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Journal Articles

Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor–Ligand Interactions That Instructs Intratumoral γδT-cell Activity

Xiaolin Wang, Hui Wang, Zhengjing Lu, Xiangjun Liu, Wenjia Chai, Wei Wang, Jun Feng, Shen Yang, Wei Yang, Haiyan Cheng, Chenghao Chen, Shihan Zhang, Nian Sun, Qiaoyin Liu, Qiliang Li, Wenqi Song, Fang Jin, Qi Zeng, Shengcai Wang, Yan Su, Huanmin Wang, Xin Ni, Jingang Gui
Journal: Cancer Research
Cancer Res (2025) 85 (2): 277–298.
https://doi.org/10.1158/0008-5472.CAN-24-1509
Published: 15 January 2025
View article titled, Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor–Ligand Interactions That Instructs Intratumoral γδT-cell Activity
Open the PDF for Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor–Ligand Interactions That Instructs Intratumoral γδT-cell Activity in another window
Includes: Supplementary data
Journal Articles

CircRREB1 Mediates Metabolic Reprogramming and Stemness Maintenance to Facilitate Pancreatic Ductal Adenocarcinoma Progression

Zeyin Rong, Jin Xu, Jianhui Yang, Wei Wang, Rong Tang, Zifeng Zhang, Zhen Tan, Qingcai Meng, Jie Hua, Jiang Liu, Bo Zhang, Chen Liang, Xianjun Yu, Si Shi
Journal: Cancer Research
Cancer Res (2024) 84 (24): 4246–4263.
https://doi.org/10.1158/0008-5472.CAN-23-3596
Published: 16 December 2024
View article titled, CircRREB1 Mediates Metabolic Reprogramming and Stemness Maintenance to Facilitate Pancreatic Ductal Adenocarcinoma Progression
Open the PDF for CircRREB1 Mediates Metabolic Reprogramming and Stemness Maintenance to Facilitate Pancreatic Ductal Adenocarcinoma Progression in another window
Includes: Supplementary data
Journal Articles

Abstract PO3-15-01: Overexpression of N-glycosylation related gene OST4 promotes chemotherapy resistance in triple-negative breast cancer

Wei Wang, Deyue Liu, Shuning Ding, Yan Fang, Jiayi Wu, Li Zhu
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO3-15-01.
https://doi.org/10.1158/1538-7445.SABCS23-PO3-15-01
Published: 02 May 2024
View article titled, Abstract PO3-15-01: Overexpression of N-glycosylation related gene OST4 promotes chemotherapy resistance in triple-negative breast cancer
Journal Articles

Abstract PO1-27-01: Comparing the Efficacy and Safety of TQB2440 versus the Reference Pertuzumab for the Treatment of HER2-Positive Early or Locally Advanced Breast Cancer: A Multicenter, Randomized, Double-Blind, Parallel-Controlled Phase 3 Trial

Qingyuan Zhang, Shusen Wang, Nanlin Li, Qiao Cheng, Yu ren, Xuchen Cao, Jianjun Huang, Caigang Liu, Hongwei Yang, Limin Wei, Zhangjun Song, Huadong Zhao, Fangling Ning, Xiaojia Wang, Dehong Zou, Xiaohua Zeng, Jie Hao, Yunjiang Liu, Huijuan Wang, Nie Jianyun, Liang Li, Lina Liu, Tao Sun, Xiaobo Hu, Zhenhua Zhai, Huihua Xiong, Yuanqi Zhang, Enxiang Zhou, Jing Sun, Zhenhai Cai, Antai Zhang, Shui Wang, Junyang Mo, Qun Su, Xiuheng Qi, Guoren Zhou, Shuqun Zhang, Guozhong Cui, Wei Wang, Mingjiang Fan, Xinyu Qian, Xinhong Wu, Zhihong Wang, Jiuda Zhao, Yonghui Luo, Yanming Zhang, Fuguo Tian, Jiye Zhang, Dongning Chai, Qingshan Li
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO1-27-01.
https://doi.org/10.1158/1538-7445.SABCS23-PO1-27-01
Published: 02 May 2024
View article titled, Abstract PO1-27-01: Comparing the Efficacy and Safety of TQB2440 versus the Reference Pertuzumab for the Treatment of HER2-Positive Early or Locally Advanced Breast Cancer: A Multicenter, Randomized, Double-Blind, Parallel-Controlled Phase 3 Trial
Journal Articles

Abstract PO5-18-09: Anthracycline-free neoadjuvant therapy with nab-paclitaxel and carboplatin in non-luminal breast cancer: a single-arm phase II trial

Deyue Liu, Li Zhu, Jiayi Wu, Wei Wang, Shuning Ding
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO5-18-09.
https://doi.org/10.1158/1538-7445.SABCS23-PO5-18-09
Published: 02 May 2024
View article titled, Abstract PO5-18-09: Anthracycline-free neoadjuvant therapy with nab-paclitaxel and carboplatin in non-luminal breast cancer: a single-arm phase II trial
Journal Articles

Abstract CT247: Updated efficacy and safety of anti-TROP2 ADC SKB264 (MK-2870) for previously treated advanced NSCLC in Phase 2 study

Wenfeng Fang, Ying Cheng, Zhendong Chen, Wei Wang, Yongsheng Li, Yongmei Yin, Xingya Li, Huiting Xu, Guohua Yu, Yanjun Mi, Zev A. Wainberg, Jordi Rodon, Xiang Wang, Xian Wang, Xiaoqing Zhang, Xiaoping Jin, Lian Lu, Junyou Ge, Jin Li, Li Zhang
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT247.
https://doi.org/10.1158/1538-7445.AM2024-CT247
Published: 05 April 2024
View article titled, Abstract CT247: Updated efficacy and safety of anti-TROP2 ADC SKB264 (MK-2870) for previously treated advanced NSCLC in Phase 2 study
Journal Articles

Abstract CT227: Anti-LAG-3 antibody LBL-007 in combination with anti-PD-1 antibody toripalimab, in patients with advanced malignant tumors: A phase Ib/II, open-label, multicenter, dose escalation/expansion study

Yunpeng Yang, Yuanyuan Zhao, Wenfeng Fang, Yan Huang, Yaxiong Zhang, Yi Ba, Zhen Wang, Chao Deng, Desheng Hu, Wei Wang, Guiling Li, Suxia Luo, Zhichao Fu, Haisheng Zhu, Huili Wang, Shiwei Zhao, Tao Li, Charles Cai, Li Zhang
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT227.
https://doi.org/10.1158/1538-7445.AM2024-CT227
Published: 05 April 2024
View article titled, Abstract CT227: Anti-LAG-3 antibody LBL-007 in combination with anti-PD-1 antibody toripalimab, in patients with advanced malignant tumors: A phase Ib/II, open-label, multicenter, dose escalation/expansion study
Journal Articles

Abstract LB448: VBC103: An innovative Trop2/Nectin4 targeted bispecific antibody drug conjugate (ADC) in bladder urothelial carcinoma (UC), triple-negative breast cancer (TNBC) and beyond

Wei Wang, Jing Li, Lingyu Guan, Man Xu, Qun Yin
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB448.
https://doi.org/10.1158/1538-7445.AM2024-LB448
Published: 05 April 2024
View article titled, Abstract LB448: VBC103: An innovative Trop2/Nectin4 targeted bispecific antibody drug conjugate (ADC) in bladder urothelial carcinoma (UC), triple-negative breast cancer (TNBC) and beyond
Journal Articles

Abstract 7279: Discovery of SHR1127, an orally bioavailable, highly potent and selective KRAS G12D inhibitor

Xin Li, Feng Shen, Limin Zhang, Wei Wang, Luyao Kong, Yong Bao, Yuchang Mao, Zaiyong Wang, Sophie Lin, Zhe Zhang, Jun Feng, Min Hu, Feng He
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7279.
https://doi.org/10.1158/1538-7445.AM2024-7279
Published: 22 March 2024
View article titled, Abstract 7279: Discovery of SHR1127, an orally bioavailable, highly potent and selective KRAS G12D inhibitor
Journal Articles

Abstract 678: Experimental therapy of triple negative breast cancer with next-generation of MDM2 inhibitors

Wei Wang, Hao Chen, Yang Xie, Sayantap Datta, Wei Li, Ruiwen Zhang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 678.
https://doi.org/10.1158/1538-7445.AM2024-678
Published: 22 March 2024
View article titled, Abstract 678: Experimental therapy of triple negative breast cancer with next-generation of MDM2 inhibitors
Journal Articles

Abstract 676: The integrated stress activator BTM-3566 overcomes therapeutic resistance in mantle cell lymphoma

Yang Liu, Heng-Huan Lee, Joseph McIntosh, Yijing Li, Tianci Zhang, Wei Wang, Matthew J. Kostura, Michael Wang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 676.
https://doi.org/10.1158/1538-7445.AM2024-676
Published: 22 March 2024
View article titled, Abstract 676: The integrated stress activator BTM-3566 overcomes therapeutic resistance in mantle cell lymphoma
Journal Articles

Abstract 1693: Mitochondrial-associated DNAJA3 variant and its role in NASH-driven hepatocellular carcinoma

Yuto Shiode, Ching-Wen Chang, Xin Wei Wang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1693.
https://doi.org/10.1158/1538-7445.AM2024-1693
Published: 22 March 2024
View article titled, Abstract 1693: Mitochondrial-associated DNAJA3 variant and its role in NASH-driven hepatocellular carcinoma
Journal Articles

Abstract 4380: Role of kindlin-2 in prostate cancer progression and metastasis

Lamyae El Khalki, Wei Wang, Neelum A. Yousaf Zai, Justin Szpendyk, Elzbieta Pluskota, Katarzyna Bialkowska, Edward F. Plow, Lucia R. Languino, Dario C. Altieri, Khalid Sossey-Alaoui
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4380.
https://doi.org/10.1158/1538-7445.AM2024-4380
Published: 22 March 2024
View article titled, Abstract 4380: Role of kindlin-2 in prostate cancer progression and metastasis
Journal Articles

Abstract 5728: YB1 is a novel therapeutic for the treatment of triple negative breast cancer tumors

Wei Wang, Lamyae El Khalki, Neelum Yousaf Zai, Justin Szpendyk, Akram Alkrekshi, Bin Su, Khalid Sossey-Alaoui
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5728.
https://doi.org/10.1158/1538-7445.AM2024-5728
Published: 22 March 2024
View article titled, Abstract 5728: YB1 is a novel therapeutic for the treatment of triple negative breast cancer tumors
Journal Articles

Abstract 4381: Role of Kindlin-2 in the regulation of integrins and TBR1 signaling in TNBC

Neelum A. Yousaf Zai, Lamyae El Khalki, Wei Wang, Justin Szpendyk, Khalid Sossey-Alaoui
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4381.
https://doi.org/10.1158/1538-7445.AM2024-4381
Published: 22 March 2024
View article titled, Abstract 4381: Role of Kindlin-2 in the regulation of integrins and TBR1 signaling in TNBC
Journal Articles

Targeting WNT/β-Catenin via Modulating EZH2 Function: A New Chapter in the Treatment of β-Catenin Mutant Hepatocellular Carcinoma?

Man Hsin Hung, Xin Wei Wang
Journal: Cancer Research
Cancer Res (2023) 83 (21): 3498–3500.
https://doi.org/10.1158/0008-5472.CAN-23-2921
Published: 01 November 2023
View article titled, Targeting WNT/β-Catenin via Modulating EZH2 Function: A New Chapter in the Treatment of β-Catenin Mutant Hepatocellular Carcinoma?
Open the PDF for Targeting WNT/β-Catenin via Modulating EZH2 Function: A New Chapter in the Treatment of β-Catenin Mutant Hepatocellular Carcinoma? in another window
Journal Articles

Abstract 2293: Tumor-informed fixed and patient-specific panels for minimal residual disease (MRD) detection in early-stage NSCLC:a head-to-head comparison

Pengpeng Zhang, Zetian Gong, Yue Yu, Xiaoxuan Wang, Lei Ye, Xiaoqiang Wang, Xuan Tang, Chao Zhang, Wanglong Deng, Chao Song, Qing Xu, Yansong Li, Wei Wang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2293.
https://doi.org/10.1158/1538-7445.AM2023-2293
Published: 04 April 2023
View article titled, Abstract 2293: Tumor-informed fixed and patient-specific panels for minimal residual disease (MRD) detection in early-stage NSCLC:a head-to-head comparison
Journal Articles

Abstract 6611: Harnessing the power of multiomics from a single sample to explore tumor heterogeneity and advancing immuno-oncology research

Bhagyashree S. Birla, Andrea O'Hara, Elizabeth Louie, Ben Niu, Haythem Latif, Vanessa Tumilasci, Yang Han, Yongjun Fan, David Corney, Pranay Vishwanath, Wei Wang, Alfredo Staffa, Ilaria DeVito, Laure Turner, Chris Mozdzierz, Peter Nowacki, Ginger Zhou
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6611.
https://doi.org/10.1158/1538-7445.AM2023-6611
Published: 04 April 2023
View article titled, Abstract 6611: Harnessing the power of multiomics from a single sample to explore tumor heterogeneity and advancing immuno-oncology research
Journal Articles

Abstract 1404: A functional genetic polymorphism of mitochondrion-associated DNAJA3 in nonalcoholic steatohepatitis-related hepatocellular carcinoma

Yuto Shiode, Ching-Wen Chang, Xin Wei Wang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1404.
https://doi.org/10.1158/1538-7445.AM2023-1404
Published: 04 April 2023
View article titled, Abstract 1404: A functional genetic polymorphism of mitochondrion-associated DNAJA3 in nonalcoholic steatohepatitis-related hepatocellular carcinoma
Journal Articles

Abstract 2786: Targeting oncogene and inflammation for cancer therapy

Wei Wang, Sayantap Datta, Sadanandan E. Velu, Ming Luo, Ruiwen Zhang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2786.
https://doi.org/10.1158/1538-7445.AM2023-2786
Published: 04 April 2023
View article titled, Abstract 2786: Targeting oncogene and inflammation for cancer therapy