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Tyler J. Curiel
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Journal Articles

Abstract 1331: MiNK-215, an IL-15 armored FAP-targeting CAR iNKT cell therapy, effectively treats human organoid models of treatment-refractory MSS colorectal cancer (CRC) liver metastases

Shanmugarajan Krishnan, Bishnu Joshi, Justin Keith, Ryan Frazier, Barbara Kalinowska, Jin San Choi, Stephanie Sanders, Shannon Boi, Olivier Le Tonqueze, Nick Kushner, Kah Teong Soh, Robert Stein, Tyler J. Curiel, Marc A. van Dijk, Enoch Kim, Eleni Chantzoura, Nils-Petter Rudqvist, Dhan Chand
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1331.
https://doi.org/10.1158/1538-7445.AM2024-1331
Published: 22 March 2024
View articletitled, Abstract 1331: MiNK-215, an IL-15 armored FAP-targeting CAR iNKT cell therapy, effectively treats human organoid models of treatment-refractory MSS colorectal cancer (CRC) liver metastases
Journal Articles

Tumor Intrinsic PD-L1 Promotes DNA Repair in Distinct Cancers and Suppresses PARP Inhibitor–Induced Synthetic Lethality

Anand V.R. Kornepati, Jacob T. Boyd, Clare E. Murray, Julia Saifetiarova, Bárbara de la Peña Avalos, Cody M. Rogers, Haiyan Bai, Alvaro S. Padron, Yiji Liao, Carlos Ontiveros, Robert S. Svatek, Robert Hromas, Rong Li, Yanfen Hu, Jose R. Conejo-Garcia, Ratna K. Vadlamudi, Weixing Zhao, Eloïse Dray, Patrick Sung, Tyler J. Curiel
Journal: Cancer Research
Cancer Res (2022) 82 (11): 2156–2170.
https://doi.org/10.1158/0008-5472.CAN-21-2076
Published: 06 June 2022
View articletitled, Tumor Intrinsic PD-L1 Promotes DNA Repair in Distinct Cancers and Suppresses PARP Inhibitor–Induced Synthetic Lethality
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Journal Articles

IgA-Dominated Humoral Immune Responses Govern Patients' Outcome in Endometrial Cancer

Gunjan Mandal, Subir Biswas, Carmen M. Anadon, Xiaoqing Yu, Chandler D. Gatenbee, Sandhya Prabhakaran, Kyle K. Payne, Ricardo A. Chaurio, Alexandra Martin, Patrick Innamarato, Carlos Moran, John J. Powers, Carly M. Harro, Jessica A. Mine, Kimberly B. Sprenger, Kristen E. Rigolizzo, Xuefeng Wang, Tyler J. Curiel, Paulo C. Rodriguez, Alexander R. Anderson, Ozlen Saglam, Jose R. Conejo-Garcia
Journal: Cancer Research
Cancer Res (2022) 82 (5): 859–871.
https://doi.org/10.1158/0008-5472.CAN-21-2376
Published: 03 March 2022
View articletitled, IgA-Dominated Humoral Immune Responses Govern Patients' Outcome in Endometrial Cancer
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Includes: Supplementary data
Journal Articles

CD122-Selective IL2 Complexes Reduce Immunosuppression, Promote Treg Fragility, and Sensitize Tumor Response to PD-L1 Blockade

Justin M. Drerup, Yilun Deng, Sri Lakshmi Pandeswara, Álvaro S. Padrón, Ryan M. Reyes, Xinyue Zhang, Jenny Mendez, Aijie Liu, Curtis A. Clark, Wanjiao Chen, José R. Conejo-Garcia, Vincent Hurez, Harshita Gupta, Tyler J. Curiel
Journal: Cancer Research
Cancer Res (2020) 80 (22): 5063–5075.
https://doi.org/10.1158/0008-5472.CAN-20-0002
Published: 13 November 2020
View articletitled, CD122-Selective IL2 Complexes Reduce Immunosuppression, Promote Treg Fragility, and Sensitize Tumor Response to PD-L1 Blockade
Open the PDF for CD122-Selective IL2 Complexes Reduce Immunosuppression, Promote Treg Fragility, and Sensitize Tumor Response to PD-L1 Blockade in another window
Includes: Supplementary data
Journal Articles

Abstract B10: High-dimensional (30-plex) imaging mass cytometry on tissue microarray identifies novel PD-L1-inclusive immunophenotypes associated with overall survival in stage III melanoma

Heather G. Hambright, Anand V.R. Kornepati, Dai Ogata, Roland R.L. Bassett, Suhendan Ekmekcioglu, Elizabeth A. Grimm, Tyler J. Curiel
Journal: Cancer Research
Cancer Res (2020) 80 (19_Supplement): B10.
https://doi.org/10.1158/1538-7445.MEL2019-B10
Published: 02 October 2020
View articletitled, Abstract B10: High-dimensional (30-plex) imaging mass cytometry on tissue microarray identifies novel PD-L1-inclusive immunophenotypes associated with overall survival in stage III melanoma
Journal Articles

Oncogenic BRAFV600E Governs Regulatory T-cell Recruitment during Melanoma Tumorigenesis

Tamer B. Shabaneh, Aleksey K. Molodtsov, Shannon M. Steinberg, Peisheng Zhang, Gretel M. Torres, Gadisti A. Mohamed, Andrea Boni, Tyler J. Curiel, Christina V. Angeles, Mary Jo Turk
Journal: Cancer Research
Cancer Res (2018) 78 (17): 5038–5049.
https://doi.org/10.1158/0008-5472.CAN-18-0365
Published: 04 September 2018
View articletitled, Oncogenic BRAFV600E Governs Regulatory T-cell Recruitment during Melanoma Tumorigenesis
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Includes: Supplementary data
Journal Articles

Abstract 3792: Intratumoral CD56bright natural killer cells are associated with improved survival in bladder cancer

Neelam Mukherjee, Niannian Ji, Maggie E. Tomasini, Vincent Hurez, Tyler J. Curiel, Maureen O. Montgomery, Andrew J. Braun, Marlo Nicolas, Marcela A. Flores, Qianqian Liu, Jianhua Ruan, Robert S. Svatek
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3792.
https://doi.org/10.1158/1538-7445.AM2018-3792
Published: 01 July 2018
View articletitled, Abstract 3792: Intratumoral CD56bright natural killer cells are associated with improved survival in bladder cancer
Journal Articles

Abstract 1608: CD122-selective IL-2/anti-IL-2 complexes reduce regulatory T cell function and promote CD8+ T cell polyfunctionality for durable ovarian cancer immunotherapy

Justin M. Drerup, Sri Lakshmi Pandeswara, Aijie Liu, Curtis A. Clark, Alvaro S. Padron, Wanjiao Chen, Vincent Hurez, Tyler J. Curiel
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1608.
https://doi.org/10.1158/1538-7445.AM2017-1608
Published: 01 July 2017
View articletitled, Abstract 1608: CD122-selective IL-2/anti-IL-2 complexes reduce regulatory T cell function and promote CD8+ T cell polyfunctionality for durable ovarian cancer immunotherapy
Journal Articles

Abstract 5649: Cell-intrinsic PD-L1 directs tumor initiating cell fate and rapamycin and interferon-γ response

Harshita B. Gupta, Curtis A. Clark, Bin Yuan, Gangadhara Sareddy, Srilakshmi Pandeswara, Alvaro S. Padron, Vincent Hurez, Jose-Conejo Garcia, Ratna Vadlamudi, Rong Li, Tyler J. Curiel
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5649.
https://doi.org/10.1158/1538-7445.AM2017-5649
Published: 01 July 2017
View articletitled, Abstract 5649: Cell-intrinsic PD-L1 directs tumor initiating cell fate and rapamycin and interferon-γ response
Journal Articles

Myeloid Cells That Impair Immunotherapy Are Restored in Melanomas with Acquired Resistance to BRAF Inhibitors

Shannon M. Steinberg, Tamer B. Shabaneh, Peisheng Zhang, Viktor Martyanov, Zhenghui Li, Brian T. Malik, Tamara A. Wood, Andrea Boni, Aleksey Molodtsov, Christina V. Angeles, Tyler J. Curiel, Michael L. Whitfield, Mary Jo Turk
Journal: Cancer Research
Cancer Res (2017) 77 (7): 1599–1610.
https://doi.org/10.1158/0008-5472.CAN-16-1755
Published: 02 April 2017
View articletitled, Myeloid Cells That Impair Immunotherapy Are Restored in Melanomas with Acquired Resistance to BRAF Inhibitors
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Includes: Supplementary data
Journal Articles

Biphasic Rapamycin Effects in Lymphoma and Carcinoma Treatment

Yang Liu, Srilakshmi Pandeswara, Vinh Dao, Álvaro Padrón, Justin M. Drerup, Shunhua Lao, Aijie Liu, Vincent Hurez, Tyler J. Curiel
Journal: Cancer Research
Cancer Res (2017) 77 (2): 520–531.
https://doi.org/10.1158/0008-5472.CAN-16-1140
Published: 16 January 2017
View articletitled, Biphasic Rapamycin Effects in Lymphoma and Carcinoma Treatment
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Includes: Supplementary data
Journal Articles

Tumor-Intrinsic PD-L1 Signals Regulate Cell Growth, Pathogenesis, and Autophagy in Ovarian Cancer and Melanoma

Curtis A. Clark, Harshita B. Gupta, Gangadhara Sareddy, Srilakshmi Pandeswara, Shunhua Lao, Bin Yuan, Justin M. Drerup, Alvaro Padron, José Conejo-Garcia, Kruthi Murthy, Yang Liu, Mary Jo Turk, Kathrin Thedieck, Vincent Hurez, Rong Li, Ratna Vadlamudi, Tyler J. Curiel
Journal: Cancer Research
Cancer Res (2016) 76 (23): 6964–6974.
https://doi.org/10.1158/0008-5472.CAN-16-0258
Published: 30 November 2016
View articletitled, Tumor-Intrinsic PD-L1 Signals Regulate Cell Growth, Pathogenesis, and Autophagy in Ovarian Cancer and Melanoma
Open the PDF for Tumor-Intrinsic PD-L1 Signals Regulate Cell Growth, Pathogenesis, and Autophagy in Ovarian Cancer and Melanoma in another window
Includes: Supplementary data
Journal Articles

Immune-Stimulatory Effects of Rapamycin Are Mediated by Stimulation of Antitumor γδ T Cells

Vinh Dao, Yang Liu, Srilakshmi Pandeswara, Robert S. Svatek, Jonathan A. Gelfond, Aijie Liu, Vincent Hurez, Tyler J. Curiel
Journal: Cancer Research
Cancer Res (2016) 76 (20): 5970–5982.
https://doi.org/10.1158/0008-5472.CAN-16-0091
Published: 13 October 2016
View articletitled, Immune-Stimulatory Effects of Rapamycin Are Mediated by Stimulation of Antitumor γδ T Cells
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Includes: Supplementary data
Journal Articles

Host miR155 Promotes Tumor Growth through a Myeloid-Derived Suppressor Cell–Dependent Mechanism

Siqi Chen, Long Wang, Jie Fan, Cong Ye, Donye Dominguez, Yi Zhang, Tyler J. Curiel, Deyu Fang, Timothy M. Kuzel, Bin Zhang
Journal: Cancer Research
Cancer Res (2015) 75 (3): 519–531.
https://doi.org/10.1158/0008-5472.CAN-14-2331
Published: 01 February 2015
View articletitled, Host miR155 Promotes Tumor Growth through a Myeloid-Derived Suppressor Cell–Dependent Mechanism
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Includes: Supplementary data
Journal Articles

Mitigating Age-Related Immune Dysfunction Heightens the Efficacy of Tumor Immunotherapy in Aged Mice

Vincent Hurez, Benjamin J. Daniel, Lishi Sun, Ai-Jie Liu, Sara M. Ludwig, Mark J. Kious, Suzanne R. Thibodeaux, Srilakshmi Pandeswara, Kruthi Murthy, Carolina B. Livi, Shawna Wall, Michael J. Brumlik, Tahiro Shin, Bin Zhang, Tyler J. Curiel
Journal: Cancer Research
Cancer Res (2012) 72 (8): 2089–2099.
https://doi.org/10.1158/0008-5472.CAN-11-3019
Published: 16 April 2012
View articletitled, Mitigating Age-Related Immune Dysfunction Heightens the Efficacy of Tumor Immunotherapy in Aged Mice
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Includes: Supplementary data
Journal Articles

Cytokine Receptor CXCR4 Mediates Estrogen-Independent Tumorigenesis, Metastasis, and Resistance to Endocrine Therapy in Human Breast Cancer

Lyndsay V. Rhodes, Sarah P. Short, Nicole F. Neel, Virgilio A. Salvo, Yun Zhu, Steven Elliott, Yongkun Wei, Dihua Yu, Menghong Sun, Shannon E. Muir, Juan P. Fonseca, Melyssa R. Bratton, Chris Segar, Syreeta L. Tilghman, Tammy Sobolik-Delmaire, Linda W. Horton, Snjezana Zaja-Milatovic, Bridgette M. Collins-Burow, Scott Wadsworth, Barbara S. Beckman, Charles E. Wood, Suzanne A. Fuqua, Kenneth P. Nephew, Paul Dent, Rebecca A. Worthylake, Tyler J. Curiel, Mien-Chie Hung, Ann Richmond, Matthew E. Burow
Journal: Cancer Research
Cancer Res (2011) 71 (2): 603–613.
https://doi.org/10.1158/0008-5472.CAN-10-3185
Published: 13 January 2011
View articletitled, Cytokine Receptor CXCR4 Mediates Estrogen-Independent Tumorigenesis, Metastasis, and Resistance to Endocrine Therapy in Human Breast Cancer
Open the PDF for Cytokine Receptor CXCR4 Mediates Estrogen-Independent Tumorigenesis, Metastasis, and Resistance to Endocrine Therapy in Human Breast Cancer in another window
Includes: Supplementary data
Journal Articles

CD73 on Tumor Cells Impairs Antitumor T-Cell Responses: A Novel Mechanism of Tumor-Induced Immune Suppression

Dachuan Jin, Jie Fan, Long Wang, Linda F. Thompson, Aijie Liu, Benjamin J. Daniel, Tahiro Shin, Tyler J. Curiel, Bin Zhang
Journal: Cancer Research
Cancer Res (2010) 70 (6): 2245–2255.
https://doi.org/10.1158/0008-5472.CAN-09-3109
Published: 14 March 2010
View articletitled, CD73 on Tumor Cells Impairs Antitumor T-Cell Responses: A Novel Mechanism of Tumor-Induced Immune Suppression
Open the PDF for CD73 on Tumor Cells Impairs Antitumor T-Cell Responses: A Novel Mechanism of Tumor-Induced Immune Suppression in another window
Includes: Supplementary data
Journal Articles

Phase II trial of Ontak to deplete regulatory T cells in treatment-refractory stage III/IV ovarian cancer

Brian G. Barnett, Jens Ruter, Pui J. Cheng, Inka Kryczek, Michael Brumlik, Jonathan Head, Robert Elliott, Weiping Zou, Tyler J. Curiel
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1148.
Published: 15 April 2006
View articletitled, Phase II trial of Ontak to deplete regulatory T cells in treatment-refractory stage III/IV ovarian cancer
Journal Articles

MEK5-Erk5 signaling promotes estrogen-independent tumorigenesis of breast carcinoma cells

Yan Tang, Virgilio A. Salvo, Steven Elliott, Yun Zhu, Barbara S. Beckman, Christopher B. Weldon, Frank E. Jones, Tyler J. Curiel, Matthew E. Burow
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 237–238.
Published: 01 May 2005
View articletitled, MEK5-Erk5 signaling promotes estrogen-independent tumorigenesis of breast carcinoma cells
Journal Articles

CXCL12 and Vascular Endothelial Growth Factor Synergistically Induce Neoangiogenesis in Human Ovarian Cancers

Ilona Kryczek, Andrzej Lange, Peter Mottram, Xavier Alvarez, Pui Cheng, Melina Hogan, Lieve Moons, Shuang Wei, Linhua Zou, Véronique Machelon, Dominique Emilie, Margarita Terrassa, Andrew Lackner, Tyler J. Curiel, Peter Carmeliet, Weiping Zou
Journal: Cancer Research
Cancer Res (2005) 65 (2): 465–472.
https://doi.org/10.1158/0008-5472.465.65.2
Published: 03 February 2005
View articletitled, CXCL12 and Vascular Endothelial Growth Factor Synergistically Induce Neoangiogenesis in Human Ovarian Cancers
Open the PDF for CXCL12 and Vascular Endothelial Growth Factor Synergistically Induce Neoangiogenesis in Human Ovarian Cancers in another window