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W. Jack Pledger
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Journal Articles

Abstract 5112: Tumor cell expression of a distinct TME gene signature defines differential drug sensitivities to EGFR/MEK/SRC targeted agents

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Mingli Yang, Michael V. Nebozhyn, Lance Pflieger, Ramani Soundararajan, Michelle Maurin, Heiman Wang, Andrey Loboda, W. Jack Pledger, Timothy J. Yeatman
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5112.
https://doi.org/10.1158/1538-7445.AM2025-5112
Published: 21 April 2025
View article titled, Abstract 5112: Tumor cell expression of a distinct TME gene signature defines differential drug sensitivities to EGFR/MEK/SRC targeted agents
Journal Articles

Abstract 5366: Hotspot mutations of TP53 sensitize APC-mutated colorectal cancer cells to cetuximab in vitro

Free
Mingli Yang, Heiman Wang, Thomas B. Davis, Lance Pflieger, Ramya Thota, W. Jack Pledger, Timothy J. Yeatman
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5366.
https://doi.org/10.1158/1538-7445.AM2022-5366
Published: 15 June 2022
View article titled, Abstract 5366: Hotspot mutations of TP53 sensitize APC-mutated colorectal cancer cells to cetuximab in vitro
Journal Articles

Abstract 1083: A novel role of SRC in mediating bypass resistance to MEK inhibition in colorectal cancer stem cells

Free
Mingli Yang, Thomas B. Davis B. Davis, Michael V. Nebozhyn, Andrey Loboda, Heiman Wang, Michael J. Schell, Lance Pflieger, Ramya Thota, W. Jack Pledger, Timothy J. Yeatman
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1083.
https://doi.org/10.1158/1538-7445.AM2021-1083
Published: 01 July 2021
View article titled, Abstract 1083: A novel role of SRC in mediating bypass resistance to MEK inhibition in colorectal cancer stem cells
Journal Articles

Abstract 5789: A novel role of APC-partnering mutations in the sidedness of colorectal cancer survival

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Mingli Yang, Michael Schell, Andrey Loboda, Michael Nebozhyn, W. Jack Pledger, Timothy Yeatman
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5789.
https://doi.org/10.1158/1538-7445.AM2020-5789
Published: 15 August 2020
View article titled, Abstract 5789: A novel role of APC-partnering mutations in the sidedness of colorectal cancer survival
Journal Articles

Abstract 2571: An integral genomic/expression analysis reveals a cooperative role of APC and TP53 mutations in identifying cetuximab-sensitive colorectal cancer

Free
Mingli Yang, Michael J. Schell, Andrey Loboda, Michael V. Nebozhyn, Jiannong Li, Jamie K. Teer, W. Jack Pledger, Timothy J. Yeatman
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2571.
https://doi.org/10.1158/1538-7445.AM2018-2571
Published: 01 July 2018
View article titled, Abstract 2571: An integral genomic/expression analysis reveals a cooperative role of APC and TP53 mutations in identifying cetuximab-sensitive colorectal cancer
Journal Articles

Abstract 4135: Inactivation/loss of PTPRS promotes ERK activation that sensitizes colorectal cancer cells to ERK inhibitors

Free
Thomas B. Davis, Mingli Yang, Michael J. Schell, Heiman Wang, Le Ma, W. Jack Pledger, Timothy J. Yeatman
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4135.
https://doi.org/10.1158/1538-7445.AM2017-4135
Published: 01 July 2017
View article titled, Abstract 4135: Inactivation/loss of PTPRS promotes ERK activation that sensitizes colorectal cancer cells to ERK inhibitors
Journal Articles

Abstract 3596: SCH727965, a cyclin-dependent kinases inhibitor, induces apoptosis in sarcoma cells through caspase 3- dependent pathway

Free
Wei Fu, Le Ma, Baoky Chu, Xue Wang, Tapan K. Bagui, Marilyn M. Bui, Jennifer Gemmer, Soner Altiok, Douglas G. Letson, W. Jack Pledger
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 3596.
https://doi.org/10.1158/1538-7445.AM2011-3596
Published: 15 April 2011
View article titled, Abstract 3596: SCH727965, a cyclin-dependent kinases inhibitor, induces apoptosis in sarcoma cells through caspase 3- dependent pathway
Journal Articles

Dasatinib Inhibits Migration and Invasion in Diverse Human Sarcoma Cell Lines and Induces Apoptosis in Bone Sarcoma Cells Dependent on Src Kinase for Survival

Free
Audrey C. Shor, Elizabeth A. Keschman, Francis Y. Lee, Carlos Muro-Cacho, G. Douglas Letson, Jonathan C. Trent, W. Jack Pledger, Richard Jove
Journal: Cancer Research
Cancer Res (2007) 67 (6): 2800–2808.
https://doi.org/10.1158/0008-5472.CAN-06-3469
Published: 15 March 2007
View article titled, Dasatinib Inhibits Migration and Invasion in Diverse Human Sarcoma Cell Lines and Induces Apoptosis in Bone Sarcoma Cells Dependent on Src Kinase for Survival
Open the PDF for Dasatinib Inhibits Migration and Invasion in Diverse Human Sarcoma Cell Lines and Induces Apoptosis in Bone Sarcoma Cells Dependent on Src Kinase for Survival in another window
Journal Articles

PDGF-R alpha expression and activation in human sarcoma.

Free
T. Christopher Windham, Gina Z. D’Amato, Elizabeth A. Keschman, Subhra Mohapatra, Audrey C. Burns, Daniel Sullivan, G. Douglas Letson, Rich Jove, W. Jack Pledger
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1176.
Published: 15 April 2006
View article titled, PDGF-R alpha expression and activation in human sarcoma.
Journal Articles

Identification of novel Bax-interacting proteins involved in p53-dependent but transcription-independent apoptosis of prostate cancer cells

Free
Subhra Mohapatra, John Koomen, Baoky Chu, Xiuhua Zhao, W. Jack Pledger
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 962.
Published: 15 April 2006
View article titled, Identification of novel Bax-interacting proteins involved in p53-dependent but transcription-independent apoptosis of prostate cancer cells
Journal Articles

p53-induced apoptosis of prostate cancer cells requires XIAP down-regulation

Free
Subhra Mohapatra, Baoky Chu, Xiuhua Zhao, W. Jack Pledger
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 531.
Published: 01 May 2005
View article titled, p53-induced apoptosis of prostate cancer cells requires XIAP down-regulation
Journal Articles

Identification of primary cellular targets of purine analogues in human tumor cell lines by microarray analysis

Free
Steven A. Enkemann, W. Jack Pledger, Subhra Mohapatra
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 552.
Published: 01 May 2005
View article titled, Identification of primary cellular targets of purine analogues in human tumor cell lines by microarray analysis
Journal Articles

p21Cip1 Nullizygosity Increases Tumor Metastasis in Irradiated Mice

Free
Rosalind J. Jackson, Robert W. Engelman, Domenico Coppola, Alan B. Cantor, Walker Wharton, W. Jack Pledger
Journal: Cancer Research
Cancer Res (2003) 63 (12): 3021–3025.
Published: 15 June 2003
View article titled, p21Cip1 Nullizygosity Increases Tumor Metastasis in Irradiated Mice
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