Search Results | Cancer Research | American Association for Cancer Research

1-20 of 239

2 3 4 5

Sort by

Sort Order Select

Journal Articles

Abstract 3947: Antitumor efficacy of combination treatment with ONC201 and enzalutamide or darolutamide in metastatic castration-resistant prostate cancer

Jinxuan Laura Wu, Lanlan Zhou, Leiqing Zhang, Kelsey E. Huntington, Benedito Carneiro, Wafik S. El-Deiry

Cancer Res (2022) 82 (12_Supplement): 3947.

DOI: https://doi.org/10.1158/1538-7445.AM2022-3947

Published: 15 June 2022

View article

Journal Articles

Abstract 1231: Prognostic and predictive drug-induced gene signatures for colorectal cancer patients personalized based on p53 status and treatment with FOLFOX, 5-FU, oxaliplatin, or irinotecan

Lindsey Carlsen, Andrew Elliott, Marzia Capelletti, Micheal Hall, Philip A. Philip, Heinz-Josef Lenz, Howard Safran, Khaldoun Almhanna, Rimini Breakstone, Alexander G. Raufi, Emil Lou, John L. Marshall, W. Michael Korn, Wafik S. El-Deiry

Cancer Res (2022) 82 (12_Supplement): 1231.

DOI: https://doi.org/10.1158/1538-7445.AM2022-1231

Published: 15 June 2022

View article

Journal Articles

Abstract 5699: Overexpression of KMT2A is associated with worse prognosis and specific immune signatures in patients with TP53-mutated hepatocellular carcinomas

Liang Sha, Jun Yin, Sungming Kim, Woojin An, Jian Zhang, Alex Farrell, Joanne Xiu, David Spetzler, Shuanzeng Wei, Dave S. Hoon, Stephen V. Liu, Emil Lou, Misako Nagasaka, Wafik S. El-Deiry, Benedito A. Carneiro, Wolfgang Michael Korn, Heinz-Josef Lenz, Yali Dou

Cancer Res (2022) 82 (12_Supplement): 5699.

DOI: https://doi.org/10.1158/1538-7445.AM2022-5699

Published: 15 June 2022

View article

Journal Articles

Abstract 3709: Synergistic activity of ABT-263 and ONC201 against solid tumor cell lines is associated with suppression of BAG3, Mcl-1, pAkt, and upregulation of Noxa along with Bax cleavage during apoptosis

Francesca R. Di Cristofano, Mara Fong, Lanlan Zhou, Wafik S. El-Deiry

Cancer Res (2022) 82 (12_Supplement): 3709.

DOI: https://doi.org/10.1158/1538-7445.AM2022-3709

Published: 15 June 2022

View article

Journal Articles

Abstract 91: Classification of cancer cells based on unexpected variation in levels and dynamics of pRb, pERK, and pAKT in response to cell synchronization from nutrient deprivation

Lindsey Carlsen, Wafik S. El-Deiry

Cancer Res (2022) 82 (12_Supplement): 91.

DOI: https://doi.org/10.1158/1538-7445.AM2022-91

Published: 15 June 2022

View article

Journal Articles

Abstract 5854: Therapeutic targeting of p73-activated c-FLIP switches cell fate from growth arrest and survival to apoptosis in p53-deficient cancer cells

Shengliang Zhang, Wafik S. El-Deiry

Cancer Res (2022) 82 (12_Supplement): 5854.

DOI: https://doi.org/10.1158/1538-7445.AM2022-5854

Published: 15 June 2022

View article

Journal Articles

Abstract 5297: ONC201 suppresses cancer cell growth in a reconstructed tumor microenvironment that includes chemotherapy-induced senescent fibroblasts

Shengliang Zhang, Kelsey E. Huntington, Bianca Kun, Lanlan Zhou, Jill Kreiling, John M. Sedivy, Wafik S. El-Deiry

Cancer Res (2022) 82 (12_Supplement): 5297.

DOI: https://doi.org/10.1158/1538-7445.AM2022-5297

Published: 15 June 2022

View article

Journal Articles

Abstract 3548: Role of the cancer cell proteome and tumor microenvironment in the hyperprogression (HP) phenotype response to immune checkpoint blockade

Andrew George, Ilyas Sahin, Shengliang Zhang, Wafik S. El-Deiry

Cancer Res (2022) 82 (12_Supplement): 3548.

DOI: https://doi.org/10.1158/1538-7445.AM2022-3548

Published: 15 June 2022

View article

Journal Articles

Abstract 4056: ONC201 in combination with carboplatin and etoposide as a novel triple drug treatment for small cell lung cancer (SCLC)

Young S. Lee, Lanlan Zhou, Christopher Azzoli, Wafik S. El-Deiry

Cancer Res (2022) 82 (12_Supplement): 4056.

DOI: https://doi.org/10.1158/1538-7445.AM2022-4056

Published: 15 June 2022

View article

Journal Articles

Abstract 4064: Synergistic activity of Lurbinectidin plus ONC201 in SCLC is associated with ATF4, CHOP and pChk1 induction

Nicholas R. Liguori, Ashley Fss Uruchurtu, Young Lee, Leiqing Zhang, Abbas Abbas, Varun Prabhu, Lanlan Zhou, Christopher J. Azzoli, Wafik S. El-Deiry

Cancer Res (2022) 82 (12_Supplement): 4064.

DOI: https://doi.org/10.1158/1538-7445.AM2022-4064

Published: 15 June 2022

View article

Journal Articles

Abstract 2783: Increased tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression in normal colonic mucosa with imipridone ONC201/TIC10 treatment: A potential biomarker for chemoprevention studies

Alexander G. Raufi, Arielle De La Cruz, Andrew George, Sean Hacking, Venkateshwar Madka, Varun Prabhu, Howard Safran, Lanlan Zhou, Dean Brenner, Chinthalapally V. Rao, Wafik S. El-Deiry

Cancer Res (2022) 82 (12_Supplement): 2783.

DOI: https://doi.org/10.1158/1538-7445.AM2022-2783

Published: 15 June 2022

View article

Journal Articles

Abstract 5607: Combining PD-1 inhibition with the TRAIL receptor agonist TLY012 promotes pancreatic ductal adenocarcinoma tumor regression in an immunocompetent mouse model

Anna D. Louie, Kelsey E. Huntington, Young Lee, Jared Mompoint, Jinxuan Wu, Seulki Lee, Wafik S. El-Deiry

Cancer Res (2022) 82 (12_Supplement): 5607.

DOI: https://doi.org/10.1158/1538-7445.AM2022-5607

Published: 15 June 2022

View article

Journal Articles

Abstract 319: Imipridone ONC212 and trametinib combination therapy demonstrates anti-neoplastic effects through immune-mediated mechanisms in pancreatic ductal adenocarcinoma cell lines

Alexander G. Raufi, Arielle De La Cruz, Lindsey Carlsen, Kelsey Huntington, Lanlan Zhou, Varun Prabhu, Joshua Allen, Wafik S. El-Deiry

Cancer Res (2022) 82 (12_Supplement): 319.

DOI: https://doi.org/10.1158/1538-7445.AM2022-319

Published: 15 June 2022

View article

Journal Articles

Abstract 1008: Cell density-related variability in chemotherapeutic resistance patterns in human cancer cells

Thomas Brown, Ujwal Punyamurtula, Jill Strandberg, Wafik S. El-Deiry

Cancer Res (2022) 82 (12_Supplement): 1008.

DOI: https://doi.org/10.1158/1538-7445.AM2022-1008

Published: 15 June 2022

View article

Journal Articles

Abstract 1856: Adaptation to dopamine impairs the anti-cancer effect of ONC201 and ONC206

Yiqun Zhang, Wafik S. El-Deiry

Cancer Res (2022) 82 (12_Supplement): 1856.

DOI: https://doi.org/10.1158/1538-7445.AM2022-1856

Published: 15 June 2022

View article

Journal Articles

Abstract LB516: MDM2/MDM4 amplification and CDKN2A deletion in melanoma brain metastases and GBM may have implications for targeted therapeutics and immunotherapy

Taylor E. Arnoff, Wafik S. El-Deiry

Cancer Res (2022) 82 (12_Supplement): LB516.

DOI: https://doi.org/10.1158/1538-7445.AM2022-LB516

Published: 15 June 2022

View article

Journal Articles

Abstract 120: HIF-1α regulation by Smurf2-mediated protein degradation in a VHL-independent manner

Shuai Zhao, Wafik S. El-Deiry

Cancer Res (2022) 82 (12_Supplement): 120.

DOI: https://doi.org/10.1158/1538-7445.AM2022-120

Published: 15 June 2022

View article

Journal Articles

Abstract 5448: Synergistic antitumor effect of ONC201, radiotherapy and temozolomide in glioblastoma mouse orthotopic models

Lanlan Zhou, Jinxuan Laura Wu, Howard P. Safran, Wafik S. El-Deiry

Cancer Res (2022) 82 (12_Supplement): 5448.

DOI: https://doi.org/10.1158/1538-7445.AM2022-5448

Published: 15 June 2022

View article

Journal Articles

Abstract 5490: Comparative activation of cellular ISR and cell death induction by p53 pathway restoring small molecules

Xiaobing Tian, Wafik S. El-Deiry

Cancer Res (2022) 82 (12_Supplement): 5490.

DOI: https://doi.org/10.1158/1538-7445.AM2022-5490

Published: 15 June 2022

View article

Journal Articles

Abstract PD6-04: Mutational landscape and immune infiltration of breast cancer metastases to gynecologic and other organs

Anna D Louie, Rani Chudasama, Sharon Wu, Marzia Capelletti, Daniel Magee, W. Michael Korn, Virginia Kaklamani, Antoinette R Tan, Pavani Chalasani, Wafik S El-Deiry, Don Dizon, Stephanie L. Graff

Cancer Res (2022) 82 (4_Supplement): PD6-04.

DOI: https://doi.org/10.1158/1538-7445.SABCS21-PD6-04

Published: 15 February 2022

View article

2 3 4 5

NARROW

Abstract 3947: Antitumor efficacy of combination treatment with ONC201 and enzalutamide or darolutamide in metastatic castration-resistant prostate cancer

Abstract 1231: Prognostic and predictive drug-induced gene signatures for colorectal cancer patients personalized based on p53 status and treatment with FOLFOX, 5-FU, oxaliplatin, or irinotecan

Abstract 5699: Overexpression of KMT2A is associated with worse prognosis and specific immune signatures in patients with TP53-mutated hepatocellular carcinomas

Abstract 3709: Synergistic activity of ABT-263 and ONC201 against solid tumor cell lines is associated with suppression of BAG3, Mcl-1, pAkt, and upregulation of Noxa along with Bax cleavage during apoptosis

Abstract 91: Classification of cancer cells based on unexpected variation in levels and dynamics of pRb, pERK, and pAKT in response to cell synchronization from nutrient deprivation

Abstract 5854: Therapeutic targeting of p73-activated c-FLIP switches cell fate from growth arrest and survival to apoptosis in p53-deficient cancer cells

Abstract 5297: ONC201 suppresses cancer cell growth in a reconstructed tumor microenvironment that includes chemotherapy-induced senescent fibroblasts

Abstract 3548: Role of the cancer cell proteome and tumor microenvironment in the hyperprogression (HP) phenotype response to immune checkpoint blockade

Abstract 4056: ONC201 in combination with carboplatin and etoposide as a novel triple drug treatment for small cell lung cancer (SCLC)

Abstract 4064: Synergistic activity of Lurbinectidin plus ONC201 in SCLC is associated with ATF4, CHOP and pChk1 induction

Abstract 2783: Increased tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression in normal colonic mucosa with imipridone ONC201/TIC10 treatment: A potential biomarker for chemoprevention studies

Abstract 5607: Combining PD-1 inhibition with the TRAIL receptor agonist TLY012 promotes pancreatic ductal adenocarcinoma tumor regression in an immunocompetent mouse model

Abstract 319: Imipridone ONC212 and trametinib combination therapy demonstrates anti-neoplastic effects through immune-mediated mechanisms in pancreatic ductal adenocarcinoma cell lines

Abstract 1008: Cell density-related variability in chemotherapeutic resistance patterns in human cancer cells

Abstract 1856: Adaptation to dopamine impairs the anti-cancer effect of ONC201 and ONC206

Abstract LB516: MDM2/MDM4 amplification and CDKN2A deletion in melanoma brain metastases and GBM may have implications for targeted therapeutics and immunotherapy

Abstract 120: HIF-1α regulation by Smurf2-mediated protein degradation in a VHL-independent manner

Abstract 5448: Synergistic antitumor effect of ONC201, radiotherapy and temozolomide in glioblastoma mouse orthotopic models

Abstract 5490: Comparative activation of cellular ISR and cell death induction by p53 pathway restoring small molecules

Abstract PD6-04: Mutational landscape and immune infiltration of breast cancer metastases to gynecologic and other organs

Email alerts

AACR Journals

Email alerts

AACR Journals

This Feature Is Available To Subscribers Only