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Walter N. Hittelman
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Journal Articles

Abstract 5974: Targeting VEGFR on tumor cells and activated vasculature through delivery of granzyme B

Khalid A. Mohamedali, Lawrence H. Cheung, Ana Alvarez-Cienfuegos, Walter N. Hittelman, Michael G. Rosenblum
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5974.
https://doi.org/10.1158/1538-7445.AM2024-5974
Published: 22 March 2024
View articletitled, Abstract 5974: Targeting VEGFR on tumor cells and activated vasculature through delivery of granzyme B
Journal Articles

Abstract 6317: Targeting cell-surface CEA with a novel human fusion construct delivers the serine protease granzyme B to solid tumor cells

Khalid A. Mohamedali, Ana Alvarez-Cienfuegos, Lawrence H. Cheung, Walter N. Hittelman, Michael G. Rosenblum
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6317.
https://doi.org/10.1158/1538-7445.AM2023-6317
Published: 04 April 2023
View articletitled, Abstract 6317: Targeting cell-surface CEA with a novel human fusion construct delivers the serine protease granzyme B to solid tumor cells
Journal Articles

Abstract 6315: Human granzyme B fusions targeting VEGFR on tumor cells and activated vasculature

Khalid A. Mohamedali, Lawrence H. Cheung, Ana Alvarez-Cienfuegos, Walter N. Hittelman, Michael G. Rosenblum
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6315.
https://doi.org/10.1158/1538-7445.AM2023-6315
Published: 04 April 2023
View articletitled, Abstract 6315: Human granzyme B fusions targeting VEGFR on tumor cells and activated vasculature
Journal Articles

Abstract 337: Development of an immune-oncology agent containing granzyme B to target VEGFR+ ovarian cancer cells and activated tumor vasculature

Khalid A. Mohamedali, Lawrence H. Cheung, Ana Alvarez-Cienfuegos, Walter N. Hittelman, Michael G. Rosenblum
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 337.
https://doi.org/10.1158/1538-7445.AM2022-337
Published: 15 June 2022
View articletitled, Abstract 337: Development of an immune-oncology agent containing granzyme B to target VEGFR+ ovarian cancer cells and activated tumor vasculature
Journal Articles

Abstract 3439: An internalizing anti-CEA construct for targeted delivery of granzyme B results in significant antitumor activity in human lung carcinoma xenografts

Lawrence H. Cheung, Khalid A. Mohamedali, Ana Alvarez-Cienfuegos, Walter N. Hittelman, Michael G. Rosenblum
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3439.
https://doi.org/10.1158/1538-7445.AM2022-3439
Published: 15 June 2022
View articletitled, Abstract 3439: An internalizing anti-CEA construct for targeted delivery of granzyme B results in significant antitumor activity in human lung carcinoma xenografts
Journal Articles

Abstract 5176: A novel, completely human fusion construct containing active Granzyme B efficiently kills Folate Receptor alpha positive tumor cells

Ana Alvarez de Cienfuegos, Laurence H. Cheung, Khalid A. Mohamedali, Walter N. Hittelman, Michael G. Rosenblum
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5176.
https://doi.org/10.1158/1538-7445.AM2020-5176
Published: 15 August 2020
View articletitled, Abstract 5176: A novel, completely human fusion construct containing active Granzyme B efficiently kills Folate Receptor alpha positive tumor cells
Journal Articles

Abstract 2780: Engineering human fusion constructs for targeted delivery of granzyme B to CD33 and CEA antigens

Lawrence H. Cheung, Khalid A. Mohamedali, Walter N. Hittelman, Michael G. Rosenblum
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2780.
https://doi.org/10.1158/1538-7445.AM2018-2780
Published: 01 July 2018
View articletitled, Abstract 2780: Engineering human fusion constructs for targeted delivery of granzyme B to CD33 and CEA antigens
Journal Articles

CDKN2A/p16 Deletion in Head and Neck Cancer Cells Is Associated with CDK2 Activation, Replication Stress, and Vulnerability to CHK1 Inhibition

Mayur A. Gadhikar, Jiexin Zhang, Li Shen, Xiayu Rao, Jing Wang, Mei Zhao, Nene N. Kalu, Faye M. Johnson, Lauren A. Byers, John Heymach, Walter N. Hittelman, Durga Udayakumar, Raj K. Pandita, Tej K. Pandita, Curtis R. Pickering, Abena B. Redwood, Helen Piwnica-Worms, Katharina Schlacher, Mitchell J. Frederick, Jeffrey N. Myers
Journal: Cancer Research
Series: Author Choice
Cancer Res (2018) 78 (3): 781–797.
https://doi.org/10.1158/0008-5472.CAN-17-2802
Published: 31 January 2018
View articletitled, CDKN2A/p16 Deletion in Head and Neck Cancer Cells Is Associated with CDK2 Activation, Replication Stress, and Vulnerability to CHK1 Inhibition
Open the PDF for CDKN2A/p16 Deletion in Head and Neck Cancer Cells Is Associated with CDK2 Activation, Replication Stress, and Vulnerability to CHK1 Inhibition in another window
Includes: Supplementary data
Journal Articles

Abstract 1646: Highly cytotoxic, completely human constructs targeting HER2 and containing the immuno-oncology payload granzyme B

Lawrence H. Cheung, Yunli Zhao, Khalid A. Mohamedali, Ana Alvarez-Cienfuegos, Walter N. Hittelman, Michael G. Rosenblum
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1646.
https://doi.org/10.1158/1538-7445.AM2017-1646
Published: 01 July 2017
View articletitled, Abstract 1646: Highly cytotoxic, completely human constructs targeting HER2 and containing the immuno-oncology payload granzyme B
Journal Articles

Abstract 518: Ionizing radiation-induced DNA damage response decreases during induced pluripotent and embryonic stem cell differentiation

Kalpana Mujoo, Raj K. Pandita, Anjana Tiwari, Vijay Charaka, Walter N. Hittelman, Murlidhar Hegde, Haibo Wang, Clayton R. Hunt, Bhuvanesh Dave, Jenny Chang, E Brian Butler, Tej K. Pandita
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 518.
https://doi.org/10.1158/1538-7445.AM2016-518
Published: 15 July 2016
View articletitled, Abstract 518: Ionizing radiation-induced DNA damage response decreases during induced pluripotent and embryonic stem cell differentiation
Journal Articles

Cell Cycle–Dependent Mechanisms Underlie Vincristine-Induced Death of Primary Acute Lymphoblastic Leukemia Cells

Anisha Kothari, Walter N. Hittelman, Timothy C. Chambers
Journal: Cancer Research
Cancer Res (2016) 76 (12): 3553–3561.
https://doi.org/10.1158/0008-5472.CAN-15-2104
Published: 14 June 2016
View articletitled, Cell Cycle–Dependent Mechanisms Underlie Vincristine-Induced Death of Primary Acute Lymphoblastic Leukemia Cells
Open the PDF for Cell Cycle–Dependent Mechanisms Underlie Vincristine-Induced Death of Primary Acute Lymphoblastic Leukemia Cells in another window
Includes: Supplementary data
Journal Articles

Abstract 4512: Construction and characterization of novel, human serine protease granzyme B-based cancer therapeutics targeting the TNFR family member Fn14

Hong Zhou, Khalid A. Mohamedali, Yu Cao, Mary Migliorini, Lawrence H. Cheung, Walter N. Hittelman, Jeffrey A. Winkles, Michael G. Rosenblum
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4512.
https://doi.org/10.1158/1538-7445.AM2014-4512
Published: 01 October 2014
View articletitled, Abstract 4512: Construction and characterization of novel, human serine protease granzyme B-based cancer therapeutics targeting the TNFR family member Fn14
Journal Articles

Abstract 4509: The fully human, proapoptotic fusion protein Granzyme B/VEGF121 targets tumor vasculature and inhibits tumor growth

Khalid A. Mohamedali, Lawrence H. Cheung, Yu Cao, Walter N. Hittelman, Michael G. Rosenblum
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4509.
https://doi.org/10.1158/1538-7445.AM2014-4509
Published: 01 October 2014
View articletitled, Abstract 4509: The fully human, proapoptotic fusion protein Granzyme B/VEGF121 targets tumor vasculature and inhibits tumor growth
Journal Articles

Antitumor Activity of a Humanized, Bivalent Immunotoxin Targeting Fn14-Positive Solid Tumors

Hong Zhou, Walter N. Hittelman, Hideo Yagita, Lawrence H. Cheung, Stuart S. Martin, Jeffrey A. Winkles, Michael G. Rosenblum
Journal: Cancer Research
Cancer Res (2013) 73 (14): 4439–4450.
https://doi.org/10.1158/0008-5472.CAN-13-0187
Published: 15 July 2013
View articletitled, Antitumor Activity of a Humanized, Bivalent Immunotoxin Targeting Fn14-Positive Solid Tumors
Open the PDF for Antitumor Activity of a Humanized, Bivalent Immunotoxin Targeting Fn14-Positive Solid Tumors in another window
Includes: Supplementary data
Journal Articles

Abstract 2185: Development and characterization of the fully human chimeric protein GrB-TWEAK targeting Fn14-positive solid tumor cells.

Hong Zhou, Mary Migliorini, Yu Cao, Lawrence H. Cheung, Walter N. Hittelman, Jeffrey A. Winkles, Michael G. Rosenblum
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2185.
https://doi.org/10.1158/1538-7445.AM2013-2185
Published: 15 April 2013
View articletitled, Abstract 2185: Development and characterization of the fully human chimeric protein GrB-TWEAK targeting Fn14-positive solid tumor cells.
Journal Articles

Abstract 860: In vitro and in vivo studies of a novel, functionalized, completely human serine protease targeting Her2/neu. Activity against Herceptin- and multi-drug resistant tumor cells .

Yu Cao, Khalid A. Mohamedali, John W. Marks, Lawrence H. Cheung, Walter N. Hittelman, Michael G. Rosenblum
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 860.
https://doi.org/10.1158/1538-7445.AM2013-860
Published: 15 April 2013
View articletitled, Abstract 860: In vitro and in vivo studies of a novel, functionalized, completely human serine protease targeting Her2/neu. Activity against Herceptin- and multi-drug resistant tumor cells .
Journal Articles

Abstract 5479: The fully human pro-apoptotic fusion toxin Granzyme B/VEGF121 targets vasculature and ablates tumor growth.

Khalid A. Mohamedali, Lawrence H. Cheung, Yu Cao, Walter N. Hittelman, Michael G. Rosenblum
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5479.
https://doi.org/10.1158/1538-7445.AM2013-5479
Published: 15 April 2013
View articletitled, Abstract 5479: The fully human pro-apoptotic fusion toxin Granzyme B/VEGF121 targets vasculature and ablates tumor growth.
Journal Articles

Abstract 3870: Construction and characterization of completely human serine protease therapeutics targeting Her2/neu

Yu Cao, Khalid A. Mohamedali, Lawrence H. Chueng, Walter N. Hittelman, Michael G. Rosenblum
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3870.
https://doi.org/10.1158/1538-7445.AM2012-3870
Published: 15 April 2012
View articletitled, Abstract 3870: Construction and characterization of completely human serine protease therapeutics targeting Her2/neu
Journal Articles

Abstract 3866: TWEAK receptor (Fn14) Is a novel target in melanoma: Characterization of unique targeted therapeutics

Hong Zhou, Suhendan Ekmekcioglu, John W. Marks, Kaushal Asrani, Keeley K. Phillips, Sharron Brown, Emily Cheng, Michele B. Weiss, Walter N. Hittelman, Nhan L. Tran, Hideo Yagita, Jeffrey A. Winkles, Michael G. Rosenblum
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3866.
https://doi.org/10.1158/1538-7445.AM2012-3866
Published: 15 April 2012
View articletitled, Abstract 3866: TWEAK receptor (Fn14) Is a novel target in melanoma: Characterization of unique targeted therapeutics
Journal Articles

Abstract 2730: Anti-Her2/neu immunotoxins: Impact of monovalent and bivalent designs on in vitro and in vivo antitumor efficacy

Yu Cao, John W. Marks, Zhigang Liu, Lawrence H. Chueng, Walter N. Hittelman, Michael G. Rosenblum
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2730.
https://doi.org/10.1158/1538-7445.AM2012-2730
Published: 15 April 2012
View articletitled, Abstract 2730: Anti-Her2/neu immunotoxins: Impact of monovalent and bivalent designs on in vitro and in vivo antitumor efficacy