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Wei Huang
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Journal Articles

Abstract 1847: Closed-loop drug delivery system to personalize chemotherapy dosing

Louis DeRidder, Kyle Hare, Ted Smierciak, Mia Chao, Aaron Lopes, Josh Jenkins, Nina Fitzgerald, Emmeline MacPherson, Niora Fabian, Josh Morimoto, Jacqueline Chu, Ameya Kirtane, Wiam Madani, Keiko Ishida, Johannes Kuosmanen, Naomi Zecharias, Christopher Colangelo, Hen-Wei Huang, Makaya Chilekwa, Nikhil Lal, Shriya Srinivasan, Alison Hayward, Brian Wolpin, David Trumper, Troy Quast, Douglas Rubinson, Robert Langer, Giovanni Traverso
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 1847.
https://doi.org/10.1158/1538-7445.AM2025-1847
Published: 21 April 2025
View articletitled, Abstract 1847: Closed-loop drug delivery system to personalize chemotherapy dosing
Journal Articles

Abstract 4319: Loss of Golga7 suppresses oncogenic Nras-driven leukemogenesis without detectable toxicity in adult mice

Bo Jiao, Lei Yan, Rui Zhang, Wei Huang, Xinru Wang, Ping Liu, Ruibao Ren
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4319.
https://doi.org/10.1158/1538-7445.AM2025-4319
Published: 21 April 2025
View articletitled, Abstract 4319: Loss of Golga7 suppresses oncogenic Nras-driven leukemogenesis without detectable toxicity in adult mice
Journal Articles

Mutant PP2A Induces IGFBP2 Secretion to Promote Development of High-Grade Uterine Cancer

Terrance J. Haanen, III, Sophie Boock, Catherine G. Callahan, Irene Peris, Kaitlin P. Zawacki, Brynne Raines, Charles A. Nino, Brian Tran, Alexis Harold, Gabrielle Hodges Onishi, Matthew Hinderman, Amanda Dowdican, Wei Huang, Derek J. Taylor, Sarah E. Taylor, Mark W. Jackson, Analisa DiFeo, Caitlin M. O’Connor, Goutham Narla
Journal: Cancer Research
Cancer Res (2025) 85 (3): 442–461.
https://doi.org/10.1158/0008-5472.CAN-24-1263
Published: 01 February 2025
View articletitled, Mutant PP2A Induces IGFBP2 Secretion to Promote Development of High-Grade Uterine Cancer
Open the PDF for Mutant PP2A Induces IGFBP2 Secretion to Promote Development of High-Grade Uterine Cancer in another window
Includes: Supplementary data
Journal Articles

Physical Activity Decreases Inflammation and Delays the Development of Obesity-Associated Pancreatic Ductal Adenocarcinoma

Valentina Pita-Grisanti, Ericka Velez-Bonet, Kaylin Chasser, Zachary Hurst, Alexus Liette, Grace Vulic, Kelly Dubay, Ali Lahooti, Niharika Badi, Olivia Ueltschi, Kristyn Gumpper-Fedus, Hsiang-Yin Hsueh, Ila Lahooti, Myrriah Chavez-Tomar, Samantha Terhorst, Sue E. Knoblaugh, Lei Cao, Wei Huang, Christopher C. Coss, Thomas A. Mace, Fouad Choueiry, Alice Hinton, Stacey Culp, Jennifer M. Mitchell, Rosemarie Schmandt, Michaela Onstad Grinsfelder, Karen Basen-Engquist, Zobeida Cruz-Monserrate
Journal: Cancer Research
Cancer Res (2024) 84 (18): 3058–3071.
https://doi.org/10.1158/0008-5472.CAN-23-1045
Published: 16 September 2024
View articletitled, Physical Activity Decreases Inflammation and Delays the Development of Obesity-Associated Pancreatic Ductal Adenocarcinoma
Open the PDF for Physical Activity Decreases Inflammation and Delays the Development of Obesity-Associated Pancreatic Ductal Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract PO4-04-07: Efficacy, safety and translational study of pyrotinib combined with albumin-bound paclitaxel as firstline treatment of HER-2 positive metastatic breast cancer

Huihui Li, Xiaochu Man, Sha Yin, Dongdong Zhou, Baoxuan Zhang, Shu Fang, Fangchao Zheng, Chao Li, Xinzhao Wang, Wei Huang, Linlin Wang, Qingqing He, Hui Fu, Yan Zhang, Changrui Liu, Lin Dong, Xianguang Zhao, Liang Xu, Xiao Sun, Bingjie Fan, Lihua Song, Zhengbo Zhou, Qiaorui Tan, Jinming Yu
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO4-04-07.
https://doi.org/10.1158/1538-7445.SABCS23-PO4-04-07
Published: 02 May 2024
View articletitled, Abstract PO4-04-07: Efficacy, safety and translational study of pyrotinib combined with albumin-bound paclitaxel as firstline treatment of HER-2 positive metastatic breast cancer
Journal Articles

Abstract PO2-01-01: Biophysical simulation using DCE-MRI to forecast response to NAT in HER2+ patients, with glucose characterization and orthogonal validation using FDG-PET

John Whitman, Vikram Adhikarla, Russell Rockne, Lusine Tumyan, Joanne Mortimer, Wei Huang, Joseph Peterson, Dorys Lopez-Ramos, John Cole
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO2-01-01.
https://doi.org/10.1158/1538-7445.SABCS23-PO2-01-01
Published: 02 May 2024
View articletitled, Abstract PO2-01-01: Biophysical simulation using DCE-MRI to forecast response to NAT in HER2+ patients, with glucose characterization and orthogonal validation using FDG-PET
Journal Articles

Abstract PO3-26-09: A novel class of RNR inhibitors that induces genomic instability and breast cancer cell death without inducing overt toxicities

Taylor Baker, Kristen Weber-Bonk, Wei Huang, Derek Taylor, Ruth Keri
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO3-26-09.
https://doi.org/10.1158/1538-7445.SABCS23-PO3-26-09
Published: 02 May 2024
View articletitled, Abstract PO3-26-09: A novel class of RNR inhibitors that induces genomic instability and breast cancer cell death without inducing overt toxicities
Journal Articles

Abstract 1175: Differential patterns of immune infiltration in the tumor immune microenvironment associate with therapeutic response in primary prostate cancer following chemohormonal therapy

Erika Heninger, Jamie M. Sperger, Kristin Weinstein, Brian P. Johnson, Peter G. Geiger, Shane Wells, Steve Y. Cho, Wei Huang, Philippos Tsourkas, Sean McIlwain, Irene M. Ong, Sheena C. Kerr, David F. Jarrard, David J. Beebe, Joshua M. Lang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1175.
https://doi.org/10.1158/1538-7445.AM2024-1175
Published: 22 March 2024
View articletitled, Abstract 1175: Differential patterns of immune infiltration in the tumor immune microenvironment associate with therapeutic response in primary prostate cancer following chemohormonal therapy
Journal Articles

Abstract 3384: Rapid and automated tumor cell phenotyping based on annexin-mediated enforce blebbing response

Wei Huang, Zheng Wang, Dennis Wai-Yin Au, Bingxian Tang, Baiqian Qi, William C. Cho, Yuan Lin
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3384.
https://doi.org/10.1158/1538-7445.AM2024-3384
Published: 22 March 2024
View articletitled, Abstract 3384: Rapid and automated tumor cell phenotyping based on annexin-mediated enforce blebbing response
Journal Articles

Abstract 3913: Molecular mechanism of action and targets of glucocorticoids in lymphoma therapy

Jaewoo Choi, Michele Ceribelli, James D. Phelan, Björn Häupl, Da Wei Huang, George W. Wright, Tony Hsiao, Vivian Morris, Francesco Ciccarese, Boya Wang, Sean Corcoran, Sebastian Scheich, Xin Yu, Weihong Xu, Yandan Yang, Hong Zhao, Joyce Zhou, Grace Zhang, Jagan Muppidi, Giorgio Ga Inghirami, Thomas Oellerich, Craig J. Thomas, Wyndham H. Wilson, Louis M. Staudt
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3913.
https://doi.org/10.1158/1538-7445.AM2024-3913
Published: 22 March 2024
View articletitled, Abstract 3913: Molecular mechanism of action and targets of glucocorticoids in lymphoma therapy
Journal Articles

Abstract A024: DCE-MRI-based biophysical simulation to forecast NAT response in HER2+ breast cancer patients, with glucose characterization and orthogonal validation using FDG-PET and 64Cu studies

John Whitman, Vikram Adhikarla, Russell Rockne, Lusine Tumyan, Joanne Mortimer, Wei Huang, Dorys Lopez Ramos, Joseph R. Peterson, John A. Cole
Journal: Cancer Research
Cancer Res (2024) 84 (3_Supplement_1): A024.
https://doi.org/10.1158/1538-7445.ADVBC23-A024
Published: 01 February 2024
View articletitled, Abstract A024: DCE-MRI-based biophysical simulation to forecast NAT response in HER2+ breast cancer patients, with glucose characterization and orthogonal validation using FDG-PET and 64Cu studies
Journal Articles

Abstract B053: Physical activity regulates targetable transcriptomic changes in the adipose tissue of obese PDAC mice

Hsiang-Yin Hsueh, Valentina Pita-Grisanti, Ericka Vélez-Bonet, Lei Cao, Wei Huang, Zobeida Cruz-Monserrate
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): B053.
https://doi.org/10.1158/1538-7445.PANCA2023-B053
Published: 16 January 2024
View articletitled, Abstract B053: Physical activity regulates targetable transcriptomic changes in the adipose tissue of obese PDAC mice
Journal Articles

Abstract PR009: SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion

Giuseppe Leuzzi, Alessandro Vasciaveo, Angelo Taglialatela, Xiao Chen, Tessa M. Firestone, Allison R. Hickman, Wendy Mao, Tanay Thakar, Alina Vaitsiankova, Jen-Wei Huang, Raquel Cuella-Martin, Samuel B. Hayward, Jordan S. Kesner, Ali Ghasemzadeh, Tarun S. Nambiar, Patricia Ho, Alexander Rialdi, Maxime Hebrard, Yinglu Li, Jinmei Gao, Saarang Gopinath, Oluwatobi A. Adeleke, Bryan Venters, Charles G. Drake, Richard Baer, Benjamin Izar, Ernesto Guccione, Michael-Christopher Keogh, Raphael Guerois, Lu Sun, Chao Lu, Andrea Califano, Alberto Ciccia
Journal: Cancer Research
Cancer Res (2024) 84 (1_Supplement): PR009.
https://doi.org/10.1158/1538-7445.DNAREPAIR24-PR009
Published: 09 January 2024
View articletitled, Abstract PR009: SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion
Journal Articles

Abstract LB338: A novel class of T cell-activators targeting germline encoded TCRβ chains promotes antitumor activity in PD1-refractory models through expansion of a clonally enriched effector memory T cell subset

Jacques Moisan, Madan Katraggada, Jonathan Hsu, Jessica Lowry, Wei Huang, Jian Tang, Roya Servattalab, Gurkan Guntas, Raj Chopra, Zhen Su, Andrew Bayliffe
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB338.
https://doi.org/10.1158/1538-7445.AM2023-LB338
Published: 14 April 2023
View articletitled, Abstract LB338: A novel class of T cell-activators targeting germline encoded TCRβ chains promotes antitumor activity in PD1-refractory models through expansion of a clonally enriched effector memory T cell subset
Journal Articles

Abstract 5408: AI powered-platform to predict gene modifications from prostate and breast cancer whole slide images

Wei Huang, Parag Jain, Chensu Xie, Hassan Muhammad, Hirak Basu, George Wilding, Rajat Roy
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5408.
https://doi.org/10.1158/1538-7445.AM2023-5408
Published: 04 April 2023
View articletitled, Abstract 5408: AI powered-platform to predict gene modifications from prostate and breast cancer whole slide images
Journal Articles

Abstract 4491: TY-0584: A potent, orally available small molecule YAP/TEAD inhibitor, exhibits anti-tumor effects in vitro and in vivo

Apeng Liang, Shengli Dong, Guangbin Liu, Zhengfei Guo, Meihua Li, Shuaibo Han, Yundi Cao, Yian Tu, Chao Zhou, Yu Yu, Linglin Xiao, Wei Huang, Xinlong Yang, Lian Fang, Haoyun Li, Chengshan Niu, Mingyu Jiang, Feng Xing, Shaoqing Chen, Jun Li, Yusheng Wu
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4491.
https://doi.org/10.1158/1538-7445.AM2023-4491
Published: 04 April 2023
View articletitled, Abstract 4491: TY-0584: A potent, orally available small molecule YAP/TEAD inhibitor, exhibits anti-tumor effects in vitro and in vivo
Journal Articles

Abstract 3636: Liver endothelium secreted LRG1 promotes metastatic colorectal cancer growth through the HER3/RSK/EIF4B AXIS

Moeez Ghani Rathore, Michelle Wright, Wei Huang, Derek Taylor, Yamu Li, Jordan Winter, Zhenghe Wang, John Greenwood, Stephen Moss, Rui Wang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3636.
https://doi.org/10.1158/1538-7445.AM2023-3636
Published: 04 April 2023
View articletitled, Abstract 3636: Liver endothelium secreted LRG1 promotes metastatic colorectal cancer growth through the HER3/RSK/EIF4B AXIS
Journal Articles

Abstract 477: Discovery of RGT-018: A potent, selective and orally bioavailable SOS1 inhibitor for mutant KRAS-driven cancers

Fei Xiao, Kailiang Wang, Xinjuan Wang, Huijuan Li, Zhilong Hu, Wei Huang, Xiaoming Ren, Teng Feng, Lili Yao, Jing Lin, Chunlai Li, Liufeng Mei, Zhuanzhuan Zhang, Yangyang Liu, Xi Chen, Xiaotian Zhu, Wenge Zhong, Zhi Xie
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 477.
https://doi.org/10.1158/1538-7445.AM2023-477
Published: 04 April 2023
View articletitled, Abstract 477: Discovery of RGT-018: A potent, selective and orally bioavailable SOS1 inhibitor for mutant KRAS-driven cancers
Journal Articles

Abstract P6-01-18: Predicting response of triple negative breast cancer to neoadjuvant chemotherapy using a deep convolutional neural network-based artificial intelligence tool

Savitri Krishnamurthy, Parag Jain, Debu Tripathy, Hassan Muhammad, Wei huang, Hua Yang, Shivaani Kummar, George Wilding, Rajat Roy, Ramandeep Randhawa
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P6-01-18.
https://doi.org/10.1158/1538-7445.SABCS22-P6-01-18
Published: 01 March 2023
View articletitled, Abstract P6-01-18: Predicting response of triple negative breast cancer to neoadjuvant chemotherapy using a deep convolutional neural network-based artificial intelligence tool
Journal Articles

Abstract 5461: H002: A wide spectrum, highly selective fourth-generation EGFR inhibitor overcoming resistance harboring C797S mutation in NSCLC

Wei Huang, Lin Zhu, Xiaoe Yan, Xin Huang, Jia Hao, Shan Li, Xiangyu Li, Zhiming Chen, Yunchuan Jia, Haibo Li, Jianming Zhang, Xianming Deng, Caihong Yun
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5461.
https://doi.org/10.1158/1538-7445.AM2022-5461
Published: 15 June 2022
View articletitled, Abstract 5461: H002: A wide spectrum, highly selective fourth-generation EGFR inhibitor overcoming resistance harboring C797S mutation in NSCLC