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Journal Articles

Mutant U2AF1-Induced Mis-Splicing of mRNA Translation Genes Confers Resistance to Chemotherapy in Acute Myeloid Leukemia

Peng Jin, Xiaoling Wang, Qiqi Jin, Yi Zhang, Jie Shen, Ge Jiang, Hongming Zhu, Ming Zhao, Dan Wang, Zeyi Li, Yan Zhou, Wenzhu Li, Wei Zhang, Yabin Liu, Siyang Wang, Wen Jin, Yuncan Cao, Guangying Sheng, Fangyi Dong, Shishuang Wu, Xiaoyang Li, Zhen Jin, Mengke He, Xiaxin Liu, Luonan Chen, Yunxiang Zhang, Kankan Wang, Junmin Li
Journal: Cancer Research
Cancer Res (2024) 84 (10): 1583–1596.
https://doi.org/10.1158/0008-5472.CAN-23-2543
Published: 15 May 2024
View article titled, Mutant U2AF1-Induced Mis-Splicing of mRNA Translation Genes Confers Resistance to Chemotherapy in Acute Myeloid Leukemia
Open the PDF for Mutant U2AF1-Induced Mis-Splicing of mRNA Translation Genes Confers Resistance to Chemotherapy in Acute Myeloid Leukemia in another window
Includes: Supplementary data
Journal Articles

Abstract PO4-07-07: The construction and clinical research value of the prediction model of sentinel lymph node metastasis based on indocyanine green fluorescence quantification in breast cancer

Yang Wu, Wei Zhang, Jinhai Tang
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO4-07-07.
https://doi.org/10.1158/1538-7445.SABCS23-PO4-07-07
Published: 02 May 2024
View article titled, Abstract PO4-07-07: The construction and clinical research value of the prediction model of sentinel lymph node metastasis based on indocyanine green fluorescence quantification in breast cancer
Journal Articles

KDM5C-Mediated Recruitment of BRD4 to Chromatin Regulates Enhancer Activation and BET Inhibitor Sensitivity

Yulong Qiang, Jiachen Fan, Chuanshuai Xie, Leilei Yan, Xiaofei Song, Nan Zhang, Yan Lin, Jie Xiong, Wei Zhang, Yu Liu, Lei Wei, Yu Li, Shizhen Chen, Kaiwei Liang, Feng Li
Journal: Cancer Research
Cancer Res (2024) 84 (8): 1252–1269.
https://doi.org/10.1158/0008-5472.CAN-23-2888
Published: 15 April 2024
View article titled, KDM5C-Mediated Recruitment of BRD4 to Chromatin Regulates Enhancer Activation and BET Inhibitor Sensitivity
Open the PDF for KDM5C-Mediated Recruitment of BRD4 to Chromatin Regulates Enhancer Activation and BET Inhibitor Sensitivity in another window
Includes: Supplementary data
Journal Articles

Abstract 3134: SDP03923-000-9106, a novel and optimized LIV-1 ADC with superior anti-tumor efficacy in breast cancer xenograft models

Yanling Gong, Xing Sun, Changyong Yang, Simeng Chen, Wei Zhang, Cheng Liao
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3134.
https://doi.org/10.1158/1538-7445.AM2024-3134
Published: 22 March 2024
View article titled, Abstract 3134: SDP03923-000-9106, a novel and optimized LIV-1 ADC with superior anti-tumor efficacy in breast cancer xenograft models
Journal Articles

Abstract 6157: Population-specific 5-hydroxymethylcytosine signatures in circulating cell-free DNA and overall survival among Blacks and Whites with multiple myeloma

Bei Wang, Zhou Zhang, Benjamin Derman, Krissana Kowitwanich, Jason Cheung, Andrezej Jakubowiak, Chuan He, Wei Zhang, Brian Chiu
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6157.
https://doi.org/10.1158/1538-7445.AM2024-6157
Published: 22 March 2024
View article titled, Abstract 6157: Population-specific 5-hydroxymethylcytosine signatures in circulating cell-free DNA and overall survival among Blacks and Whites with multiple myeloma
Journal Articles

Abstract 5065: Integrating blood based liquid biopsies with TNM stage improves survival prediction model for non-small cell lung cancer

Lauren Schmalz, Cetin Urtis, Liang Liu, Elizabeth Forbes, Fang-Chi Hsu, Nury Steuerwald, Alberto de Hoyos, Thomas Lycan, Jimmy Ruiz, William Petty, Wei Zhang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5065.
https://doi.org/10.1158/1538-7445.AM2024-5065
Published: 22 March 2024
View article titled, Abstract 5065: Integrating blood based liquid biopsies with TNM stage improves survival prediction model for non-small cell lung cancer
Journal Articles

Abstract 1634: Cyclin D1 induces Akt1 activity in RB deficient prostate cancer

Xuanmao Jiao, Anthony W. Ashton, Zhiping Li, Ritika Harish, Danni Li, Gordon Robertson, Duanwen Shen, Xiaoming Ju, Ke Chen, Wei Zhang, Samuel Archilefu, Kenneth A. Iczkowski, Hallgeir Rui, Beatrice Knudsen, Paul Timpson, Max Nobis, Richard G. Pestell
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1634.
https://doi.org/10.1158/1538-7445.AM2024-1634
Published: 22 March 2024
View article titled, Abstract 1634: Cyclin D1 induces Akt1 activity in RB deficient prostate cancer
Journal Articles

Abstract 1113: USP18 impairs the sensitivity of radiotherapy for nasopharyngeal carcinoma by promoting the ubiquitination and nuclear translocation of TRIM29

Jia-Yi Lin, Wei-Wei Zhang, Qing-Jie Li, Xue-Liang Fang, Jun-Yan Li, Shi-Wei He, Ying-Qin Li, Jun Ma, Na Liu, Yin Zhao, Rui Guo
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1113.
https://doi.org/10.1158/1538-7445.AM2024-1113
Published: 22 March 2024
View article titled, Abstract 1113: USP18 impairs the sensitivity of radiotherapy for nasopharyngeal carcinoma by promoting the ubiquitination and nuclear translocation of TRIM29
Journal Articles

Abstract 6827: Myocardin and myocardin-related transcription factor as potential drivers of the myofibroblastic cancer-associated fibroblast phenotype in colorectal cancer

Alec B. Cornelio, Katherine A. Johnson, Yousef Gadalla, Sharanya Nath, Cheri A. Pasch, Wei Zhang, Kristina A. Matkowskyj, Dustin A. Deming
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6827.
https://doi.org/10.1158/1538-7445.AM2024-6827
Published: 22 March 2024
View article titled, Abstract 6827: Myocardin and myocardin-related transcription factor as potential drivers of the myofibroblastic cancer-associated fibroblast phenotype in colorectal cancer
Journal Articles

Abstract 1835: Discovery of HSN003839, a highly potent inhibitor of ubiquitin-specific protease USP21 for cancer therapy

Xiaohui Liu, Ying Wang, Dongliang Xia, Wei Zhang, Yan He, Shijie Tian, Xuerong Feng, Xia Yang, Qi Zhang, Fei Liu, Shiyi Jiang, Ran Hu, Ming Tang, Xuelin Tang, Yuqing Liu, Weijiao Yuan, Xuedan You
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1835.
https://doi.org/10.1158/1538-7445.AM2024-1835
Published: 22 March 2024
View article titled, Abstract 1835: Discovery of HSN003839, a highly potent inhibitor of ubiquitin-specific protease USP21 for cancer therapy
Journal Articles

Abstract 1834: Discovery of a novel and highly selective PARP7 inhibitor for cancer immunotherapy

Xiaohui Liu, Ying Wang, Dongliang Xia, Wei Zhang, Shijie Tian, Yan He, Xuerong Feng, Xia Yang, Qi Zhang, Shiyi Jiang, Meifeng Wu, Jianfeng Deng, Yeye Wang, Yuxi Su, Min Yao, Weijiao Yuan, Xuedan You
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1834.
https://doi.org/10.1158/1538-7445.AM2024-1834
Published: 22 March 2024
View article titled, Abstract 1834: Discovery of a novel and highly selective PARP7 inhibitor for cancer immunotherapy
Journal Articles

Abstract 2650: IGFBP2 assists EGFRvIII-positive glioblastoma to evade immune elimination

Jikang Fan, Xisen Wang, Tao Li, Xuejun Yang, Wei Zhang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2650.
https://doi.org/10.1158/1538-7445.AM2024-2650
Published: 22 March 2024
View article titled, Abstract 2650: IGFBP2 assists EGFRvIII-positive glioblastoma to evade immune elimination
Journal Articles

Abstract 1749: Esophageal adenocarcinoma single-cell resolution ecotypes and subtypes mediate chemoradiation resistance

Rui Ye, Yawei Qiao, Shanshan Bai, Emi Sei, Min Hu, Jianzhong He, Nan Li, Yifan Wang, Pablo Lopez, Wei Zhang, Fei Ye, Brian Weston, Emmanuel Coronel, William Ross, Phillip Ge, Bhutani Manoop, Nicholas Navin, Steven Lin
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1749.
https://doi.org/10.1158/1538-7445.AM2024-1749
Published: 22 March 2024
View article titled, Abstract 1749: Esophageal adenocarcinoma single-cell resolution ecotypes and subtypes mediate chemoradiation resistance
Journal Articles

Abstract 99: Versican regulates T cell abundance within the colorectal cancer microenvironment

Sean Kraus, Philip Emmerich, Mitch Hayes, Kristina Matkowskyj, Wei Zhang, Cheri Pasch, Fotis Asimakopoulos, Dustin A. Deming
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 99.
https://doi.org/10.1158/1538-7445.AM2024-99
Published: 22 March 2024
View article titled, Abstract 99: Versican regulates T cell abundance within the colorectal cancer microenvironment
Journal Articles

Abstract 6126: Understanding disparities in lung cancer using single cell RNA sequencing data transformed by the Gerchberg Saxton algorithm

Seha Ay, Liang Liu, Elizabeth Forbes, Umit Topaloglu, Wei Zhang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6126.
https://doi.org/10.1158/1538-7445.AM2024-6126
Published: 22 March 2024
View article titled, Abstract 6126: Understanding disparities in lung cancer using single cell RNA sequencing data transformed by the Gerchberg Saxton algorithm
Journal Articles

Abstract 5646: Altered intronic polyadenylation by mutant p53 impairs transcription of DNA repair genes in lung cancer

Liang Liu, Elizabeth Forbes, Wei Zhang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5646.
https://doi.org/10.1158/1538-7445.AM2024-5646
Published: 22 March 2024
View article titled, Abstract 5646: Altered intronic polyadenylation by mutant p53 impairs transcription of DNA repair genes in lung cancer
Journal Articles

Abstract 2113: HMPL-506, a novel, highly potent and differentiated menin-MLL inhibitor for the treatment of MLL-rearrangedand NPM1mutant acute leukemia in preclinical models

Min Cheng, Liang Ge, Zhihu Gao, Zeyu Zhong, An Jiang, Wei Zhang, Jia Hu, Shuwen Jiang, Na Li, Na Yang, Jian Wang, Yang Sai, Weiguo Qing, Yongxin Ren, Weiguo Su
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2113.
https://doi.org/10.1158/1538-7445.AM2024-2113
Published: 22 March 2024
View article titled, Abstract 2113: HMPL-506, a novel, highly potent and differentiated menin-MLL inhibitor for the treatment of <em>MLL-rearranged</em>and <em>NPM1</em>mutant acute leukemia in preclinical models
Journal Articles

Abstract 5940: JAB-30355: A highly potent, orally bioavailable p53-Y220C reactivator

Qian Zheng, Peng Wang, Chen Liang, Yao Li, Xin Sun, Amin Li, Wei Zhang, Wei Long, Yanping Wang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5940.
https://doi.org/10.1158/1538-7445.AM2024-5940
Published: 22 March 2024
View article titled, Abstract 5940: JAB-30355: A highly potent, orally bioavailable p53-Y220C reactivator
Journal Articles

Abstract A006: Reckless mitotic entry as a novel chemosensitization approach for alkylating agents

Fengchao Lang, James Cornwell, Karambir Kaur, Omar Elmogazy, Wei Zhang, Meili Zhang, Hua Song, Zhonghe Sun, Xiaolin Wu, Mirit I. Aladjem, Michael Aregger, Steven Cappell, Chunzhang Yang
Journal: Cancer Research
Cancer Res (2024) 84 (5_Supplement_1): A006.
https://doi.org/10.1158/1538-7445.BRAIN23-A006
Published: 04 March 2024
View article titled, Abstract A006: Reckless mitotic entry as a novel chemosensitization approach for alkylating agents
Journal Articles

DPP9 Stabilizes NRF2 to Suppress Ferroptosis and Induce Sorafenib Resistance in Clear Cell Renal Cell Carcinoma

Kun Chang, Yingji Chen, Xuanzhi Zhang, Wei Zhang, Ning Xu, Bohan Zeng, Yue Wang, Tao Feng, Bo Dai, Fujiang Xu, Dingwei Ye, Chenji Wang
Journal: Cancer Research
Cancer Res (2023) 83 (23): 3940–3955.
https://doi.org/10.1158/0008-5472.CAN-22-4001
Published: 01 December 2023
View article titled, DPP9 Stabilizes NRF2 to Suppress Ferroptosis and Induce Sorafenib Resistance in Clear Cell Renal Cell Carcinoma
Open the PDF for DPP9 Stabilizes NRF2 to Suppress Ferroptosis and Induce Sorafenib Resistance in Clear Cell Renal Cell Carcinoma in another window
Includes: Supplementary data