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Ulrich Keilholz
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Journal Articles

Abstract 5222: AI-driven, mIF-based cell-omics reveals spatially resolved cell signature for outcome prediction in NSCLC patients

Simon Schallenberg, Gabriel Dernbach, Sharon Ruane, Cornelius Böhm, Lukas Ruff, Kai Standvoss, Sandip Ghosh, Marco Frentsch, Mihnea Dragomir, Rebecca Fritz, Ines Koch, Corinna Friedrich, Il-Kang Na, Sabine Merkelbach-Bruse, Alexander Quaas, Nikolaj Frost, Kyrill Boschung, Winfried Randerath, Georg Schlachtenberger, Matthias Heldwein, Ulrich Keilholz, Khosro Hekmat, Jens Rückert, Reinhard Büttner, Angela Vasaturo, David Horst, Maximilian Alber, Frederick Klauschen
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5222.
https://doi.org/10.1158/1538-7445.AM2024-5222
Published: 22 March 2024
View article titled, Abstract 5222: AI-driven, mIF-based cell-omics reveals spatially resolved cell signature for outcome prediction in NSCLC patients
Journal Articles

Abstract 5221: TTF-1 status in early-stage lung adenocarcinoma is an independent predictor of relapse and survival superior to tumor grading

Simon Schallenberg, Gabriel Dernbach, Mihnea Dragomir, Georg Schlachtenberger, Kyrill Boschung, Corinna Friedrich, Kai Standvoss, Lukas Ruff, Philipp Anders, Christian Grohe, Winfried Randerath, Sabine Merkelbach-Bruse, Alexander Quaas, Matthias Heldwein, Ulrich Keilholz, Khosro Hekmat, Jens Rückert, Reinhard Büttner, David Horst, Frederick Klauschen, Nikolaj Frost
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5221.
https://doi.org/10.1158/1538-7445.AM2024-5221
Published: 22 March 2024
View article titled, Abstract 5221: TTF-1 status in early-stage lung adenocarcinoma is an independent predictor of relapse and survival superior to tumor grading
Journal Articles

Abstract 1674: Correlation of the mutational pattern and gene expression data of patient-derived Non-Hodgkin lymphoma xenografts (PDX) with the response to targeted therapies

Bernadette Brzezicha, Theresia Conrad, Michael Becker, Aitomi Bittner, Martin Janz, Clemens A. Schmitt, Ulrich Keilholz, Jens Hoffmann
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1674.
https://doi.org/10.1158/1538-7445.AM2020-1674
Published: 15 August 2020
View article titled, Abstract 1674: Correlation of the mutational pattern and gene expression data of patient-derived Non-Hodgkin lymphoma xenografts (PDX) with the response to targeted therapies
Journal Articles

Abstract 821: Comprehensive genomic analysis of rare cancers: Results of the MASTER precision oncology trial of the German Cancer Consortium

Peter Horak, Christoph Heining, Andreas Mock, Simon Kreutzfeldt, Andreas Lassmann, Lino Möhrmann, Jennifer Hüllein, Dorothea Hanf, Arne Jahn, Leo Ruhnke, Laura Gieldon, Christoph E. Heilig, Veronica Teleanu, Martina Fröhlich, Sebastian Uhrig, Katja Beck, Daniela Richter, Stephan Wolf, Katrin Pfütze, Christina Geörg, Bettina Meissburger, Frederick Klauschen, Ulrich Keilholz, Sebastian Ochsenreither, Gunnar Folprecht, Jens Siveke, Sebastian Bauer, Thomas Kindler, Christian Brandts, Melanie Boerries, Anna L. Illert, Nikolas von Bubnoff, Karsten Spiekermann, Philipp J. Jost, Klaus Schulze-Osthoff, Michael Bitzer, Peter Schirmacher, Christof von Kalle, Richard F. Schlenk, Barbara Klink, Barbara Hutter, Daniel Hübschmann, Albrecht Stenzinger, Wilko Weichert, Evelin Schröck, Benedikt Brors, Hanno Glimm, Stefan Fröhling, German Cancer Consortium (DKTK)
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 821.
https://doi.org/10.1158/1538-7445.AM2020-821
Published: 15 August 2020
View article titled, Abstract 821: Comprehensive genomic analysis of rare cancers: Results of the MASTER precision oncology trial of the German Cancer Consortium
Journal Articles

Abstract 5059: Breast cancer patient-derived xenograft models for pre- and co-clinical investigation of immune based therapies

Annika Wulf-Goldenberg, Verena Kiver, Maria Stecklum, Bernadette Brzezicha, Philipp Jurmeister, Caroline Schweiger, Jens-Uwe Blohmer, Ulrich Keilholz, Jens Hoffmann
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5059.
https://doi.org/10.1158/1538-7445.AM2020-5059
Published: 15 August 2020
View article titled, Abstract 5059: Breast cancer patient-derived xenograft models for pre- and co-clinical investigation of immune based therapies
Journal Articles

Abstract 1069: New panel of patient derived lymphoma xenografts (PDX) for preclinical research and immune oncology

Bernadette Brzezicha, Michael Becker, Maria Stecklum, Teresia Conrad, Martin Janz, Aitomi Bittner, Clemens Schmitt, Ulrich Keilholz, Jens Hoffmann
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1069.
https://doi.org/10.1158/1538-7445.AM2019-1069
Published: 01 July 2019
View article titled, Abstract 1069: New panel of patient derived lymphoma xenografts (PDX) for preclinical research and immune oncology
Journal Articles

Abstract 919: Clinical relevance of comprehensive genomic analysis in patients with advanced-stage neuroendocrine neoplasms: Results from the MASTER trial of the German Cancer Consortium

Simon Kreutzfeldt, Leonidas Apostolidis, Malgorzata Oles, Peter Horak, Christoph E. Heilig, Christoph Heining, Barbara Hutter, Laura Gieldon, Barbara Klink, Mario Lamping, Damian T. Rieke, Sebastian Uhrig, Henning Jann, Ulrich F. Pape, Albrecht Stenzinger, Eva C. Winkler, Bertram Wiedenmann, Dirk Jäger, Benedikt Brors, Evelin Schröck, Ulrich Keilholz, Marianne Pavel, Hanno Glimm, Stefan Fröhling
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 919.
https://doi.org/10.1158/1538-7445.AM2019-919
Published: 01 July 2019
View article titled, Abstract 919: Clinical relevance of comprehensive genomic analysis in patients with advanced-stage neuroendocrine neoplasms: Results from the MASTER trial of the German Cancer Consortium
Journal Articles

Abstract 1823: Identification of molecular determinants of vinorelbine resistance in BRAF(V600E) mutated chemorefractory metastatic colorectal cancer patients

Loredana Vecchione, Ines Beumer, Antonio Mulero-Sanchez, Mireille Snel, Filippo Pietrantonio, Chiara Cremolini, Fotios Loupakis, Antonia Martinetti, Giovanni Fuca', Roberto Moretto, Gabriella Fontanini, Matteo Fassan, Sara Lonardi, Marta Schirripa, Ulrich Keilholz, Rene' Bernards
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1823.
https://doi.org/10.1158/1538-7445.AM2018-1823
Published: 01 July 2018
View article titled, Abstract 1823: Identification of molecular determinants of vinorelbine resistance in BRAF(V600E) mutated chemorefractory metastatic colorectal cancer patients
Journal Articles

Abstract 4099: Novel patient-derived 3D (PD3D) cell models and matched patient-derived xenografts (PDX) from peritoneal metastasis of colorectal cancer for drug testing and biomarker analysis

Christian RA Regenbrecht, Guido Gambara, Eva Pachmayr, Alessandra Silvestri, Mathias Dahlmann, Bernadette Brzezicha, Britta Buettner, Beate Rau, Ulrich Keilholz, Urike Stein, Wolfgang Walther
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4099.
https://doi.org/10.1158/1538-7445.AM2018-4099
Published: 01 July 2018
View article titled, Abstract 4099: Novel patient-derived 3D (PD3D) cell models and matched patient-derived xenografts (PDX) from peritoneal metastasis of colorectal cancer for drug testing and biomarker analysis
Journal Articles

Abstract CT111: Avelumab (anti-PD-L1) as first-line maintenance (1L mn) or second-line (2L) therapy in patients with advanced gastric or gastroesophageal junction cancer (GC/GEJC): updated phase Ib results from the JAVELIN Solid Tumor trial

Hyun Cheol Chung, Hendrik-Tobias Arkenau, Jeeyun Lee, Sun Young Rha, Do-Youn Oh, Lucjan Wyrwicz, Yoon-Koo Kang, Keun-Wook Lee, Todd M. Bauer, Sung Sook Lee, Margaret Kemeny, Ulrich Keilholz, Bohuslav Melichar, Alain Mita, Ruth Plummer, Denis Smith, Arnold B. Gelb, Huiling Xiong, Janet Hong, Vikram Chand, Howard Safran
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): CT111.
https://doi.org/10.1158/1538-7445.AM2018-CT111
Published: 01 July 2018
View article titled, Abstract CT111: Avelumab (anti-PD-L1) as first-line maintenance (1L mn) or second-line (2L) therapy in patients with advanced gastric or gastroesophageal junction cancer (GC/GEJC): updated phase Ib results from the JAVELIN Solid Tumor trial
Journal Articles

Abstract 5013: Rapid generation of phenomic and functional profiles of patient-derived 3D cell culture models for identification of treatment vulnerabilities of breast cancer: Early results of the EFRE-PoP project

Verena I. Kiver, Guido Gambara, Olga Gorea, Jens-Uwe Blohmer, Philipp Jurmeister, Carsten Denkert, Alessandra Silvestri, Caroline M. Schweiger, Maxine Silvestrov, Ulrich Keilholz, Christian R. Regenbrecht
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5013.
https://doi.org/10.1158/1538-7445.AM2018-5013
Published: 01 July 2018
View article titled, Abstract 5013: Rapid generation of phenomic and functional profiles of patient-derived 3D cell culture models for identification of treatment vulnerabilities of breast cancer: Early results of the EFRE-PoP project
Journal Articles

Abstract 2841: Her2/neu expression as potential marker of regorafenib resistance in CRC

Loredana Vecchione, Stefania Napolitano, Valentina Belli, Erika Martinelli, Nunzia Matrone, Christophe Hapke, Ulrich Keilholz, Josep Tabernero, Fortunato Ciardiello, Teresa Troiani
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2841.
https://doi.org/10.1158/1538-7445.AM2018-2841
Published: 01 July 2018
View article titled, Abstract 2841: Her2/neu expression as potential marker of regorafenib resistance in CRC
Journal Articles

Abstract 3149: Enumeration and mutational profiling of CTCs and comparison to ctDNA and colorectal cancer liver metastases

Evelyn Kidess-Sigal, Haiyan E. Liu, Melanie Triboulet, James Che, Georges A. Poultsides, Brendan C. Visser, Andre Marziali, Marc Lee, Valentina Vysotskaia, Matthew Wiggin, Vishnu C. Ramani, Ulrich Keilholz, Ingeborg Tinhofer, Amin Zia, John Coller, Jeffrey A. Norton, Elodie Sollier, Stefanie S. Jeffrey
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3149.
https://doi.org/10.1158/1538-7445.AM2016-3149
Published: 15 July 2016
View article titled, Abstract 3149: Enumeration and mutational profiling of CTCs and comparison to ctDNA and colorectal cancer liver metastases
Journal Articles

Abstract 1715: Whole transcriptome analysis of patient-derived 3D in vitro and xenograft models of colon cancer identifies placental genes required for the survival of cancer stem cells

Joseph L. Regan, Stephanie Staudte, Dirk Schumacher, Ulrich Keilholz, Johannes Haybaeck, Hans Lehrach, Marie-Laure Yaspo, David Henderson, Andreas Steffen, Joern Toedling, Ralf Lesche, Reinhold Schaefer, Christian R. Regenbrecht, Dominik Mumberg, Martin Lange
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1715.
https://doi.org/10.1158/1538-7445.AM2016-1715
Published: 15 July 2016
View article titled, Abstract 1715: Whole transcriptome analysis of patient-derived 3D in vitro and xenograft models of colon cancer identifies placental genes required for the survival of cancer stem cells
Journal Articles

Abstract 1714: The role of Hedgehog signaling in the regulation of human colon cancer stem cells

Joseph L. Regan, Stephanie Staudte, Dirk Schumacher, Ulrich Keilholz, Johannes Haybaeck, Hans Lehrach, Marie-Laure Yaspo, David Henderson, Andreas Steffen, Joern Toedling, Ralf Lesche, Reinhold Schaefer, Christian R. Regenbrecht, Dominik Mumberg, Martin Lange
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1714.
https://doi.org/10.1158/1538-7445.AM2016-1714
Published: 15 July 2016
View article titled, Abstract 1714: The role of Hedgehog signaling in the regulation of human colon cancer stem cells
Journal Articles

Abstract 977: 3D-models of patient-derived colon tumors for the identification of genetic factors important in the regulation of cancer stem cells

Joseph L. Regan, Dirk Schumacher, Stephanie Staudte, Karsten Boehnke, Ulrich Keilholz, Johannes Haybaeck, Hans Lehrach, David Henderson, Reinhold Schaefer, Christian R. Regenbrecht, Dominik Mumberg, Martin Lange
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 977.
https://doi.org/10.1158/1538-7445.AM2015-977
Published: 01 August 2015
View article titled, Abstract 977: 3D-models of patient-derived colon tumors for the identification of genetic factors important in the regulation of cancer stem cells
Journal Articles

Abstract 2978: Generation of drug response data from 57 new patient-derived colon cancer xenografts and 3D cell cultures for systematic correlation with tumor biology within the OncoTrack* project

Maria Rivera, Marlen Keil, Karsten Boehnke, Martin Lange, Dirk Schumacher, Reinhold Schäfer, Christian R. Regenbrecht, David Henderson, Ulrich Keilholz, Alexander Kuehn, Amin El-Heliebi, Tabea Hohensee, Johannes Haybäck, Christoph Reinhard, Juan A. Velasco, Hans Lehrach, Pilar Garin-Chesa, Garry Beran, Jens Hoffmann
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2978.
https://doi.org/10.1158/1538-7445.AM2014-2978
Published: 01 October 2014
View article titled, Abstract 2978: Generation of drug response data from 57 new patient-derived colon cancer xenografts and 3D cell cultures for systematic correlation with tumor biology within the OncoTrack* project
Journal Articles

Abstract 2018: A pipeline within the OncoTrack project for generating Patient-tumor-derived 3D cell cultures (PT3DC) and their application for individualized, targeted drug sensitivity assays

Dirk Schumacher, Karsten Boehnke, Martin Lange, Yvonne Welte, Cathrin Davies, Maria Rivera, Marlen Keil, Ulrich Keilholz, Johannes Haybaeck, Juan Angel Velasco, Marie-Laure Yaspo, Hans Lehrach, David Henderson, Christoph Reinhard, Jens Hoffmann, Reinhold Schaefer, Christian Regenbrecht
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2018.
https://doi.org/10.1158/1538-7445.AM2014-2018
Published: 01 October 2014
View article titled, Abstract 2018: A pipeline within the OncoTrack project for generating Patient-tumor-derived 3D cell cultures (PT3DC) and their application for individualized, targeted drug sensitivity assays
Journal Articles

Abstract 901: Plasma proteins characterize second-line therapy response in progressive renal cell carcinoma

Sebastian Hölters, Lothar Bergmann, Viktor Grünwald, Ulrich Keilholz, Carsten Ohlmann, Michael Staehler, Diana Schmerler, Kerstin Junker
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 901.
https://doi.org/10.1158/1538-7445.AM2014-901
Published: 01 October 2014
View article titled, Abstract 901: Plasma proteins characterize second-line therapy response in progressive renal cell carcinoma
Journal Articles

Abstract 3875: Functional and molecular characterization of colon cancer stem cells in tumor heterogeneity and disease relapse using a 3D-model of patient-derived tumors

Joseph L. Regan, Dirk Schumacher, Karsten Boehnke, Cathrin Davies, Ulrich Keilholz, Johannes Haybaeck, Christoph Reinhard, Hans Lehrach, David Henderson, Reinhold Schaefer, Christian Regenbrecht, Martin Lange
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3875.
https://doi.org/10.1158/1538-7445.AM2014-3875
Published: 01 October 2014
View article titled, Abstract 3875: Functional and molecular characterization of colon cancer stem cells in tumor heterogeneity and disease relapse using a 3D-model of patient-derived tumors