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Journal Articles

Abstract 2750: Alternative enhancer usage of PER2 locus regulating 3D genome architecture in epithelial-mesenchymal states

Free
Yi-Chia Chiu, Qing You Pang, Tuan Zea Tan, Wendy W. Hwang-Verslues, Ruby Y. J. Huang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2750.
https://doi.org/10.1158/1538-7445.AM2025-2750
Published: 21 April 2025
View article titled, Abstract 2750: Alternative enhancer usage of PER2 locus regulating 3D genome architecture in epithelial-mesenchymal states
Journal Articles

Abstract B008: Alternative PER2 (Period2) enhancer usage drives epithelial-mesenchymal transition (EMT) in epithelial ovarian cancer (OC)

Free
Yi Chia Chiu, Qing You Pang, Yu Jie Chen, Tuan Zea Tan, Divya Malathy Ravinath, Wendy Hwang-Verslues, Ruby Yun Ju Huang
Journal: Cancer Research
Cancer Res (2024) 84 (5_Supplement_2): B008.
https://doi.org/10.1158/1538-7445.OVARIAN23-B008
Published: 04 March 2024
View article titled, Abstract B008: Alternative PER2 (Period2) enhancer usage drives epithelial-mesenchymal transition (EMT) in epithelial ovarian cancer (OC)
Journal Articles

Histone Methyltransferase NSD2 Activates PKCα to Drive Metabolic Reprogramming and Lenalidomide Resistance in Multiple Myeloma

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Phyllis S.Y. Chong, Jing-Yuan Chooi, Julia S.L. Lim, Aaron C.Y. Leow, Sabrina Hui Min Toh, Irfan Azaman, Mun Yee Koh, Phaik Ju Teoh, Tuan Zea Tan, Tae-Hoon Chung, Wee Joo Chng
Journal: Cancer Research
Cancer Res (2023) 83 (20): 3414–3427.
https://doi.org/10.1158/0008-5472.CAN-22-3481
Published: 13 October 2023
View article titled, Histone Methyltransferase NSD2 Activates PKCα to Drive Metabolic Reprogramming and Lenalidomide Resistance in Multiple Myeloma
Open the PDF for Histone Methyltransferase NSD2 Activates PKCα to Drive Metabolic Reprogramming and Lenalidomide Resistance in Multiple Myeloma in another window
Includes: Supplementary data
Journal Articles

Abstract 5173: Digital spatial profiling of metastatic clear cell carcinoma reveals intra-tumor heterogeneity in epithelial-mesenchymal gradient

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Duncan Y.T. Wang, Tuan Zea Tan, Ya-Ting Tai, Jieru Ye, Wei-Chou Lin, Lin-Hung Wei, Ruby Y. J. Huang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5173.
https://doi.org/10.1158/1538-7445.AM2022-5173
Published: 15 June 2022
View article titled, Abstract 5173: Digital spatial profiling of metastatic clear cell carcinoma reveals intra-tumor heterogeneity in epithelial-mesenchymal gradient
Journal Articles

Abstract 66: BCG can subvert patients antitumor immune response by downregulating HLA-I expression on cancer cells

Free
Mathieu Rouanne, Julien Adam, Camélia Radulescu, Séverine Mouraud, Delphine Bredel, Diane Letourneur, Tuan Zea Tan, Nicolas Signolle, Amélie Bigorgne, Michael Dussiot, Sandrine Susini, Lambros Tselikas, François-Xavier Danlos, Roman Chabanon, Anna K. Schneider, Sophie Vacher, Thierry Lebret, Ivan Bièche, Yves Allory, Jean-Charles Soria, Jean Paul Thiery, Laurence Zitvogel, Aurélien Marabelle
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 66.
https://doi.org/10.1158/1538-7445.AM2021-66
Published: 01 July 2021
View article titled, Abstract 66: BCG can subvert patients antitumor immune response by downregulating HLA-I expression on cancer cells
Journal Articles

Abstract 2438: Genetic activation of JUN fuels the core regulatory circuitry of de-differentiated liposarcoma

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Ye Chen, Pushkar Dakle, Tuan Zea Tan, Ruby Yu-Tong Lin, Mark E. Puhaindran, Sigal Gery, Liang Xu, Phillip H. Koeffler
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2438.
https://doi.org/10.1158/1538-7445.AM2021-2438
Published: 01 July 2021
View article titled, Abstract 2438: Genetic activation of JUN fuels the core regulatory circuitry of de-differentiated liposarcoma
Journal Articles

Abstract 2123: Chromatin profiling of glioblastoma tissues identifies core oncogenic dependency and therapeutic opportunities

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Liang Xu, Ye Chen, Yulun Huang, Edwin Sandanaraj, John S. Yu, Ruby Yu-Tong Lin, Pushkar Dakle, Xin-Yu Ke, Yuk Kien Chong, Lynnette Koh, Anand Mayakonda, Kassoum Nacro, Jeffrey Hill, Mo-Li Huang, Sigal Gery, See Wee Lim, Zhengyun Huang, Ying Xu, Jianxiang Chen, Longchuan Bai, Shaomeng Wang, Hiroaki Wakimoto, Tseng Tsai Yeo, Beng Ti Ang, Markus Müschen, Carol Tang, Tuan Zea Tan, Phillip H. Koeffler
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2123.
https://doi.org/10.1158/1538-7445.AM2021-2123
Published: 01 July 2021
View article titled, Abstract 2123: Chromatin profiling of glioblastoma tissues identifies core oncogenic dependency and therapeutic opportunities
Journal Articles

SMARCA2 Is a Novel Interactor of NSD2 and Regulates Prometastatic PTP4A3 through Chromatin Remodeling in t(4;14) Multiple Myeloma

Available to Purchase
Phyllis S.Y. Chong, Jing Yuan Chooi, Julia S.L. Lim, Sabrina Hui Min Toh, Tuan Zea Tan, Wee-Joo Chng
Journal: Cancer Research
Cancer Res (2021) 81 (9): 2332–2344.
https://doi.org/10.1158/0008-5472.CAN-20-2946
Published: 01 May 2021
View article titled, SMARCA2 Is a Novel Interactor of NSD2 and Regulates Prometastatic PTP4A3 through Chromatin Remodeling in t(4;14) Multiple Myeloma
Open the PDF for SMARCA2 Is a Novel Interactor of NSD2 and Regulates Prometastatic PTP4A3 through Chromatin Remodeling in t(4;14) Multiple Myeloma in another window
Includes: Supplementary data
Journal Articles

Abstract PO-008: Know thy neighbor: Deciphering the intra-tumor heterogeneity in ovarian cancer with molecular assessment of subtype heterogeneity (MASH)

Free
Tuan Zea Tan, Valerie Heong, Jieru Ye, Diana Lim, Jeffrey Low, Mahesh Choolani, Clare Scott, David S.P. Tan, Ruby Y.J. Huang
Journal: Cancer Research
Cancer Res (2020) 80 (21_Supplement): PO-008.
https://doi.org/10.1158/1538-7445.TUMHET2020-PO-008
Published: 03 November 2020
View article titled, Abstract PO-008: Know thy neighbor: Deciphering the intra-tumor heterogeneity in ovarian cancer with molecular assessment of subtype heterogeneity (MASH)
Journal Articles

TGFβ Promotes Genomic Instability after Loss of RUNX3

Free
Vaidehi Krishnan, Yu Lin Chong, Tuan Zea Tan, Madhura Kulkarni, Muhammad Bakhait Bin Rahmat, Lavina Sierra Tay, Haresh Sankar, Doorgesh S. Jokhun, Amudha Ganesan, Linda Shyue Huey Chuang, Dominic C. Voon, GV Shivashankar, Jean-Paul Thiery, Yoshiaki Ito
Journal: Cancer Research
Series: Author Choice
Cancer Res (2018) 78 (1): 88–102.
https://doi.org/10.1158/0008-5472.CAN-17-1178
Published: 02 January 2018
View article titled, TGFβ Promotes Genomic Instability after Loss of RUNX3
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Includes: Supplementary data
Journal Articles

Abstract 1430: Transcriptional regulatory loops among SNAI1, TWIST1, ZEB1, and ZEB2 defines the epithelial-mesenchymal transition (EMT) spectrum in epithelial ovarian cancer (EOC)

Free
Ming Tan, Vin Yee Chuang, Tuan Zea Tan, Jean Paul Thiery, Ruby Yun-Ju Huang
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1430.
https://doi.org/10.1158/1538-7445.AM2015-1430
Published: 01 August 2015
View article titled, Abstract 1430: Transcriptional regulatory loops among SNAI1, TWIST1, ZEB1, and ZEB2 defines the epithelial-mesenchymal transition (EMT) spectrum in epithelial ovarian cancer (EOC)
Journal Articles

Abstract 1058: Grainyhead-like 2 regulates molecular subtype switching in epithelial ovarian cancer

Free
Vin Yee Chung, Meng Kang Wong, Kuee Theng Kuay, Tuan Zea Tan, Ernesto Guccione, Jean Paul Thiery, Ruby Yun-Ju Huang
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1058.
https://doi.org/10.1158/1538-7445.AM2014-1058
Published: 01 October 2014
View article titled, Abstract 1058: Grainyhead-like 2 regulates molecular subtype switching in epithelial ovarian cancer
Journal Articles

Epithelial-to-Mesenchymal Transition and Autophagy Induction in Breast Carcinoma Promote Escape from T-cell–Mediated Lysis

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Intissar Akalay, Bassam Janji, Meriem Hasmim, Muhammad Zaeem Noman, Fabrice André, Patricia De Cremoux, Philippe Bertheau, Cécile Badoual, Philippe Vielh, Annette K. Larsen, Michèle Sabbah, Tuan Zea Tan, Joan Herr Keira, Nicole Tsang Ying Hung, Jean Paul Thiery, Fathia Mami-Chouaib, Salem Chouaib
Journal: Cancer Research
Cancer Res (2013) 73 (8): 2418–2427.
https://doi.org/10.1158/0008-5472.CAN-12-2432
Published: 15 April 2013
View article titled, Epithelial-to-Mesenchymal Transition and Autophagy Induction in Breast Carcinoma Promote Escape from T-cell–Mediated Lysis
Open the PDF for Epithelial-to-Mesenchymal Transition and Autophagy Induction in Breast Carcinoma Promote Escape from T-cell–Mediated Lysis in another window
Includes: Supplementary data
Journal Articles

Abstract 2979: Epithelial-mesenchymal gene expression signature defines clinically relevant subtypes in epithelial ovarian cancer

Free
Ruby YJ Huang, Tuan Zea Tan, Meng Kang Wong, Noriomi Matsumura, Hung Cheng Lai, Vin Yee Chung, Jieru Ye, Seiichi Mori, Jean Paul Thiery
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2979.
https://doi.org/10.1158/1538-7445.AM2012-2979
Published: 15 April 2012
View article titled, Abstract 2979: Epithelial-mesenchymal gene expression signature defines clinically relevant subtypes in epithelial ovarian cancer