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W. Marston Linehan
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Journal Articles

TFE3-Splicing Factor Fusions Represent Functional Drivers and Druggable Targets in Translocation Renal Cell Carcinoma

Nur P. Damayanti, Ricardo A. Cordova, Christopher Rupert, Ilaria Delle Fontane, Li Shen, Sabrina Orsi, Angela J. Klunk, W. Marston Linehan, Kirk A. Staschke, Peter C. Hollenhorst, David E. Heppner, Roberto Pili
Journal: Cancer Research
Cancer Res (2024) 84 (8): 1286–1302.
https://doi.org/10.1158/0008-5472.CAN-23-1789
Published: 15 April 2024
View article titled, TFE3-Splicing Factor Fusions Represent Functional Drivers and Druggable Targets in Translocation Renal Cell Carcinoma
Open the PDF for TFE3-Splicing Factor Fusions Represent Functional Drivers and Druggable Targets in Translocation Renal Cell Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract CT221: Belzutifan, a hypoxia-inducible factor-2α (HIF-2α) inhibitor, for von Hippel-Lindau (VHL) disease-associated neoplasms: Long-term results of the phase 2 LITESPARK-004 study

Ramaprasad Srinivasan, Othon Iliopoulos, Kathryn E. Beckermann, Vivek Narayan, Benjamin L. Maughan, Stephane Oudard, Tobias Else, Jodi K. Maranchie, Ane B. Iversen, Jerry Cornell, Rodolfo F. Perini, Yanfang Liu, W. Marston Linehan, Eric Jonasch
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT221.
https://doi.org/10.1158/1538-7445.AM2024-CT221
Published: 05 April 2024
View article titled, Abstract CT221: Belzutifan, a hypoxia-inducible factor-2α (HIF-2α) inhibitor, for von Hippel-Lindau (VHL) disease-associated neoplasms: Long-term results of the phase 2 LITESPARK-004 study
Journal Articles

Abstract 7544: Bromodomain and extra-terminal protein inhibitors deplete nuclear factor 1C and reduce stemness and growth of human small cell lung cancer cells in vitro and in vivo

Haitao Wang, Ruihong Wang, Frank Villa-Hernandez, Vivek Shukla, Lyuba Varticovski, Songjoon Baek, Frank Echtenkamp, Sudheer Kumar Gara, Mary R. Zhang, Stephanie Shiffka, Razi Raziuddin, Leonard M. Neckers, W. Marston Linehan, Gordon L. Hager, Shamus R. Carr, Chuong D. Hoang, Haobin Chen, David S. Schrump
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7544.
https://doi.org/10.1158/1538-7445.AM2024-7544
Published: 22 March 2024
View article titled, Abstract 7544: Bromodomain and extra-terminal protein inhibitors deplete nuclear factor 1C and reduce stemness and growth of human small cell lung cancer cells in vitro and in vivo
Journal Articles

Abstract 4221: Anti-Tumor activity of the multityrosine kinase inhibitor dasatinib in type 1 papillary renal cell carcinoma

Roma Pahwa, Janhavi Dubhashi, Abhigya Giri, Craig Thomas, Michele Ceribelli, Parthav Jailwala, Alexei Lobanov, Anand Singh, Carole Sourbier, Christopher J. Ricketts, Cathy D. Vocke, Youfeng Yang, W. Marston Linehan, Ramaprasad Srinivasan
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4221.
https://doi.org/10.1158/1538-7445.AM2020-4221
Published: 15 August 2020
View article titled, Abstract 4221: Anti-Tumor activity of the multityrosine kinase inhibitor dasatinib in type 1 papillary renal cell carcinoma
Journal Articles

Abstract 4708: Comprehensive analysis of 71 VHL germline deletions and rearrangements

Cathy D. Vocke, Christopher J. Ricketts, Laura S. Schmidt, Mark W. Ball, James Peterson, Lindsay A. Middelton, W Marston Linehan
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4708.
https://doi.org/10.1158/1538-7445.AM2020-4708
Published: 15 August 2020
View article titled, Abstract 4708: Comprehensive analysis of 71 <em>VHL</em> germline deletions and rearrangements
Journal Articles

Abstract 4719: Novel germline variants in hereditary renal cell carcinoma genes elucidated by whole genome sequencing

Cathy D. Vocke, Christopher J. Ricketts, Daniel R. Crooks, Martin Lang, Laura S. Schmidt, Mayank Tandon, Bao Tran, Christina Fitzsimmons, Pedro J. Batista, Mark W. Ball, W. Marston Linehan
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4719.
https://doi.org/10.1158/1538-7445.AM2020-4719
Published: 15 August 2020
View article titled, Abstract 4719: Novel germline variants in hereditary renal cell carcinoma genes elucidated by whole genome sequencing
Journal Articles

Abstract 2340: Differences in risk factors for molecular subtypes of clear cell renal cell carcinoma in a case-control study

Mark P. Purdue, Jongeun Rhee, Lee Moore, Xiaohua Gao, Xuezheng Sun, Erin Kirk, Catherine Callahan, Vladimir Bencko, Vladimir Janout, Dana Mates, Lenka Foretova, Neonilia Szeszenia-Dabrowska, Vsevolod Matveev, David Zaridze, Stacey Petruzella, A. Ari Hakimi, Maria Merino, W. Marston Linehan, Paul Brennan, Helena Furberg, Melissa Troester, Nathaniel Rothman
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 2340.
https://doi.org/10.1158/1538-7445.AM2020-2340
Published: 15 August 2020
View article titled, Abstract 2340: Differences in risk factors for molecular subtypes of clear cell renal cell carcinoma in a case-control study
Journal Articles

Abstract 2760: Photoinducible detection of the oncometabolite fumarate

Chloe Briney, Sarah Bergholtz, Rhushikesh Kulkarni, Daniel Crooks, Chandrasekhar Mushti, Stephen Lockett, Rolf Swenson, W. Marston Linehan, Jordan Meier
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2760.
https://doi.org/10.1158/1538-7445.AM2019-2760
Published: 01 July 2019
View article titled, Abstract 2760: Photoinducible detection of the oncometabolite fumarate
Journal Articles

Abstract 2759: Chemoproteomic profiling of the oncometabolite fumarate

Sarah E. Bergholtz, Chloe A. Briney, Rhushikesh A. Kulkarni, David Wei, Daniel W. Bak, Jonathan H. Shrimp, Eranthie Weerapana, W. Marston Linehan, Jordan L. Meier
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2759.
https://doi.org/10.1158/1538-7445.AM2019-2759
Published: 01 July 2019
View article titled, Abstract 2759: Chemoproteomic profiling of the oncometabolite fumarate
Journal Articles

Pathologic Oxidation of PTPN12 Underlies ABL1 Phosphorylation in Hereditary Leiomyomatosis and Renal Cell Carcinoma

Yang Xu, Paul Taylor, Joshua Andrade, Beatrix Ueberheide, Brian Shuch, Peter M. Glazer, Ranjit S. Bindra, Michael F. Moran, W. Marston Linehan, Benjamin G. Neel
Journal: Cancer Research
Series: Author Choice
Cancer Res (2018) 78 (23): 6539–6548.
https://doi.org/10.1158/0008-5472.CAN-18-0901
Published: 03 December 2018
View article titled, Pathologic Oxidation of PTPN12 Underlies ABL1 Phosphorylation in Hereditary Leiomyomatosis and Renal Cell Carcinoma
Open the PDF for Pathologic Oxidation of PTPN12 Underlies ABL1 Phosphorylation in Hereditary Leiomyomatosis and Renal Cell Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 3842: Potent antitumor activity of the HSP90 inhibitor SNX-2112 in type 1 papillary renal cell carcinoma

Roma Pahwa, Abhigya Giri, Carole Sourbier, Craig Thomas, W Marston Linehan, Len Neckers, Ramaprasad Srinivasan
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3842.
https://doi.org/10.1158/1538-7445.AM2018-3842
Published: 01 July 2018
View article titled, Abstract 3842: Potent antitumor activity of the HSP90 inhibitor SNX-2112 in type 1 papillary renal cell carcinoma
Journal Articles

Abstract 1244: BHD-associated kidney cancer exhibits unique molecular characteristics and a wide variety of mutations in chromatin remodeling genes

Ryosuke Jikuya, Mitsuko Furuya, Masaya Baba, Hiroyuki Aburatani, Adam R. Metwalli, Laura S. Schmidt, W. Marston Linehan, Masahiro Yao, Hisashi Hasumi
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1244.
https://doi.org/10.1158/1538-7445.AM2018-1244
Published: 01 July 2018
View article titled, Abstract 1244: BHD-associated kidney cancer exhibits unique molecular characteristics and a wide variety of mutations in chromatin remodeling genes
Journal Articles

Abstract 1169: Novel renal medullary carcinoma cell lines, UOK353 and UOK360, provide preclinical tools to identify new therapeutics

Darmood Wei, Youfeng Yang, Christopher J. Ricketts, Cathy D. Vocke, Mark W. Ball, Carole Sourbier, Darawalee Wangsa, Danny Wangsa, Rajarshi Guha, Xiaohu Zhang, Paul Meltzer, Thomas Reid, Craig J. Thomas, Maria J. Merino, W. Marston Linehan
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1169.
https://doi.org/10.1158/1538-7445.AM2018-1169
Published: 01 July 2018
View article titled, Abstract 1169: Novel renal medullary carcinoma cell lines, UOK353 and UOK360, provide preclinical tools to identify new therapeutics
Journal Articles

Abstract 1439: Asparagine stimulates growth and endoplasmic reticulum stress response in a fumarate hydratase-deficient renal cell carcinoma cell line

Rony Panarsky, Youfeng Yang, W. Marston Linehan, Jeffrey A. Moscow
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1439.
https://doi.org/10.1158/1538-7445.AM2018-1439
Published: 01 July 2018
View article titled, Abstract 1439: Asparagine stimulates growth and endoplasmic reticulum stress response in a fumarate hydratase-deficient renal cell carcinoma cell line
Journal Articles

Abstract 4237: Differences in the frequencies of tumor VHL mutation and HIF-2α expression between black and white patients with clear cell renal carcinoma

Catherine L. Callahan, Lee E. Moore, Petra Lenz, Kendra Schwartz, Julie Ruterbusch, Faith Davis, Wong-Ho Chow, W. Marston Linehan, Maria J. Merino, Stephen M. Hewitt, Nathaniel Rothman, Jonathan N. Hofmann, Michael L. Nickerson, Mark P. Purdue
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4237.
https://doi.org/10.1158/1538-7445.AM2018-4237
Published: 01 July 2018
View article titled, Abstract 4237: Differences in the frequencies of tumor <em>VHL</em> mutation and HIF-2α expression between black and white patients with clear cell renal carcinoma
Journal Articles

Abstract 3527: Clarification of the molecular mechanism for cancer development in Xp11.2 translocation renal cell carcinoma

Masaya Baba, Ying Huang, Takanobu Motoshima, Hisashi Hasumi, Yukiko Hasumi, Mitsuko Furuya, Yoji Nagashima, Masahiro Yao, Yuichi Oike, Tomomi Kamba, Laura S. Schmidt, W. Marston Linehan
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3527.
https://doi.org/10.1158/1538-7445.AM2017-3527
Published: 01 July 2017
View article titled, Abstract 3527: Clarification of the molecular mechanism for cancer development in Xp11.2 translocation renal cell carcinoma
Journal Articles

Abstract 3179: Germline deletion of FH in hereditary leiomyomatosis and renal cell carcinoma (HLRCC)

Cathy D. Vocke, Christopher J. Ricketts, Lindsay A. Middelton, Youfeng Yang, W. Marston Linehan.
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3179.
https://doi.org/10.1158/1538-7445.AM2016-3179
Published: 15 July 2016
View article titled, Abstract 3179: Germline deletion of FH in hereditary leiomyomatosis and renal cell carcinoma (HLRCC)
Journal Articles

Abstract LB-184: Hyperpolarized 13C-pyruvate magnetic resonance spectroscopic imaging of prostate cancer tumor xenografts

Bradley T. Scroggins, Masayuki Matsuo, Jeeva P. Munasinghe, Ayla O. White, Carole Sourbier, Shingo Matsumoto, W. Marston Linehan, James B. Mitchell, Murali C. Krishna, Deborah E. Citrin
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-184.
https://doi.org/10.1158/1538-7445.AM2016-LB-184
Published: 15 July 2016
View article titled, Abstract LB-184: Hyperpolarized <sup>13</sup>C-pyruvate magnetic resonance spectroscopic imaging of prostate cancer tumor xenografts
Journal Articles

Abstract 1288: Targeting the Hippo pathway in NF-2 deficient papillary kidney cancers

Carole Sourbier, Penny Liao, Christopher J. Ricketts, Darmood Wei, Youfeng Yang, Sarah M. Baranes, Toshiki Kijima, Louis S. Krane, Myriem Boufraqech, Lernik Ohanjanian, Ben Gibbs, Ming-Hui Wei, Len Neckers, Cathy D. Vocke, W. Marston Linehan.
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1288.
https://doi.org/10.1158/1538-7445.AM2016-1288
Published: 15 July 2016
View article titled, Abstract 1288: Targeting the Hippo pathway in NF-2 deficient papillary kidney cancers
Journal Articles

Abstract 2660: A renal CpG island methylator phenotype (R-CIMP) in kidney tumors associated with germline mutations of FH and SDHB

Christopher Ricketts, J. Keith Killian, Cathy D. Vocke, Carole Sourbier, Youfeng Yang, Maria J. Merino, Paul S. Meltzer, W. Marston Linehan.
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2660.
https://doi.org/10.1158/1538-7445.AM2016-2660
Published: 15 July 2016
View article titled, Abstract 2660: A renal CpG island methylator phenotype (R-CIMP) in kidney tumors associated with germline mutations of <em>FH</em> and <em>SDHB</em>