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Journal Articles

Abstract 3094: Aurora-A inhibition sensitizes HPV-driven cancers to anti-CTLA-4 immunotherapy by modulating the tumor immune microenvironment

Free
Soma Ghosh, Madison P. O’Hara, Tuhina Mazumdar, Lacin Yapindi, Li Shen, Jing Wang, Mitchell J. Frederick, Jagannadha K. Sastry, Faye M. Johnson
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3094.
https://doi.org/10.1158/1538-7445.AM2025-3094
Published: 21 April 2025
View articletitled, Abstract 3094: Aurora-A inhibition sensitizes HPV-driven cancers to anti-CTLA-4 immunotherapy by modulating the tumor immune microenvironment
Journal Articles

Abstract PR007: The combination of TRIP13 and Aurora kinase A inhibition caused cell cycle specific DNA damage and death in Rb-deficient cancers

Free
Lacin Yapindi, Soma Ghosh, Tuhina Mazumdar, Faye M. Johnson
Journal: Cancer Research
Cancer Res (2024) 84 (1_Supplement): PR007.
https://doi.org/10.1158/1538-7445.DNAREPAIR24-PR007
Published: 09 January 2024
View articletitled, Abstract PR007: The combination of TRIP13 and Aurora kinase A inhibition caused cell cycle specific DNA damage and death in Rb-deficient cancers
Journal Articles

Abstract 2847: Concurrent inactivation of PI3K and PLK1 is synergistic and overcomes acquired resistance to PI3K inhibitors in NOTCH1MUT HNSCC

Free
Pooja A. Shah, Tuhina Mazumdar, Reid T. Powell, Li Shen, Jing Wang, Clifford C. Stephen, Mitchell J. Frederick, Faye M. Johnson
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2847.
https://doi.org/10.1158/1538-7445.AM2023-2847
Published: 04 April 2023
View articletitled, Abstract 2847: Concurrent inactivation of PI3K and PLK1 is synergistic and overcomes acquired resistance to PI3K inhibitors in NOTCH1MUT HNSCC
Journal Articles

Abstract 1564: Novel combination of TRIP13 and Aurora kinase A inhibition demonstrated extensive DNA damage and immunogenic cell death in RB-deficient cancers

Free
Soma Ghosh, Tuhina Mazumdar, Lacin Yapindi, Pragya Sinha, Jagannadha Sastry, Faye M. Johnson
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1564.
https://doi.org/10.1158/1538-7445.AM2023-1564
Published: 04 April 2023
View articletitled, Abstract 1564: Novel combination of TRIP13 and Aurora kinase A inhibition demonstrated extensive DNA damage and immunogenic cell death in RB-deficient cancers
Journal Articles

Sustained Aurora Kinase B Expression Confers Resistance to PI3K Inhibition in Head and Neck Squamous Cell Carcinoma

Available to Purchase
Pooja A. Shah, Vaishnavi Sambandam, Anne M. Fernandez, Hongyun Zhao, Tuhina Mazumdar, Li Shen, Qi Wang, Kazi M. Ahmed, Soma Ghosh, Mitchell J. Frederick, Jing Wang, Faye M. Johnson
Journal: Cancer Research
Cancer Res (2022) 82 (23): 4444–4456.
https://doi.org/10.1158/0008-5472.CAN-22-1175
Published: 02 December 2022
View articletitled, Sustained Aurora Kinase B Expression Confers Resistance to PI3K Inhibition in Head and Neck Squamous Cell Carcinoma
Open the PDF for Sustained Aurora Kinase B Expression Confers Resistance to PI3K Inhibition in Head and Neck Squamous Cell Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 1858: Rb deficient HPV+ HNSCC experienced enhanced sensitivity to aurora kinase inhibitors by altering the balance of MAD2 and TRIP13 levels

Free
Soma Ghosh, Tuhina Mazumdar, Wei Xu, Reid T. Powell, Clifford Stephan, Li Shen, Curtis R. Pickering, Jing Wang, Faye M. Johnson
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1858.
https://doi.org/10.1158/1538-7445.AM2022-1858
Published: 15 June 2022
View articletitled, Abstract 1858: Rb deficient HPV+ HNSCC experienced enhanced sensitivity to aurora kinase inhibitors by altering the balance of MAD2 and TRIP13 levels
Journal Articles

Abstract 3251: Aurora kinase B expression shields HNSCC from PI3K inhibition-induced apoptosis through downstream mediators AKT and PDK1

Free
Pooja A. Shah, Anne M. Fernandez, Vaishnavi Sambandam, Hongyun Zhao, Tuhina Mazumdar, Li Shen, Jing Wang, Faye M. Johnson
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3251.
https://doi.org/10.1158/1538-7445.AM2022-3251
Published: 15 June 2022
View articletitled, Abstract 3251: Aurora kinase B expression shields HNSCC from PI3K inhibition-induced apoptosis through downstream mediators AKT and PDK1
Journal Articles

Abstract 368: Aurora kinase inhibitors cause cell death in HPV+ cells: A plausible treatment option for HPV+ cancers

Free
Tuhina Mazumdar, Li Shen, Wei Xu, Soma Ghosh, Reid T. Powell, Clifford Stephan, Curtis R. Pickering, Jeffery N. Myers, Jing Wang, Faye M. Johnson
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 368.
https://doi.org/10.1158/1538-7445.AM2021-368
Published: 01 July 2021
View articletitled, Abstract 368: Aurora kinase inhibitors cause cell death in HPV+ cells: A plausible treatment option for HPV+ cancers
Journal Articles

Abstract 369: Identification of pathways that enhance cell death in NOTCH1-mutant HNSCC

Free
Pooja A. Shah, Tuhina Mazumdar, Reid T. Powell, Li Shen, Jing Wang, Clifford C. Stephen, Mitchell J. Frederick, Faye M. Johnson
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 369.
https://doi.org/10.1158/1538-7445.AM2021-369
Published: 01 July 2021
View articletitled, Abstract 369: Identification of pathways that enhance cell death in NOTCH1-mutant HNSCC
Journal Articles

Abstract 3913: PDK1 drives susceptibility of NOTCH1 mutant head and neck squamous carcinoma to PI3K/mTOR pathway inhibition

Free
Vaishnavi Sambandam, Li Shen, Shaohua Peng, Tuhina Mazumdar, Curtis Pickering, Jeffrey Myers, Jing Wang, Mitchell Frederick, Faye Johnson
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3913.
https://doi.org/10.1158/1538-7445.AM2019-3913
Published: 01 July 2019
View articletitled, Abstract 3913: PDK1 drives susceptibility of NOTCH1 mutant head and neck squamous carcinoma to PI3K/mTOR pathway inhibition
Journal Articles

Abstract 2977: PI3K/mTOR pathway inhibition induces Aurora B mediated cell death in NOTCH1 mutant head and neck squamous (HNSCC) cells

Free
Vaishnavi Sambandam, Li Shen, Pan Tong, Shaohua Peng, Tuhina Mazumdar, Ratnakar Singh, Curtis R. Pickering, Jeffrey N. Myers, Jing Wang, Mitchell Frederick, Faye M. Johnson
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2977.
https://doi.org/10.1158/1538-7445.AM2018-2977
Published: 01 July 2018
View articletitled, Abstract 2977: PI3K/mTOR pathway inhibition induces Aurora B mediated cell death in NOTCH1 mutant head and neck squamous (HNSCC) cells
Journal Articles

Abstract 4646: Pharmacogenomic screen identifies KMT2D mutations as a biomarker of sensitivity to Aurora kinase inhibition in head and neck and cervical squamous cell carcinoma

Free
Tuhina Mazumdar, Nene N. Kalu, Shaohua Peng, Pan Tong, Li Shen, Jing Wang, Jeffrey N. Myers, Curtis R. Pickering, David Brunell, Clifford C. Stephan, Faye M. Johnson
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4646.
https://doi.org/10.1158/1538-7445.AM2018-4646
Published: 01 July 2018
View articletitled, Abstract 4646: Pharmacogenomic screen identifies KMT2D mutations as a biomarker of sensitivity to Aurora kinase inhibition in head and neck and cervical squamous cell carcinoma
Journal Articles

Abstract 2992: Identification of NOTCH1 inactivating mutation as a therapeutic vulnerability to PI3K/mTOR pathway inhibition in head and neck squamous cell carcinoma (HNSCC)

Free
Vaishnavi Sambandam, Li Shen, Pan Tong, Tuhina Mazumdar, Curtis Pickering, Jeffrey N. Myers, Jing Wang, Mitchell Frederick, Faye M. Johnson
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2992.
https://doi.org/10.1158/1538-7445.AM2017-2992
Published: 01 July 2017
View articletitled, Abstract 2992: Identification of NOTCH1 inactivating mutation as a therapeutic vulnerability to PI3K/mTOR pathway inhibition in head and neck squamous cell carcinoma (HNSCC)
Journal Articles

Abstract 4757: Identification of biomarkers that predict response of head and neck squamous cell carcinoma to mitotic inhibitors

Free
Ming Zhang, Shaohua Peng, Tuhina Mazumdar, Vaishnavi Sambandam, Li Shen, Pan Tong, Lerong Li, Lauren Byers, Curtis Pickering, Mitchell Frederick, Jeffrey N. Myers, Jing Wang, Faye M. Johnson
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4757.
https://doi.org/10.1158/1538-7445.AM2016-4757
Published: 15 July 2016
View articletitled, Abstract 4757: Identification of biomarkers that predict response of head and neck squamous cell carcinoma to mitotic inhibitors
Journal Articles

Abstract 393: NOTCH1 inactivating mutation mediates sensitivity to PI3K/mTOR inhibitors in head and neck squamous cell carcinoma

Free
Faye M. Johnson, Vaishnavi Sambandam, Li Shen, Ming Zhang, Rishi Saigal, Pan Tong, Tuhina Mazumdar, Lauren A. Byers, Curtis Pickering, Jeffrey N. Myers, Jing Wang, Mitchell Frederick
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 393.
https://doi.org/10.1158/1538-7445.AM2016-393
Published: 15 July 2016
View articletitled, Abstract 393: NOTCH1 inactivating mutation mediates sensitivity to PI3K/mTOR inhibitors in head and neck squamous cell carcinoma
Journal Articles

Abstract 3793: Cell-based, high-throughput screen for small molecule inducers of cell death in HPV-associated head and neck cancers

Free
Nene N. Kalu, Tuhina Mazumdar, Pan Tong, Li Shen, Jing Wang, Lauren Averett Byers, Faye M. Johnson
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3793.
https://doi.org/10.1158/1538-7445.AM2016-3793
Published: 15 July 2016
View articletitled, Abstract 3793: Cell-based, high-throughput screen for small molecule inducers of cell death in HPV-associated head and neck cancers
Journal Articles

Abstract 1826: Characterization of HPV-positive head and neck cancer cell lines as preclinical models for targeted therapy

Free
Nene N. Kalu, Tuhina Mazumdar, Lixia Diao, Patrick Kwok Shing Ng, Jing Wang, Jeffery Myers, Faye M. Johnson, Lauren Averett Byers
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1826.
https://doi.org/10.1158/1538-7445.AM2015-1826
Published: 01 August 2015
View articletitled, Abstract 1826: Characterization of HPV-positive head and neck cancer cell lines as preclinical models for targeted therapy
Journal Articles

Abstract 2427: The difference of drug sensitivity between HPV-positive and HPV-negative head and neck squamous cell carcinoma cell lines

Free
Ming Zhang, Tuhina Mazumdar, Shaohua Peng, Pan Tong, Vaishnavi Sambandam, Lauren A. Byers, Jeffrey N. Myers, Jing Wang, Faye M. Johnson
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2427.
https://doi.org/10.1158/1538-7445.AM2015-2427
Published: 01 August 2015
View articletitled, Abstract 2427: The difference of drug sensitivity between HPV-positive and HPV-negative head and neck squamous cell carcinoma cell lines
Journal Articles

Abstract 903: Evaluation of predictive biomarkers and resistance mechanisms of PI3K pathway inhibition in head and neck squamous cell carcinoma

Free
Tuhina Mazumdar, Lauren A. Byers, Patrick Ng, Gordon B. Mills, Shaohua Peng, Lixia Diao, Youhong Fan, Katherine Stemke-Hale, John V. Heymach, Jeffrey N. Myers, Bonnie S. Glisson, Faye M. Johnson
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 903.
https://doi.org/10.1158/1538-7445.AM2014-903
Published: 01 October 2014
View articletitled, Abstract 903: Evaluation of predictive biomarkers and resistance mechanisms of PI3K pathway inhibition in head and neck squamous cell carcinoma
Journal Articles

Abstract 3707: The multitargeted kinase inhibitor dasatinib induces DNA damage, Hippo pathway engagement and senescence in lung cancer cell lines that possess kinase-inactivating BRAF mutations

Free
Banibrata Sen, Shaohua Peng, Tuhina Mazumdar, Lauren A. Byers, Humam Kadara, Faye M. Johnson
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3707.
https://doi.org/10.1158/1538-7445.AM2014-3707
Published: 01 October 2014
View articletitled, Abstract 3707: The multitargeted kinase inhibitor dasatinib induces DNA damage, Hippo pathway engagement and senescence in lung cancer cell lines that possess kinase-inactivating BRAF mutations