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Journal Articles

Abstract CT051: Preliminary results from LuCa-MERIT-1, a first-in-human Phase I trial evaluating the fixed antigen mRNA vaccine BNT116 + docetaxel in patients with advanced non-small cell lung cancer

Bala Başak Öven, David Vicente Baz, Jürgen Wolf, Ozturk Ates, Erdem Göker, Patrick Brück, Michael Wenger, Neru Munshi, Iryna Tsyhankova, Iryna Tsyhankova, Malgorzata Kaczorowska, Thomas Schell, Janet L. Markman, Huyuan Yang, Özlem Türeci, Uğur Şahin, Patrick Forde, Akin Atmaca
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT051.
https://doi.org/10.1158/1538-7445.AM2024-CT051
Published: 05 April 2024
View article titled, Abstract CT051: Preliminary results from LuCa-MERIT-1, a first-in-human Phase I trial evaluating the fixed antigen mRNA vaccine BNT116 + docetaxel in patients with advanced non-small cell lung cancer
Journal Articles

Abstract LB198: A first-in-human, open-label, multicenter study of intratumoral SAR441000 (mixture of cytokine encoding mRNAs), as monotherapy and in combination with cemiplimab in patients with advanced solid tumors

Oliver Bechter, Carmen Loquai, Stephane Champiat, Jean Francois Baurain, Jean-Jacques Grob, Jochen Utikal, Sylvie Rottey, Alfonso Berrocal, Jessica Hassel, Ana Arance, Miguel F. Sanmamed, Marye Boers-Sonderen, Brian Gastman, Christoffer Gebhardt, Brant Delafontaine, Ugur Sahin, Özlem Türeci, Giovanni Abbadessa, Gianfranco Di Genova, Patrick Brueck, Rahul Marpadga, Helen Lee, Céleste Lebbe
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB198.
https://doi.org/10.1158/1538-7445.AM2023-LB198
Published: 14 April 2023
View article titled, Abstract LB198: A first-in-human, open-label, multicenter study of intratumoral SAR441000 (mixture of cytokine encoding mRNAs), as monotherapy and in combination with cemiplimab in patients with advanced solid tumors
Journal Articles

Abstract 3283: GEN1046 (DuoBody®-PD-L1x4-1BB) in combination with PD-1 blockade potentiates anti-tumor immunity

Michela Capello, Angelica Sette, Theo Plantinga, Vanessa Spires, Kristina Nuermberger, Jordan Blum, Alexander Muik, Carol Costa Sa, Omar Jabado, Saskia Burm, Aras Toker, Sina Fellermeier-Kopf, Tahi Ahmadi, Brandon Higgs, Suzana Couto, Özlem Türeci, Mark Fereshteh, Ugur Sahin, Maria Jure-Kunkel, Nora Pencheva
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3283.
https://doi.org/10.1158/1538-7445.AM2023-3283
Published: 04 April 2023
View article titled, Abstract 3283: GEN1046 (DuoBody®-PD-L1x4-1BB) in combination with PD-1 blockade potentiates anti-tumor immunity
Journal Articles

Abstract 3281: GEN1042 (DuoBody-CD40x4-1BB)®in combination with PD-1 blockade reverses T-cell exhaustion in vitro

Vanessa M. Spires, Gregg Masters, Christina Yu, Matt Hancock, Monique N. Luijten, Alexander Muik, Kristina Nuermberger, Friederike Gieseke, Tahamtan Ahmadi, Özlem Türeci, Maria Jure-Kunkel, Ugur Sahin, Mark Fereshteh, Homer C. Adams, Jordan M. Blum
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3281.
https://doi.org/10.1158/1538-7445.AM2023-3281
Published: 04 April 2023
View article titled, Abstract 3281: GEN1042 (DuoBody-CD40x4-1BB)<sup>®</sup>in combination with PD-1 blockade reverses T-cell exhaustion <em>in vitro</em>
Journal Articles

Abstract CT002: BNT211: A Phase I trial to evaluate safety and efficacy of CLDN6 CAR-T cells and CARVac-mediated in vivo expansion in patients with CLDN6-positive advanced solid tumors

John BAG Haanen, Andreas Mackensen, Christian Koenecke, Winfried Alsdorf, Eva Wagner-Drouet, Daniel Heudobler, Peter Borchmann, Carsten Bokemeyer, Sebastian Klobuch, Alexander Desuki, Florian Lüke, Erol Wiegert, Catrine Schulz, Benjamin Rengstl, Liane Preussner, Özlem Türeci, Ugur Sahin
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT002.
https://doi.org/10.1158/1538-7445.AM2022-CT002
Published: 15 June 2022
View article titled, Abstract CT002: BNT211: A Phase I trial to evaluate safety and efficacy of CLDN6 CAR-T cells and CARVac-mediated in vivo expansion in patients with CLDN6-positive advanced solid tumors
Journal Articles

Abstract 1846: DuoBody-CD40×4-1BB (GEN1042) induces dendritic-cell maturation and enhances T-cell activation and effector functions in vitro by conditional CD40 and 4-1BB agonist activity

Alexander Muik, Rachelle Kosoff, Friederike Gieseke, Isil Altintas, Kristina Schödel, Saskia Burm, Eliana Stanganello, Fulvia Vascotto, Aras Toker, Homer Adams, III, Esther Breij, Mustafa Diken, Tahamtan Ahmadi, Kate Sasser, Özlem Türeci, Mark Fereshteh, Ugur Sahin, Maria Jure-Kunkel
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1846.
https://doi.org/10.1158/1538-7445.AM2021-1846
Published: 01 July 2021
View article titled, Abstract 1846: DuoBody-CD40×4-1BB (GEN1042) induces dendritic-cell maturation and enhances T-cell activation and effector functions <em>in vitro</em> by conditional CD40 and 4-1BB agonist activity
Journal Articles

Abstract LB-383: An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors

Katharina Reinhard, Benjamin Rengstl, Petra Oehm, Özlem Türeci, Ugur Sahin
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): LB-383.
https://doi.org/10.1158/1538-7445.AM2020-LB-383
Published: 15 August 2020
View article titled, Abstract LB-383: An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors
Journal Articles

Abstract 4451: Combination of local mRNA immunotherapy with systemic immune checkpoint blockade demonstrates anti-tumor activity across a diverse range of preclinical syngeneic tumor models

Natalia V. Malkova, Tatiana Tolstykh, Mikhail Levit, Joachim Theilhaber, Andrew Hebert, Kevin Atchison, Adalis Maisonet, Christian Hotz, Ugur Sahin, Alexei Protopopov, Jack Pollard, Sukhvinder Sidhu, Dmitri Wiederschain, Timothy R. Wagenaar
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4451.
https://doi.org/10.1158/1538-7445.AM2020-4451
Published: 15 August 2020
View article titled, Abstract 4451: Combination of local mRNA immunotherapy with systemic immune checkpoint blockade demonstrates anti-tumor activity across a diverse range of preclinical syngeneic tumor models
Journal Articles

Abstract CT301: A phase Ib study to evaluate RO7198457, an individualized Neoantigen Specific immunoTherapy (iNeST), in combination with atezolizumab in patients with locally advanced or metastatic solid tumors

Juanita S. Lopez, Ross Camidge, Marco Iafolla, Sylvie Rottey, Martin Schuler, Matthew Hellmann, Ani Balmanoukian, Luc Dirix, Michael Gordon, Ryan Sullivan, Brian S. Henick, Charles Drake, Kit Wong, Patricia LoRusso, Patrick Ott, Lawrence Fong, Aglaia Schiza, Jeffery Yachnin, Christian Ottensmeier, Fadi Braiteh, Johanna Bendell, Rom Leidner, George Fisher, Guy Jerusalem, Laura Molenaar-Kuijsten, Marcus Schmidt, Scott A. Laurie, Raid Aljumaily, Achim Rittmeyer, Eelke Gort, Ignacio Melero, Lars Mueller, Rachel Sabado, Patrick Twomey, Jack Huang, Manesh Yadav, Jingbin Zhang, Felicitas Mueller, Evelyna Derhovanessian, Ugur Sahin, Özlem Türeci, Thomas Powles
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): CT301.
https://doi.org/10.1158/1538-7445.AM2020-CT301
Published: 15 August 2020
View article titled, Abstract CT301: A phase Ib study to evaluate RO7198457, an individualized Neoantigen Specific immunoTherapy (iNeST), in combination with atezolizumab in patients with locally advanced or metastatic solid tumors
Journal Articles

Abstract CT169: A phase Ia study to evaluate RO7198457, an individualized Neoantigen Specific immunoTherapy (iNeST), in patients with locally advanced or metastatic solid tumors

Fadi Braiteh, Patricia LoRusso, Ani Balmanoukian, Sam Klempner, D R. Camidge, Matthew Hellmann, Michael Gordon, Johanna Bendell, Lars Mueller, Rachel Sabado, Patrick Twomey, Leila Delamarre, Jack Huang, Mahesh Yadav, Jingbin Zhang, Patrick McDonald, Felicitas Müller, Evelyna Derhovanessian, Özlem Türeci, Ugur Sahin, Lillian Siu
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): CT169.
https://doi.org/10.1158/1538-7445.AM2020-CT169
Published: 15 August 2020
View article titled, Abstract CT169: A phase Ia study to evaluate RO7198457, an individualized Neoantigen Specific immunoTherapy (iNeST), in patients with locally advanced or metastatic solid tumors
Journal Articles

Abstract P1-10-23: Prediction of pathological complete response (pCR) upon neoadjuvant chemotherapy by MammaTyper® pCR score

Silvana Saracchini, Anna Bassini, Wally Marus, Serena Corsetti, Ilaria Specogna, Manuela Bertola, Elvia Micheli, Ralph M Wirtz, Mark Laible, Ugur Sahin, Daniele Generali, Sandro Sulfaro
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P1-10-23.
https://doi.org/10.1158/1538-7445.SABCS19-P1-10-23
Published: 15 February 2020
View article titled, Abstract P1-10-23: Prediction of pathological complete response (pCR) upon neoadjuvant chemotherapy by MammaTyper® pCR score
Journal Articles

Abstract P3-07-08: Comparison of MammaTyper® RT-qPCR based subtyping with simulated breast cancer prognostic signatures

Mark Laible, Sebastian Aulmann, Alfred Etzrodt, Marcus Schmidt, Cheryl Crozier, Ralph Wirtz, Jane Bayani, Ugur Sahin, John MS Bartlett
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P3-07-08.
https://doi.org/10.1158/1538-7445.SABCS19-P3-07-08
Published: 15 February 2020
View article titled, Abstract P3-07-08: Comparison of MammaTyper® RT-qPCR based subtyping with simulated breast cancer prognostic signatures
Journal Articles

Abstract CT221: Mutanome engineered RNA immuno-therapy (MERIT) for patients with triple negative breast cancer (TNBC)

Ludwig Heesen, Katrin Frenzel, Stefanie Bolte, Valesca Bukur, Mustafa Diken, Evelyna Derhovanessian, Sebastian Kreiter, Andreas N. Kuhn, Klaus Kühlcke, Martin Löwer, Henrik Lindman, Steve Pascolo, Marcus Schmidt, Andreas Schneeweiss, Tobias Sjöblom, Kris Thielemans, Laurence Zitvogel, Özlem Türeci, Ugur Sahin
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): CT221.
https://doi.org/10.1158/1538-7445.AM2019-CT221
Published: 01 July 2019
View article titled, Abstract CT221: Mutanome engineered RNA immuno-therapy (MERIT) for patients with triple negative breast cancer (TNBC)
Journal Articles

Abstract LB-130: Combinatorial treatment with intratumoral cytokine mRNAs results in high frequency of tumor rejection and development of anti-tumor immunity across a range of preclinical cancer models

Timothy R. Wagenaar, Christian Hotz, Friederike Gieseke, Hui Cao, Jan Diekmann, Mustafa Diken, Christian Grunwitz, Andy Hebert, Karl Hsu, Marie Jordan, Katalin Kariko, Sebastian Kreiter, Andreas N. Kuhn, Mikhail Levit, Natalia Malkova, Serena Masciari, Jack Pollard, Hui Qu, Abderaouf Selmi, Julia Schlereth, Fangxian Sun, Bodo Tillmann, Tatiana Tolstykh, Lena Wicke, Sonja Witzel, Qunyan Yu, Yu-An Zhang, Gang Zheng, Gary Nabel, Joanne Lager, Ugur Sahin, Dmitri Wiederschain
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-130.
https://doi.org/10.1158/1538-7445.AM2018-LB-130
Published: 01 July 2018
View article titled, Abstract LB-130: Combinatorial treatment with intratumoral cytokine mRNAs results in high frequency of tumor rejection and development of anti-tumor immunity across a range of preclinical cancer models
Journal Articles

Abstract 1907: Claudin 6 is a carcinoembryonic antigen with cancer stem cell marker features

Özlem Türeci, Meike Wagner, Claudia Paret, Maria M. Kreuzberg, Stefan Wöll, Korden Walter, Sabine C. Häcker, Ikumi Nakajo, Tomohiro Yamada, Ugur Sahin
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1907.
https://doi.org/10.1158/1538-7445.AM2018-1907
Published: 01 July 2018
View article titled, Abstract 1907: Claudin 6 is a carcinoembryonic antigen with cancer stem cell marker features
Journal Articles

Abstract 1728: Nonalcoholic steatohepatitis (NASH) impairs treatment of intrahepatic metastases with CD4+ T cell dependent RNA vaccine

Bernd Heinrich, Zachary J. Brown, Vormehr Mathias, Qiong Fu, Chi Ma, Su Jong Yu, Ugur Sahin, Tim F. Greten
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1728.
https://doi.org/10.1158/1538-7445.AM2018-1728
Published: 01 July 2018
View article titled, Abstract 1728: Nonalcoholic steatohepatitis (NASH) impairs treatment of intrahepatic metastases with CD4<sup>+</sup> T cell dependent RNA vaccine
Journal Articles

Abstract 1778: Preclinical characterization of the safety and antitumor activity of IMAB027-vcMMAE, an anticlaudin 6 antibody-drug conjugate

Özlem Türeci, Maria Kreuzberg, Korden Walter, Stefan Wöll, Ramona Schmitt, Tomohiro Yamada, Ikumi Nakajo, Ugur Sahin
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1778.
https://doi.org/10.1158/1538-7445.AM2018-1778
Published: 01 July 2018
View article titled, Abstract 1778: Preclinical characterization of the safety and antitumor activity of IMAB027-vcMMAE, an anticlaudin 6 antibody-drug conjugate
Journal Articles

Abstract CT156: A first-in-human phase I/II clinical trial assessing novel mRNA-lipoplex nanoparticles encoding shared tumor antigens for immunotherapy of malignant melanoma

Robert A. Jabulowsky, Carmen Loquai, Heidrun Mitzel-Rink, Jochen Utikal, Christoffer Gebhardt, Jessica C. Hassel, Roland Kaufmann, Andreas Pinter, Evelyna Derhovanessian, Christine Anft, Sebastian Attig, Alexandra Deubel, Mustafa Diken, Maike Gold, Claudia Guertler, Heinrich Haas, Ludwig Heesen, Alexandra Kemmer-Brück, Lena M. Kranz, Klaus Kuehlcke, Andreas Kuhn, Peter Langguth, Ulrich Luxemburger, Daniel Maurus, Martin Meng, Felicitas Müller, Richard Rae, Fatih Sari, Katharina Schreeb, Doreen Schwarck-Kokarakis, Malte Stein, Dirk Jäger, Stephan Grabbe, Sebastian Kreiter, Christoph Huber, Özlem Türeci, Ugur Sahin
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): CT156.
https://doi.org/10.1158/1538-7445.AM2018-CT156
Published: 01 July 2018
View article titled, Abstract CT156: A first-in-human phase I/II clinical trial assessing novel mRNA-lipoplex nanoparticles encoding shared tumor antigens for immunotherapy of malignant melanoma
Journal Articles

Abstract 763: PLAC1 interacts with FGF7 and promotes phosphorylation of FGFR2 and AKT

Diana Barea Roldan, Christoph Hartmann, Stefanie Hubich-Rau, Tim Beissert, Claudia Paret, Giuseppe Cagna, Christoph Rohde, Stefan Wöll, Ugur Sahin, Ozlem Tureci
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 763.
https://doi.org/10.1158/1538-7445.AM2018-763
Published: 01 July 2018
View article titled, Abstract 763: PLAC1 interacts with FGF7 and promotes phosphorylation of FGFR2 and AKT
Journal Articles

Abstract 882: The anti-claudin 6 antibody, IMAB027, induces antibody-dependent cellular and complement-dependent cytotoxicity in claudin 6-expressing cancer cells

Özlem Türeci, Maria Kreuzberg, Korden Walter, Stefan Wöll, Ramona Schmitt, Rita Mitnacht-Kraus, Ikumi Nakajo, Tomohiro Yamada, Ugur Sahin
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 882.
https://doi.org/10.1158/1538-7445.AM2018-882
Published: 01 July 2018
View article titled, Abstract 882: The anti-claudin 6 antibody, IMAB027, induces antibody-dependent cellular and complement-dependent cytotoxicity in claudin 6-expressing cancer cells