1-20 of 39
Ultan McDermott
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Abstract 2945: Using pooled minimal genome-wide sgRNA libraries to drive oncology drug discovery

Sebastian Lukasiak, Alex Kalinka, Nikhil Gupta, Khalid Saeed, Angelos Papadopoulos, Ultan McDermott, Gregory J. Hannon, Douglas Ross-Thriepland, David Walter
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2945.
https://doi.org/10.1158/1538-7445.AM2024-2945
Published: 22 March 2024
View article titled, Abstract 2945: Using pooled minimal genome-wide sgRNA libraries to drive oncology drug discovery
Journal Articles

Abstract 5321: Large scale pan cancer drug combination screening to identify effective and actionable combinations and biomarker hypothesis

Azadeh Bashi, Elizabeth A. Coker, Krishna Bulusu, Marta Milo, Claire Crafter, James Lynch, David Jenkins, Howard Lightfoot, Brandon Willis, Courtney Andersen, Omid Tavana, Kevin Mongeon, Jacob Gordon, Paul Smith, Simon Barry, Ultan McDermott, Lisa Drew, Susan Critchlow, Mathew J. Garnett, Jerome Mettetal
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5321.
https://doi.org/10.1158/1538-7445.AM2023-5321
Published: 04 April 2023
View article titled, Abstract 5321: Large scale pan cancer drug combination screening to identify effective and actionable combinations and biomarker hypothesis
Journal Articles

Abstract LB129: Stratification of radiotherapy and fluoropyrimidine-based chemotherapy from multi-omic profiling in rectal cancer biopsies

Enric Domingo, Sanjay Rathee, Andrew Blake, Leslie M. Samuel, Graeme I. Murray, David Sebag-Montefiore, Simon Gollins, Nicholas West, Rubina Begum, Marian Duggan, Laura White, Susan Richman, Philip Quirke, James Robineau, Keara Redmond, Aikaterini Chatzipli, Ultan McDermott, Ian Tomlinson, Philip Dunne, Francesca Buffa, Tim Maughan
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB129.
https://doi.org/10.1158/1538-7445.AM2021-LB129
Published: 01 July 2021
View article titled, Abstract LB129: Stratification of radiotherapy and fluoropyrimidine-based chemotherapy from multi-omic profiling in rectal cancer biopsies
Journal Articles

Abstract 393: Predictive biomarker evaluation and molecular differentiation for imipridones ONC201 and ONC206

Sara Morrow, Kirti Nath, Yiqun Zhang, Mathew J. Garnett, Ultan McDermott, Cyril H. Benes, Joel Basken, Wafik S. El-Deiry, Joshua E. Allen, Varun V. Prabhu
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 393.
https://doi.org/10.1158/1538-7445.AM2021-393
Published: 01 July 2021
View article titled, Abstract 393: Predictive biomarker evaluation and molecular differentiation for imipridones ONC201 and ONC206
Journal Articles

Abstract 1081: Genome-wide CRISPR screens reveal Hippo pathway activation as a resistance mechanism in BRAF mutant colon cancer

Jonathan S. Brammeld, Hannah Thorpe, Mar Arias Garcia, Stacey Price, Jamie Young, Matthias Pfeifer, Barbara Lupo, Kosuke Yusa, Livio Trusolino, Mathew Garnett, Andrea Bertotti, Chris Bakal, Ultan McDermott
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1081.
https://doi.org/10.1158/1538-7445.AM2021-1081
Published: 01 July 2021
View article titled, Abstract 1081: Genome-wide CRISPR screens reveal Hippo pathway activation as a resistance mechanism in BRAF mutant colon cancer
Journal Articles

Abstract 1100: Gain and loss of function genome-wide CRISPR screens identify Hippo signaling as an important driver of resistance in EGFR mutant lung cancer

Matthias Pfeifer, Jonathan S. Brammeld, Stacey Price, Matthew Martin, Hannah Thorpe, Aurelie Bornot, Erica Banks, Nin Guan, Shanade Dunn, Maria Luisa Guerriero, Daniel O'Neill, James Pilling, Davide Gianni, James Brownell, Paul Smith, Ultan McDermott
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1100.
https://doi.org/10.1158/1538-7445.AM2021-1100
Published: 01 July 2021
View article titled, Abstract 1100: Gain and loss of function genome-wide CRISPR screens identify Hippo signaling as an important driver of resistance in <em>EGFR</em> mutant lung cancer
Journal Articles

Abstract 3379: Cancer dependency signatures for line of sight genomic alterations in squamous cell lung cancer yield rational targets

Miika Ahdesmäki, Joshua Armenia, Krishna Bulusu, Ben Sidders, Jonathan Dry, Ultan McDermott
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3379.
https://doi.org/10.1158/1538-7445.AM2020-3379
Published: 15 August 2020
View article titled, Abstract 3379: Cancer dependency signatures for line of sight genomic alterations in squamous cell lung cancer yield rational targets
Journal Articles

Abstract 5688: IND-enabling characterization of ONC206 as the next bitopic antagonist for oncology

Varun Vijay Prabhu, Sara Morrow, Caroline A. Cuoco, Abed R. Kawakibi, Jinkyu Jung, Neel Madhukar, Matthew J. Garnett, Ultan McDermott, Cyril H. Benes, Robert Wechsler-Reya, Lakshmi Anantharaman, Neil Charter, Joseph B. Rucker, Benjamin J. Doranz, Joel Basken, Olivier Elemento, R. Benjamin Free, David R. Sibley, Martin Stogniew, Wolfgang Oster, Mark R. Gilbert, Sharon DeMorrow
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5688.
https://doi.org/10.1158/1538-7445.AM2020-5688
Published: 15 August 2020
View article titled, Abstract 5688: IND-enabling characterization of ONC206 as the next bitopic antagonist for oncology
Journal Articles

Abstract 4446: Assessment of tissue composition with digital pathology in colorectal cancer

Enric Domingo, Aikaterini Chatzipli, Susan Richman, Andrew Blake, Claire Hardy, Celina Whalley, Keara Redmon, Ian Tomlinson, Philip Dunne, Steven Walker, Andrew Beggs, Ultan McDermott, Graeme I. Murray, Leslie M. Samuel, Matthew Seymour, Philip Quirke, Tim Maughan, Viktor H. Koelzer
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4446.
https://doi.org/10.1158/1538-7445.AM2019-4446
Published: 01 July 2019
View article titled, Abstract 4446: Assessment of tissue composition with digital pathology in colorectal cancer
Journal Articles

Abstract 3877: IND-enabling characterization of DRD2/3 imipridone antagonist ONC206 for oncology

Varun V. Prabhu, Abed Rahman Kawakibi, Neel Madhukar, Mathew J. Garnett, Ultan McDermott, Cyril H. Benes, Lakshmi Anantharaman, Neil Charter, Sean Deacon, Alexander VanEngelenburg, Joseph B. Rucker, Benjamin J. Doranz, Jessica Rusert, Robert Wechsler-Reya, Olivier Elemento, Martin Stogniew, Wolfgang Oster, Sharon DeMorrow, R. Benjamin Free, David R. Sibley, Joshua E. Allen
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3877.
https://doi.org/10.1158/1538-7445.AM2019-3877
Published: 01 July 2019
View article titled, Abstract 3877: IND-enabling characterization of DRD2/3 imipridone antagonist ONC206 for oncology
Journal Articles

Abstract 2749: Defining structure activity relationships for GPCR engagement and anti-cancer efficacy of imipridone small molecules

Varun V. Prabhu, Abed Rahman Kawakibi, Neel S. Madhukar, Lakshmi Anantharaman, Sean Deacon, Neil S. Charter, Mathew J. Garnett, Ultan McDermott, Cyril H. Benes, Wolfgang Oster, Olivier Elemento, Martin Stogniew, Joshua E. Allen
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2749.
https://doi.org/10.1158/1538-7445.AM2019-2749
Published: 01 July 2019
View article titled, Abstract 2749: Defining structure activity relationships for GPCR engagement and anti-cancer efficacy of imipridone small molecules
Journal Articles

Abstract 1821: Genome-wide genetic screens define the drug resistance landscape of BRAF mutant colon cancer

Jonathan Brammeld, Marco Ranzani, Elizabeth A. Coker, Stacey Price, Theodoros I. Roumeliotis, Barbara Lupo, Mi Petljak, Steven P. Williams, Francesco Iorio, Francesco Sassi, Nanne Aben, Kosuke Yusa, Livio Trusolino, Lodewyk Wessels, David J. Adams, Mathew Garnett, Bissan Al-Lazikani, Jyoti S. Choudhary, Andrea Bertotti, Ultan McDermott
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1821.
https://doi.org/10.1158/1538-7445.AM2018-1821
Published: 01 July 2018
View article titled, Abstract 1821: Genome-wide genetic screens define the drug resistance landscape of BRAF mutant colon cancer
Journal Articles

Abstract 4957: The novel imipridone ONC212 highly synergizes with the BCL-2 inhibitor ABT-199 in AML and activates orphan receptor GPR132

Takenobu Nii, Jo Ishizawa, Varun V. Prabhu, Vivian Ruvolo, Neel Madhukar, Ran Zhao, Hong Mu, Lauren Heese, Kensuke Kojima, Mathew Garnett, Ultan McDermott, Cyril Benes, Neil Charter, Sean Deacon, Olivier Elemento, Joshua Allen, Wolfgang Oster, Martin Stogniew, Michael Andreeff
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4957.
https://doi.org/10.1158/1538-7445.AM2018-4957
Published: 01 July 2018
View article titled, Abstract 4957: The novel imipridone ONC212 highly synergizes with the BCL-2 inhibitor ABT-199 in AML and activates orphan receptor GPR132
Journal Articles

Abstract 4874: Receptor pharmacology and anti-cancer activity of selective DRD2/3 antagonist imipridone ONC206

Varun Vijay Prabhu, Neel Madhukar, Rohinton Tarapore, Mathew Garnett, Ultan McDermott, Cyril Benes, Neil Charter, Sean Deacon, Alexander VanEngelenburg, Joseph Rucker, Benjamin Doranz, Olivier Elemento, Wolfgang Oster, Martin Stogniew, Joshua Allen
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4874.
https://doi.org/10.1158/1538-7445.AM2018-4874
Published: 01 July 2018
View article titled, Abstract 4874: Receptor pharmacology and anti-cancer activity of selective DRD2/3 antagonist imipridone ONC206
Journal Articles

Abstract 1041: XenofilteR: Computational dissection of mouse and human reads in PDX and xenograft sequence data

Oscar Krijgsman, Roelof JC Kluin, Kristel Kemper, Thomas Kuilman, Julian R. de Ruiter, Vivek Iyer, Josep V. Forment, Paulien Cornelissen-Steijger, Iris de Rink, Petra ter Brugge, Ji-Ying Song, Sjoerd Klarenbeek, Ultan McDermott, Jos Jonkers, Arno Velds, David J. Adams, Daniel S. Peeper
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1041.
https://doi.org/10.1158/1538-7445.AM2018-1041
Published: 01 July 2018
View article titled, Abstract 1041: XenofilteR: Computational dissection of mouse and human reads in PDX and xenograft sequence data
Journal Articles

Abstract 1155: Potent anti-cancer effects of selective GPR132/G2A agonist imipridone ONC212 in leukemia and lymphoma

Varun Vijay Prabhu, Neel Madhukar, Rohinton Tarapore, Mathew Garnett, Ultan McDermott, Cyril Benes, Neil Charter, Sean Deacon, Wolfgang Oster, Michael Andreeff, Olivier Elemento, Martin Stogniew, Joshua Allen
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1155.
https://doi.org/10.1158/1538-7445.AM2017-1155
Published: 01 July 2017
View article titled, Abstract 1155: Potent anti-cancer effects of selective GPR132/G2A agonist imipridone ONC212 in leukemia and lymphoma
Journal Articles

Abstract 3717: New therapies for the treatment of BRAF/NRAS wild type melanoma

Marco Ranzani, Kristel Kemper, Magali Michaut, Oscar Krijgsman, Vivek Iyer, Anneliese Speak, Jeremie Nsengimana, Kim Wong, Vera Grinkevich, Nanne Aben, Martin Del Castillo Velasco-Herrera, Clara Alsinet, Marcela Sjoberg, Mamunur Rashid, Gemma Turner, Fiona Behan, Emmanuelle Supper, Nicola Thompson, Graham Bignell, Ken Dutton-Regester, Antonia Pritchard, Chi Wong, Ultan McDermott, Nicholas K. Hayward, Kosuke Yusa, Julia Newton-Bishop, Lodewyk Wessels, Mathew Garnett, Daniel Peeper, David Adams
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3717.
https://doi.org/10.1158/1538-7445.AM2017-3717
Published: 01 July 2017
View article titled, Abstract 3717: New therapies for the treatment of <em>BRAF/NRAS</em> wild type melanoma
Journal Articles

Abstract 2792: The small molecule imipridone ONC201 is active in tumor types with dysregulation of the DRD2 pathway

Neel Madhukar, Varun Vijay Prabhu, Etienne Dardenne, Faye Doherty, Alexander VanEngelenburg, Rohinton Tarapore, Mathew Garnett, Ultan McDermott, Cyril Benes, Wolfgang Oster, Wafik El-Deiry, Mark Stein, David Rickman, Joshua Allen, Olivier Elemento
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2792.
https://doi.org/10.1158/1538-7445.AM2017-2792
Published: 01 July 2017
View article titled, Abstract 2792: The small molecule imipridone ONC201 is active in tumor types with dysregulation of the DRD2 pathway
Journal Articles

Abstract 4147A: Potent anti-cancer activity of the imipridone ONC206: A selective dopamine D2-like receptor antagonist

Varun Vijay Prabhu, Neel Madhukar, Jessica Wagner, Rohinton Tarapore, Mathew Garnett, Ultan McDermott, Cyril Benes, Neil Charter, Sean Deacon, Alexander VanEngelenburg, Olivier Elemento, Wafik El-Deiry, Martin Stogniew, Wolfgang Oster, Joshua Allen
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4147A.
https://doi.org/10.1158/1538-7445.AM2017-4147A
Published: 01 July 2017
View article titled, Abstract 4147A: Potent anti-cancer activity of the imipridone ONC206: A selective dopamine D2-like receptor antagonist
Journal Articles

Abstract 1236: ONC201 sensitivity profiling indicates pronounced sensitivity in lymphoid, prostate, colon and brain tumors

Rohinton Tarapore, Mathew Garnett, Ultan McDermott, Cyril Benes, Joshua Allen
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1236.
https://doi.org/10.1158/1538-7445.AM2016-1236
Published: 15 July 2016
View article titled, Abstract 1236: ONC201 sensitivity profiling indicates pronounced sensitivity in lymphoid, prostate, colon and brain tumors