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Vasudha Sehgal
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Journal Articles

Abstract CT141: mRNA-4157 (V940) individualized neoantigen therapy (INT) + pembrolizumab (pembro) in advanced unresectable HPV- head & neck carcinoma (HNSCC): Clinical & translational analysis

Julie E. Bauman, Ricklie A. Julian, Jessica L. Geiger, Janice M. Mehnert, Jeffrey M. Clarke, Manish R. Patel, Martin Gutierrez, Justin F. Gainor, Shyam Srivats, Zhaojie Zhang, Anjali Rao, Vasudha Sehgal, Peijie Hou, Manju Morrissey, Igor Feldman, Lakshmi Srinivasan, Praveen Aanur, Michelle Brown, Robert S. Meehan
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT141.
https://doi.org/10.1158/1538-7445.AM2024-CT141
Published: 05 April 2024
View article titled, Abstract CT141: mRNA-4157 (V940) individualized neoantigen therapy (INT) + pembrolizumab (pembro) in advanced unresectable HPV- head & neck carcinoma (HNSCC): Clinical & translational analysis
Journal Articles

Abstract 6552: Intratumoral (ITu) delivery of mRNA-2752 encoding human OX40L/IL-23/IL-36γ in combination with durvalumab induces an immunostimulatory effect within the tumor microenvironment (TME) of patients with advanced solid tumors

Michael Abadier, Ryan J. Sullivan, Jacky Chow, Vasudha Sehgal, Randy F. Sweis, Adil Daud, Ronnie Shapira-Frommer, Ruth Perets, Shivaani Kummar, Meredith McKean, Ravit Geva, Manish R. Patel, Adnan Khattak, Pablo Fernandez-Peñas, Sima Zacharek, Natalia Wahl, Russell M. Walker, Linh Van, Praveen Aanur, Jim Ward, Khanh T. Do, Georgina V. Long
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6552.
https://doi.org/10.1158/1538-7445.AM2024-6552
Published: 22 March 2024
View article titled, Abstract 6552: Intratumoral (ITu) delivery of mRNA-2752 encoding human OX40L/IL-23/IL-36γ in combination with durvalumab induces an immunostimulatory effect within the tumor microenvironment (TME) of patients with advanced solid tumors
Journal Articles

Abstract CT224: mRNA-4157, a personalized cancer vaccine, in combination with pembrolizumab, demonstrates trend for improved recurrence free survival compared to pembrolizumab alone in adjuvant melanoma patients across tumor mutational burden subgroups

Ryan J. Sullivan, Matteo Carlino, Jeffrey S. Weber, Tarek Meniawy, Matthew H. Taylor, Kevin Kim, Meredith McKean, Georgiana V. Long, Mark Faries, C. Lance Cowey, Andrew Pecora, Geoffrey T. Gibney, Jason Luke, Sajeve Thomas, Vasudha Sehgal, Igor Feldman, Praveen Aanur, Michelle Brown, Robert S. Meehan, Celine Robert-Tissot, Adnan Khattak
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT224.
https://doi.org/10.1158/1538-7445.AM2023-CT224
Published: 29 May 2023
View article titled, Abstract CT224: mRNA-4157, a personalized cancer vaccine, in combination with pembrolizumab, demonstrates trend for improved recurrence free survival compared to pembrolizumab alone in adjuvant melanoma patients across tumor mutational burden subgroups
Journal Articles

Abstract 4960: First-in-class, highly BDII-selective BET family inhibitor ABBV-744 displays potent anti-tumor activity in androgen receptor positive prostate cancer models and an improved tolerability profile

Emily J. Faivre, Denise Wilcox, Mai Ha-Bui, Paul Hessler, Vasudha Sehgal, Xin Lu, Tamar Uziel, Gaurav Mehta, Daniel H. Albert, Keith McDaniel, Warren Kati, Yu Shen
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4960.
https://doi.org/10.1158/1538-7445.AM2018-4960
Published: 01 July 2018
View article titled, Abstract 4960: First-in-class, highly BDII-selective BET family inhibitor ABBV-744 displays potent anti-tumor activity in androgen receptor positive prostate cancer models and an improved tolerability profile
Journal Articles

Sustained Adrenergic Signaling Promotes Intratumoral Innervation through BDNF Induction

Julie K. Allen, Guillermo N. Armaiz-Pena, Archana S. Nagaraja, Nouara C. Sadaoui, Tatiana Ortiz, Robert Dood, Merve Ozcan, Danielle M. Herder, Monika Haemmerle, Kshipra M. Gharpure, Rajesha Rupaimoole, Rebecca A. Previs, Sherry Y. Wu, Sunila Pradeep, Xiaoyun Xu, Hee Dong Han, Behrouz Zand, Heather J. Dalton, Morgan Taylor, Wei Hu, Justin Bottsford-Miller, Myrthala Moreno-Smith, Yu Kang, Lingegowda S. Mangala, Cristian Rodriguez-Aguayo, Vasudha Sehgal, Erika L. Spaeth, Prahlad T. Ram, Stephen T.C. Wong, Frank C. Marini, Gabriel Lopez-Berestein, Steve W. Cole, Susan K. Lutgendorf, Mariella De Biasi, Anil K. Sood
Journal: Cancer Research
Series: Author Choice
Cancer Res (2018) 78 (12): 3233–3242.
https://doi.org/10.1158/0008-5472.CAN-16-1701
Published: 14 June 2018
View article titled, Sustained Adrenergic Signaling Promotes Intratumoral Innervation through BDNF Induction
Open the PDF for Sustained Adrenergic Signaling Promotes Intratumoral Innervation through BDNF Induction in another window
Includes: Multimedia, Supplementary data
Journal Articles

Abstract 5466: Integrative TCGA analyses identify Basonuclin1 (BNC1) as a key mediator for platinum resistance

Sherry Y. Wu, Justyna Filant, Michael McGuire, Rajesha Rupaimoole, Sunila Pradeep, Anna Unruh, Herbrich Shelley, Cristina Ivan, Ruder Dennis, Cristian Rodriguez-Aguayo, Vasudha Sehgal, Takahito Miyake, Archana Nagaraja, Kshipra Gharpure, Guillermo Armaiz, Rebecca Previs, Gabriel Lopez-Berestein, Prahlad Ram, Keith Baggerly, Anil Sood
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 5466.
https://doi.org/10.1158/1538-7445.AM2015-5466
Published: 01 August 2015
View article titled, Abstract 5466: Integrative TCGA analyses identify Basonuclin1 (BNC1) as a key mediator for platinum resistance
Journal Articles

Abstract 1204: Design of phenotype-driven flux analysis approach for personalized metabolic models of cancer patients

Abhinav Achreja, Lifeng Yang, Tyler Moss, Vasudha Sehgal, Juan Marini, Prahlad T. Ram, Deepak Nagrath
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1204.
https://doi.org/10.1158/1538-7445.AM2015-1204
Published: 01 August 2015
View article titled, Abstract 1204: Design of phenotype-driven flux analysis approach for personalized metabolic models of cancer patients
Journal Articles

Inhibition of mTORC1/2 Overcomes Resistance to MAPK Pathway Inhibitors Mediated by PGC1α and Oxidative Phosphorylation in Melanoma

Y.N. Vashisht Gopal, Helen Rizos, Guo Chen, Wanleng Deng, Dennie T. Frederick, Zachary A. Cooper, Richard A. Scolyer, Gulietta Pupo, Kakajan Komurov, Vasudha Sehgal, Jiexin Zhang, Lalit Patel, Cristiano G. Pereira, Bradley M. Broom, Gordon B. Mills, Prahlad Ram, Paul D. Smith, Jennifer A. Wargo, Georgina V. Long, Michael A. Davies
Journal: Cancer Research
Cancer Res (2014) 74 (23): 7037–7047.
https://doi.org/10.1158/0008-5472.CAN-14-1392
Published: 30 November 2014
View article titled, Inhibition of mTORC1/2 Overcomes Resistance to MAPK Pathway Inhibitors Mediated by PGC1α and Oxidative Phosphorylation in Melanoma
Open the PDF for Inhibition of mTORC1/2 Overcomes Resistance to MAPK Pathway Inhibitors Mediated by PGC1α and Oxidative Phosphorylation in Melanoma in another window
Includes: Supplementary data
Journal Articles

Notch3 Pathway Alterations in Ovarian Cancer

Wei Hu, Tao Liu, Cristina Ivan, Yunjie Sun, Jie Huang, Lingegowda S. Mangala, Takahito Miyake, Heather J. Dalton, Sunila Pradeep, Rajesh Rupaimoole, Rebecca A. Previs, Hee Dong Han, Justin Bottsford-Miller, Behrouz Zand, Yu Kang, Chad V. Pecot, Alpa M. Nick, Sherry Y. Wu, Ju-Seog Lee, Vasudha Sehgal, Prahlad Ram, Jinsong Liu, Susan L. Tucker, Gabriel Lopez-Berestein, Keith A. Baggerly, Robert L. Coleman, Anil K. Sood
Journal: Cancer Research
Cancer Res (2014) 74 (12): 3282–3293.
https://doi.org/10.1158/0008-5472.CAN-13-2066
Published: 12 June 2014
View article titled, Notch3 Pathway Alterations in Ovarian Cancer
Open the PDF for Notch3 Pathway Alterations in Ovarian Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 2036: Overcoming platinum-resistance in ovarian cancer via targeting basonuclin1 (BNC1).

Sherry Y. Wu, Anna K. Unruh, Rajesha Rupaimoole, Cristina Ivan, Dennis Ruder, Sunila Pradeep, Vasudha Sehgal, Cristian Rodriguez-Aguayo, Chad Pecot, Takahito Miyake, Gabriel Lopez-Berestein, Prahlad Ram, Keith A. Baggerly, Anil K. Sood
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2036.
https://doi.org/10.1158/1538-7445.AM2013-2036
Published: 15 April 2013
View article titled, Abstract 2036: Overcoming platinum-resistance in ovarian cancer via targeting basonuclin1 (BNC1).