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Journal Articles

Correction: CXCR4 in Tumor Epithelial Cells Mediates Desmoplastic Reaction in Pancreatic Ductal Adenocarcinoma

Toshihiro Morita, Yuzo Kodama, Masahiro Shiokawa, Katsutoshi Kuriyama, Saiko Marui, Takeshi Kuwada, Yuko Sogabe, Tomoaki Matsumori, Nobuyuki Kakiuchi, Teruko Tomono, Atsushi Mima, Tatsuki Ueda, Motoyuki Tsuda, Yuki Yamauchi, Yoshihiro Nishikawa, Yojiro Sakuma, Yuji Ota, Takahisa Maruno, Norimitsu Uza, Takashi Nagasawa, Tsutomu Chiba, Hiroshi Seno
Journal: Cancer Research
Cancer Res (2021) 81 (12): 3427.
https://doi.org/10.1158/0008-5472.CAN-21-1255
Published: 15 June 2021
View articletitled, Correction: CXCR4 in Tumor Epithelial Cells Mediates Desmoplastic Reaction in Pancreatic Ductal Adenocarcinoma
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Journal Articles

Hes1 Is Essential in Proliferating Ductal Cell–Mediated Development of Intrahepatic Cholangiocarcinoma

Tomoaki Matsumori, Yuzo Kodama, Atsushi Takai, Masahiro Shiokawa, Yoshihiro Nishikawa, Tomonori Matsumoto, Haruhiko Takeda, Saiko Marui, Hirokazu Okada, Tomonori Hirano, Takeshi Kuwada, Yuko Sogabe, Nobuyuki Kakiuchi, Teruko Tomono, Atsushi Mima, Toshihiro Morita, Tatsuki Ueda, Motoyuki Tsuda, Yuki Yamauchi, Katsutoshi Kuriyama, Yojiro Sakuma, Yuji Ota, Takahisa Maruno, Norimitsu Uza, Hiroyuki Marusawa, Ryoichiro Kageyama, Tsutomu Chiba, Hiroshi Seno
Journal: Cancer Research
Series: Author Choice
Cancer Res (2020) 80 (23): 5305–5316.
https://doi.org/10.1158/0008-5472.CAN-20-1161
Published: 02 December 2020
View articletitled, Hes1 Is Essential in Proliferating Ductal Cell–Mediated Development of Intrahepatic Cholangiocarcinoma
Open the PDF for Hes1 Is Essential in Proliferating Ductal Cell–Mediated Development of Intrahepatic Cholangiocarcinoma in another window
Includes: Supplementary data
Journal Articles

CXCR4 in Tumor Epithelial Cells Mediates Desmoplastic Reaction in Pancreatic Ductal Adenocarcinoma

Toshihiro Morita, Yuzo Kodama, Masahiro Shiokawa, Katsutoshi Kuriyama, Saiko Marui, Takeshi Kuwada, Yuko Sogabe, Tomoaki Matsumori, Nobuyuki Kakiuchi, Teruko Tomono, Atsushi Mima, Tatsuki Ueda, Motoyuki Tsuda, Yuki Yamauchi, Yoshihiro Nishikawa, Yojiro Sakuma, Yuji Ota, Takahisa Maruno, Norimitsu Uza, Takashi Nagasawa, Tsutomu Chiba, Hiroshi Seno
Journal: Cancer Research
Cancer Res (2020) 80 (19): 4058–4070.
https://doi.org/10.1158/0008-5472.CAN-19-2745
Published: 02 October 2020
View articletitled, CXCR4 in Tumor Epithelial Cells Mediates Desmoplastic Reaction in Pancreatic Ductal Adenocarcinoma
Open the PDF for CXCR4 in Tumor Epithelial Cells Mediates Desmoplastic Reaction in Pancreatic Ductal Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Rb and p53 Execute Distinct Roles in the Development of Pancreatic Neuroendocrine Tumors

Yuki Yamauchi, Yuzo Kodama, Masahiro Shiokawa, Nobuyuki Kakiuchi, Saiko Marui, Takeshi Kuwada, Yuko Sogabe, Teruko Tomono, Atsushi Mima, Toshihiro Morita, Tomoaki Matsumori, Tatsuki Ueda, Motoyuki Tsuda, Yoshihiro Nishikawa, Katsutoshi Kuriyama, Yojiro Sakuma, Yuji Ota, Takahisa Maruno, Norimitsu Uza, Atsuhiro Masuda, Hisato Tatsuoka, Daisuke Yabe, Sachiko Minamiguchi, Toshihiko Masui, Nobuya Inagaki, Shinji Uemoto, Tsutomu Chiba, Hiroshi Seno
Journal: Cancer Research
Cancer Res (2020) 80 (17): 3620–3630.
https://doi.org/10.1158/0008-5472.CAN-19-2232
Published: 02 September 2020
View articletitled, Rb and p53 Execute Distinct Roles in the Development of Pancreatic Neuroendocrine Tumors
Open the PDF for Rb and p53 Execute Distinct Roles in the Development of Pancreatic Neuroendocrine Tumors in another window
Includes: Supplementary data
Journal Articles

Abstract 5126: Genetic analysis of metachronous pancreatic cancers

Hirano Tomonori, Nobuyuki Kakiuchi, Yasuhide Takeuchi, Yoshikage Inoue, Tomomi Nishimura, Yoichi Fujii, Akira Yokoyama, Hideki Makishima, Toshihiko Masui, Shinji Uemoto, Sachiko Minamiguchi, Hironori Haga, Kenichi Chiba, Hiroko Tanaka, Yuichi Shiraishi, Satoru Miyano, Norimitsu Uza, Yuzo Kodama, Hiroshi Seno, Tsutomu Chiba, Seishi Ogawa
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 5126.
https://doi.org/10.1158/1538-7445.AM2019-5126
Published: 01 July 2019
View articletitled, Abstract 5126: Genetic analysis of metachronous pancreatic cancers
Journal Articles

Proliferating EpCAM-Positive Ductal Cells in the Inflamed Liver Give Rise to Hepatocellular Carcinoma

Tomonori Matsumoto, Atsushi Takai, Yuji Eso, Kazuo Kinoshita, Toshiaki Manabe, Hiroshi Seno, Tsutomu Chiba, Hiroyuki Marusawa
Journal: Cancer Research
Cancer Res (2017) 77 (22): 6131–6143.
https://doi.org/10.1158/0008-5472.CAN-17-1800
Published: 14 November 2017
View articletitled, Proliferating EpCAM-Positive Ductal Cells in the Inflamed Liver Give Rise to Hepatocellular Carcinoma
Open the PDF for Proliferating EpCAM-Positive Ductal Cells in the Inflamed Liver Give Rise to Hepatocellular Carcinoma in another window
Includes: Supplementary data
Journal Articles

Distinct Roles of HES1 in Normal Stem Cells and Tumor Stem-like Cells of the Intestine

Norihiro Goto, Taro Ueo, Akihisa Fukuda, Kenji Kawada, Yoshiharu Sakai, Hiroyuki Miyoshi, Makoto Mark Taketo, Tsutomu Chiba, Hiroshi Seno
Journal: Cancer Research
Cancer Res (2017) 77 (13): 3442–3454.
https://doi.org/10.1158/0008-5472.CAN-16-3192
Published: 02 July 2017
View articletitled, Distinct Roles of HES1 in Normal Stem Cells and Tumor Stem-like Cells of the Intestine
Open the PDF for Distinct Roles of HES1 in Normal Stem Cells and Tumor Stem-like Cells of the Intestine in another window
Includes: Supplementary data
Journal Articles

Abstract 3518: Brg1 plays a critical role in PanIN formation through regulating Sox9 expression

Motoyuki Tsuda, Akihisa Fukuda, Satoshi Ogawa, Kenji Masuo, Norihiro Goto, Yukiko Hiramatsu, Yu Muta, Kozo Ikuta, Yoshito Kimura, Yoshihide Matsumoto, Yutaka Takada, Takuto Yoshioka, Takahisa Maruno, Haruhiko Akiyama, Kyoichi Takaori, Shinji Uemoto, Tsutomu Chiba, Hiroshi Seno
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3518.
https://doi.org/10.1158/1538-7445.AM2017-3518
Published: 01 July 2017
View articletitled, Abstract 3518: Brg1 plays a critical role in PanIN formation through regulating Sox9 expression
Journal Articles

Abstract 4771: The role of Hes1 in the normal and tumor stem cells of the intestine

Norihiro Goto, Akihisa Fukuda, Tsutomu Chiba, Hiroshi Seno
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4771.
https://doi.org/10.1158/1538-7445.AM2017-4771
Published: 01 July 2017
View articletitled, Abstract 4771: The role of Hes1 in the normal and tumor stem cells of the intestine
Journal Articles

MSH2 Dysregulation Is Triggered by Proinflammatory Cytokine Stimulation and Is Associated with Liver Cancer Development

Yuji Eso, Atsushi Takai, Tomonori Matsumoto, Tadashi Inuzuka, Takahiro Horie, Koh Ono, Shinji Uemoto, Kyeryoung Lee, Winfried Edelmann, Tsutomu Chiba, Hiroyuki Marusawa
Journal: Cancer Research
Cancer Res (2016) 76 (15): 4383–4393.
https://doi.org/10.1158/0008-5472.CAN-15-2926
Published: 31 July 2016
View articletitled, MSH2 Dysregulation Is Triggered by Proinflammatory Cytokine Stimulation and Is Associated with Liver Cancer Development
Open the PDF for MSH2 Dysregulation Is Triggered by Proinflammatory Cytokine Stimulation and Is Associated with Liver Cancer Development in another window
Includes: Supplementary data
Journal Articles

Activation-Induced Cytidine Deaminase Contributes to Pancreatic Tumorigenesis by Inducing Tumor-Related Gene Mutations

Yugo Sawai, Yuzo Kodama, Takahiro Shimizu, Yuji Ota, Takahisa Maruno, Yuji Eso, Akira Kurita, Masahiro Shiokawa, Yoshihisa Tsuji, Norimitsu Uza, Yuko Matsumoto, Toshihiko Masui, Shinji Uemoto, Hiroyuki Marusawa, Tsutomu Chiba
Journal: Cancer Research
Cancer Res (2015) 75 (16): 3292–3301.
https://doi.org/10.1158/0008-5472.CAN-14-3028
Published: 13 August 2015
View articletitled, Activation-Induced Cytidine Deaminase Contributes to Pancreatic Tumorigenesis by Inducing Tumor-Related Gene Mutations
Open the PDF for Activation-Induced Cytidine Deaminase Contributes to Pancreatic Tumorigenesis by Inducing Tumor-Related Gene Mutations in another window
Includes: Supplementary data
Journal Articles

Abstract 5346: Notch3-mediated squamous cell differentiation shows anti-tumor effect on esophageal squamous cell carcinoma as well as reduces its resistance to 5-Fluorouracil

Osamu Kikuchi, Shinya Ohashi, Yukie Nakai, Yusuke Amanuma, Masahiro Yoshioka, Shin'ichi Miyamoto, Mitsuteru Natsuizaka, Hiroshi Nakagawa, Tsutomu Chiba, Manabu Muto
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 5346.
https://doi.org/10.1158/1538-7445.AM2015-5346
Published: 01 August 2015
View articletitled, Abstract 5346: Notch3-mediated squamous cell differentiation shows anti-tumor effect on esophageal squamous cell carcinoma as well as reduces its resistance to 5-Fluorouracil
Journal Articles

Abstract 5350: Aberrant activation-induced cytidine deaminase (AID) expression is induced in the process of hepatitis C virus-associated hepatocarcinogenesis

Soo K. Kim, Hiroyuki Marusawa, Tsutomu Chiba
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 5350.
https://doi.org/10.1158/1538-7445.AM2014-5350
Published: 01 October 2014
View articletitled, Abstract 5350: Aberrant activation-induced cytidine deaminase (AID) expression is induced in the process of hepatitis C virus-associated hepatocarcinogenesis
Journal Articles

Abstract 5366: Mutation signature of TP53 gene in H. pylori-associated inflamed gastric mucosa during gastric carcinogenesis

Takahiro Shimizu, Hiroyuki Marusawa, Tsutomu Chiba
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 5366.
https://doi.org/10.1158/1538-7445.AM2014-5366
Published: 01 October 2014
View articletitled, Abstract 5366: Mutation signature of TP53 gene in H. pylori-associated inflamed gastric mucosa during gastric carcinogenesis
Journal Articles

Abstract 4708: Anti-tumor phenotype of tumor-associated macrophages are induced by COX-2 inhibition via the up-regulation of IFN-γ.

Yuki Nakanishi, Masato Nakatsuji, Hiroshi Seno, Tsutomu Chiba
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4708.
https://doi.org/10.1158/1538-7445.AM2013-4708
Published: 15 April 2013
View articletitled, Abstract 4708: Anti-tumor phenotype of tumor-associated macrophages are induced by COX-2 inhibition via the up-regulation of IFN-γ.
Journal Articles

Abstract 5012: Intestinal tumors are continuously renewed by Dclk1-positive tumor stem cells.

Yuki Nakanishi, Hiroshi Seno, Taro Ueo, Tsutomu Chiba
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5012.
https://doi.org/10.1158/1538-7445.AM2013-5012
Published: 15 April 2013
View articletitled, Abstract 5012: Intestinal tumors are continuously renewed by Dclk1-positive tumor stem cells.
Journal Articles

Abstract #695: Predictive biomarker for hematological toxicities of gemcitabine identified by proteomics

Junichi Matsubara, Masaya Ono, Hideki Ueno, Takuji Okusaka, Junji Furuse, Koh Furuta, Emiko Sugiyama, Yoshiro Saito, Nahoko Kaniwa, Junichi Sawada, Tomohiro Sakuma, Tsutomu Chiba, Nagahiro Saijo, Tesshi Yamada
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 695.
Published: 01 May 2009
View articletitled, Abstract #695: Predictive biomarker for hematological toxicities of gemcitabine identified by proteomics
Journal Articles

Abstract #258: Ligand-specific antibody to insulin-like growth factors suppresses the intestinal polyp formation in APC+/- mouse

Shin-ichi Miyamoto, Toshihiro Matsunaka, Tsutomu Chiba, Kenya Shitara, Tetsuo Noda, Atushi Ochiai
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 258.
Published: 01 May 2009
View articletitled, Abstract #258: Ligand-specific antibody to insulin-like growth factors suppresses the intestinal polyp formation in APC+/- mouse
Journal Articles

Activation-induced cytidine deaminase serves as a link between inflammation to colitis-associated colorectal cancers

Yoko Endo, Hiroyuki Marusawa, Kazuo Kinoshita, Tasuku Honjo, Tsutomu Chiba
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 5776.
Published: 01 May 2008
View articletitled, Activation-induced cytidine deaminase serves as a link between inflammation to colitis-associated colorectal cancers
Journal Articles

Activation-induced cytidine deaminase contributes to gastric carcinogenesis through the accumulation of genetic alterations.

Hiroyuki Marusawa, Yuko Matsumoto, Kazuo Kinoshita, Yoko Endo, Tasuku Honjo, Tsutomu Chiba
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 4736.
Published: 01 May 2008
View articletitled, Activation-induced cytidine deaminase contributes to gastric carcinogenesis through the accumulation of genetic alterations.