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Ulrich Steidl
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Journal Articles

Abstract 1703: SMARCA2/4 degraders relieve the differentiation block in AML via changes in chromatin looping and accessibility

Sarah Aminov, Kith Pradhan, Srabani Sahu, Shanisha Gordon-Mitchell, Emma Rabinovich, Ariel Fromowitz, Joyeeta Chakraborty, Srinivas Aluri, Rongbao Zhao, Nayem Haque, Milagros Carbajal, Aditi Shastri, Ulrich Steidl, Susanta Samajdarr, Akhil Kumar, Murali Ramachandra, Robert A. Coleman, Kristy Stengel, Amit K. Verma
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1703.
https://doi.org/10.1158/1538-7445.AM2024-1703
Published: 22 March 2024
View article titled, Abstract 1703: SMARCA2/4 degraders relieve the differentiation block in AML via changes in chromatin looping and accessibility
Journal Articles

Abstract GS1-07: Treatment persistence of residual breast tumors through an embryonic diapause-like cancer cell state with suppressed myc activity

Eugen Dhimolea, Ricardo De Matos Simoes, Dhvanir Kansara, Juliette Bouyssou, Jennifer Roth, Michal Sheffer, Rinath Jeselsohn, Nathanael Gray, Ulrich Steidl, Boris Bartholdy, Myles Brown, Aedin Culhane, Constantine Mitsiades
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): GS1-07.
https://doi.org/10.1158/1538-7445.SABCS20-GS1-07
Published: 15 February 2021
View article titled, Abstract GS1-07: Treatment persistence of residual breast tumors through an embryonic diapause-like cancer cell state with suppressed myc activity
Journal Articles

Abstract PO-045: Interleukin 1 receptor accessory protein (IL1RAP) in novel targetable pathway in pancreatic cancer

Yang Zhang, Xiaoyi Chen, Shanisha Gordon-Mitchell, Kith Pradhan, Gaurav Choudhary, Tushar D. Bhagat, Beamon Agarwal, Ulrich Steidl, Anirban Maitra, Amit Verma
Journal: Cancer Research
Cancer Res (2020) 80 (22_Supplement): PO-045.
https://doi.org/10.1158/1538-7445.PANCA20-PO-045
Published: 13 November 2020
View article titled, Abstract PO-045: Interleukin 1 receptor accessory protein (IL1RAP) in novel targetable pathway in pancreatic cancer
Journal Articles

Abstract 3480: TMEM30A loss-of-function mutations drive lymphomagenesis and confer therapeutically exploitable vulnerability in B-cell lymphoma

Shannon Healy, Daisuke Ennishi, Ali Bashashati, Saeed Saberi, Christoffer Hother, Anja Mottok, Fong Chun Chan, Lauren Chong, Robert Kridel, Merrill Boyle, Barbara Meissner, Tomohiro Aoki, Katsuyoshi Takata, Bruce W. Woolcock, Elena Vigano, Libin Abraham, Michael Gold, Adele Telenius, Pedro Farinha, Graham Slack, Susana Ben-Neriah, Daniel Lai, Allen W. Zhang, Sohrab Salehi, Hennady P. Shulha, Derek S. Chiu, Sara Mostafavi, Alina S. Gerrie, Diego Villa, Laurie H. Sehn, Kerry J. J. Savage, Andrew J. J. Mungall, Andrew P. Weng, Marcel Bally, Ryan D. Morin, Gabriela V. Cohen Freue, Joseph M. Connors, Marco A. Marra, Sohrab P. Shah, Randy D. Gascoyne1, David W. Scott, Christian Steidl, Ulrich Steidl
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3480.
https://doi.org/10.1158/1538-7445.AM2019-3480
Published: 01 July 2019
View article titled, Abstract 3480: <em>TMEM30A</em> loss-of-function mutations drive lymphomagenesis and confer therapeutically exploitable vulnerability in B-cell lymphoma
Journal Articles

Abstract 951: Direct small-molecule BAX activation in acute myeloid leukemia

Denis Reyna, Thomas Garner, Andrea Lopez, Felix Kopp, Gaurav Choudhary, Ashwin Sridharan, Swathi-Rao Narayanagari, Kelly Mitchell, Baoxia Dong, Boris Bartholdy, Loren Walensky, Amit Verma, Ulrich Steidl, Evripidis Gavathiotis
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 951.
https://doi.org/10.1158/1538-7445.AM2018-951
Published: 01 July 2018
View article titled, Abstract 951: Direct small-molecule BAX activation in acute myeloid leukemia
Journal Articles

Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/β-Catenin Activation

Tushar D. Bhagat, Si Chen, Matthias Bartenstein, A. Trevor Barlowe, Dagny Von Ahrens, Gaurav S. Choudhary, Patrick Tivnan, Elianna Amin, A. Mario Marcondes, Mathijs A. Sanders, Remco M. Hoogenboezem, Suman Kambhampati, Nandini Ramachandra, Iaonnis Mantzaris, Vineeth Sukrithan, Remi Laurence, Robert Lopez, Prafulla Bhagat, Orsi Giricz, Davendra Sohal, Amittha Wickrema, Cecilia Yeung, Kira Gritsman, Peter Aplan, Konrad Hochedlinger, Yiting Yu, Kith Pradhan, Jinghang Zhang, John M. Greally, Siddhartha Mukherjee, Andrea Pellagatti, Jacqueline Boultwood, Britta Will, Ulrich Steidl, Marc H.G.P. Raaijmakers, H. Joachim Deeg, Michael G. Kharas, Amit Verma
Journal: Cancer Research
Series: Author Choice
Cancer Res (2017) 77 (18): 4846–4857.
https://doi.org/10.1158/0008-5472.CAN-17-0282
Published: 14 September 2017
View article titled, Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/β-Catenin Activation
Open the PDF for Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/β-Catenin Activation in another window
Includes: Supplementary data
Journal Articles

Abstract 954: TGF-ß signaling inhibition counteracts myelofibrosis in MPN

Matthias Bartenstein, Lanzhu Yue, Wanke Zhao, Wanting Tina Ho, Cem Murdun, Adam W. Mailloux, Ling Zhang, Anjali Budhakoti, Kith Pradhan, Franck Rapaport, Huaquan Wang, Zonghong Shao, Ulrich Steidl, Ross L. Levine, Zhizhuang Joe Zhao, Amit K. Verma, Pearlie K. Epling-Burnette
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 954.
https://doi.org/10.1158/1538-7445.AM2017-954
Published: 01 July 2017
View article titled, Abstract 954: TGF-ß signaling inhibition counteracts myelofibrosis in MPN
Journal Articles

Abstract 127: Efficacy of novel IRAK4 inhibitor CA4948 in AML and MDS

Gaurav S. Choudhary, Tushar D. Bhagat, Maria Elena S. Samson, Shanisha Gordon, Dagny Von Ahrens, Kith Pradhan, Aditi Shastri, Andrea Pellagatti, Jacqueline Boutlwood, Robert N. Booher, Ulrich Steidl, Amit Verma
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 127.
https://doi.org/10.1158/1538-7445.AM2017-127
Published: 01 July 2017
View article titled, Abstract 127: Efficacy of novel IRAK4 inhibitor CA4948 in AML and MDS
Journal Articles

Pexmetinib: A Novel Dual Inhibitor of Tie2 and p38 MAPK with Efficacy in Preclinical Models of Myelodysplastic Syndromes and Acute Myeloid Leukemia

Lohith Bachegowda, Kerry Morrone, Shannon L. Winski, Ioannis Mantzaris, Matthias Bartenstein, Nandini Ramachandra, Orsi Giricz, Vineeth Sukrithan, George Nwankwo, Samira Shahnaz, Tushar D. Bhagat, Sanchari Bhattacharyya, Amer Assal, Aditi Shastri, Shanisha Gordon-Mitchell, Andrea Pellagatti, Jacqueline Boultwood, Carolina Schinke, Yiting Yu, Chandan Guha, James Rizzi, Jennifer Garrus, Suzy Brown, Lance Wollenberg, Grant Hogeland, Dale Wright, Mark Munson, Mareli Rodriguez, Stefan Gross, David Chantry, Yiyu Zou, Leonidas C. Platanias, Laurence E. Burgess, Kith Pradhan, Ulrich Steidl, Amit Verma
Journal: Cancer Research
Cancer Res (2016) 76 (16): 4841–4849.
https://doi.org/10.1158/0008-5472.CAN-15-3062
Published: 14 August 2016
View article titled, Pexmetinib: A Novel Dual Inhibitor of Tie2 and p38 MAPK with Efficacy in Preclinical Models of Myelodysplastic Syndromes and Acute Myeloid Leukemia
Open the PDF for Pexmetinib: A Novel Dual Inhibitor of Tie2 and p38 MAPK with Efficacy in Preclinical Models of Myelodysplastic Syndromes and Acute Myeloid Leukemia in another window
Includes: Supplementary data
Journal Articles

Abstract 5224: MicroRNA mediated regulation of TGF-β signaling leads to stem cell alterations in myelodysplastic syndromes

Tushar D. Bhagat, Li Zhou, Lubomir Sokol, Ioannis Mantzaris, Sanchari Bhattacharyya, Shanisha A.K. Gordon, Yiting Yu, Krishna Gundabolu, Sangeeta Nischal, Rahul Polineni, Carolina Schinke, Grigorios Chrysofakis, Amittha Wickrema, Andrea Pellagatti, Jacqueline Boultwood, Ulrich Steidl, Gang Liu, Alan F. List, Markus Bitzer, Amit Verma
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 5224.
https://doi.org/10.1158/1538-7445.AM2014-5224
Published: 01 October 2014
View article titled, Abstract 5224: MicroRNA mediated regulation of TGF-β signaling leads to stem cell alterations in myelodysplastic syndromes
Journal Articles

Abstract 2945: Characterization of a novel protein-coding gene named TIHL (Translocated in Hodgkin's Lymphoma)

Ujunwa C. Okoye-Okafor, Laura Barreyro, Mario Pujato, Heng Rui Wang, Boris Bartholdy, Britta Will, Tihomira I. Todorova, Masahiro Kawahara, Bruce Woolcock, Andras Fiser, Randy Gascoyne, Christian Steidl, Ulrich Steidl
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2945.
https://doi.org/10.1158/1538-7445.AM2014-2945
Published: 01 October 2014
View article titled, Abstract 2945: Characterization of a novel protein-coding gene named TIHL (Translocated in Hodgkin's Lymphoma)
Journal Articles

Abstract 4231: Genome wide hydroxymethylation tested using the HELP-GT assay shows redistribution in cancer.

Sanchari Bhattacharyya, Yiting Yu, Masako Suzuki, Nathaniel Cambpell, Jozef Mazdo, Aparna Vasantkumar, Tushar D. Bhagat, Sangeeta Nischal, Ulrich Steidl, Lucy Godley, Anirban Maitra, John M. Greally, Amit Verma
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4231.
https://doi.org/10.1158/1538-7445.AM2013-4231
Published: 15 April 2013
View article titled, Abstract 4231: Genome wide hydroxymethylation tested using the HELP-GT assay shows redistribution in cancer.
Journal Articles

Methylome Profiling Reveals Distinct Alterations in Phenotypic and Mutational Subgroups of Myeloproliferative Neoplasms

Sangeeta Nischal, Sanchari Bhattacharyya, Maximilian Christopeit, Yiting Yu, Li Zhou, Tushar D. Bhagat, Davendra Sohal, Britta Will, Yongkai Mo, Masako Suzuki, Animesh Pardanani, Michael McDevitt, Jaroslaw P. Maciejewski, Ari M. Melnick, John M. Greally, Ulrich Steidl, Alison Moliterno, Amit Verma
Journal: Cancer Research
Cancer Res (2013) 73 (3): 1076–1085.
https://doi.org/10.1158/0008-5472.CAN-12-0735
Published: 31 January 2013
View article titled, Methylome Profiling Reveals Distinct Alterations in Phenotypic and Mutational Subgroups of Myeloproliferative Neoplasms
Open the PDF for Methylome Profiling Reveals Distinct Alterations in Phenotypic and Mutational Subgroups of Myeloproliferative Neoplasms in another window
Includes: Supplementary data
Journal Articles

Reduced SMAD7 Leads to Overactivation of TGF-β Signaling in MDS that Can Be Reversed by a Specific Inhibitor of TGF-β Receptor I Kinase

Li Zhou, Christine McMahon, Tushar Bhagat, Cristina Alencar, Yiting Yu, Melissa Fazzari, Davendra Sohal, Christoph Heuck, Krishna Gundabolu, Chun Ng, Yongkai Mo, Wa Shen, Amittha Wickrema, Guanghui Kong, Ellen Friedman, Lubomir Sokol, Giannis Mantzaris, Andrea Pellagatti, Jacqueline Boultwood, Leonidas C. Platanias, Ulrich Steidl, Lei Yan, Jonathan M. Yingling, Michael M. Lahn, Alan List, Markus Bitzer, Amit Verma
Journal: Cancer Research
Cancer Res (2011) 71 (3): 955–963.
https://doi.org/10.1158/0008-5472.CAN-10-2933
Published: 01 February 2011
View article titled, Reduced SMAD7 Leads to Overactivation of TGF-β Signaling in MDS that Can Be Reversed by a Specific Inhibitor of TGF-β Receptor I Kinase
Open the PDF for Reduced SMAD7 Leads to Overactivation of TGF-β Signaling in MDS that Can Be Reversed by a Specific Inhibitor of TGF-β Receptor I Kinase in another window
Journal Articles

Abstract #2786: Apoptosis induced by JAK2 inhibition requires Bim and is enhanced by a BH3 mimetic ABT-737 in JAK2 mutant human erythroid cells

Tanya Siddiqi, Britta Will, Daniel Costa, Ulrich Steidl, Daniel Tenen, Susumu Kobayashi
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 2786.
Published: 01 May 2009
View article titled, Abstract #2786: Apoptosis induced by JAK2 inhibition requires Bim and is enhanced by a BH3 mimetic ABT-737 in JAK2 mutant human erythroid cells
Journal Articles

Metastasis suppressor 1 is a target gene of BCR/ABL in leukemic stem cells

Mirle Schemionek, Christian Elling, Shuchi Agrawal, Martin Stehling, Claudia Huettner, Ulrich Steidl, Daniel Tenen, Ashley Hamilton, Tessa Holyoake, Danilo Perrotti, Thomas Buchner, Wolfgang Berdel, Hubert Serve, Carsten Muller-Tidow, Steffen Koschmieder
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 869.
Published: 01 May 2008
View article titled, Metastasis suppressor 1 is a target gene of BCR/ABL in leukemic stem cells
Journal Articles

Transcriptional Profiling Identifies Cyclin D1 as a Critical Downstream Effector of Mutant Epidermal Growth Factor Receptor Signaling

Susumu Kobayashi, Takeshi Shimamura, Stefano Monti, Ulrich Steidl, Christopher J. Hetherington, April M. Lowell, Todd Golub, Matthew Meyerson, Daniel G. Tenen, Geoffrey I. Shapiro, Balázs Halmos
Journal: Cancer Research
Cancer Res (2006) 66 (23): 11389–11398.
https://doi.org/10.1158/0008-5472.CAN-06-2318
Published: 04 December 2006
View article titled, Transcriptional Profiling Identifies Cyclin D1 as a Critical Downstream Effector of Mutant Epidermal Growth Factor Receptor Signaling
Open the PDF for Transcriptional Profiling Identifies Cyclin D1 as a Critical Downstream Effector of Mutant Epidermal Growth Factor Receptor Signaling in another window
Includes: Supplementary data
Journal Articles

Gene expression analysis to identify genes whose expression profiles correlate with sensitivity of non-small cell lung cancer cells to EGFR tyrosine kinase inhibitors

Susumu Kobayashi, Takeshi Shimamura, Stefano Monti, Ulrich Steidl, Mattew L. Meyerson, Todd R. Golub, Geoffrey I. Shapiro, Daniel G. Tenen, Balazs Halmos
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 344.
Published: 15 April 2006
View article titled, Gene expression analysis to identify genes whose expression profiles correlate with sensitivity of non-small cell lung cancer cells to EGFR tyrosine kinase inhibitors
Journal Articles

Increased expression of neurobiological receptors in highly enriched malignant CD34+ cells from patients with CML in comparison with normal CD34+ cells

Ralf Kronenwett, Ulf Butterweck, Ulrich Steidl, Frank Neumann, Nicole Roes, Slawomir Kliszewski, Thomas Schroeder, Christian Maercker, Norbert Gattermann, Rainer Haas
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 376.
Published: 01 April 2004
View article titled, Increased expression of neurobiological receptors in highly enriched malignant CD34+ cells from patients with CML in comparison with normal CD34+ cells