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Vincent W. Keng
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Journal Articles

EPHB2 Activates β-Catenin to Enhance Cancer Stem Cell Properties and Drive Sorafenib Resistance in Hepatocellular Carcinoma

Hoi Wing Leung, Carmen Oi Ning Leung, Eunice Y. Lau, Katherine Po Sin Chung, Etienne H. Mok, Martina Mang Leng Lei, Rainbow Wing Hei Leung, Man Tong, Vincent W. Keng, Cong Ma, Qian Zhao, Irene Oi Lin Ng, Stephanie Ma, Terence K. Lee
Journal: Cancer Research
Cancer Res (2021) 81 (12): 3229–3240.
https://doi.org/10.1158/0008-5472.CAN-21-0184
Published: 15 June 2021
View article titled, EPHB2 Activates β-Catenin to Enhance Cancer Stem Cell Properties and Drive Sorafenib Resistance in Hepatocellular Carcinoma
Open the PDF for EPHB2 Activates β-Catenin to Enhance Cancer Stem Cell Properties and Drive Sorafenib Resistance in Hepatocellular Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 5183: Using transposon elements to elucidate the genetic mechanisms of HCC-associated lung metastases

Lilian H. Lo, Amy P. Chiu, Xiao-Xiao Li, Barbara R. Tschida, Dewi K. Rowlands, David A. Largaespada, Vincent W. Keng
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5183.
https://doi.org/10.1158/1538-7445.AM2018-5183
Published: 01 July 2018
View article titled, Abstract 5183: Using transposon elements to elucidate the genetic mechanisms of HCC-associated lung metastases
Journal Articles

Sleeping Beauty Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors

Barbara R. Tschida, Nuri A. Temiz, Timothy P. Kuka, Lindsey A. Lee, Jesse D. Riordan, Carlos A. Tierrablanca, Robert Hullsiek, Sandra Wagner, Wendy A. Hudson, Michael A. Linden, Khalid Amin, Pauline J. Beckmann, Rachel A. Heuer, Aaron L. Sarver, Ju Dong Yang, Lewis R. Roberts, Joseph H. Nadeau, Adam J. Dupuy, Vincent W. Keng, David A. Largaespada
Journal: Cancer Research
Cancer Res (2017) 77 (23): 6576–6588.
https://doi.org/10.1158/0008-5472.CAN-17-2281
Published: 30 November 2017
View article titled, <em>Sleeping Beauty</em> Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors
Open the PDF for <em>Sleeping Beauty</em> Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors in another window
Includes: Supplementary data
Journal Articles

Abstract 63: A transposon-based forward genetic screen for steatosis-associated liver cancer drivers

Barbara R. Tschida, N. Alpay Temiz, Ju D. Yang, Vincent W. Keng, David A. Largaespada
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 63.
https://doi.org/10.1158/1538-7445.AM2016-63
Published: 15 July 2016
View article titled, Abstract 63: A transposon-based forward genetic screen for steatosis-associated liver cancer drivers
Journal Articles

Abstract 929: Identification of ZBTB20 as a novel oncogene associated with the gender bias occurrence of hepatocellular carcinoma

Vincent W. Keng, Barbara R. Tschida, Timothy P. Kuka, Branden S. Moriarity, Jason B. Bell, David A. Largaespada
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 929.
https://doi.org/10.1158/1538-7445.AM2014-929
Published: 01 October 2014
View article titled, Abstract 929: Identification of ZBTB20 as a novel oncogene associated with the gender bias occurrence of hepatocellular carcinoma
Journal Articles

Abstract 354: Conditional inactivation of Pten and overexpression of EGFR in Schwann cells results in early high-grade peripheral nerve sheath tumor development.

Vincent W. Keng, Adrienne L. Watson, Eric P. Rahrmann, Hua Li, Barbara R. Tschida, Branden S. Moriarity, Kwangmin Choi, Tilat A. Rizvi, Margaret H. Collins, Margaret R. Wallace, Nancy Ratner, David A. Largaespada
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 354.
https://doi.org/10.1158/1538-7445.AM2013-354
Published: 15 April 2013
View article titled, Abstract 354: Conditional inactivation of <em>Pten</em> and overexpression of <em>EGFR</em> in Schwann cells results in early high-grade peripheral nerve sheath tumor development.
Journal Articles

PTEN and NF1 Inactivation in Schwann Cells Produces a Severe Phenotype in the Peripheral Nervous System That Promotes the Development and Malignant Progression of Peripheral Nerve Sheath Tumors

Vincent W. Keng, Eric P. Rahrmann, Adrienne L. Watson, Barbara R. Tschida, Christopher L. Moertel, Walter J. Jessen, Tilat A. Rizvi, Margaret H. Collins, Nancy Ratner, David A. Largaespada
Journal: Cancer Research
Cancer Res (2012) 72 (13): 3405–3413.
https://doi.org/10.1158/0008-5472.CAN-11-4092
Published: 01 July 2012
View article titled, <em>PTEN</em> and <em>NF1</em> Inactivation in Schwann Cells Produces a Severe Phenotype in the Peripheral Nervous System That Promotes the Development and Malignant Progression of Peripheral Nerve Sheath Tumors
Open the PDF for <em>PTEN</em> and <em>NF1</em> Inactivation in Schwann Cells Produces a Severe Phenotype in the Peripheral Nervous System That Promotes the Development and Malignant Progression of Peripheral Nerve Sheath Tumors in another window
Includes: Supplementary data
Journal Articles

Abstract 4182: A screen for genes that define the strong gender bias nature of hepatocellular carcinoma using a transposon mutagenesis murine model

Vincent W. Keng, Barbara J. Ryan, Kevin A.T. Silverstein, Aaron Sarver, Danhua Fan, Adam J. Dupuy, Nancy A. Jenkins, Neal G. Copeland, David A. Largaespada
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 4182.
https://doi.org/10.1158/1538-7445.AM10-4182
Published: 15 April 2010
View article titled, Abstract 4182: A screen for genes that define the strong gender bias nature of hepatocellular carcinoma using a transposon mutagenesis murine model
Journal Articles

Abstract 2199: A murine insertional mutagenesis screen to identify oncogenes and tumor suppressor genes involved in Schwann cell tumorigenesis

David A. Largaespada, Eric P. Rahrmann, Vincent W. Keng, H B. Clark, Adam J. Dupuy, Lino Tessarollo, Nancy A. Jenkins, Neal G. Copeland, Nancy Ratner
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2199.
https://doi.org/10.1158/1538-7445.AM10-2199
Published: 15 April 2010
View article titled, Abstract 2199: A murine insertional mutagenesis screen to identify oncogenes and tumor suppressor genes involved in Schwann cell tumorigenesis
Journal Articles

Abstract 236: Sleeping Beauty transposon integration within the Dlk1-Dio3 imprinted domain is associated with hepatocellular carcinoma development

Jesse D. Riordan, Vincent W. Keng, Barbara J. Ryan, Kelly M. Podetz-Pedersen, Neal G. Copeland, Nancy A. Jenkins, David A. Largaespada, Adam J. Dupuy
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 236.
https://doi.org/10.1158/1538-7445.AM10-236
Published: 15 April 2010
View article titled, Abstract 236: Sleeping Beauty transposon integration within the Dlk1-Dio3 imprinted domain is associated with hepatocellular carcinoma development