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Valentina M. Factor
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Journal Articles

MYC Activates Stem-like Cell Potential in Hepatocarcinoma by a p53-Dependent Mechanism

Hirofumi Akita, Jens U. Marquardt, Marian E. Durkin, Mitsuteru Kitade, Daekwan Seo, Elizabeth A. Conner, Jesper B. Andersen, Valentina M. Factor, Snorri S. Thorgeirsson
Journal: Cancer Research
Cancer Res (2014) 74 (20): 5903–5913.
https://doi.org/10.1158/0008-5472.CAN-14-0527
Published: 14 October 2014
View article titled, MYC Activates Stem-like Cell Potential in Hepatocarcinoma by a p53-Dependent Mechanism
Open the PDF for MYC Activates Stem-like Cell Potential in Hepatocarcinoma by a p53-Dependent Mechanism in another window
Includes: Supplementary data
Journal Articles

Antitumor Effects in Hepatocarcinoma of Isoform-Selective Inhibition of HDAC2

Yun-Han Lee, Daekwan Seo, Kyung-Ju Choi, Jesper B. Andersen, Min-Ah Won, Mitsuteru Kitade, Luis E. Gómez-Quiroz, Adam D. Judge, Jens U. Marquardt, Chiara Raggi, Elizabeth A. Conner, Ian MacLachlan, Valentina M. Factor, Snorri S. Thorgeirsson
Journal: Cancer Research
Cancer Res (2014) 74 (17): 4752–4761.
https://doi.org/10.1158/0008-5472.CAN-13-3531
Published: 01 September 2014
View article titled, Antitumor Effects in Hepatocarcinoma of Isoform-Selective Inhibition of HDAC2
Open the PDF for Antitumor Effects in Hepatocarcinoma of Isoform-Selective Inhibition of HDAC2 in another window
Includes: Supplementary data
Journal Articles

CLPTM1L Promotes Growth and Enhances Aneuploidy in Pancreatic Cancer Cells

Jinping Jia, Allen D. Bosley, Abbey Thompson, Jason W. Hoskins, Adam Cheuk, Irene Collins, Hemang Parikh, Zhen Xiao, Kris Ylaya, Marta Dzyadyk, Wendy Cozen, Brenda Y. Hernandez, Charles F. Lynch, Jadranka Loncarek, Sean F. Altekruse, Lizhi Zhang, Christopher J. Westlake, Valentina M. Factor, Snorri Thorgeirsson, William R. Bamlet, Stephen M. Hewitt, Gloria M. Petersen, Thorkell Andresson, Laufey T. Amundadottir
Journal: Cancer Research
Cancer Res (2014) 74 (10): 2785–2795.
https://doi.org/10.1158/0008-5472.CAN-13-3176
Published: 14 May 2014
View article titled, CLPTM1L Promotes Growth and Enhances Aneuploidy in Pancreatic Cancer Cells
Open the PDF for CLPTM1L Promotes Growth and Enhances Aneuploidy in Pancreatic Cancer Cells in another window
Includes: Supplementary data
Journal Articles

Abstract 5661: Nanoparticle based combinatorial siRNA therapy against human hepatocellular carcinoma (HCC) .

Thomas Decaens, Valentina M. Factor, Iva Kulic, Jesper B. Andersen, Daekwan Seo, Yun-Han Lee, Adam D. Judge, Elizabeth A. Conner, Ian MacLachlan, Snorri S. Thorgeirsson
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5661.
https://doi.org/10.1158/1538-7445.AM2013-5661
Published: 15 April 2013
View article titled, Abstract 5661: Nanoparticle based combinatorial siRNA therapy against human hepatocellular carcinoma (HCC) .
Journal Articles

Abstract 2653: Direct oncogenic reprogramming of adult mouse hepatocytes into cancer stem cells.

Agnes Holczbauer, Valentina M. Factor, Jesper B. Andersen, David E. Kleiner, Jens U. Marquardt, Chiara Raggi, Mitsuteru Kitade, Daekwan Seo, Akita Hirofumi, Marian E. Durkin, Snorri S. Thorgeirsson
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2653.
https://doi.org/10.1158/1538-7445.AM2013-2653
Published: 15 April 2013
View article titled, Abstract 2653: Direct oncogenic reprogramming of adult mouse hepatocytes into cancer stem cells.
Journal Articles

Abstract 4261: Epigenetic reprogramming affects malignant properties of human liver cancer cells

Chiara Raggi, Jens U. Marquardt, Daekwan Seo, Jesper B. Andersen, Valentina M. Factor, Snorri S. Thorgeirsson
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4261.
https://doi.org/10.1158/1538-7445.AM2012-4261
Published: 15 April 2012
View article titled, Abstract 4261: Epigenetic reprogramming affects malignant properties of human liver cancer cells
Journal Articles

Abstract 4927: Translational genomics analyses of cholangiocarcinoma identify patients who may respond to tyrosine kinase inhibitors

Jesper Boeje Andersen, Matthew Gillen, Elisabeth A. Conner, Valentina M. Factor, Snorri S. Thorgeirsson
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4927.
https://doi.org/10.1158/1538-7445.AM2012-4927
Published: 15 April 2012
View article titled, Abstract 4927: Translational genomics analyses of cholangiocarcinoma identify patients who may respond to tyrosine kinase inhibitors
Journal Articles

Abstract 1644: siRNA targeting of cell cycle kinase Wee1 inhibits hepatocullar carconima growth in vitro and in vivo

Yun-Han Lee, Jesper B. Andersen, Adam D. Judge, Daekwan Seo, Chiara Raggi, Marquardt U. Jens, Elizabeth A. Conner, Ian MacLachlan, Valentina M. Factor, Snorri S. Thorgeirsson
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 1644.
https://doi.org/10.1158/1538-7445.AM2011-1644
Published: 15 April 2011
View article titled, Abstract 1644: siRNA targeting of cell cycle kinase Wee1 inhibits hepatocullar carconima growth <em>in vitro</em> and <em>in vivo</em>
Journal Articles

Abstract 2460: Tumorigenic potential is independent of sphere phenotype in liver cancer

Chiara Raggi, Jens U. Marquardt, Jesper B. Andersen, Valentina M. Factor, Snorri S. Thorgeirsson
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2460.
https://doi.org/10.1158/1538-7445.AM2011-2460
Published: 15 April 2011
View article titled, Abstract 2460: Tumorigenic potential is independent of sphere phenotype in liver cancer
Journal Articles

Abstract 2452: Generation of hepatocellular carcinomas with cancer stem cell properties from primary mouse hepatocytes

Agnes Holczbauer, Valentina M. Factor, Jens U. Marquardt, David Kleiner, Daekwan Seo, Chiara Raggi, Mitsuteru Kitade, Jesper B. Andersen, Marian Durkin, Snorri S. Thorgeirsson
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2452.
https://doi.org/10.1158/1538-7445.AM2011-2452
Published: 15 April 2011
View article titled, Abstract 2452: Generation of hepatocellular carcinomas with cancer stem cell properties from primary mouse hepatocytes
Journal Articles

Definition of Ubiquitination Modulator COP1 as a Novel Therapeutic Target in Human Hepatocellular Carcinoma

Yun-Han Lee, Jesper B. Andersen, Ho-Taek Song, Adam D. Judge, Daekwan Seo, Tsuyoshi Ishikawa, Jens U. Marquardt, Mitsuteru Kitade, Marian E. Durkin, Chiara Raggi, Hyun Goo Woo, Elizabeth A. Conner, Itzhak Avital, Ian MacLachlan, Valentina M. Factor, Snorri S. Thorgeirsson
Journal: Cancer Research
Cancer Res (2010) 70 (21): 8264–8269.
https://doi.org/10.1158/0008-5472.CAN-10-0749
Published: 31 October 2010
View article titled, Definition of Ubiquitination Modulator COP1 as a Novel Therapeutic Target in Human Hepatocellular Carcinoma
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Includes: Supplementary data
Journal Articles

Abstract 1576: Molecular targeting of histone deacetylase 2 for treatment of human hepatocellular carcinoma

Yun-Han Lee, Jesper B. Andersen, Adam D. Judge, Daekwan Seo, Jens U. Marquardt, Tsuyoshi Ishikawa, Itzhak Avital, Elizabeth A. Conner, Ian MacLachlan, Valentina M. Factor, Snorri S. Thorgeirsson
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1576.
https://doi.org/10.1158/1538-7445.AM10-1576
Published: 15 April 2010
View article titled, Abstract 1576: Molecular targeting of histone deacetylase 2 for treatment of human hepatocellular carcinoma
Journal Articles

Abstract 11: Asymmetric division via nonrandom chromosomal cosegregation potentially defines a novel class of universal cancer stem cells

Hong-Wu Xin, Danielle M. Hari, Kshama R. Jaiswal, Bo-Kyu Kim, Satyajit Ray, Tomotake Koizumi, Gordon W. Wiegand, Seth M. Steinberg, Susan H. Garfield, Jesper B. Andersen, Valentina M. Factor, Snorri S. Thorgeirsson, Itzhak Avital
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 11.
https://doi.org/10.1158/1538-7445.AM10-11
Published: 15 April 2010
View article titled, Abstract 11: Asymmetric division via nonrandom chromosomal cosegregation potentially defines a novel class of universal cancer stem cells
Journal Articles

Abstract 4181: Comparison of tumorigenic proficiency at different stages of hepatocyte differentiation

Agnes Holczbauer, Jens U. Marquardt, Marian Durkin, Daekwan Seo, Jesper B. Andersen, Dongho Choi, Chiara Raggi, Valentina M. Factor, Snorri S. Thorgeirsson
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 4181.
https://doi.org/10.1158/1538-7445.AM10-4181
Published: 15 April 2010
View article titled, Abstract 4181: Comparison of tumorigenic proficiency at different stages of hepatocyte differentiation
Journal Articles

Abstract 4252: Mechanistic and clinical implications of epigenetic modulation in liver cancer stem cells

Jens U. Marquardt, Chiara Raggi, Jesper B. Andersen, Deakwan Seo, Itzhak Avital, Agnes Holczbauer, Valentina M. Factor, Snorri S. Thorgeirsson
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 4252.
https://doi.org/10.1158/1538-7445.AM10-4252
Published: 15 April 2010
View article titled, Abstract 4252: Mechanistic and clinical implications of epigenetic modulation in liver cancer stem cells
Journal Articles

Abstract 4297: Selective enrichment of liver cancer stem cell by DNA methyltransferase inhibition

Chiara Raggi, Jens U. Marquardt, Jesper B. Andersen, Valentina M. Factor, Snorri S. Thorgeirsson
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 4297.
https://doi.org/10.1158/1538-7445.AM10-4297
Published: 15 April 2010
View article titled, Abstract 4297: Selective enrichment of liver cancer stem cell by DNA methyltransferase inhibition
Journal Articles

Abstract 2173: Cytokeratin-19, a predictive marker and an early determinant of progenitor-derived hepatocellular carcinoma

Jesper B. Andersen, Roberto Loi, Andrea Perra, Valentina M. Factor, Giovanna M. Ledda-Columbano, Amedeo Columbano, Snorri S. Thorgeirsson
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2173.
https://doi.org/10.1158/1538-7445.AM10-2173
Published: 15 April 2010
View article titled, Abstract 2173: Cytokeratin-19, a predictive marker and an early determinant of progenitor-derived hepatocellular carcinoma
Journal Articles

Central Role of c-Myc during Malignant Conversion in Human Hepatocarcinogenesis

Pal Kaposi-Novak, Louis Libbrecht, Hyun Goo Woo, Yun-Han Lee, Nathaniel C. Sears, Elizabeth A. Conner, Valentina M. Factor, Tania Roskams, Snorri S. Thorgeirsson
Journal: Cancer Research
Cancer Res (2009) 69 (7): 2775–2782.
https://doi.org/10.1158/0008-5472.CAN-08-3357
Published: 01 April 2009
View article titled, Central Role of c-Myc during Malignant Conversion in Human Hepatocarcinogenesis
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Includes: Supplementary data
Journal Articles

Loss of Hepatocyte Growth Factor/c-Met Signaling Pathway Accelerates Early Stages of N-nitrosodiethylamine–Induced Hepatocarcinogenesis

Taro Takami, Pal Kaposi-Novak, Koichi Uchida, Luis E. Gomez-Quiroz, Elizabeth A. Conner, Valentina M. Factor, Snorri S. Thorgeirsson
Journal: Cancer Research
Cancer Res (2007) 67 (20): 9844–9851.
https://doi.org/10.1158/0008-5472.CAN-07-1905
Published: 17 October 2007
View article titled, Loss of Hepatocyte Growth Factor/c-Met Signaling Pathway Accelerates Early Stages of <em>N</em>-nitrosodiethylamine–Induced Hepatocarcinogenesis
Open the PDF for Loss of Hepatocyte Growth Factor/c-Met Signaling Pathway Accelerates Early Stages of <em>N</em>-nitrosodiethylamine–Induced Hepatocarcinogenesis in another window
Includes: Supplementary data
Journal Articles

Oncogene-specific gene expression signature at preneoplastic stage defines distinct mechanisms of hepatocarcinogenesis in E2f1, c-Myc, and E2f1/c-Myc transgenic mice

Cedric Coulouarn, Luis Gomez-Quiroz, Ju-Seog Lee, Pal Kaposi-Novak, Elizabeth A. Conner, Valentina M. Factor, Snorri S. Thorgeirsson
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 195.
Published: 15 April 2006
View article titled, Oncogene-specific gene expression signature at preneoplastic stage defines distinct mechanisms of hepatocarcinogenesis in E2f1, c-Myc, and E2f1/c-Myc transgenic mice