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Journal Articles

Tumor-Derived Small Extracellular Vesicles Inhibit the Efficacy of CAR T Cells against Solid Tumors

Wenqun Zhong, Zebin Xiao, Zhiyuan Qin, Jingbo Yang, Yi Wen, Ziyan Yu, Yumei Li, Neil C. Sheppard, Serge Y. Fuchs, Xiaowei Xu, Meenhard Herlyn, Carl H. June, Ellen Puré, Wei Guo
Journal: Cancer Research
Cancer Res (2023) 83 (16): 2790–2806.
https://doi.org/10.1158/0008-5472.CAN-22-2220
Published: 15 August 2023
View article titled, Tumor-Derived Small Extracellular Vesicles Inhibit the Efficacy of CAR T Cells against Solid Tumors
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Includes: Supplementary data
Journal Articles

Abstract CT017: Pan-mutant and isoform selective PI3Kα inhibitor, RLY-2608, demonstrates selective targeting in a first-in-human study of PIK3CA-mutant solid tumor patients, ReDiscover trial

Andreas Varkaris, Komal Jhaveri, Cesar A. Perez, Janice S. Kim, Jason T. Henry, Vivek Subbiah, Alexander I. Spira, Lucía Sanz Gómez, Angel I. Guerrero-Zotano, Kari B. Wisinski, Xiaoyan Li, Gege Tan, Ramin Samadani, Tamieka Lauz Hunter, Wei Guo, Alison Timm, Djuro Karanovic, Beni B. Wolf, Erika P. Hamilton, Alison M. Schram
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT017.
https://doi.org/10.1158/1538-7445.AM2023-CT017
Published: 29 May 2023
View article titled, Abstract CT017: Pan-mutant and isoform selective PI3Kα inhibitor, RLY-2608, demonstrates selective targeting in a first-in-human study of <em>PIK3CA-</em>mutant solid tumor patients, ReDiscover trial
Journal Articles

Abstract 112: Multi-omics analysis of molecular landscape and heterogeneity in fetal adenocarcinoma of the lung

Wei Guo, Li Sun, Xiaoxi Chen, Haitao Zhou, Shi Yan, Gang Zhao, Haimeng Tang, Hua Bao, Xue Wu, Yang Shao, Lin Lin
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 112.
https://doi.org/10.1158/1538-7445.AM2023-112
Published: 04 April 2023
View article titled, Abstract 112: Multi-omics analysis of molecular landscape and heterogeneity in fetal adenocarcinoma of the lung
Journal Articles

Abstract P4-08-02: LOXO-783: A potent, highly mutant selective and brain-penetrant allosteric PI3Kα H1047R inhibitor in combination with standard of care (SOC) treatments in preclinical PI3Kα H1047R-mutant breast cancer models

Loredana Puca, Michele S. Dowless, Carmen M. Perez-Ferreiro, Maria Jesus Ortiz-Ruiz, Gregory P. Donoho, Andrew Capen, Lysiane Huber, Sarah M. Bogner, Dongling Fei, Jason R. Manro, Chun Ping Yu, Wei Guo Xu, Rui Wang, Shuang Chen, Mark A. Hicks, Parisa Zolfaghari, Andrew Faber, Raymond Gilmour, Monica D. Ramstetter, Matthew T. Chang, Maria Jose Lallena, Xuequian Gong, David M. Hyman, Lillian M. Smyth, Barbara J. Brandhuber, Barry S. Taylor, Anke Klippel
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P4-08-02.
https://doi.org/10.1158/1538-7445.SABCS22-P4-08-02
Published: 01 March 2023
View article titled, Abstract P4-08-02: LOXO-783: A potent, highly mutant selective and brain-penetrant allosteric PI3Kα H1047R inhibitor in combination with standard of care (SOC) treatments in preclinical PI3Kα H1047R-mutant breast cancer models
Journal Articles

Abstract 5801: Xanthine oxidoreductase mediates the survival of starved lung adenocarcinoma cells by inducing UPR and autophagic degradation

Manman Chen, Wei Guo, Xiaozhen Guo, Cen Xie, Linghua Meng
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5801.
https://doi.org/10.1158/1538-7445.AM2022-5801
Published: 15 June 2022
View article titled, Abstract 5801: Xanthine oxidoreductase mediates the survival of starved lung adenocarcinoma cells by inducing UPR and autophagic degradation
Journal Articles

Abstract 5669: Distinct genetic features between osteosarcomas firstly metastasizing to bone and to lung

Lu Xie, Zhenyu Cai, Xiaodong Tang, Wei Guo, Fanfei Meng, Xin Zhang, Xiaoliang Shi, Fei Pang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5669.
https://doi.org/10.1158/1538-7445.AM2022-5669
Published: 15 June 2022
View article titled, Abstract 5669: Distinct genetic features between osteosarcomas firstly metastasizing to bone and to lung
Journal Articles

Abstract 5240: S-phase cyclinA associated protein in the ER(SCAPER)rs3812908 T>C promotes the nuclear translocation of CyclinA2 and enhances DNA damage repair in radioresistance of colorectal cancer

Hai-na Yu, Ting Jiang, Shuang Liu, Yan Yuan, Shao-yan Xi, Zhi-wei Guo, Yuan-hong Yuan, Yan Li, Wei-wei Xiao
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5240.
https://doi.org/10.1158/1538-7445.AM2022-5240
Published: 15 June 2022
View article titled, Abstract 5240: S-phase cyclinA associated protein in the ER(<em>SCAPER)</em>rs3812908 T&gt;C promotes the nuclear translocation of CyclinA2 and enhances DNA damage repair in radioresistance of colorectal cancer
Journal Articles

Abstract LB168: Platelet RNA signature enables early and accurate detection of ovarian cancer: An intercontinental, biomarker identification study

Yue Gao, Chun-Jie Liu, Hua-Yi Li, Xiao-Ming Xiong, Sjors G.j.g. In ‘t Veld, Gui-Ling Li, Jia-Hao Liu, Guang-Yao Cai, Gui-Yan Xie, Shao-Qing Zeng, Yuan Wu, Jian-Hua Chi, Qiong Zhang, Xiao-Fei Jiao, Lin-Li Shi, Wan-Rong Lu, Wei-Guo Lv, Xing-Sheng Yang, Jurgen M.j. Piek, Cornelis D de Kroon, C.a.r. Lok, Anna Supernat, Sylwia Łapińska-Szumczyk, Anna Łojkowska, Anna J. Żaczek, Jacek Jassem, Bakhos A. Tannous, Nik Sol, Edward Post, Myron G. Best, Bei-Hua Kong, Xing Xie, Ding Ma, Thomas Wurdinger, An-Yuan Guo, Qing-Lei Gao
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB168.
https://doi.org/10.1158/1538-7445.AM2022-LB168
Published: 15 June 2022
View article titled, Abstract LB168: Platelet RNA signature enables early and accurate detection of ovarian cancer: An intercontinental, biomarker identification study
Journal Articles

Correction: The EZH2-PHACTR2-AS1- Ribosome Axis Induces Genomic Instability and Promotes Growth and Metastasis in Breast Cancer

Wenhui Chu, Xi Zhang, Lihua Qi, Yenan Fu, Peng Wang, Wei Zhao, Juan Du, Jing Zhang, Jun Zhan, Yunling Wang, Wei-Guo Zhu, Yu Yu, Hongquan Zhang
Journal: Cancer Research
Cancer Res (2022) 82 (4): 735.
https://doi.org/10.1158/0008-5472.CAN-21-4346
Published: 15 February 2022
View article titled, Correction: The EZH2-PHACTR2-AS1- Ribosome Axis Induces Genomic Instability and Promotes Growth and Metastasis in Breast Cancer
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Journal Articles

Abstract 2332: Correlation of lifestyle factors with epigenetic aging unveiled in the practice of a DNA methylation-based age test

Wei Guo, Yap Ching Chew, Xiaojing Yang, Michiko Suwoto, Taikun Yamada, Xi Yu Jia
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 2332.
https://doi.org/10.1158/1538-7445.AM2020-2332
Published: 15 August 2020
View article titled, Abstract 2332: Correlation of lifestyle factors with epigenetic aging unveiled in the practice of a DNA methylation-based age test
Journal Articles

The EZH2–PHACTR2–AS1–Ribosome Axis induces Genomic Instability and Promotes Growth and Metastasis in Breast Cancer

Wenhui Chu, Xi Zhang, Lihua Qi, Yenan Fu, Peng Wang, Wei Zhao, Juan Du, Jing Zhang, Jun Zhan, Yunling Wang, Wei-Guo Zhu, Yu Yu, Hongquan Zhang
Journal: Cancer Research
Cancer Res (2020) 80 (13): 2737–2750.
https://doi.org/10.1158/0008-5472.CAN-19-3326
Published: 20 April 2020
View article titled, The EZH2–PHACTR2–AS1–Ribosome Axis induces Genomic Instability and Promotes Growth and Metastasis in Breast Cancer
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Journal Articles

ARRB1-Promoted NOTCH1 Degradation Is Suppressed by OncomiR miR-223 in T-cell Acute Lymphoblastic Leukemia

Yi Shu, Yi Wang, Wen-Qiong Lv, Dan-Yi Peng, Juan Li, Hang Zhang, Guang-Jie Jiang, Bi-Jie Yang, Shan Liu, Jia Zhang, Yan-Hua Chen, Shi Tang, Ke-Xing Wan, Jun-Tao Yuan, Wei Guo, Guo Fu, Xin-Kun Qi, Zhi-Dai Liu, Hai-Yan Liu, Chao Yang, Ling-Huan Zhang, Fang-Jie Liu, Jie Yu, Peng-Hui Zhang, Bin Qu, Hui Zhao, Tong-Chuan He, Lin Zou
Journal: Cancer Research
Cancer Res (2020) 80 (5): 988–998.
https://doi.org/10.1158/0008-5472.CAN-19-1471
Published: 02 March 2020
View article titled, ARRB1-Promoted NOTCH1 Degradation Is Suppressed by OncomiR miR-223 in T-cell Acute Lymphoblastic Leukemia
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Includes: Supplementary data
Journal Articles

Abstract 1028: Extracellular matrix dimensionality reduces cellular cortical tension to stimulate pro-survival signaling in mammary epithelial cells

FuiBoon Kai, Guanqing Ou, Alexandra Long, Wei Guo, Richard Tourdot, Ravi Radhakrishnan, Christopher Chen, Sophie Dumont, Valerie M. Weaver
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1028.
https://doi.org/10.1158/1538-7445.AM2019-1028
Published: 01 July 2019
View article titled, Abstract 1028: Extracellular matrix dimensionality reduces cellular cortical tension to stimulate pro-survival signaling in mammary epithelial cells
Journal Articles

Abstract 828: Accelerated epigenetic aging in bladder cancer patients

Yap Ching Chew, Wei Guo, Xiaojing Yang, Paolo Piatti, Mingda Jin, Keith Booher, Benjamin Jara, Xi-Yu Jia
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 828.
https://doi.org/10.1158/1538-7445.AM2019-828
Published: 01 July 2019
View article titled, Abstract 828: Accelerated epigenetic aging in bladder cancer patients
Journal Articles

Abstract 68: Comparative transcriptome analysis of primary tumor and matched tumor thrombus reveals that coagulation cascades activation contributes to the venous metastases of osteosarcoma

Tao Ji, Yifei Wang, Yi Guo, Dasen Li, Haijie Liang, Tingting Ren, Wei Guo
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 68.
https://doi.org/10.1158/1538-7445.AM2019-68
Published: 01 July 2019
View article titled, Abstract 68: Comparative transcriptome analysis of primary tumor and matched tumor thrombus reveals that coagulation cascades activation contributes to the venous metastases of osteosarcoma
Journal Articles

Abstract 4373: Lack of FGF21 promotes NASH-HCC transition via exosome-mediated carcinogenetic signaling

Youxi Yu, Robert C. Martin, Qianqian Zheng, Xiaoju Shi, Xingkai Liu, Wei Guo, Suping Li, Ping Zhang, Yan Li
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4373.
https://doi.org/10.1158/1538-7445.AM2019-4373
Published: 01 July 2019
View article titled, Abstract 4373: Lack of FGF21 promotes NASH-HCC transition via exosome-mediated carcinogenetic signaling
Journal Articles

Abstract 5162: Role of IFN-gamma-activation of distinct tumor and stromal cell populations in colorectal carcinoma pathogenesis

Nathalie Britzen-Laurent, Wei Guo, Victoria Langer, Svetlana Khoziainova, Thomas Weisenburger, Thomas H. Winkler, Julia Straube, Maximilian J. Waldner, Christoph Becker, Elisabeth Naschberger, Lisa Skottke, Tripal Philipp, Sergei Grivennikov, Michael Stürzl
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 5162.
https://doi.org/10.1158/1538-7445.AM2019-5162
Published: 01 July 2019
View article titled, Abstract 5162: Role of IFN-gamma-activation of distinct tumor and stromal cell populations in colorectal carcinoma pathogenesis
Journal Articles

Abstract 1515: NCOA3 promotes tumor growth by activating telomerase reverse transcriptase and predicts poor prognosis in hepatocellular carcinoma

Miao Chen, Wenbin Li, Yixin Li, Changlin Zhang, Ge Qin, Qian Long, Dingbo Shi, Wei Guo, Shuihan Shi, Kefang Zhang, Wuguo Deng
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1515.
https://doi.org/10.1158/1538-7445.AM2018-1515
Published: 01 July 2018
View article titled, Abstract 1515: NCOA3 promotes tumor growth by activating telomerase reverse transcriptase and predicts poor prognosis in hepatocellular carcinoma
Journal Articles

Abstract CT053: Preliminary safety, efficacy, and PK/PD characterization from GARNET, a phase 1 clinical trial of the anti-PD-1 monoclonal antibody, TSR-042, in patients with recurrent or advanced NSCLC and MSI-H endometrial cancer

Victor Moreno, Maria-Pilar Barretina-Ginesta, Wei Guo, Sharon Lu, David Jenkins, Kristen McEachern, Vienna Reichert, Steven Dunlap, Ellie Im, Lucy Gilbert, Ana Oaknin, Charles Leath, III, Janakiraman Subramanian
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): CT053.
https://doi.org/10.1158/1538-7445.AM2018-CT053
Published: 01 July 2018
View article titled, Abstract CT053: Preliminary safety, efficacy, and PK/PD characterization from GARNET, a phase 1 clinical trial of the anti-PD-1 monoclonal antibody, TSR-042, in patients with recurrent or advanced NSCLC and MSI-H endometrial cancer
Journal Articles

SHMT2 Desuccinylation by SIRT5 Drives Cancer Cell Proliferation

Xin Yang, Zhe Wang, Xin Li, Boya Liu, Minghui Liu, Lu Liu, Shuaiyi Chen, Mengmeng Ren, Yankun Wang, Miao Yu, Bo Wang, Junhua Zou, Wei-Guo Zhu, Yuxin Yin, Wei Gu, Jianyuan Luo
Journal: Cancer Research
Series: Author Choice
Cancer Res (2018) 78 (2): 372–386.
https://doi.org/10.1158/0008-5472.CAN-17-1912
Published: 15 January 2018
View article titled, SHMT2 Desuccinylation by SIRT5 Drives Cancer Cell Proliferation
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Includes: Supplementary data