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Wayne D. Tilley
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Journal Articles

ACSM1 and ACSM3 Regulate Fatty Acid Metabolism to Support Prostate Cancer Growth and Constrain Ferroptosis

Raj K. Shrestha, Zeyad D. Nassar, Adrienne R. Hanson, Richard Iggo, Scott L. Townley, Jonas Dehairs, Chui Y. Mah, Madison Helm, Mohammadreza Alizadeh-Ghodsi, Marie Pickering, Bart Ghesquière, Matthew J. Watt, Lake-Ee Quek, Andrew J. Hoy, Wayne D. Tilley, Johannes V. Swinnen, Lisa M. Butler, Luke A. Selth
Journal: Cancer Research
Cancer Res (2024) 84 (14): 2313–2332.
https://doi.org/10.1158/0008-5472.CAN-23-1489
Published: 15 July 2024
View article titled, ACSM1 and ACSM3 Regulate Fatty Acid Metabolism to Support Prostate Cancer Growth and Constrain Ferroptosis
Open the PDF for ACSM1 and ACSM3 Regulate Fatty Acid Metabolism to Support Prostate Cancer Growth and Constrain Ferroptosis in another window
Includes: Supplementary data
Journal Articles

Abstract P4-08-16: Selective Androgen Receptor Modulators in combination with CDK4/6 inhibitors demonstrate anti-cancer activity in preclinical treatment resistant ER+AR+ breast cancer models

Allegra Freelander, Geraldine laven-Law, Leila Eshraghi, Nimmy Geetha, Peta Somerville, Marie Pickering, Sarah Alexandrou, C. Elizabeth Caldon, Wayne D. Tilley, Theresa E. Hickey, Elgene Lim
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P4-08-16.
https://doi.org/10.1158/1538-7445.SABCS22-P4-08-16
Published: 01 March 2023
View article titled, Abstract P4-08-16: Selective Androgen Receptor Modulators in combination with CDK4/6 inhibitors demonstrate anti-cancer activity in preclinical treatment resistant ER+AR+ breast cancer models
Journal Articles

Abstract PD2-02: Combination CDK4/6 inhibition and AR agonism suppresses the growth of CDK4/6 inhibitor resistant breast cancers

Allegra Freelander, Geraldine Laven-Law, Leila Eshraghi, Kee Ming Chia, Marie Pickering, Aliza Yong, Ashleigh Wilkinson, Sarah Alexandrou, C. Elizabeth Caldon, Theresa E Hickey, Wayne D Tilley, Elgene Lim
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): PD2-02.
https://doi.org/10.1158/1538-7445.SABCS21-PD2-02
Published: 15 February 2022
View article titled, Abstract PD2-02: Combination CDK4/6 inhibition and AR agonism suppresses the growth of CDK4/6 inhibitor resistant breast cancers
Journal Articles

Lipidomic Profiling of Clinical Prostate Cancer Reveals Targetable Alterations in Membrane Lipid Composition

Lisa M. Butler, Chui Yan Mah, Jelle Machiels, Andrew D. Vincent, Swati Irani, Shadrack M. Mutuku, Xander Spotbeen, Muralidhararao Bagadi, David Waltregny, Max Moldovan, Jonas Dehairs, Frank Vanderhoydonc, Katarzyna Bloch, Rajdeep Das, Jurgen Stahl, James G. Kench, Thomas Gevaert, Rita Derua, Etienne Waelkens, Zeyad D. Nassar, Luke A. Selth, Paul J. Trim, Marten F. Snel, David J. Lynn, Wayne D. Tilley, Lisa G. Horvath, Margaret M. Centenera, Johannes V. Swinnen
Journal: Cancer Research
Cancer Res (2021) 81 (19): 4981–4993.
https://doi.org/10.1158/0008-5472.CAN-20-3863
Published: 01 October 2021
View article titled, Lipidomic Profiling of Clinical Prostate Cancer Reveals Targetable Alterations in Membrane Lipid Composition
Open the PDF for Lipidomic Profiling of Clinical Prostate Cancer Reveals Targetable Alterations in Membrane Lipid Composition in another window
Includes: Supplementary data
Journal Articles

ELOVL5 Is a Critical and Targetable Fatty Acid Elongase in Prostate Cancer

Margaret M. Centenera, Julia S. Scott, Jelle Machiels, Zeyad D. Nassar, Deanna C. Miller, Irene Zinonos, Jonas Dehairs, Ingrid J.G. Burvenich, Giorgia Zadra, Paolo M. Chetta, Clyde Bango, Emma Evergren, Natalie K. Ryan, Joanna L. Gillis, Chui Yan Mah, Terence Tieu, Adrienne R. Hanson, Ryan Carelli, Katarzyna Bloch, Vasilios Panagopoulos, Etienne Waelkens, Rita Derua, Elizabeth D. Williams, Andreas Evdokiou, Anna Cifuentes-Rius, Nicolas H. Voelcker, Ian G. Mills, Wayne D. Tilley, Andrew M. Scott, Massimo Loda, Luke A. Selth, Johannes V. Swinnen, Lisa M. Butler
Journal: Cancer Research
Cancer Res (2021) 81 (7): 1704–1718.
https://doi.org/10.1158/0008-5472.CAN-20-2511
Published: 01 April 2021
View article titled, ELOVL5 Is a Critical and Targetable Fatty Acid Elongase in Prostate Cancer
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Includes: Supplementary data
Journal Articles

Abstract PO-036: ACSM1 and ACSM3 regulate fatty acid oxidation in prostate cancer to promote growth and protect against oxidative stress

Raj Kumar Shrestha, Scott Townley, Adrienne Hanson, Marie Pickering, Zeyad D. Nassar, Chui Yan Mah, Mohammadreza A. Ghodsi, Andrew J. Hoy, Lake-Ee Quek, Wayne D. Tilley, Lisa M. Butler, Luke A. Selth
Journal: Cancer Research
Cancer Res (2020) 80 (23_Supplement): PO-036.
https://doi.org/10.1158/1538-7445.EPIMETAB20-PO-036
Published: 02 December 2020
View article titled, Abstract PO-036: ACSM1 and ACSM3 regulate fatty acid oxidation in prostate cancer to promote growth and protect against oxidative stress
Journal Articles

Endonuclease FEN1 Coregulates ERα Activity and Provides a Novel Drug Interface in Tamoxifen-Resistant Breast Cancer

Koen D. Flach, Manikandan Periyasamy, Ajit Jadhav, Dorjbal Dorjsuren, Joseph C. Siefert, Theresa E. Hickey, Mark Opdam, Hetal Patel, Sander Canisius, David M. Wilson, III, Maria Donaldson Collier, Stefan Prekovic, Marja Nieuwland, Roelof J.C. Kluin, Alexey V. Zakharov, Jelle Wesseling, Lodewyk F.A. Wessels, Sabine C. Linn, Wayne D. Tilley, Anton Simeonov, Simak Ali, Wilbert Zwart
Journal: Cancer Research
Cancer Res (2020) 80 (10): 1914–1926.
https://doi.org/10.1158/0008-5472.CAN-19-2207
Published: 15 May 2020
View article titled, Endonuclease FEN1 Coregulates ERα Activity and Provides a Novel Drug Interface in Tamoxifen-Resistant Breast Cancer
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Includes: Supplementary data
Journal Articles

Abstract GS2-03: The androgen receptor is a tumour suppressor in estrogen receptor positive breast cancer

Elgene Lim, Theresa A Hickey, Luke A Selth, Kee Ming Chia, Heloisa H Milioli, Daniel Roden, Geraldine Laven-Law, Shalini Jindal, Mun Hui, Esmaeil Ebrahimie, Stephen N Birrell, Suzan Stelloo, C. Elizabeth Caldon, Jessica Finlay-Schultz, Tarek M Abdel-Fatah, Ian O Ellis, Willbert Zwart, Carlo Palmieri, Carol A Sartorius, Alex Swarbrick, Jason S Carroll, Wayne D Tilley
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): GS2-03.
https://doi.org/10.1158/1538-7445.SABCS19-GS2-03
Published: 15 February 2020
View article titled, Abstract GS2-03: The androgen receptor is a tumour suppressor in estrogen receptor positive breast cancer
Journal Articles

Abstract 4433: Novel and highly selective CDK9 inhibitors suppress proliferation of triple negative breast cancer (TNBC) cells in vitro

Jean M. Winter, Ebtihal H. Mustafa, Shudong Wang, Luke A. Selth, Theresa E. Hickey, Wayne D. Tilley
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4433.
https://doi.org/10.1158/1538-7445.AM2019-4433
Published: 01 July 2019
View article titled, Abstract 4433: Novel and highly selective CDK9 inhibitors suppress proliferation of triple negative breast cancer (TNBC) cells <em>in vitro</em>
Journal Articles

Abstract 3741: Deciphering the regulome of androgen receptor variants in prostate cancer

Mark L. Daniel, Theresa E. Hickey, Jason S. Carroll, Wayne D. Tilley, Luke A. Selth, Scott M. Dehm
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3741.
https://doi.org/10.1158/1538-7445.AM2018-3741
Published: 01 July 2018
View article titled, Abstract 3741: Deciphering the regulome of androgen receptor variants in prostate cancer
Journal Articles

Novel Selective Agents for the Degradation of Androgen Receptor Variants to Treat Castration-Resistant Prostate Cancer

Suriyan Ponnusamy, Christopher C. Coss, Thirumagal Thiyagarajan, Kate Watts, Dong-Jin Hwang, Yali He, Luke A. Selth, Iain J. McEwan, Charles B. Duke, Jayaprakash Pagadala, Geetika Singh, Robert W. Wake, Christopher Ledbetter, Wayne D. Tilley, Tudor Moldoveanu, James T. Dalton, Duane D. Miller, Ramesh Narayanan
Journal: Cancer Research
Cancer Res (2017) 77 (22): 6282–6298.
https://doi.org/10.1158/0008-5472.CAN-17-0976
Published: 14 November 2017
View article titled, Novel Selective Agents for the Degradation of Androgen Receptor Variants to Treat Castration-Resistant Prostate Cancer
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Includes: Supplementary data
Journal Articles

Novel Androgen Receptor Coregulator GRHL2 Exerts Both Oncogenic and Antimetastatic Functions in Prostate Cancer

Steve Paltoglou, Rajdeep Das, Scott L. Townley, Theresa E. Hickey, Gerard A. Tarulli, Isabel Coutinho, Rayzel Fernandes, Adrienne R. Hanson, Iza Denis, Jason S. Carroll, Scott M. Dehm, Ganesh V. Raj, Stephen R. Plymate, Wayne D. Tilley, Luke A. Selth
Journal: Cancer Research
Cancer Res (2017) 77 (13): 3417–3430.
https://doi.org/10.1158/0008-5472.CAN-16-1616
Published: 02 July 2017
View article titled, Novel Androgen Receptor Coregulator GRHL2 Exerts Both Oncogenic and Antimetastatic Functions in Prostate Cancer
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Includes: Supplementary data
Journal Articles

Abstract 1152: Lipid elongation: an unexplored therapeutic target in prostate cancer

Zeyad D. Nassar, Margaret M. Centenera, Jelle Machiels, Samuel J. Polacek, Katarzyna Bloch, Wayne D. Tilley, Luke A. Selth, Johannes V. Swinnen, Lisa Butler
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1152.
https://doi.org/10.1158/1538-7445.AM2017-1152
Published: 01 July 2017
View article titled, Abstract 1152: Lipid elongation: an unexplored therapeutic target in prostate cancer
Journal Articles

Disrupting Androgen Receptor Signaling Induces Snail-Mediated Epithelial–Mesenchymal Plasticity in Prostate Cancer

Lu Miao, Lin Yang, Rui Li, Daniel N. Rodrigues, Mateus Crespo, Jer-Tsong Hsieh, Wayne D. Tilley, Johann de Bono, Luke A. Selth, Ganesh V. Raj
Journal: Cancer Research
Cancer Res (2017) 77 (11): 3101–3112.
https://doi.org/10.1158/0008-5472.CAN-16-2169
Published: 31 May 2017
View article titled, Disrupting Androgen Receptor Signaling Induces Snail-Mediated Epithelial–Mesenchymal Plasticity in Prostate Cancer
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Includes: Supplementary data
Journal Articles

MicroRNA-194 Promotes Prostate Cancer Metastasis by Inhibiting SOCS2

Rajdeep Das, Philip A. Gregory, Rayzel C. Fernandes, Iza Denis, Qingqing Wang, Scott L. Townley, Shuang G. Zhao, Adrienne R. Hanson, Marie A. Pickering, Heather K. Armstrong, Noor A. Lokman, Esmaeil Ebrahimie, Elai Davicioni, Robert B. Jenkins, R. Jeffrey Karnes, Ashley E. Ross, Robert B. Den, Eric A. Klein, Kim N. Chi, Hayley S. Ramshaw, Elizabeth D. Williams, Amina Zoubeidi, Gregory J. Goodall, Felix Y. Feng, Lisa M. Butler, Wayne D. Tilley, Luke A. Selth
Journal: Cancer Research
Cancer Res (2017) 77 (4): 1021–1034.
https://doi.org/10.1158/0008-5472.CAN-16-2529
Published: 14 February 2017
View article titled, MicroRNA-194 Promotes Prostate Cancer Metastasis by Inhibiting SOCS2
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Includes: Supplementary data
Journal Articles

Androgen and Estrogen Receptors in Breast Cancer Coregulate Human UDP-Glucuronosyltransferases 2B15 and 2B17

Dong G. Hu, Luke A. Selth, Gerard A. Tarulli, Robyn Meech, Dhilushi Wijayakumara, Apichaya Chanawong, Roslin Russell, Carlos Caldas, Jessica L.L. Robinson, Jason S. Carroll, Wayne D. Tilley, Peter I. Mackenzie, Theresa E. Hickey
Journal: Cancer Research
Series: Author Choice
Cancer Res (2016) 76 (19): 5881–5893.
https://doi.org/10.1158/0008-5472.CAN-15-3372
Published: 02 October 2016
View article titled, Androgen and Estrogen Receptors in Breast Cancer Coregulate Human UDP-Glucuronosyltransferases 2B15 and 2B17
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Includes: Supplementary data
Journal Articles

Abstract C8: Targeting the DNA-damage repair and transcriptional regulatory functions of PARP1 therapeutically in prostate cancer

Matthew J. Schiewer, Adam P. Dicker, Jonathan R. Brody, John M. Pascal, Lisa M. Butler, Wayne D. Tilley, Felix Y. Feng, Karen E. Knudsen, Jonathan F. Goodwin, J Chad Brenner, Michael A. Augello, Fengzhi Liu, Jamie L. Planck, Randy S. Schrecengost, Arul M. Chinnaiyan, Ganesh V. Raj
Journal: Cancer Research
Cancer Res (2012) 72 (4_Supplement): C8.
https://doi.org/10.1158/1538-7445.PRCA2012-C8
Published: 09 May 2013
View article titled, Abstract C8: Targeting the DNA-damage repair and transcriptional regulatory functions of PARP1 therapeutically in prostate cancer
Journal Articles

Abstract C6: Targeting Hsp90-dependent functional maturation of the androgen receptor in human prostate cancer

Margaret M. Centenera, Sarah L. Carter, Joanna L. Gillis, Luke A. Selth, Peter D. Sutherland, Wayne D. Tilley, Lisa M. Butler
Journal: Cancer Research
Cancer Res (2012) 72 (4_Supplement): C6.
https://doi.org/10.1158/1538-7445.PRCA2012-C6
Published: 09 May 2013
View article titled, Abstract C6: Targeting Hsp90-dependent functional maturation of the androgen receptor in human prostate cancer
Journal Articles

Abstract 274: The combined actions of DHT and MPA lead to altered AR signaling in normal and malignant post-menopausal breast epithelial cells

Aleksandra M. Ochnik, Nicole L. Moore, Stephen N. Birrell, Lisa M. Butler, Shalini Jindal, Luke Selth, Wayne D. Tilley, Theresa E. Hickey
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 274.
https://doi.org/10.1158/1538-7445.AM2012-274
Published: 15 April 2012
View article titled, Abstract 274: The combined actions of DHT and MPA lead to altered AR signaling in normal and malignant post-menopausal breast epithelial cells
Journal Articles

Abstract 2922: Androgen receptor driven transcription in a subtype of estrogen receptor negative breast cancer is controlled by FoxA1

Jessica L. Robinson, Gordon D. Brown, David E. Neal, Wayne D. Tilley, Jason S. Carroll
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2922.
https://doi.org/10.1158/1538-7445.AM2012-2922
Published: 15 April 2012
View article titled, Abstract 2922: Androgen receptor driven transcription in a subtype of estrogen receptor negative breast cancer is controlled by FoxA1