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Journal Articles

Abstract 4031: In vivo studies demonstrate differences in target inhibition and anticancer efficacy between NXP900 and dasatinib in ovarian clear cell carcinoma model

Saúl Navarro-Marchal, Carolin Temps, Iñigo Lanzagorta-Calvillo, John C. Dawson, Enrique Poradosu, Neil O. Carragher, Valerie G. Brunton, Asier Unciti-Broceta

Cancer Res (2023) 83 (7_Supplement): 4031.

https://doi.org/10.1158/1538-7445.AM2023-4031

Published: 04 April 2023

View article titled, Abstract 4031: <em>In vivo</em> studies demonstrate differences in target inhibition and anticancer efficacy between NXP900 and dasatinib in ovarian clear cell carcinoma model

Journal Articles

Editor's Note: Identification of Src-Specific Phosphorylation Site on Focal Adhesion Kinase: Dissection of the Role of Src SH2 and Catalytic Functions and Their Consequences for Tumor Cell Behavior

Valerie G. Brunton, Egle Avizienyte, Valerie J. Fincham, Bryan Serrels, Chester A. Metcalf, III, Tomi K. Sawyer, Margaret C. Frame

Cancer Res (2022) 82 (13): 2500.

https://doi.org/10.1158/0008-5472.CAN-22-1587

Published: 05 July 2022

View article titled, Editor's Note: Identification of Src-Specific Phosphorylation Site on Focal Adhesion Kinase: Dissection of the Role of Src SH2 and Catalytic Functions and Their Consequences for Tumor Cell Behavior

Journal Articles

Loss of Integrin-Linked Kinase Sensitizes Breast Cancer to SRC Inhibitors

Henry Beetham, Billie G.C. Griffith, Olga Murina, Alexander E.P. Loftus, David A. Parry, Carolin Temps, Jayne Culley, Morwenna Muir, Asier Unciti-Broceta, Andrew H. Sims, Adam Byron, Valerie G. Brunton

Cancer Res (2022) 82 (4): 632–647.

https://doi.org/10.1158/0008-5472.CAN-21-0373

Published: 15 February 2022

View article titled, Loss of Integrin-Linked Kinase Sensitizes Breast Cancer to SRC Inhibitors

Includes: Supplementary data

Journal Articles

A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability

Cancer Res (2021) 81 (21): 5438–5450.

https://doi.org/10.1158/0008-5472.CAN-21-0613

Published: 01 November 2021

View article titled, A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability

Includes: Supplementary data

Journal Articles

Abstract 6158: The relevance of endoglin and MMP14 to the metastatic potential of Ewing sarcoma cells

Pilar Puerto-Camacho, Ana Teresa Amaral, Juan Diaz-Martin, Alfonso Bolado-Carrancio, Carmen Jordan-Perez, Carmen Salguero-Aranda, Marina Esteban-Medina, Inmaculada Alamo-Alvarez, Joaquin Dopazo, Carmelo Bernabeu, Adam Byron, Valerie G. Brunton, Enrique de Álava

Cancer Res (2020) 80 (16_Supplement): 6158.

https://doi.org/10.1158/1538-7445.AM2020-6158

Published: 15 August 2020

View article titled, Abstract 6158: The relevance of endoglin and MMP14 to the metastatic potential of Ewing sarcoma cells

Journal Articles

Abstract 5267: Utilizing stimulated Raman scattering microscopy to study intracellular distribution of label-free ponatinib in live cells

Kristel Sepp, Martin Lee, Marie T. Bluntzer, G. Vignir Helgason, Alison N. Hulme, Valerie G. Brunton

Cancer Res (2020) 80 (16_Supplement): 5267.

https://doi.org/10.1158/1538-7445.AM2020-5267

Published: 15 August 2020

View article titled, Abstract 5267: Utilizing stimulated Raman scattering microscopy to study intracellular distribution of label-free ponatinib in live cells

Journal Articles

Kindlin-1 Promotes Pulmonary Breast Cancer Metastasis

Sana Sarvi, Hitesh Patel, Jun Li, Georgia L. Dodd, Helen Creedon, Morwenna Muir, Jocelyn Ward, John C. Dawson, Martin Lee, Jayne Culley, Donald M. Salter, Andrew H. Sims, Adam Byron, Valerie G. Brunton

Cancer Res (2018) 78 (6): 1484–1496.

https://doi.org/10.1158/0008-5472.CAN-17-1518

Published: 14 March 2018

View article titled, Kindlin-1 Promotes Pulmonary Breast Cancer Metastasis

Includes: Supplementary data

Journal Articles

Nuclear FAK and Runx1 Cooperate to Regulate IGFBP3, Cell-Cycle Progression, and Tumor Growth

Marta Canel, Adam Byron, Andrew H. Sims, Jessy Cartier, Hitesh Patel, Margaret C. Frame, Valerie G. Brunton, Bryan Serrels, Alan Serrels

Cancer Res (2017) 77 (19): 5301–5312.

https://doi.org/10.1158/0008-5472.CAN-17-0418

Published: 01 October 2017

View article titled, Nuclear FAK and Runx1 Cooperate to Regulate IGFBP3, Cell-Cycle Progression, and Tumor Growth

Includes: Supplementary data

Journal Articles

Intravital FLIM-FRET Imaging Reveals Dasatinib-Induced Spatial Control of Src in Pancreatic Cancer

Max Nobis, Ewan J. McGhee, Jennifer P. Morton, Juliane P. Schwarz, Saadia A. Karim, Jean Quinn, Mike Edward, Andrew D. Campbell, Lynn C. McGarry, T.R. Jeffry Evans, Valerie G. Brunton, Margaret C. Frame, Neil O. Carragher, Yingxiao Wang, Owen J. Sansom, Paul Timpson, Kurt I. Anderson

Cancer Res (2013) 73 (15): 4674–4686.

https://doi.org/10.1158/0008-5472.CAN-12-4545

Published: 31 July 2013

View article titled, Intravital FLIM-FRET Imaging Reveals Dasatinib-Induced Spatial Control of Src in Pancreatic Cancer

Includes: Multimedia, Supplementary data

Journal Articles

Abstract 4307: The effect of ablating ADF/cofilin pathway during skin homeostasis and tumorigenesis

Jing Zhou, Hitesh Patel, Valerie G. Brunton, Margaret C. Frame

Cancer Res (2012) 72 (8_Supplement): 4307.

https://doi.org/10.1158/1538-7445.AM2012-4307

Published: 15 April 2012

View article titled, Abstract 4307: The effect of ablating ADF/cofilin pathway during skin homeostasis and tumorigenesis

Journal Articles

Spatial Regulation of RhoA Activity during Pancreatic Cancer Cell Invasion Driven by Mutant p53

Paul Timpson, Ewan J. McGhee, Jennifer P. Morton, Alex von Kriegsheim, Juliane P. Schwarz, Saadia A. Karim, Brendan Doyle, Jean A. Quinn, Neil O. Carragher, Mike Edward, Michael F. Olson, Margaret C. Frame, Valerie G. Brunton, Owen J. Sansom, Kurt I. Anderson

Cancer Res (2011) 71 (3): 747–757.

https://doi.org/10.1158/0008-5472.CAN-10-2267

Published: 01 February 2011

View article titled, Spatial Regulation of RhoA Activity during Pancreatic Cancer Cell Invasion Driven by Mutant p53

Includes: Multimedia, Supplementary data

Journal Articles

Quantitative In vivo Imaging of the Effects of Inhibiting Integrin Signaling via Src and FAK on Cancer Cell Movement: Effects on E-cadherin Dynamics

Marta Canel, Alan Serrels, Derek Miller, Paul Timpson, Bryan Serrels, Margaret C. Frame, Valerie G. Brunton

Cancer Res (2010) 70 (22): 9413–9422.

https://doi.org/10.1158/0008-5472.CAN-10-1454

Published: 14 November 2010

View article titled, Quantitative <em>In vivo</em> Imaging of the Effects of Inhibiting Integrin Signaling via Src and FAK on Cancer Cell Movement: Effects on E-cadherin Dynamics

Includes: Multimedia, Supplementary data

Journal Articles

Real-time Study of E-Cadherin and Membrane Dynamics in Living Animals: Implications for Disease Modeling and Drug Development

Alan Serrels, Paul Timpson, Marta Canel, Juliane P. Schwarz, Neil O. Carragher, Margaret C. Frame, Valerie G. Brunton, Kurt I. Anderson

Cancer Res (2009) 69 (7): 2714–2719.

https://doi.org/10.1158/0008-5472.CAN-08-4308

Published: 01 April 2009

View article titled, Real-time Study of E-Cadherin and Membrane Dynamics in Living Animals: Implications for Disease Modeling and Drug Development

Includes: Multimedia, Supplementary data

Journal Articles

Chemoresistant KM12C Colon Cancer Cells Are Addicted to Low Cyclic AMP Levels in a Phosphodiesterase 4–Regulated Compartment via Effects on Phosphoinositide 3-Kinase

David G. McEwan, Valerie G. Brunton, George S. Baillie, Nicholas R. Leslie, Miles D. Houslay, Margaret C. Frame

Cancer Res (2007) 67 (11): 5248–5257.

https://doi.org/10.1158/0008-5472.CAN-07-0097

Published: 01 June 2007

View article titled, Chemoresistant KM12C Colon Cancer Cells Are Addicted to Low Cyclic AMP Levels in a Phosphodiesterase 4–Regulated Compartment via Effects on Phosphoinositide 3-Kinase

Journal Articles

Suppression of tumour formation and malignant conversion in a mouse model of skin carcinogenesis by the dual Src/Bcr-Abl tyrosine kinase inhibitor AZD0530

Bryan Serrels, Tim Green, Margaret C. Frame, Valerie G. Brunton

Cancer Res (2006) 66 (8_Supplement): 888.

Published: 15 April 2006

View article titled, Suppression of tumour formation and malignant conversion in a mouse model of skin carcinogenesis by the dual Src/Bcr-Abl tyrosine kinase inhibitor AZD0530

Journal Articles

Identification of Src-Specific Phosphorylation Site on Focal Adhesion Kinase: Dissection of the Role of Src SH2 and Catalytic Functions and Their Consequences for Tumor Cell Behavior

Valerie G. Brunton, Egle Avizienyte, Valerie J. Fincham, Bryan Serrels, Chester A. Metcalf, III, Tomi K. Sawyer, Margaret C. Frame

Cancer Res (2005) 65 (4): 1335–1342.

https://doi.org/10.1158/0008-5472.CAN-04-1949

Published: 25 February 2005

View article titled, Identification of Src-Specific Phosphorylation Site on Focal Adhesion Kinase: Dissection of the Role of Src SH2 and Catalytic Functions and Their Consequences for Tumor Cell Behavior

Includes: Multimedia, Supplementary data

Journal Articles

Role of Src and FAK tyrosine kinase signalling in the progression of colon cancer

Valerie G. Brunton, Egle Avizienyte, Margaret C. Frame

Cancer Res (2004) 64 (7_Supplement): 1136.

Published: 01 April 2004

View article titled, Role of Src and FAK tyrosine kinase signalling in the progression of colon cancer

NARROW

Abstract 4031: In vivo studies demonstrate differences in target inhibition and anticancer efficacy between NXP900 and dasatinib in ovarian clear cell carcinoma model

Editor's Note: Identification of Src-Specific Phosphorylation Site on Focal Adhesion Kinase: Dissection of the Role of Src SH2 and Catalytic Functions and Their Consequences for Tumor Cell Behavior

Loss of Integrin-Linked Kinase Sensitizes Breast Cancer to SRC Inhibitors

A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability

Abstract 6158: The relevance of endoglin and MMP14 to the metastatic potential of Ewing sarcoma cells

Abstract 5267: Utilizing stimulated Raman scattering microscopy to study intracellular distribution of label-free ponatinib in live cells

Kindlin-1 Promotes Pulmonary Breast Cancer Metastasis

Nuclear FAK and Runx1 Cooperate to Regulate IGFBP3, Cell-Cycle Progression, and Tumor Growth

Intravital FLIM-FRET Imaging Reveals Dasatinib-Induced Spatial Control of Src in Pancreatic Cancer

Abstract 4307: The effect of ablating ADF/cofilin pathway during skin homeostasis and tumorigenesis

Spatial Regulation of RhoA Activity during Pancreatic Cancer Cell Invasion Driven by Mutant p53

Quantitative In vivo Imaging of the Effects of Inhibiting Integrin Signaling via Src and FAK on Cancer Cell Movement: Effects on E-cadherin Dynamics

Real-time Study of E-Cadherin and Membrane Dynamics in Living Animals: Implications for Disease Modeling and Drug Development

Chemoresistant KM12C Colon Cancer Cells Are Addicted to Low Cyclic AMP Levels in a Phosphodiesterase 4–Regulated Compartment via Effects on Phosphoinositide 3-Kinase

Suppression of tumour formation and malignant conversion in a mouse model of skin carcinogenesis by the dual Src/Bcr-Abl tyrosine kinase inhibitor AZD0530

Identification of Src-Specific Phosphorylation Site on Focal Adhesion Kinase: Dissection of the Role of Src SH2 and Catalytic Functions and Their Consequences for Tumor Cell Behavior

Role of Src and FAK tyrosine kinase signalling in the progression of colon cancer

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