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Journal Articles

CD122-Selective IL2 Complexes Reduce Immunosuppression, Promote Treg Fragility, and Sensitize Tumor Response to PD-L1 Blockade

Justin M. Drerup, Yilun Deng, Sri Lakshmi Pandeswara, Álvaro S. Padrón, Ryan M. Reyes, Xinyue Zhang, Jenny Mendez, Aijie Liu, Curtis A. Clark, Wanjiao Chen, José R. Conejo-Garcia, Vincent Hurez, Harshita Gupta, Tyler J. Curiel

Cancer Res (2020) 80 (22): 5063–5075.

DOI: https://doi.org/10.1158/0008-5472.CAN-20-0002

Published: 13 November 2020

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Includes: Supplementary data

Journal Articles

Abstract 3792: Intratumoral CD56^bright natural killer cells are associated with improved survival in bladder cancer

Neelam Mukherjee, Niannian Ji, Maggie E. Tomasini, Vincent Hurez, Tyler J. Curiel, Maureen O. Montgomery, Andrew J. Braun, Marlo Nicolas, Marcela A. Flores, Qianqian Liu, Jianhua Ruan, Robert S. Svatek

Cancer Res (2018) 78 (13_Supplement): 3792.

DOI: https://doi.org/10.1158/1538-7445.AM2018-3792

Published: 01 July 2018

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Journal Articles

Abstract 1608: CD122-selective IL-2/anti-IL-2 complexes reduce regulatory T cell function and promote CD8⁺ T cell polyfunctionality for durable ovarian cancer immunotherapy

Justin M. Drerup, Sri Lakshmi Pandeswara, Aijie Liu, Curtis A. Clark, Alvaro S. Padron, Wanjiao Chen, Vincent Hurez, Tyler J. Curiel

Cancer Res (2017) 77 (13_Supplement): 1608.

DOI: https://doi.org/10.1158/1538-7445.AM2017-1608

Published: 01 July 2017

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Journal Articles

Abstract 3696: Tumor-intrinsic PD-L1 alters tumor chemokines, NK cell trafficking and function, and renders distant PD-L1 null tumors responsive to αPD-L1

Curtis A. Clark, Harshita B. Gupta, Alvaro Padron, Deyi Zhang, Vincent Hurez, Mary Jo Turk, Rong Li, Tyler Curiel

Cancer Res (2017) 77 (13_Supplement): 3696.

DOI: https://doi.org/10.1158/1538-7445.AM2017-3696

Published: 01 July 2017

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Journal Articles

Abstract 5649: Cell-intrinsic PD-L1 directs tumor initiating cell fate and rapamycin and interferon-γ response

Harshita B. Gupta, Curtis A. Clark, Bin Yuan, Gangadhara Sareddy, Srilakshmi Pandeswara, Alvaro S. Padron, Vincent Hurez, Jose-Conejo Garcia, Ratna Vadlamudi, Rong Li, Tyler J. Curiel

Cancer Res (2017) 77 (13_Supplement): 5649.

DOI: https://doi.org/10.1158/1538-7445.AM2017-5649

Published: 01 July 2017

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Journal Articles

Biphasic Rapamycin Effects in Lymphoma and Carcinoma Treatment

Yang Liu, Srilakshmi Pandeswara, Vinh Dao, Álvaro Padrón, Justin M. Drerup, Shunhua Lao, Aijie Liu, Vincent Hurez, Tyler J. Curiel

Cancer Res (2017) 77 (2): 520–531.

DOI: https://doi.org/10.1158/0008-5472.CAN-16-1140

Published: 16 January 2017

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Includes: Supplementary data

Journal Articles

Tumor-Intrinsic PD-L1 Signals Regulate Cell Growth, Pathogenesis, and Autophagy in Ovarian Cancer and Melanoma

Curtis A. Clark, Harshita B. Gupta, Gangadhara Sareddy, Srilakshmi Pandeswara, Shunhua Lao, Bin Yuan, Justin M. Drerup, Alvaro Padron, José Conejo-Garcia, Kruthi Murthy, Yang Liu, Mary Jo Turk, Kathrin Thedieck, Vincent Hurez, Rong Li, Ratna Vadlamudi, Tyler J. Curiel

Cancer Res (2016) 76 (23): 6964–6974.

DOI: https://doi.org/10.1158/0008-5472.CAN-16-0258

Published: 30 November 2016

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Includes: Supplementary data

Journal Articles

Immune-Stimulatory Effects of Rapamycin Are Mediated by Stimulation of Antitumor γδ T Cells

Vinh Dao, Yang Liu, Srilakshmi Pandeswara, Robert S. Svatek, Jonathan A. Gelfond, Aijie Liu, Vincent Hurez, Tyler J. Curiel

Cancer Res (2016) 76 (20): 5970–5982.

DOI: https://doi.org/10.1158/0008-5472.CAN-16-0091

Published: 13 October 2016

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Includes: Supplementary data

Journal Articles

Abstract LB-259: Interferon-α enhances clinical benefits of regulatory T cell depletion in ovarian cancer through direct T cell effects and by inducing bystander IL-6

Suzanne Thibodeaux, Vincent Hurez, Shawna Wall, Srilakshmi Pandeswara, Benjamin Daniel, Aijie Liu, Lishi Sun, Leslie Wood, Weiping Zou, Tyler Curiel

Cancer Res (2014) 74 (19_Supplement): LB-259.

DOI: https://doi.org/10.1158/1538-7445.AM2014-LB-259

Published: 01 October 2014

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Journal Articles

Mitigating Age-Related Immune Dysfunction Heightens the Efficacy of Tumor Immunotherapy in Aged Mice

Vincent Hurez, Benjamin J. Daniel, Lishi Sun, Ai-Jie Liu, Sara M. Ludwig, Mark J. Kious, Suzanne R. Thibodeaux, Srilakshmi Pandeswara, Kruthi Murthy, Carolina B. Livi, Shawna Wall, Michael J. Brumlik, Tahiro Shin, Bin Zhang, Tyler J. Curiel

Cancer Res (2012) 72 (8): 2089–2099.

DOI: https://doi.org/10.1158/0008-5472.CAN-11-3019

Published: 16 April 2012

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Includes: Supplementary data

NARROW

CD122-Selective IL2 Complexes Reduce Immunosuppression, Promote Treg Fragility, and Sensitize Tumor Response to PD-L1 Blockade

Abstract 3792: Intratumoral CD56^bright natural killer cells are associated with improved survival in bladder cancer

Abstract 1608: CD122-selective IL-2/anti-IL-2 complexes reduce regulatory T cell function and promote CD8⁺ T cell polyfunctionality for durable ovarian cancer immunotherapy

Abstract 3696: Tumor-intrinsic PD-L1 alters tumor chemokines, NK cell trafficking and function, and renders distant PD-L1 null tumors responsive to αPD-L1

Abstract 5649: Cell-intrinsic PD-L1 directs tumor initiating cell fate and rapamycin and interferon-γ response

Biphasic Rapamycin Effects in Lymphoma and Carcinoma Treatment

Tumor-Intrinsic PD-L1 Signals Regulate Cell Growth, Pathogenesis, and Autophagy in Ovarian Cancer and Melanoma

Immune-Stimulatory Effects of Rapamycin Are Mediated by Stimulation of Antitumor γδ T Cells

Abstract LB-259: Interferon-α enhances clinical benefits of regulatory T cell depletion in ovarian cancer through direct T cell effects and by inducing bystander IL-6

Mitigating Age-Related Immune Dysfunction Heightens the Efficacy of Tumor Immunotherapy in Aged Mice

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