1-20 of 35
Wan-Ching Yen
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Abstract 3129: Predictive biomarker identification for response to vantictumab (OMP-18R5; anti-Frizzled) using primary patient-derived human pancreatic tumor xenografts

CHUN ZHANG, Fiore Cattaruzza, Pete Yeung, Wan-Ching Yen, Marcus Fischer, Claire Guo, Alayne Brunner, Min Wang, Belinda Cancilla, Austin Gurney, Rainer Brachmann, John Lewicki, Tim Hoey, Ann M. Kapoun
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3129.
DOI: https://doi.org/10.1158/1538-7445.AM2016-3129
Published: 15 July 2016
View article
Journal Articles

Abstract 4652: Effects of anti-DLL4 treatment on non-small cell lung cancer (NSCLC) human xenograft tumors

Alayne Brunner, Fiore Cattaruzza, Wan-Ching Yen, Pete Yeung, Marcus Fischer, Belinda Cancilla, Gilbert O’Young, Raymond Tam, Yu-Wang Liu, Austin Gurney, John Lewicki, Tim Hoey, Min Wang, Ann M. Kapoun
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4652.
DOI: https://doi.org/10.1158/1538-7445.AM2016-4652
Published: 15 July 2016
View article
Journal Articles

Abstract 404: Development of a RSPO3 CLIA-validated assay as a predictive biomarker for response to anti-RSPO3 antibody treatment in patients with solid tumors

Chun Zhang, Yuwang Liu, Min Wang, Gilbert OYoung, Joy Kavanagh, Cheryl McFarlane, Fiore Cattaruzza, Pete Yeung, Jennifer Cain, Wan-Ching Yen, Marcus Fischer, Belinda Cancilla, Edwina Dobbin, Michelle McCarthy, Austin Gurney, Leonardo Faoro, John Lewicki, Tim Hoey, Ann M. Kapoun
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 404.
DOI: https://doi.org/10.1158/1538-7445.AM2016-404
Published: 15 July 2016
View article
Journal Articles

Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates β-Catenin Signaling and Tumorigenesis in Multiple Cancer Types

Cecile Chartier, Janak Raval, Fumiko Axelrod, Chris Bond, Jennifer Cain, Cristina Dee-Hoskins, Shirley Ma, Marcus M. Fischer, Jalpa Shah, Jie Wei, May Ji, Andrew Lam, Michelle Stroud, Wan-Ching Yen, Pete Yeung, Belinda Cancilla, Gilbert O'Young, Min Wang, Ann M. Kapoun, John Lewicki, Timothy Hoey, Austin Gurney
Journal: Cancer Research
Series: Author Choice
Cancer Res (2016) 76 (3): 713–723.
DOI: https://doi.org/10.1158/0008-5472.CAN-15-0561
Published: 31 January 2016
View article
PDF
Includes: Supplementary data
Journal Articles

Abstract 2576: Enhanced antitumor efficacy by sequential application of Wnt pathway antagonists in combination with taxanes

Wan-Ching Yen, Marcus Fischer, Belinda Cancilla, Fiore Cattaruzza, Tracy Tang, Pete Yeung, John Lewicki, Austin Gurney, Timothy Hoey
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2576.
DOI: https://doi.org/10.1158/1538-7445.AM2015-2576
Published: 01 August 2015
View article
Journal Articles

Abstract 2323: Tarextumab (Anti-NOTCH2/3) reverses NOTCH2 and NOTCH3-dependent tumorigenicity and metastases in small cell lung cancer

Jalpa Shah, Gilbert O'Young, Jie Wei, Marcus Fischer, Wan-Ching Yen, Belinda Cancilla, Ann Kapoun, John Lewicki, Jennifer Cain, Timothy Hoey
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2323.
DOI: https://doi.org/10.1158/1538-7445.AM2015-2323
Published: 01 August 2015
View article
Journal Articles

Abstract 4367: Discovery and evaluation of pharmacodynamic and predictive biomarkers for anti-RSPO3, a treatment that reduces tumor growth and cancer stem cell frequency in patient derived xenograft tumor models

Fiore Cattaruzza, Pete Yeung, Wan-Ching Yen, Alayne Brunner, Min Wang, YuWang Liu, Marcus Fischer, Gilbert O'Young, Cecile Chartier, Austin Gurney, Tim Hoey, John Lewicki, Ann M. Kapoun
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4367.
DOI: https://doi.org/10.1158/1538-7445.AM2015-4367
Published: 01 August 2015
View article
Journal Articles

Abstract 4233: Wnt pathway antagonist ipafricept (FZD8-Fc, OMP-54F28) inhibits tumor growth and reduces tumor-initiating cell frequency in ovarian patient-derived xenograft models

Marcus M. Fischer, Wan-Ching Yen, Chun Zheng, Randall Henner, Fiore Cattaruzza, Tracy Tang, Pete Yeung, Tanuka Biswas, John Lewicki, Austin Gurney, Ann M. Kapoun, Timothy Hoey
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4233.
DOI: https://doi.org/10.1158/1538-7445.AM2015-4233
Published: 01 August 2015
View article
Journal Articles

Abstract 1764: Inhibition of R-spondin (RSPO) signaling reduces the growth of multiple human tumors

Austin Gurney, Fumiko Axelrod, Chris Bond, Jennifer Cain, Cecile Chartier, Marcus Fischer, May Ji, Chris Murriel, Janak Raval, Jalpa Shah, Min Wang, Wan-Ching Yen, Ann Kapoun, John Lewicki, Timothy Hoey
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1764.
DOI: https://doi.org/10.1158/1538-7445.AM2014-1764
Published: 01 October 2014
View article
Journal Articles

Abstract 1907: Wnt pathway antagonist OMP-54F28 (FZD8-Fc) inhibits tumor growth and reduces tumor-initiating cell frequency in patient-derived hepatocellular carcinoma and ovarian cancer xenograft models

Pete Yeung, Lucia Beviglia, Belinda Cancilla, Cristina Dee-Hoskins, James W. Evans, Marcus M. Fischer, Wan-Ching Yen, Austin Gurney, John Lewicki, Timothy Hoey, Ann M. Kapoun
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1907.
DOI: https://doi.org/10.1158/1538-7445.AM2014-1907
Published: 01 October 2014
View article
Journal Articles

Abstract 1898: The combination of gemcitabine/nab-paclitaxel and anti-DLL4 (demcizumab) produces synergistic growth inhibition, delays tumor recurrence and reduces tumor initiating cells in pancreatic cancer

Wan-Ching Yen, Marcus Fischer, John Lewicki, Austin Gurney, Timothy Hoey
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1898.
DOI: https://doi.org/10.1158/1538-7445.AM2014-1898
Published: 01 October 2014
View article
Journal Articles

Abstract 2830: Predictive biomarker identification for response to vantictumab (OMP-18R5; anti-Frizzled) by mining gene expression data of human breast cancer xenografts

Chun Zhang, Pete Yeung, Lucia Beviglia, Belinda Cancilla, Tracy Tang, Wan-Ching Yen, Austin Gurney, John Lewicki, Timothy Hoey, Ann M. Kapoun
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2830.
DOI: https://doi.org/10.1158/1538-7445.AM2014-2830
Published: 01 October 2014
View article
Journal Articles

Abstract 3048: OMP-59R5 (Anti-Notch2/3) inhibits tumor growth and reduces cancer stem cell frequency in patient derived SCLC xenografts

Marcus M. Fischer, Jalpa Shah, Jennifer Cain, Belinda Cancilla, James W. Evans, Christopher L. Murriel, Tracy Tang, Jie Wei, Wan-Ching Yen, Chun Zhang, Austin Gurney, John Lewicki, Ann M. Kapoun, Timothy Hoey
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3048.
DOI: https://doi.org/10.1158/1538-7445.AM2014-3048
Published: 01 October 2014
View article
Journal Articles

Abstract 207: Dual targeting of DLL4 and VEGF signaling by a novel bispecific antibody inhibits tumor growth and reduces cancer stem cell frequency

Wan-Ching Yen, Fumiko Axelrod, Chris Bond, Jennifer Cain, Cecile Chartier, Marcus Fischer, Shirley Ma, Rene Meisner, Janak Raval, Jalpa Shah, Austin Gurney, John Lewicki, Timothy Hoey
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 207.
DOI: https://doi.org/10.1158/1538-7445.AM2014-207
Published: 01 October 2014
View article
Journal Articles

Abstract 910: NOTCH3 expression is predictive of efficacy in pancreas tumor models treated with OMP-59R5, a monoclonal antibody targeting the NOTCH2 and NOTCH3 receptors

Belinda Cancilla, Wan-Ching Yen, Chun Zhang, Marcus M. Fischer, May Ji, Tracy Tang, Yu-Wang Liu, Raymond S. Tam, Min Wang, Austin Gurney, Timothy Hoey, John Lewicki, Ann M. Kapoun
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 910.
DOI: https://doi.org/10.1158/1538-7445.AM2014-910
Published: 01 October 2014
View article
Journal Articles

Abstract 4547: Enhanced anti-tumor effect of WNT pathway antagonists in combination with taxanes

Wan-Ching Yen, Marcus M. Fischer, John Lewicki, Austin Gurney, Timothy Hoey
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4547.
DOI: https://doi.org/10.1158/1538-7445.AM2014-4547
Published: 01 October 2014
View article
Journal Articles

Abstract B44: Targeting Notch signaling with a dual Notch 2/3 antagonist, OMP-59R5, inhibits tumor growth and decreases cancer stem cell frequency in pancreatic cancer.

Wan-Ching Yen, Marcus Fischer, Aaron Sato, Min Wang, Ann M. Kapoun, John Lewicki, Austin Gurney, Timothy Hoey
Journal: Cancer Research
Cancer Res (2012) 72 (14_Supplement): B44.
DOI: https://doi.org/10.1158/1538-7445.PANCA2012-B44
Published: 03 April 2014
View article
Journal Articles

Abstract 3725: Anti-DLL4 (demcizumab) inhibits tumor growth and reduces cancer stem cell frequency in patient-derived ovarian cancer xenografts.

Wan-Ching Yen, Marcus M. Fischer, Jalpa Shah, Jie Wei, Jennifer Cain, Pete Yeung, Lucia Beviglia, Belinda Cancilla, Ann Kapoun, John Lewicki, Austin Gurney, Timothy Hoey
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3725.
DOI: https://doi.org/10.1158/1538-7445.AM2013-3725
Published: 15 April 2013
View article
Journal Articles

Abstract 218: R-Spondin (RSPO) signaling drives the growth of multiple human tumor types.

Austin Gurney, Cecile Chartier, Fumiko Axelrod, Jennifer Cain, Wan-Ching Yen, Christopher Murriel, Janak Raval, Marcus Fischer, Jalpa Shah, May Ji, Christopher Bond, Ann Kapoun, John Lewicki, Timothy Hoey
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 218.
DOI: https://doi.org/10.1158/1538-7445.AM2013-218
Published: 15 April 2013
View article
Journal Articles

Abstract 3357: Targeting cancer stem cells by an anti-DLL4 antibody inhibits epithelial-to-mesenchymal transition, delays tumor recurrence and overcomes drug resistance in breast and pancreatic cancer

Wan-Ching Yen, Marcus Fischer, John Lewicki, Austin Gurney, Timothy Hoey
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3357.
DOI: https://doi.org/10.1158/1538-7445.AM2012-3357
Published: 15 April 2012
View article