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Journal Articles

Tie2–FGFR1 Interaction Induces Adaptive PI3K Inhibitor Resistance by Upregulating Aurora A/PLK1/CDK1 Signaling in Glioblastoma

Xiaolong Li, Emmanuel Martinez-Ledesma, Chen Zhang, Feng Gao, Siyuan Zheng, Jie Ding, Shaofang Wu, Nghi Nguyen, Stephan C. Clifford, Patrick Y. Wen, Keith L. Ligon, W.K. Alfred Yung, Dimpy Koul
Journal: Cancer Research
Cancer Res (2019) 79 (19): 5088–5101.
https://doi.org/10.1158/0008-5472.CAN-19-0325
Published: 01 October 2019
View article titled, Tie2–FGFR1 Interaction Induces Adaptive PI3K Inhibitor Resistance by Upregulating Aurora A/PLK1/CDK1 Signaling in Glioblastoma
Open the PDF for Tie2–FGFR1 Interaction Induces Adaptive PI3K Inhibitor Resistance by Upregulating Aurora A/PLK1/CDK1 Signaling in Glioblastoma in another window
Includes: Supplementary data
Journal Articles

Abstract 4032: Pharmacogenomic analysis of acquired resistance can reveal effective drug combination in glioblastoma

Xiaolong Li, Juan Martinez-Ledesma, Chen Zhang, Feng Gao, W.K. Alfred Yung, Dimpy Koul
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4032.
https://doi.org/10.1158/1538-7445.AM2018-4032
Published: 01 July 2018
View article titled, Abstract 4032: Pharmacogenomic analysis of acquired resistance can reveal effective drug combination in glioblastoma
Journal Articles

Abstract 2122: Downregulation of RGS10 induces PI3K/mTOR inhibitor resistance by Ras activation in glioblastoma

Xiaolong Li, Shaofang Wu, Dimpy Koul, W.K. Alfred Yung.
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2122.
https://doi.org/10.1158/1538-7445.AM2016-2122
Published: 15 July 2016
View article titled, Abstract 2122: Downregulation of RGS10 induces PI3K/mTOR inhibitor resistance by Ras activation in glioblastoma
Journal Articles

Abstract 3298: ABL1 is required for Tie2-mediated DNA repair in brain tumor stem cells

Mohammad B. Hossain, Rehnuma Shifat, David G. Johnson, Mark T. Bedford, Mien-Chie Hung, Nahir Cortes-Santiago, Konrad Gabrusiewicz, Joy Gumin, Ravesanker Ezhilarasan, Erik P. Sulman, Frederick Lang, Raymond Sawaya, W.K. Alfred Yung, Juan Fueyo, Candelaria Gomez-Manzano
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3298.
https://doi.org/10.1158/1538-7445.AM2015-3298
Published: 01 August 2015
View article titled, Abstract 3298: ABL1 is required for Tie2-mediated DNA repair in brain tumor stem cells
Journal Articles

Abstract 936: Comprehensive and integrative genomic characterization of diffuse lower grade gliomas

Roel G.W. Verhaak, Lee A.D. Cooper, Sofie S. Salama, Kenneth Aldape, W.K. Alfred Yung, Daniel J. Brat
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 936.
https://doi.org/10.1158/1538-7445.AM2014-936
Published: 01 October 2014
View article titled, Abstract 936: Comprehensive and integrative genomic characterization of diffuse lower grade gliomas
Journal Articles

Novel HSP90 Inhibitor NVP-HSP990 Targets Cell-Cycle Regulators to Ablate Olig2-Positive Glioma Tumor–Initiating Cells

Jun Fu, Dimpy Koul, Jun Yao, Shuzhen Wang, Ying Yuan, Howard Colman, Erik. P. Sulman, Frederick. F. Lang, W.K. Alfred Yung
Journal: Cancer Research
Cancer Res (2013) 73 (10): 3062–3074.
https://doi.org/10.1158/0008-5472.CAN-12-2033
Published: 12 May 2013
View article titled, Novel HSP90 Inhibitor NVP-HSP990 Targets Cell-Cycle Regulators to Ablate Olig2-Positive Glioma Tumor–Initiating Cells
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Includes: Supplementary data
Journal Articles

Abstract 3347: A proneural signature profile predicts response to Notch inhibition in glioma stem cells

Norihiko Saito, Jun Fu, Jun Yao, Roel GW Verhaak, Dimpy Koul, W.K. Alfred Yung
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3347.
https://doi.org/10.1158/1538-7445.AM2012-3347
Published: 15 April 2012
View article titled, Abstract 3347: A proneural signature profile predicts response to Notch inhibition in glioma stem cells
Journal Articles

Abstract 5214: Functional interaction between foxm1 and β-catenin

Aihua Gong, Guanzhen Yu, Nu Zhang, Ping Wei, Kenneth D. Aldape, Howard Colman, Jianfei Xue, Mingguang Liu, Raymond Sawaya, Keping Xie, W.K. Alfred Yung, René H. Medema, Xi He, Suyun Huang
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 5214.
https://doi.org/10.1158/1538-7445.AM2012-5214
Published: 15 April 2012
View article titled, Abstract 5214: Functional interaction between foxm1 and β-catenin
Journal Articles

Abstract 1982: Analyzing TCGA data: A novel, systems-oriented method for diagnosing batch effects and adjusting for them

Nianxiang Zhang, Rehan Akbani, Li Zhang, Bradley Broom, Keith A. Baggerly, Gordon B. Mills, W.K. Alfred Yung, John N. Weinstein
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1982.
https://doi.org/10.1158/1538-7445.AM10-1982
Published: 15 April 2010
View article titled, Abstract 1982: Analyzing TCGA data: A novel, systems-oriented method for diagnosing batch effects and adjusting for them
Journal Articles

Adenovirus-Based Strategies Overcome Temozolomide Resistance by Silencing the O6-Methylguanine-DNA Methyltransferase Promoter

Marta M. Alonso, Candelaria Gomez-Manzano, B. Nebiyou Bekele, W.K. Alfred Yung, Juan Fueyo
Journal: Cancer Research
Cancer Res (2007) 67 (24): 11499–11504.
https://doi.org/10.1158/0008-5472.CAN-07-5312
Published: 18 December 2007
View article titled, Adenovirus-Based Strategies Overcome Temozolomide Resistance by Silencing the O<sup>6</sup>-Methylguanine-DNA Methyltransferase Promoter
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Journal Articles

Cell Cycle–Dependent Nuclear Export of Phosphatase and Tensin Homologue Tumor Suppressor Is Regulated by the Phosphoinositide-3-Kinase Signaling Cascade

Juinn-Lin Liu, Zhenyu Mao, Tiffany A. LaFortune, Marta M. Alonso, Gary E. Gallick, Juan Fueyo, W.K. Alfred Yung
Journal: Cancer Research
Cancer Res (2007) 67 (22): 11054–11063.
https://doi.org/10.1158/0008-5472.CAN-07-1263
Published: 15 November 2007
View article titled, Cell Cycle–Dependent Nuclear Export of Phosphatase and Tensin Homologue Tumor Suppressor Is Regulated by the Phosphoinositide-3-Kinase Signaling Cascade
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Journal Articles

Transgenic E2F1 Expression in the Mouse Brain Induces a Human-Like Bimodal Pattern of Tumors

Melissa V. Olson, David G. Johnson, Hong Jiang, Jing Xu, Marta M. Alonso, Kenneth D. Aldape, Gregory N. Fuller, B. Nebiyou Bekele, W.K. Alfred Yung, Candelaria Gomez-Manzano, Juan Fueyo
Journal: Cancer Research
Cancer Res (2007) 67 (9): 4005–4009.
https://doi.org/10.1158/0008-5472.CAN-06-2973
Published: 04 May 2007
View article titled, Transgenic E2F1 Expression in the Mouse Brain Induces a Human-Like Bimodal Pattern of Tumors
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Includes: Multimedia, Supplementary data
Journal Articles

Polyamine catabolism drug N1, N11-Diethylnorspermine caused cell death in glioblastoma cells via inhibition of mTOR-regulated protein initiation

Woonyoung Choi, Rongcai Jiang, Asad Khan, W.K. Alfred Yung, Eugene Gerner, Stanley Hamilton, Wei Zhang
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 4076.
Published: 01 May 2007
View article titled, Polyamine catabolism drug N<sup>1</sup>, N<sup>11</sup>-Diethylnorspermine caused cell death in glioblastoma cells via inhibition of mTOR-regulated protein initiation
Journal Articles

PAX6 Suppresses the Invasiveness of Glioblastoma Cells and the Expression of the Matrix Metalloproteinase-2 Gene

Debra A. Mayes, Yuanjie Hu, Yue Teng, Eric Siegel, Xiaosong Wu, Kishori Panda, Fang Tan, W.K. Alfred Yung, Yi-Hong Zhou
Journal: Cancer Research
Cancer Res (2006) 66 (20): 9809–9817.
https://doi.org/10.1158/0008-5472.CAN-05-3877
Published: 17 October 2006
View article titled, PAX6 Suppresses the Invasiveness of Glioblastoma Cells and the Expression of the Matrix Metalloproteinase-2 Gene
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Journal Articles

Exportin 1-mediated nuclear export of adenovirus E1A protein: a novel target for generation of oncolytic viruses

Hong Jiang, Melissa V. Olson, Jing Xu, Ok-Hee Lee, Yuji Piao, W.k Alfred Yung, Juan Fueyo
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 702.
Published: 15 April 2006
View article titled, Exportin 1-mediated nuclear export of adenovirus E1A protein: a novel target for generation of oncolytic viruses
Journal Articles

Transgenic mouse model provides the first direct evidence supporting the oncogenic role of E2F1 in brain

Melissa V. Olson, David G. Johnson, Kenneth D. Aldape, Gregory N. Fuller, Hong Jiang, W.k. Alfred Yung, Abhijit Guha, Candelaria Gomez-Manzano, Juan Fueyo-Margareto
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 643.
Published: 15 April 2006
View article titled, Transgenic mouse model provides the first direct evidence supporting the oncogenic role of E2F1 in brain
Journal Articles

The Excitatory Amino Acid Transporter-2 Induces Apoptosis and Decreases Glioma Growth In vitro and In vivo

John F. de Groot, Ta Jen Liu, Gregory Fuller, W.K. Alfred Yung
Journal: Cancer Research
Cancer Res (2005) 65 (5): 1934–1940.
https://doi.org/10.1158/0008-5472.CAN-04-3626
Published: 07 March 2005
View article titled, The Excitatory Amino Acid Transporter-2 Induces Apoptosis and Decreases Glioma Growth <em>In vitro</em> and <em>In vivo</em>
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Journal Articles

Integrated Array-Comparative Genomic Hybridization and Expression Array Profiles Identify Clinically Relevant Molecular Subtypes of Glioblastoma

Janice M. Nigro, Anjan Misra, Li Zhang, Ivan Smirnov, Howard Colman, Chandi Griffin, Natalie Ozburn, Mingang Chen, Edward Pan, Dimpy Koul, W.K. Alfred Yung, Burt G. Feuerstein, Kenneth D. Aldape
Journal: Cancer Research
Cancer Res (2005) 65 (5): 1678–1686.
https://doi.org/10.1158/0008-5472.CAN-04-2921
Published: 07 March 2005
View article titled, Integrated Array-Comparative Genomic Hybridization and Expression Array Profiles Identify Clinically Relevant Molecular Subtypes of Glioblastoma
Open the PDF for Integrated Array-Comparative Genomic Hybridization and Expression Array Profiles Identify Clinically Relevant Molecular Subtypes of Glioblastoma in another window
Includes: Supplementary data