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Journal Articles

Abstract IA-08: Syndecan 1 is a therapeutic target for KRAS-driven pancreatic cancer

Mitsunobu Takeda, Zecheng Yang, Madeline S Theardy, Alexey Sorokin, Oluwadara Coker, Shuaitong Chen, Long T Vien, Laura Bover, Haoqiang Ying, Scott Kopetz, Wantong Yao
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): IA-08.
https://doi.org/10.1158/1538-7445.PANCREATIC24-IA-08
Published: 15 September 2024
View articletitled, Abstract IA-08: Syndecan 1 is a therapeutic target for KRAS-driven pancreatic cancer
Journal Articles

Abstract C019: A novel SDC1-targeted therapeutic antibody inhibits macropinocytosis and induces anti-tumor immunity in pancreatic cancer

Zecheng Yang, Madelaine S Theardy, Shuaitong Chen, Yongkun Wei, Mitsunobu Takeda, Xiaofei Wang, Jun Yao, Jennifer Li, Jangho Park, Yangxi Zheng, Long T Vien, Laura Bover, Haoqiang Ying, Wantong Yao
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): C019.
https://doi.org/10.1158/1538-7445.PANCREATIC24-C019
Published: 15 September 2024
View articletitled, Abstract C019: A novel SDC1-targeted therapeutic antibody inhibits macropinocytosis and induces anti-tumor immunity in pancreatic cancer
Journal Articles

Abstract 6532: Blockade of CD24 sensitizes pancreatic cancer to Kras inhibitors

Yongkun Wei, Minghui Liu, Er-Yen Yen, Jun Yao, Phuoc T. Nguyen, Xiaofei Wang, Zecheng Yang, Abdelrahman Yousef, Dean Pan, Yanqing Jin, Madelaine S. Theady, Jangho Park, Yiming Cai, Mitsunobu Takeda, Matthew Vasquez, Yong Zhou, Hong Zhao, Andrea Viale, Huamin Wang, Dan Zhao, Ronald A. DePinho, Wantong Yao, Haoqiang Ying
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6532.
https://doi.org/10.1158/1538-7445.AM2024-6532
Published: 22 March 2024
View articletitled, Abstract 6532: Blockade of CD24 sensitizes pancreatic cancer to Kras inhibitors
Journal Articles

Abstract 3009: ATRX loss blocks the differentiation of mesenchymal stem cells and promotes undifferentiated sarcoma development

Yiming Cai, Jun Yao, Dean N. Pan, Yanqiang Jin, James M. You, Wantong Yao, Haoqiang Ying
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3009.
https://doi.org/10.1158/1538-7445.AM2024-3009
Published: 22 March 2024
View articletitled, Abstract 3009: ATRX loss blocks the differentiation of mesenchymal stem cells and promotes undifferentiated sarcoma development
Journal Articles

Abstract C097: KRASG12C exhibits allele-specific biology in pancreatic cancer and targeting CD24 sensitizes KRASG12C-driven tumors to sotorasib treatment

Yongkun Wei, Minghui Liu, Phuoc T. Nguyen, Dean N. Pan, Wantong Yao, Haoqiang Ying
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): C097.
https://doi.org/10.1158/1538-7445.PANCA2023-C097
Published: 16 January 2024
View articletitled, Abstract C097: KRASG12C exhibits allele-specific biology in pancreatic cancer and targeting CD24 sensitizes KRASG12C-driven tumors to sotorasib treatment
Journal Articles

Abstract C096: Targeting Syndecan1 to overcome acquired resistant to KRAS inhibitor in gastrointestinal cancer

Mitsunobu Takeda, Alexey Sorokin, Madelaine Theardy, Oluwadara Coker, Scott Kopetz, Haoqiang Ying, Giulio Draetta, Ronald A. DePinho, Wantong Yao
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): C096.
https://doi.org/10.1158/1538-7445.PANCA2023-C096
Published: 16 January 2024
View articletitled, Abstract C096: Targeting Syndecan1 to overcome acquired resistant to KRAS inhibitor in gastrointestinal cancer
Journal Articles

Abstract C034: Genome-wide CRISPR screen identifies novel immunotherapeutic targets in pancreatic cancer

Xiaofei Wang, Jintan Liu, Giulio Draetta, Haoqiang Ying, Wantong Yao
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): C034.
https://doi.org/10.1158/1538-7445.PANCA2023-C034
Published: 16 January 2024
View articletitled, Abstract C034: Genome-wide CRISPR screen identifies novel immunotherapeutic targets in pancreatic cancer
Journal Articles

Abstract A011: DPY30 regulates immunoediting by suppressing uncoordinated DNA replication in pancreatic cancer

Francesca Citron, Luigi Perelli, Chiara Balestrieri, Luca Cecchetto, Yanshuo Chu, I-Lin Ho, Li Zhang, Er-Yen Yen, Luis Castillo Montanez, Rutvi Shah, Sergio Attanasio, Sanjana Srinivasan, Charles Dyke, Ko-Chien Chen, Shan Jiang, Jing Pan, Sisi Gao, Huamin Wang, Wantong Yao, Linghua Wang, Mauro Di Pilato, Giannicola Genovese, Andrea Viale, Giulio Draetta
Journal: Cancer Research
Cancer Res (2024) 84 (1_Supplement): A011.
https://doi.org/10.1158/1538-7445.DNAREPAIR24-A011
Published: 09 January 2024
View articletitled, Abstract A011: DPY30 regulates immunoediting by suppressing uncoordinated DNA replication in pancreatic cancer
Journal Articles

Abstract 303: DPY30 loss leads to DNA re-replication and immunoediting in pancreatic ductal adenocarcinoma

Francesca Citron, Luigi Perelli, Yanshuo Chu, Sanjana Srinivasan, I-Lin Ho, Er-Yen Yen, Rutvi Shah, Sergio Attanasio, Luis Castillo Montanez, Mauro Di Pilato, Shan Jiang, Wantong Yao, Sisi Gao, Angela Deem, Giannicola Genovese, Linghua Wang, Virginia Giuliani, Andrea Viale, Giulio F. Draetta
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 303.
https://doi.org/10.1158/1538-7445.AM2023-303
Published: 04 April 2023
View articletitled, Abstract 303: DPY30 loss leads to DNA re-replication and immunoediting in pancreatic ductal adenocarcinoma
Journal Articles

Abstract 6558: Defining differentiation States in well-differentiated and de-differentiated liposarcoma

Danh Truong, Hannah C. Beird, Chia-Chin Wu, Sandhya Krishnan, Davis Ingram, Alexander Lazar, Emily Keung, Christina Roland, Wantong Yao, Robert Benjamin, Neeta Somaiah, Barry W. Feig, Joseph A. Ludwig
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6558.
https://doi.org/10.1158/1538-7445.AM2023-6558
Published: 04 April 2023
View articletitled, Abstract 6558: Defining differentiation States in well-differentiated and de-differentiated liposarcoma
Journal Articles

Abstract 1327: Epithelial memory of resolved inflammation cooperates with oncogenic KRAS to limit tissue damage while promoting pancreatic cancer

I-Lin Ho, Edoardo Del Poggetto, Chiara Balestrieri, Er-Yen Yen, Francesca Citron, Rutvi Shah, Shaojun Zhang, Shan Jiang, Wantong Yao, Haoqiang Ying, Giannicola Genovese, Timothy Heffernan, Anirban Maitra, Linghua Wang, Timothy Wang, Giulio Draetta, Alessandro Carugo, Gioacchino Natoli, Andrea Viale
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1327.
https://doi.org/10.1158/1538-7445.AM2022-1327
Published: 15 June 2022
View articletitled, Abstract 1327: Epithelial memory of resolved inflammation cooperates with oncogenic KRAS to limit tissue damage while promoting pancreatic cancer
Journal Articles

Targeting Glucose Metabolism Sensitizes Pancreatic Cancer to MEK Inhibition

Liang Yan, Bo Tu, Jun Yao, Jing Gong, Alessandro Carugo, Christopher A. Bristow, Qiuyun Wang, Cihui Zhu, Bingbing Dai, Ya'an Kang, Leng Han, Ningping Feng, Yanqing Jin, Jason Fleming, Timothy P. Heffernan, Wantong Yao, Haoqiang Ying
Journal: Cancer Research
Cancer Res (2021) 81 (15): 4054–4065.
https://doi.org/10.1158/0008-5472.CAN-20-3792
Published: 01 August 2021
View articletitled, Targeting Glucose Metabolism Sensitizes Pancreatic Cancer to MEK Inhibition
Open the PDF for Targeting Glucose Metabolism Sensitizes Pancreatic Cancer to MEK Inhibition in another window
Includes: Supplementary data
Journal Articles

Abstract 2136: Diversity across the pancreatic ductal adenocarcinoma disease spectrum revealed by network-anchored functional genomics

Sanjana Srinivasan, Johnathon Rose, Wantong Yao, Sahil Seth, Michael Peoples, Annette Machado, Chieh-Yuan Li, I Lin Ho, Jaewon J. Lee, Paola A. Guerrera, Eiru Kim, Mustafa Syed, Joseph Daniele, Angela K. Deem, Michael Kim, Christopher A. Bristow, Eugene Koay, Giannicola Genovese, Andrea Viale, Timothy P. Heffernan, Anirban Maitra, Traver Hart, Alessandro Carugo, Giulio Draetta
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2136.
https://doi.org/10.1158/1538-7445.AM2021-2136
Published: 01 July 2021
View articletitled, Abstract 2136: Diversity across the pancreatic ductal adenocarcinoma disease spectrum revealed by network-anchored functional genomics
Journal Articles

Abstract C12: Lipids signaling contributes to glucose-independent metabolic adaptation in pancreatic ductal adenocarcinoma

Ziheng Chen, Jintan Liu, I-Lin Ho, Johnathan Rose, Liang Yan, Wantong Yao, Andrea Viale, Alessandro Carugo, Haoqiang Ying, Giulio Draetta
Journal: Cancer Research
Cancer Res (2019) 79 (24_Supplement): C12.
https://doi.org/10.1158/1538-7445.PANCA19-C12
Published: 13 December 2019
View articletitled, Abstract C12: Lipids signaling contributes to glucose-independent metabolic adaptation in pancreatic ductal adenocarcinoma
Journal Articles

Abstract 392: Reverse functional genomics: Identifying differentially regulated functional networks as predictive biomarkers of pivotal vulnerabilities in pancreatic cancer

Johnathon L. Rose, Alessandro Carugo, Wantong Yao, Sahil Seth, Sanjana Srinivasan, Michael Peoples, Traver Hart, Timothy Heffernan, Giulio Draetta
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 392.
https://doi.org/10.1158/1538-7445.AM2018-392
Published: 01 July 2018
View articletitled, Abstract 392: Reverse functional genomics: Identifying differentially regulated functional networks as predictive biomarkers of pivotal vulnerabilities in pancreatic cancer
Journal Articles

Abstract 1701: Identification of epigenetic modifiers able to suppress growth of pancreatic ductal adenocarcinoma: A patient-oriented in vivo functional platform

Alessandro Carugo, Giannicola Genovese, Sahil Seth, Luigi Nezi, Johnathon L. Rose, Andrea Viale, Piergiorgio F. Pettazzoni, Angelo Cicalese, Daniela Bossi, Wantong Yao, Jason B. Fleming, Luisa Lanfrancone, Timothy P. Heffernan, Giulio F. Draetta
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1701.
https://doi.org/10.1158/1538-7445.AM2015-1701
Published: 01 August 2015
View articletitled, Abstract 1701: Identification of epigenetic modifiers able to suppress growth of pancreatic ductal adenocarcinoma: A patient-oriented in vivo functional platform
Journal Articles

Abstract A94: Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer

Avnish Kapoor, Wantong Yao, Haoqiang Ying, Sujun Hua, Alison Liewen, Anguraj Sadanandam, Ramsey Al-Khalil, Andrea Viale, Piergiorgio Pettazzoni, Nora Sanchez, Alexei Protopopov, Jianhua Zhang, Timothy Heffernan, Randy L. Johnson, Lynda Chin, Y. Alan Wang, Giulio Draetta, Ronald A. DePinho
Journal: Cancer Research
Cancer Res (2015) 75 (13_Supplement): A94.
https://doi.org/10.1158/1538-7445.PANCA2014-A94
Published: 30 June 2015
View articletitled, Abstract A94: Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer
Journal Articles

Abstract A18: Syndecan-1 is required for oncogenic Kras-driven PDAC tumorigenesis and maintenance

Wantong Yao, Wei Wang, Ayumu Taguchi, Avnish Kapoor, Amin Momin, Hong Jiang, Johnathon Rose, Muge Celiktas, Angela Deem, Samir Hanash, Ronald DePinho, Haoqiang Ying, Giulio Draetta
Journal: Cancer Research
Cancer Res (2015) 75 (13_Supplement): A18.
https://doi.org/10.1158/1538-7445.PANCA2014-A18
Published: 30 June 2015
View articletitled, Abstract A18: Syndecan-1 is required for oncogenic Kras-driven PDAC tumorigenesis and maintenance
Journal Articles

Genetic Events That Limit the Efficacy of MEK and RTK Inhibitor Therapies in a Mouse Model of KRAS-Driven Pancreatic Cancer

Piergiorgio Pettazzoni, Andrea Viale, Parantu Shah, Alessandro Carugo, Haoqiang Ying, Huamin Wang, Giannicola Genovese, Sahil Seth, Rosalba Minelli, Tessa Green, Emmet Huang-Hobbs, Denise Corti, Nora Sanchez, Luigi Nezi, Matteo Marchesini, Avnish Kapoor, Wantong Yao, Maria E. Di Francesco, Alessia Petrocchi, Angela K. Deem, Kenneth Scott, Simona Colla, Gordon B. Mills, Jason B. Fleming, Timothy P. Heffernan, Philip Jones, Carlo Toniatti, Ronald A. DePinho, Giulio F. Draetta
Journal: Cancer Research
Series: Author Choice
Cancer Res (2015) 75 (6): 1091–1101.
https://doi.org/10.1158/0008-5472.CAN-14-1854
Published: 12 March 2015
View articletitled, Genetic Events That Limit the Efficacy of MEK and RTK Inhibitor Therapies in a Mouse Model of KRAS-Driven Pancreatic Cancer
Open the PDF for Genetic Events That Limit the Efficacy of MEK and RTK Inhibitor Therapies in a Mouse Model of KRAS-Driven Pancreatic Cancer in another window
Includes: Supplementary data