682: A patient-specific, tumor-informed, circulating tumor DNA (ctDNA)-based minimal residual disease (MRD) assay in surgical patients with biliary tract cancer

Tianqiang Song, Qiang Wu, Yunlong Cui, Huikai Li, Wei Zhang, Feng Fang, Qingqing Xiong
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6682.
https://doi.org/10.1158/1538-7445.AM2023-6682
Published: 04 April 2023
View article titled, Abstract 6682: A patient-specific, tumor-informed, circulating tumor DNA (ctDNA)-based minimal residual disease (MRD) assay in surgical patients with biliary tract cancer
Journal Articles

Abstract 4647: Potential of TIMP3 regulating the versican status in the colorectal cancer tumor microenvironment

Anna Field, Sean Kraus, Kristina Matkowskyj, Dustin Deming, Cheri A. Pasch, Wei Zhang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4647.
https://doi.org/10.1158/1538-7445.AM2023-4647
Published: 04 April 2023
View article titled, Abstract 4647: Potential of TIMP3 regulating the versican status in the colorectal cancer tumor microenvironment
Journal Articles

Abstract 2938: Preclinical development of a novel bispecific mAb-Trap fusion protein, IMM2902, targeting both HER2 and CD47 as cancer immunotherapy

Binglei Zhang, Song Li, Dianze Chen, Dandan Liu, Huiqin Guo, Chunmei Yang, Li Zhang, Wei Zhang, Xiaoping Tu, Liang Peng, Gui Zhao, Ruliang Zhang, Frank X. Gan, Wenzhi Tian, Fan Zhang, Yongping Song
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2938.
https://doi.org/10.1158/1538-7445.AM2023-2938
Published: 04 April 2023
View article titled, Abstract 2938: Preclinical development of a novel bispecific mAb-Trap fusion protein, IMM2902, targeting both HER2 and CD47 as cancer immunotherapy
Journal Articles

Abstract 2357: Fibroblast activation protein (FAP) expression as a target for colorectal cancer treatment

Anna L. Lippert, Katherine A. Johnson, Cheri A. Pasch, Wei Zhang, Kristina A. Matkowskyj, Aaron M. LeBeau, Dustin A. Deming
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2357.
https://doi.org/10.1158/1538-7445.AM2023-2357
Published: 04 April 2023
View article titled, Abstract 2357: Fibroblast activation protein (FAP) expression as a target for colorectal cancer treatment
Journal Articles

Abstract 4020: HMPL-760 is a highly potent and selective reversible BTK inhibitor, targeting BTK and BTKC481S in B-cell malignancies

Linfang Wang, Junqing Liang, Zhihu Gao, Jia Hu, Weigang He, Xianwen Yang, Fangfang Mao, Wei Zhang, Ying Yu, Qihang Zhang, Na Yang, Chun Zhang, Jian Wang, Yu Cai, Xiong Li, Weiguo Qing, Guangxiu Dai, Yongxin Ren, Michael Shi, Weiguo Su
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4020.
https://doi.org/10.1158/1538-7445.AM2023-4020
Published: 04 April 2023
View article titled, Abstract 4020: HMPL-760 is a highly potent and selective reversible BTK inhibitor, targeting BTK and BTK<sup>C481S</sup> in B-cell malignancies
Journal Articles

Abstract 6341: Preclinical development of a monoclonal antibody targeting CD70 as cancer immunotherapy

Wenzhi Tian, Song Li, Dianze Chen, Dandan Liu, Huiqin Guo, Chunmei Yang, Li Zhang, Wei Zhang, Xiaoping Tu, Liang Peng, Gui Zhao, Ruliang Zhang, Fan Zhang, Frank X. Gan
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6341.
https://doi.org/10.1158/1538-7445.AM2023-6341
Published: 04 April 2023
View article titled, Abstract 6341: Preclinical development of a monoclonal antibody targeting CD70 as cancer immunotherapy
Journal Articles

Abstract 6340: Preclinical development of a monoclonal antibody targeting CD24 as cancer immunotherapy

Wenzhi Tian, Song Li, Dianze Chen, Dandan Liu, Huiqin Guo, Chunmei Yang, Li Zhang, Wei Zhang, Xiaoping Tu, Liang Peng, Gui Zhao, Ruliang Zhang, Fan Zhang, Frank X. Gan
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6340.
https://doi.org/10.1158/1538-7445.AM2023-6340
Published: 04 April 2023
View article titled, Abstract 6340: Preclinical development of a monoclonal antibody targeting CD24 as cancer immunotherapy
Journal Articles

Abstract 6321: HMPL-453, a highly selective inhibitor of fibroblast growth factor receptors 1, 2, and 3, displays potent activity in FGFR-altered tumor models

Jia Hu, Jun Ni, Longxian Jiao, Jinghong Zhou, Shiming Fan, Renxiang Tang, Wei Zhang, Xuelei Ge, Qihang Zhang, Juntao Yu, Ying Yu, Dongxia Shi, Min Cheng, Weifang Xue, Sumei Xia, Zeyu Zhong, Jian Wang, Yang Sai, Weiguo Qing, Guangxiu Dai, Yongxin Ren, Michael Shi, Weiguo Su
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6321.
https://doi.org/10.1158/1538-7445.AM2023-6321
Published: 04 April 2023
View article titled, Abstract 6321: HMPL-453, a highly selective inhibitor of fibroblast growth factor receptors 1, 2, and 3, displays potent activity in FGFR-altered tumor models
Journal Articles

Abstract PD4-05: PD4-05 Integrated multi-cohort profiling identifies CCL19+ dendritic cells to potentiate immunotherapy efficacy in triple-negative breast cancer

Song-Yang Wu, Si-Wei Zhang, Ding Ma, Xi Jin, Yi-Zhou Jiang, Zhi-Ming Shao
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): PD4-05.
https://doi.org/10.1158/1538-7445.SABCS22-PD4-05
Published: 01 March 2023
View article titled, Abstract PD4-05: PD4-05 Integrated multi-cohort profiling identifies CCL19+ dendritic cells to potentiate immunotherapy efficacy in triple-negative breast cancer
Journal Articles

Abstract 2552: Effects of liver endothelium on pancreatic cancer growth and metabolism

Wei Zhang, Michel'le Wright, Moeez Rathore, Mehrdad Zarei, Jordan Winter, Rui Wang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2552.
https://doi.org/10.1158/1538-7445.AM2022-2552
Published: 15 June 2022
View article titled, Abstract 2552: Effects of liver endothelium on pancreatic cancer growth and metabolism
Journal Articles

Abstract 1095: Establishment and characterization of a topotecan resistant lung cancer NCI H460/TPT10 cell line and a tumor xenograft model

Qiu-Xu Teng, Zi-Ning Lei, Wei Zhang, Ying-Fang Fan, Jing-Quan Wang, Chao-Yun Cai, Dong-Hua Yang, John Wurpel, Zhe-Sheng Chen
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1095.
https://doi.org/10.1158/1538-7445.AM2022-1095
Published: 15 June 2022
View article titled, Abstract 1095: Establishment and characterization of a topotecan resistant lung cancer NCI H460/TPT10 cell line and a tumor xenograft model