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Webster K. Cavenee
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Journal Articles

Blockade of a Laminin-411–Notch Axis with CRISPR/Cas9 or a Nanobioconjugate Inhibits Glioblastoma Growth through Tumor-Microenvironment Cross-talk

Tao Sun, Rameshwar Patil, Anna Galstyan, Dmytro Klymyshyn, Hui Ding, Alexandra Chesnokova, Webster K. Cavenee, Frank B. Furnari, Vladimir A. Ljubimov, Ekaterina S. Shatalova, Shawn Wagner, Debiao Li, Adam N. Mamelak, Serguei I. Bannykh, Chirag G. Patil, Jeremy D. Rudnick, Jethro Hu, Zachary B. Grodzinski, Arthur Rekechenetskiy, Vida Falahatian, Alexander V. Lyubimov, Yongmei L. Chen, Lai S. Leoh, Tracy R. Daniels-Wells, Manuel L. Penichet, Eggehard Holler, Alexander V. Ljubimov, Keith L. Black, Julia Y. Ljubimova
Journal: Cancer Research
Series: Author Choice
Cancer Res (2019) 79 (6): 1239–1251.
https://doi.org/10.1158/0008-5472.CAN-18-2725
Published: 15 March 2019
View article titled, Blockade of a Laminin-411–Notch Axis with CRISPR/Cas9 or a Nanobioconjugate Inhibits Glioblastoma Growth through Tumor-Microenvironment Cross-talk
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Includes: Multimedia, Supplementary data
Journal Articles

A Urokinase Receptor–Bim Signaling Axis Emerges during EGFR Inhibitor Resistance in Mutant EGFR Glioblastoma

Jill Wykosky, Jingjing Hu, German G. Gomez, Tiffany Taylor, Genaro R. Villa, Donald Pizzo, Scott R. VandenBerg, Amy Haseley Thorne, Clark C. Chen, Paul S. Mischel, Steven L. Gonias, Webster K. Cavenee, Frank B. Furnari
Journal: Cancer Research
Cancer Res (2015) 75 (2): 394–404.
https://doi.org/10.1158/0008-5472.CAN-14-2004
Published: 14 January 2015
View article titled, A Urokinase Receptor–Bim Signaling Axis Emerges during EGFR Inhibitor Resistance in Mutant EGFR Glioblastoma
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Includes: Supplementary data
Journal Articles

Abstract A4: Guanylate binding protein‐1 promotes glioma cell invasion through induction of MMP1 expression

Ming Li, Frank B. Furnari, Webster K. Cavenee
Journal: Cancer Research
Cancer Res (2009) 69 (23_Supplement): A4.
https://doi.org/10.1158/0008-5472.FBCR09-A4
Published: 28 October 2014
View article titled, Abstract A4: Guanylate binding protein‐1 promotes glioma cell invasion through induction of MMP1 expression
Journal Articles

Abstract 5253: PTEN represses oncogene expression by regulating Daxx-H3.3 deposition in the chromatin

Jorge A. Benitez, Webster K. Cavenee, Frank F. Furnari
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 5253.
https://doi.org/10.1158/1538-7445.AM2014-5253
Published: 01 October 2014
View article titled, Abstract 5253: PTEN represses oncogene expression by regulating Daxx-H3.3 deposition in the chromatin
Journal Articles

Abstract 2737: Modulation of mitotic DNA damage as a paradigm for glioblastoma therapy

Ying Shen, Masayuki Nitta, Jie Li, Diahnn Futalan, Tyler Steed, Zack Taich, Jeffrey M. Treiber, Deanna Stevens, Mark A. Schroeder, Jann N. Sarkaria, Hong-Zhuan Chen, Tao Jiang, Bob S. Carter, Fumiko Esashi, Jill Wakosky, Frank Furnari, Webster K. Cavenee, Arshad Desai, Clark C. Chen
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2737.
https://doi.org/10.1158/1538-7445.AM2014-2737
Published: 01 October 2014
View article titled, Abstract 2737: Modulation of mitotic DNA damage as a paradigm for glioblastoma therapy
Journal Articles

Abstract B05: The tumor suppressor gene pten regulates gene expression through histone H3.3 deposition and Daxx interaction

Jorge A. Benitez, Webster K. Cavenee, Frank B. Furnari
Journal: Cancer Research
Cancer Res (2013) 73 (13_Supplement): B05.
https://doi.org/10.1158/1538-7445.CEC13-B05
Published: 13 May 2014
View article titled, Abstract B05: The tumor suppressor gene pten regulates gene expression through histone H3.3 deposition and Daxx interaction
Journal Articles

Suppression of MicroRNA-9 by Mutant EGFR Signaling Upregulates FOXP1 to Enhance Glioblastoma Tumorigenicity

German G. Gomez, Stefano Volinia, Carlo M. Croce, Ciro Zanca, Ming Li, Ryan Emnett, David H. Gutmann, Cameron W. Brennan, Frank B. Furnari, Webster K. Cavenee
Journal: Cancer Research
Cancer Res (2014) 74 (5): 1429–1439.
https://doi.org/10.1158/0008-5472.CAN-13-2117
Published: 02 March 2014
View article titled, Suppression of MicroRNA-9 by Mutant EGFR Signaling Upregulates FOXP1 to Enhance Glioblastoma Tumorigenicity
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Includes: Supplementary data
Journal Articles

Heterogeneity Maintenance in Glioblastoma: A Social Network

Rudy Bonavia, Maria-del-Mar Inda, Webster K. Cavenee, Frank B. Furnari
Journal: Cancer Research
Cancer Res (2011) 71 (12): 4055–4060.
https://doi.org/10.1158/0008-5472.CAN-11-0153
Published: 14 June 2011
View article titled, Heterogeneity Maintenance in Glioblastoma: A Social Network
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Journal Articles

Abstract 3126: Tumor heterogeneity in glioblastoma is an active process driven by a mutant EGFR-induced paracrine circuit

Maria-del-Mar Inda, Rudy Bonavia, Dinah WY Sah, Scott Vandenberg, Cameron Brennan, Terrance G. Johns, Philipp Hadwiger, Pamela Tan, Webster K. Cavenee, Frank B. Furnari
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3126.
https://doi.org/10.1158/1538-7445.AM10-3126
Published: 15 April 2010
View article titled, Abstract 3126: Tumor heterogeneity in glioblastoma is an active process driven by a mutant EGFR-induced paracrine circuit
Journal Articles

Abstract 582: Targeting the blood-brain barrier with a non-canonical iron-mimicry mechanism: A translational approach for the detection and treatment of human brain tumors

Fernanda I. Staquicini, Michael G. Ozawa, Catherine A. Moya, Wouter H.P. Driessen, Elena Magda Barbu, Suren Soghomonyan, Leo G. Flores, 2nd, Mian M. Alauddin, Juri G. Gelovani, Xiaowen Liang, Magnus Hook, James P. Basilion, Oliver Bogler, Richard L. Sidman, Webster K. Cavenee, Renata Pasqualini, Wadih Arap
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 582.
https://doi.org/10.1158/1538-7445.AM10-582
Published: 15 April 2010
View article titled, Abstract 582: Targeting the blood-brain barrier with a non-canonical iron-mimicry mechanism: A translational approach for the detection and treatment of human brain tumors
Journal Articles

Fyn and Src Are Effectors of Oncogenic Epidermal Growth Factor Receptor Signaling in Glioblastoma Patients

Kan V. Lu, Shaojun Zhu, Anna Cvrljevic, Tiffany T. Huang, Shawn Sarkaria, David Ahkavan, Julie Dang, Eduard B. Dinca, Seema B. Plaisier, Isaac Oderberg, Yohan Lee, Zugen Chen, Jeremy S. Caldwell, Yongmin Xie, Joseph A. Loo, David Seligson, Arnab Chakravari, Francis Y. Lee, Roberto Weinmann, Timothy F. Cloughesy, Stanley F. Nelson, Gabriele Bergers, Thomas Graeber, Frank B. Furnari, C. David James, Webster K. Cavenee, Terrance G. Johns, Paul S. Mischel
Journal: Cancer Research
Cancer Res (2009) 69 (17): 6889–6898.
https://doi.org/10.1158/0008-5472.CAN-09-0347
Published: 31 August 2009
View article titled, Fyn and Src Are Effectors of Oncogenic Epidermal Growth Factor Receptor Signaling in Glioblastoma Patients
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Includes: Supplementary data
Journal Articles

EGFRvIII and DNA Double-Strand Break Repair: A Molecular Mechanism for Radioresistance in Glioblastoma

Bipasha Mukherjee, Brian McEllin, Cristel V. Camacho, Nozomi Tomimatsu, Shyam Sirasanagandala, Suraj Nannepaga, Kimmo J. Hatanpaa, Bruce Mickey, Christopher Madden, Elizabeth Maher, David A. Boothman, Frank Furnari, Webster K. Cavenee, Robert M. Bachoo, Sandeep Burma
Journal: Cancer Research
Cancer Res (2009) 69 (10): 4252–4259.
https://doi.org/10.1158/0008-5472.CAN-08-4853
Published: 15 May 2009
View article titled, EGFRvIII and DNA Double-Strand Break Repair: A Molecular Mechanism for Radioresistance in Glioblastoma
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Journal Articles

Mammalian Target of Rapamycin Inhibition Promotes Response to Epidermal Growth Factor Receptor Kinase Inhibitors in PTEN-Deficient and PTEN-Intact Glioblastoma Cells

Maria Y. Wang, Kan V. Lu, Shaojun Zhu, Ederlyn Q. Dia, Igor Vivanco, Gregory M. Shackleford, Webster K. Cavenee, Ingo K. Mellinghoff, Timothy F. Cloughesy, Charles L. Sawyers, Paul S. Mischel
Journal: Cancer Research
Cancer Res (2006) 66 (16): 7864–7869.
https://doi.org/10.1158/0008-5472.CAN-04-4392
Published: 15 August 2006
View article titled, Mammalian Target of Rapamycin Inhibition Promotes Response to Epidermal Growth Factor Receptor Kinase Inhibitors in PTEN-Deficient and PTEN-Intact Glioblastoma Cells
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Includes: Supplementary data
Journal Articles

EGFRvIII sensitizes PTEN-expressing glioblastoma cells to erlotinib: A critical role for PI3K pathway modulation

Yinglin Wang, Shaojun Zhu, Kan V. Lu, Ederlyn Q. Dia, Gregory M. Shackleford, Webster K. Cavenee, Timothy F. Cloughesy, Charles L. Sawyers, Paul S. Mischel
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 803.
Published: 01 May 2005
View article titled, EGFRvIII sensitizes PTEN-expressing glioblastoma cells to erlotinib: A critical role for PI3K pathway modulation
Journal Articles

PCAF regulates PI3-kinase signaling by acetylation of PTEN

Koichi Okumura, Webster K. Cavenee, Frank B. Furnari
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 1276–1277.
Published: 01 April 2004
View article titled, PCAF regulates PI3-kinase signaling by acetylation of PTEN
Journal Articles

Mutant Epidermal Growth Factor Receptor Signaling Down-Regulates p27 through Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway in Glioblastomas

Yoshitaka Narita, Motoo Nagane, Kazuhiko Mishima, H-J. Su Huang, Frank B. Furnari, Webster K. Cavenee
Journal: Cancer Research
Cancer Res (2002) 62 (22): 6764–6769.
Published: 15 November 2002
View article titled, Mutant Epidermal Growth Factor Receptor Signaling Down-Regulates p27 through Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway in Glioblastomas
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Journal Articles

Vascular Endothelial Growth Factor Isoforms Display Distinct Activities in Promoting Tumor Angiogenesis at Different Anatomic Sites

Ping Guo, Li Xu, Shi Pan, Rolf A. Brekken, Shu-Ting Yang, G. Brian Whitaker, Motoo Nagane, Philip E. Thorpe, Jan S. Rosenbaum, H.-J. Su Huang, Webster K. Cavenee, Shi-Yuan Cheng
Journal: Cancer Research
Cancer Res (2001) 61 (23): 8569–8577.
Published: 01 December 2001
View article titled, Vascular Endothelial Growth Factor Isoforms Display Distinct Activities in Promoting Tumor Angiogenesis at Different Anatomic Sites
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Journal Articles

Growth Suppression of Intracranial Xenografted Glioblastomas Overexpressing Mutant Epidermal Growth Factor Receptors by Systemic Administration of Monoclonal Antibody (mAb) 806, a Novel Monoclonal Antibody Directed to the Receptor

Kazuhiko Mishima, Terrance G. Johns, Rodney B. Luwor, Andrew M. Scott, Elisabeth Stockert, Achim A. Jungbluth, Xiang-Dong Ji, Padma Suvarna, Joseph R. Voland, Lloyd J. Old, H-J. Su Huang, Webster K. Cavenee
Journal: Cancer Research
Cancer Res (2001) 61 (14): 5349–5354.
Published: 01 July 2001
View article titled, Growth Suppression of Intracranial Xenografted Glioblastomas Overexpressing Mutant Epidermal Growth Factor Receptors by Systemic Administration of Monoclonal Antibody (mAb) 806, a Novel Monoclonal Antibody Directed to the Receptor
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Journal Articles

Monoclonal Antibody 806 Inhibits the Growth of Tumor Xenografts Expressing Either the de2–7 or Amplified Epidermal Growth Factor Receptor (EGFR) but not Wild-Type EGFR

Rodney B. Luwor, Terrance G. Johns, Carmel Murone, H-J. Su Huang, Webster K. Cavenee, Gerd Ritter, Lloyd J. Old, Antony W. Burgess, Andrew M. Scott
Journal: Cancer Research
Cancer Res (2001) 61 (14): 5355–5361.
Published: 01 July 2001
View article titled, Monoclonal Antibody 806 Inhibits the Growth of Tumor Xenografts Expressing Either the de2–7 or Amplified Epidermal Growth Factor Receptor (EGFR) but not Wild-Type EGFR
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Journal Articles

Increased Death Receptor 5 Expression by Chemotherapeutic Agents in Human Gliomas Causes Synergistic Cytotoxicity with Tumor Necrosis Factor-related Apoptosis-inducing Ligand in Vitro and in Vivo

Motoo Nagane, Guohua Pan, Jessie J. Weddle, Vishva M. Dixit, Webster K. Cavenee, H.-J. Su Huang
Journal: Cancer Research
Cancer Res (2000) 60 (4): 847–853.
Published: 01 February 2000
View article titled, Increased Death Receptor 5 Expression by Chemotherapeutic Agents in Human Gliomas Causes Synergistic Cytotoxicity with Tumor Necrosis Factor-related Apoptosis-inducing Ligand <em>in Vitro</em> and <em>in Vivo</em>
Open the PDF for Increased Death Receptor 5 Expression by Chemotherapeutic Agents in Human Gliomas Causes Synergistic Cytotoxicity with Tumor Necrosis Factor-related Apoptosis-inducing Ligand <em>in Vitro</em> and <em>in Vivo</em> in another window