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Gemcitabine-Induced TIMP1 Attenuates Therapy Response and Promotes Tumor Growth and Liver Metastasis in Pancreatic Cancer

Zenobia D'Costa, Keaton Jones, Abul Azad, Ruud van Stiphout, Su Y. Lim, Ana L. Gomes, Paul Kinchesh, Sean C. Smart, W. Gillies McKenna, Francesca M. Buffa, Owen J. Sansom, Ruth J. Muschel, Eric O'Neill, Emmanouil Fokas

Cancer Res (2017) 77 (21): 5952–5962.

DOI: https://doi.org/10.1158/0008-5472.CAN-16-2833

Published: 31 October 2017

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Includes: Supplementary data

Journal Articles

Dual Inhibition of the PI3K/mTOR Pathway Increases Tumor Radiosensitivity by Normalizing Tumor Vasculature

Emmanouil Fokas, Jae Hong Im, Sally Hill, Sabira Yameen, Michael Stratford, John Beech, Wolfgang Hackl, Sauveur-Michel Maira, Eric J. Bernhard, W. Gillies McKenna, Ruth J. Muschel

Cancer Res (2012) 72 (1): 239–248.

DOI: https://doi.org/10.1158/0008-5472.CAN-11-2263

Published: 02 January 2012

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Includes: Supplementary data

Journal Articles

A Small Interfering RNA Screen of Genes Involved in DNA Repair Identifies Tumor-Specific Radiosensitization by POLQ Knockdown

Geoff S. Higgins, Remko Prevo, Yin-Fai Lee, Thomas Helleday, Ruth J. Muschel, Steve Taylor, Michio Yoshimura, Ian D. Hickson, Eric J. Bernhard, W. Gillies McKenna

Cancer Res (2010) 70 (7): 2984–2993.

DOI: https://doi.org/10.1158/0008-5472.CAN-09-4040

Published: 31 March 2010

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Includes: Supplementary data

Journal Articles

Tumor Vascular Changes Mediated by Inhibition of Oncogenic Signaling

Naseer Qayum, Ruth J. Muschel, Jae Hong Im, Lukxmi Balathasan, Cameron J. Koch, Sonal Patel, W. Gillies McKenna, Eric J. Bernhard

Cancer Res (2009) 69 (15): 6347–6354.

DOI: https://doi.org/10.1158/0008-5472.CAN-09-0657

Published: 29 July 2009

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Includes: Supplementary data

Journal Articles

Abstract #3970: Cells deficient in the base excision repair protein, DNA polymerase beta, are hypersensitive to oxaliplatin chemotherapy: A scientific rationale for chemo-radiation treatment

Nils Nicolay, Jian Yang, Jason Parsons, Simona Caporali, Stefania D'Atri, Christopher Harrington, Raj Singh, Peter Farmer, Patrick Johnson, Mark Middleton, W. Gillies McKenna, Grigory Dianov, Ricky Sharma

Cancer Res (2009) 69 (9_Supplement): 3970.

Published: 01 May 2009

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Journal Articles

Class I PI3 Kinase Inhibition by the Pyridinylfuranopyrimidine Inhibitor PI-103 Enhances Tumor Radiosensitivity

Remko Prevo, Eric Deutsch, Oliver Sampson, Julie Diplexcito, Keith Cengel, Jane Harper, Peter O'Neill, W. Gillies McKenna, Sonal Patel, Eric J. Bernhard

Cancer Res (2008) 68 (14): 5915–5923.

DOI: https://doi.org/10.1158/0008-5472.CAN-08-0757

Published: 15 July 2008

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Includes: Supplementary data

Journal Articles

HIV Protease Inhibitors Block Akt Signaling and Radiosensitize Tumor Cells Both In vitro and In vivo

Anjali K. Gupta, George J. Cerniglia, Rosemarie Mick, W. Gillies McKenna, Ruth J. Muschel

Cancer Res (2005) 65 (18): 8256–8265.

DOI: https://doi.org/10.1158/0008-5472.CAN-05-1220

Published: 15 September 2005

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Journal Articles

Pancreatic Cancer Cell Radiation Survival and Prenyltransferase Inhibition: The Role of K-Ras

Thomas B. Brunner, Keith A. Cengel, Stephen M. Hahn, Junmin Wu, Douglas L. Fraker, W. Gillies McKenna, Eric J. Bernhard

Cancer Res (2005) 65 (18): 8433–8441.

DOI: https://doi.org/10.1158/0008-5472.CAN-05-0158

Published: 15 September 2005

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Journal Articles

Selective Inhibition of Ras, Phosphoinositide 3 Kinase, and Akt Isoforms Increases the Radiosensitivity of Human Carcinoma Cell Lines

In-Ah Kim, Sun-Sik Bae, Annemarie Fernandes, JunMin Wu, Ruth J. Muschel, W. Gillies McKenna, Morris J. Birnbaum, Eric J. Bernhard

Cancer Res (2005) 65 (17): 7902–7910.

DOI: https://doi.org/10.1158/0008-5472.CAN-05-0513

Published: 01 September 2005

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Journal Articles

H-Ras as a target of farnesyltransferase-mediated radiosensitization in mutant K-ras expressing colon and pancreatic carcinoma cells

Keith A. Cengel, Thomas B. Brunner, Laurence Maggiorella, Eric J. Stanbridge, W. Gillies McKenna, Eric J. Bernhard

Cancer Res (2005) 65 (9_Supplement): 1120.

Published: 01 May 2005

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Journal Articles

The use of HIV protease inhibitors as radiosensitizers

Anjali K. Gupta, George J. Cerniglia, Rosemarie Mick, Ruth J. Muschel, W. Gillies McKenna

Cancer Res (2005) 65 (9_Supplement): 285.

Published: 01 May 2005

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Journal Articles

Resistance to Small Molecule Inhibitors of Epidermal Growth Factor Receptor in Malignant Gliomas

Bin Li, Chi-Ming Chang, Min Yuan, W. Gillies McKenna, Hui-Kuo G. Shu

Cancer Res (2003) 63 (21): 7443–7450.

Published: 11 November 2003

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Journal Articles

Farnesyltransferase Inhibitors: An Overview of the Results of Preclinical and Clinical Investigations

Thomas B. Brunner, Stephen M. Hahn, Anjali K. Gupta, Ruth J. Muschel, W. Gillies McKenna, Eric J. Bernhard

Cancer Res (2003) 63 (18): 5656–5668.

Published: 01 October 2003

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Journal Articles

The Ras Radiation Resistance Pathway

Anjali K. Gupta, Vincent J. Bakanauskas, George J. Cerniglia, Yi Cheng, Eric J. Bernhard, Ruth J. Muschel, W. Gillies McKenna

Cancer Res (2001) 61 (10): 4278–4282.

Published: 01 May 2001

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Journal Articles

The Farnesyltransferase Inhibitor L744,832 Reduces Hypoxia in Tumors Expressing Activated H-ras

Elizabeth Cohen-Jonathan, Sydney M. Evans, Cameron J. Koch, Ruth J. Muschel, W. Gillies McKenna, JunMin Wu, Eric J. Bernhard

Cancer Res (2001) 61 (5): 2289–2293.

Published: 01 March 2001

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Journal Articles

Direct Evidence for the Contribution of Activated N-ras and K-ras Oncogenes to Increased Intrinsic Radiation Resistance in Human Tumor Cell Lines

Eric J. Bernhard, Eric J. Stanbridge, Swati Gupta, Anjali K. Gupta, Daniel Soto, Vincent J. Bakanauskas, George J. Cerniglia, Ruth J. Muschel, W. Gillies McKenna

Cancer Res (2000) 60 (23): 6597–6600.

Published: 01 December 2000

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Journal Articles

Detection of Hypoxia in Human Squamous Cell Carcinoma by EF5 Binding

Sydney M. Evans, Stephen Hahn, Deirdre R. Pook, W. Timothy Jenkins, Ara A. Chalian, Paul Zhang, Craig Stevens, Randall Weber, Gregory Weinstein, Ivor Benjamin, Natasha Mirza, Mark Morgan, Steven Rubin, W. Gillies McKenna, Edith M. Lord, Cameron J. Koch

Cancer Res (2000) 60 (7): 2018–2024.

Published: 01 April 2000

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Journal Articles

The G₂ Block Induced by DNA Damage: A Caffeine-resistant Component Independent of Cdc25C, MPM-2 Phosphorylation, and H1 Kinase Activity

Ruth A. Barratt, Gary Kao, W. Gillies McKenna, Jian Kuang, Ruth J. Muschel

Cancer Res (1998) 58 (12): 2639–2645.

Published: 01 June 1998

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Journal Articles

Inhibiting Ras Prenylation Increases the Radiosensitivity of Human Tumor Cell Lines with Activating Mutations of ras Oncogenes

Eric J. Bernhard, W. Gillies McKenna, Andrew D. Hamilton, Said M. Sebti, Yimin Qian, JunMin Wu, Ruth J. Muschel

Cancer Res (1998) 58 (8): 1754–1761.

Published: 01 April 1998

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Journal Articles

Cyclin B1 Availability Is a Rate-limiting Component of the Radiation-induced G₂ Delay in HeLa Cells

Gary D. Kao, W. Gillies McKenna, Amit Maity, Kenneth Blank, Ruth J. Muschel

Cancer Res (1997) 57 (4): 753–758.

Published: 01 February 1997

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NARROW

Gemcitabine-Induced TIMP1 Attenuates Therapy Response and Promotes Tumor Growth and Liver Metastasis in Pancreatic Cancer

Dual Inhibition of the PI3K/mTOR Pathway Increases Tumor Radiosensitivity by Normalizing Tumor Vasculature

A Small Interfering RNA Screen of Genes Involved in DNA Repair Identifies Tumor-Specific Radiosensitization by POLQ Knockdown

Tumor Vascular Changes Mediated by Inhibition of Oncogenic Signaling

Abstract #3970: Cells deficient in the base excision repair protein, DNA polymerase beta, are hypersensitive to oxaliplatin chemotherapy: A scientific rationale for chemo-radiation treatment

Class I PI3 Kinase Inhibition by the Pyridinylfuranopyrimidine Inhibitor PI-103 Enhances Tumor Radiosensitivity

HIV Protease Inhibitors Block Akt Signaling and Radiosensitize Tumor Cells Both In vitro and In vivo

Pancreatic Cancer Cell Radiation Survival and Prenyltransferase Inhibition: The Role of K-Ras

Selective Inhibition of Ras, Phosphoinositide 3 Kinase, and Akt Isoforms Increases the Radiosensitivity of Human Carcinoma Cell Lines

H-Ras as a target of farnesyltransferase-mediated radiosensitization in mutant K-ras expressing colon and pancreatic carcinoma cells

The use of HIV protease inhibitors as radiosensitizers

Resistance to Small Molecule Inhibitors of Epidermal Growth Factor Receptor in Malignant Gliomas

Farnesyltransferase Inhibitors: An Overview of the Results of Preclinical and Clinical Investigations

The Ras Radiation Resistance Pathway

The Farnesyltransferase Inhibitor L744,832 Reduces Hypoxia in Tumors Expressing Activated H-ras

Direct Evidence for the Contribution of Activated N-ras and K-ras Oncogenes to Increased Intrinsic Radiation Resistance in Human Tumor Cell Lines

Detection of Hypoxia in Human Squamous Cell Carcinoma by EF5 Binding

The G₂ Block Induced by DNA Damage: A Caffeine-resistant Component Independent of Cdc25C, MPM-2 Phosphorylation, and H1 Kinase Activity

Inhibiting Ras Prenylation Increases the Radiosensitivity of Human Tumor Cell Lines with Activating Mutations of ras Oncogenes

Cyclin B1 Availability Is a Rate-limiting Component of the Radiation-induced G₂ Delay in HeLa Cells

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