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Journal Articles

A Hyperactive RelA/p65-Hexokinase 2 Signaling Axis Drives Primary Central Nervous System Lymphoma

Kensuke Tateishi, Yohei Miyake, Masahito Kawazu, Nobuyoshi Sasaki, Taishi Nakamura, Jo Sasame, Yukie Yoshii, Toshihide Ueno, Akio Miyake, Jun Watanabe, Yuko Matsushita, Norio Shiba, Naoko Udaka, Kentaro Ohki, Alexandria L. Fink, Shilpa S. Tummala, Manabu Natsumeda, Naoki Ikegaya, Mayuko Nishi, Makoto Ohtake, Ryohei Miyazaki, Jun Suenaga, Hidetoshi Murata, Ichio Aoki, Julie J. Miller, Yukihiko Fujii, Akihide Ryo, Shoji Yamanaka, Hiroyuki Mano, Daniel P. Cahill, Hiroaki Wakimoto, Andrew S. Chi, Tracy T. Batchelor, Motoo Nagane, Koichi Ichimura, Tetsuya Yamamoto
Journal: Cancer Research
Cancer Res (2020) 80 (23): 5330–5343.
https://doi.org/10.1158/0008-5472.CAN-20-2425
Published: 02 December 2020
View article titled, A Hyperactive RelA/p65-Hexokinase 2 Signaling Axis Drives Primary Central Nervous System Lymphoma
Open the PDF for A Hyperactive RelA/p65-Hexokinase 2 Signaling Axis Drives Primary Central Nervous System Lymphoma in another window
Includes: Supplementary data
Journal Articles

Abstract 4729: Identifying genomic drivers of lung adenocarcinoma brain metastases

Naema Nayyar, David J. Shih, Ivanna Bihun, Ibiayi Dagogo-Jack, Corey M. Gill, Elisa Aquilanti, Mia Bertalan, Alexander Kaplan, Megan R. D'Andrea, Ugonma Chukwueke, Christopher Alvarez-Breckenridge, Matthew Lastrapes, Ben Kuter, Matthew R. Strickland, Juan Carlos Martinez-Gutierrez, Deepika Nagabhushan, Magali De Sauvage, Michael D. White, Brandyn A. Castro, Kaitlin Hoang, Sun Ha Paek, Sun Hye Park, Maria Martinez-Lage, Anna S. Berghoff, Parker Merrill, Elizabeth R. Gerstner, Tracy T. Batchelor, Matthew P. Frosch, Ryan P. Frazier, Darrell R. Borger, A John Iafrate, Sandro Santagata, Matthias Preusser, Daniel P. Cahill, Scott L. Carter, Priscilla K. Brastianos
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4729.
https://doi.org/10.1158/1538-7445.AM2020-4729
Published: 15 August 2020
View article titled, Abstract 4729: Identifying genomic drivers of lung adenocarcinoma brain metastases
Journal Articles

The Alkylating Chemotherapeutic Temozolomide Induces Metabolic Stress in IDH1-Mutant Cancers and Potentiates NAD+ Depletion–Mediated Cytotoxicity

Kensuke Tateishi, Fumi Higuchi, Julie J. Miller, Mara V.A. Koerner, Nina Lelic, Ganesh M. Shankar, Shota Tanaka, David E. Fisher, Tracy T. Batchelor, A. John Iafrate, Hiroaki Wakimoto, Andrew S. Chi, Daniel P. Cahill
Journal: Cancer Research
Cancer Res (2017) 77 (15): 4102–4115.
https://doi.org/10.1158/0008-5472.CAN-16-2263
Published: 01 August 2017
View article titled, The Alkylating Chemotherapeutic Temozolomide Induces Metabolic Stress in <em>IDH1</em>-Mutant Cancers and Potentiates NAD<sup>+</sup> Depletion–Mediated Cytotoxicity
Open the PDF for The Alkylating Chemotherapeutic Temozolomide Induces Metabolic Stress in <em>IDH1</em>-Mutant Cancers and Potentiates NAD<sup>+</sup> Depletion–Mediated Cytotoxicity in another window
Includes: Supplementary data
Journal Articles

Abstract B12: Adding angiotensin-system inhibitors to anti-angiogenic therapy reduces vasogenic edema in newly diagnosed glioblastomas but not in recurrent disease

Kyrre E. Emblem, Elizabeth R. Gerstner, A Gregory Sorensen, Bruce R. Rosen, Patrick Y. Wen, Tracy T. Batchelor, Rakesh K. Jain
Journal: Cancer Research
Cancer Res (2017) 77 (2_Supplement): B12.
https://doi.org/10.1158/1538-7445.EPSO16-B12
Published: 16 January 2017
View article titled, Abstract B12: Adding angiotensin-system inhibitors to anti-angiogenic therapy reduces vasogenic edema in newly diagnosed glioblastomas but not in recurrent disease
Journal Articles

Abstract 3975: Matrix-depleting anti-hypertensives decompress tumor blood vessels and improve perfusion in patients with glioblastomas receiving anti-angiogenic therapy

Kyrre E. Emblem, Elizabeth R. Gerstner, Gregory Sorensen, Bruce R. Rosen, Patrick Y. Wen, Tracy T. Batchelor, Rakesh K. Jain
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3975.
https://doi.org/10.1158/1538-7445.AM2016-3975
Published: 15 July 2016
View article titled, Abstract 3975: Matrix-depleting anti-hypertensives decompress tumor blood vessels and improve perfusion in patients with glioblastomas receiving anti-angiogenic therapy
Journal Articles

Abstract LB-209: D2-like dopamine receptor antagonism by ONC201 identified by confluence of computational, receptor binding, and clinical studies

Neel S. Madhukar, Olivier Elemento, Cyril H. Benes, Mathew J. Garnett, Mark Stein, Joseph R. Bertino, Howard L. Kaufman, Isabel Arrillaga-Romany, Tracy T. Batchelor, Lee Schalop, Wolfgang Oster, Martin Stogniew, Michael Andreeff, Wafik S. El-Deiry, Joshua E. Allen
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-209.
https://doi.org/10.1158/1538-7445.AM2016-LB-209
Published: 15 July 2016
View article titled, Abstract LB-209: D2-like dopamine receptor antagonism by ONC201 identified by confluence of computational, receptor binding, and clinical studies
Journal Articles

Abstract LB-347: Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival

Jonas Kloepper, Lars Riedemann, Zohreh Amoozgar, Giorgio Seano, Katharina H. Susek, Veronica Yu, Nisha Dalvie, Robin L. Amelung, Meenal Datta, Jonathan W. Song, Vasileios Askoxylakis, Jennie W. Taylor, Christine Lu-Emerson, Ana Batista, Nathaniel D. Kirkpatrick, Keehoon Jung, Matija Snuderl, Alona Muzikansky, Kay G. Stubenrauch, Oliver Krieter, Hiroaki Wakimoto, Lei Xu, Lance L. Munn, Dan G. Duda, Dai Fukumura, Tracy T. Batchelor, Rakesh K. Jain
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-347.
https://doi.org/10.1158/1538-7445.AM2016-LB-347
Published: 15 July 2016
View article titled, Abstract LB-347: Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival
Journal Articles

Abstract LB-346: Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages

Zohreh Amoozgar, Teresa E. Peterson, Nathaniel D. Kirkpatrick, Yuhui Huang, Christian T. Farrar, Koen A. Marijt, Jonas Kloepper, Meenal Datta, Giorgio Seano, Keehoon Jung, Walid S. Kamoun, Trupti Vardam, Matija Snuderl, Jermaine Goveia, Sampurna Chatterjee, Ana Batista, Alona Muzikansky, Ching Ching Leow, Lei Xu, Tracy T. Batchelor, Dan G. Duda, Dai Fukumura, Jain K. Jain
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-346.
https://doi.org/10.1158/1538-7445.AM2016-LB-346
Published: 15 July 2016
View article titled, Abstract LB-346: Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages
Journal Articles

Abstract 2675: Metabolic addiction in IDH1 mutant cancers

Andrew S. Chi, Kensuke Tateishi, Wakimoto Hiroaki, Tracy T. Batchelor, Anthony J. Iafrate, Daniel P. Cahill
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2675.
https://doi.org/10.1158/1538-7445.AM2016-2675
Published: 15 July 2016
View article titled, Abstract 2675: Metabolic addiction in IDH1 mutant cancers
Journal Articles

Abstract 2497: ONC201 targets cancer stem cells in colorectal, prostate and glioblastoma multiforme tumors via modulation of stem cell-related gene expression

Varun Vijay Prabhu, Joshua E. Allen, Dan Zhao, Amriti R. Lulla, Christina Leah B. Kline, A. Pieter J. van den Heuvel, Avital Lev, Tracy T. Batchelor, David T. Dicker, Andrew S. Chi, Wafik S. El-Deiry
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2497.
https://doi.org/10.1158/1538-7445.AM2016-2497
Published: 15 July 2016
View article titled, Abstract 2497: ONC201 targets cancer stem cells in colorectal, prostate and glioblastoma multiforme tumors via modulation of stem cell-related gene expression
Journal Articles

Abstract PR04: Genomic characterization of brain metastases reveals branched evolution and metastasis-specific mutations

Priscilla K. Brastianos, Scott L. Carter, Sandro Santagata, Daniel Cahill, Amaro Taylor-Weiner, Robert T. Jones, Eliezer Van Allen, Peleg Horowitz, Keith L. Ligon, William T. Curry, Ian F. Dunn, Paul Van Hummelen, Matthew Meyerson, Levi Garraway, Josep Tabernero, Joan Seoane, Stacey Gabriel, Eric S. Lander, Rameen Beroukhim, Tracy T. Batchelor, Jose Baselga, David N. Louis, William C. Hahn, Gad Getz
Journal: Cancer Research
Cancer Res (2015) 75 (23_Supplement): PR04.
https://doi.org/10.1158/1538-7445.BRAIN15-PR04
Published: 09 December 2015
View article titled, Abstract PR04: Genomic characterization of brain metastases reveals branched evolution and metastasis-specific mutations
Journal Articles

Abstract NG03: Genomic characterization of 101 brain metastases and paired primary tumors reveals patterns of clonal evolution and selection of driver mutations

Priscilla K. Brastianos, Scott L. Carter, Sandro Santagata, Amaro Taylor-Weiner, Robert T. Jones, Peleg M. Horowitz, Keith L. Ligon, Joan Seaone, Elena Martinez-Saez, Josep Tabernero, Daniel P. Cahill, Sun-Ha Paek, Ian F. Dunn, Bruce E. Johnson, Toni K. Choueiri, Michael S. Rabin, Eric P. Winer, Nancy U. Lin, Paul Van Hummelen, Anat Stemmer-Rachamimov, Rameen Beroukhim, David L. Louis, Tracy T. Batchelor, Jose Baselga, Gad Getz, William C. Hahn
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): NG03.
https://doi.org/10.1158/1538-7445.AM2014-NG03
Published: 01 October 2014
View article titled, Abstract NG03: Genomic characterization of 101 brain metastases and paired primary tumors reveals patterns of clonal evolution and selection of driver mutations
Journal Articles

Abstract LB-297: Vessel architectural imaging identifies cancer patient responders to anti-angiogenic therapy.

Kyrre E. Emblem, Kim Mouridsen, Atle Bjornerud, Christian T. Farrar, Dominique Jennings, Ronald J.H Borra, Patrick Y. Wen, Percy Ivy, Tracy T. Batchelor, Bruce R. Rosen, Rakesh K. Jain, A. Gregory Sorensen
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): LB-297.
https://doi.org/10.1158/1538-7445.AM2013-LB-297
Published: 15 April 2013
View article titled, Abstract LB-297: Vessel architectural imaging identifies cancer patient responders to anti-angiogenic therapy.
Journal Articles

Abstract LB-339: Increase in tumor-associated macrophages (TAMs) after antiangiogenic therapy is associated with poor survival in recurrent glioblastoma (GBM) patients.

Christine Lu-Emerson, Matija Snuderl, Nathaniel D. Kirkpatrick, Jermaine Goveia, Jennie Taylor, Christian Davidson, Yuhui Huang, Lars Riedemann, S. Percy Ivy, G. Dan Duda, Marek Ancukiewicz3, Scott R. Plotkin, Andrew Chi, Elizabeth R. Gerstner, April F. Eichler, Jorg Dietrich, Anat O. Stemmer-Rachamimov, Tracy T. Batchelor, Rakesh K. Jain
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): LB-339.
https://doi.org/10.1158/1538-7445.AM2013-LB-339
Published: 15 April 2013
View article titled, Abstract LB-339: Increase in tumor-associated macrophages (TAMs) after antiangiogenic therapy is associated with poor survival in recurrent glioblastoma (GBM) patients.
Journal Articles

Increased Survival of Glioblastoma Patients Who Respond to Antiangiogenic Therapy with Elevated Blood Perfusion

A. Gregory Sorensen, Kyrre E. Emblem, Pavlina Polaskova, Dominique Jennings, Heisoog Kim, Marek Ancukiewicz, Meiyun Wang, Patrick Y. Wen, Percy Ivy, Tracy T. Batchelor, Rakesh K. Jain
Journal: Cancer Research
Cancer Res (2012) 72 (2): 402–407.
https://doi.org/10.1158/0008-5472.CAN-11-2464
Published: 16 January 2012
View article titled, Increased Survival of Glioblastoma Patients Who Respond to Antiangiogenic Therapy with Elevated Blood Perfusion
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Includes: Supplementary data
Journal Articles

Serial Magnetic Resonance Spectroscopy Reveals a Direct Metabolic Effect of Cediranib in Glioblastoma

Heisoog Kim, Ciprian Catana, Eva-Maria Ratai, Ovidiu C. Andronesi, Dominique L. Jennings, Tracy T. Batchelor, Rakesh K. Jain, A. Gregory Sorensen
Journal: Cancer Research
Cancer Res (2011) 71 (11): 3745–3752.
https://doi.org/10.1158/0008-5472.CAN-10-2991
Published: 31 May 2011
View article titled, Serial Magnetic Resonance Spectroscopy Reveals a Direct Metabolic Effect of Cediranib in Glioblastoma
Open the PDF for Serial Magnetic Resonance Spectroscopy Reveals a Direct Metabolic Effect of Cediranib in Glioblastoma in another window
Includes: Supplementary data
Journal Articles

Glioblastoma Recurrence after Cediranib Therapy in Patients: Lack of “Rebound” Revascularization as Mode of Escape

Emmanuelle di Tomaso, Matija Snuderl, Walid S. Kamoun, Dan G. Duda, Pavan K. Auluck, Ladan Fazlollahi, Ovidiu C. Andronesi, Matthew P. Frosch, Patrick Y. Wen, Scott R. Plotkin, E. Tessa Hedley-Whyte, A. Gregory Sorensen, Tracy T. Batchelor, Rakesh K. Jain
Journal: Cancer Research
Cancer Res (2011) 71 (1): 19–28.
https://doi.org/10.1158/0008-5472.CAN-10-2602
Published: 02 January 2011
View article titled, Glioblastoma Recurrence after Cediranib Therapy in Patients: Lack of “Rebound” Revascularization as Mode of Escape
Open the PDF for Glioblastoma Recurrence after Cediranib Therapy in Patients: Lack of “Rebound” Revascularization as Mode of Escape in another window
Includes: Supplementary data
Journal Articles

A “Vascular Normalization Index” as Potential Mechanistic Biomarker to Predict Survival after a Single Dose of Cediranib in Recurrent Glioblastoma Patients

A. Gregory Sorensen, Tracy T. Batchelor, Wei-Ting Zhang, Poe-Jou Chen, Priscilla Yeo, Meiyun Wang, Dominique Jennings, Patrick Y. Wen, Johanna Lahdenranta, Marek Ancukiewicz, Emmanuelle di Tomaso, Dan G. Duda, Rakesh K. Jain
Journal: Cancer Research
Cancer Res (2009) 69 (13): 5296–5300.
https://doi.org/10.1158/0008-5472.CAN-09-0814
Published: 01 July 2009
View article titled, A “Vascular Normalization Index” as Potential Mechanistic Biomarker to Predict Survival after a Single Dose of Cediranib in Recurrent Glioblastoma Patients
Open the PDF for A “Vascular Normalization Index” as Potential Mechanistic Biomarker to Predict Survival after a Single Dose of Cediranib in Recurrent Glioblastoma Patients in another window
Includes: Multimedia, Supplementary data
Journal Articles

Abstract LB-247: A multidisciplinary phase II study of AZD2171 (cediranib), an oral pan-VEGF receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma

Tracy T Batchelor, Gregory Sorensen, Emmanuelle di Tomaso, Dan G Duda, Wei-Ting Zhang, Marek Ancukiewicz, Johanna Lahdenranta, David Louis, Scott Plotkin, Percy Ivy, Jay S Loeffler, Patrick Wen, Rakesh K Jain
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): LB-247.
https://doi.org/10.1158/1538-7445.AM2008-LB-247
Published: 15 May 2008
View article titled, Abstract LB-247: A multidisciplinary phase II study of AZD2171 (cediranib), an oral pan-VEGF receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma
Journal Articles

A Hypermutation Phenotype and Somatic MSH6 Mutations in Recurrent Human Malignant Gliomas after Alkylator Chemotherapy

Chris Hunter, Raffaella Smith, Daniel P. Cahill, Philip Stephens, Claire Stevens, Jon Teague, Chris Greenman, Sarah Edkins, Graham Bignell, Helen Davies, Sarah O'Meara, Adrian Parker, Tim Avis, Syd Barthorpe, Lisa Brackenbury, Gemma Buck, Adam Butler, Jody Clements, Jennifer Cole, Ed Dicks, Simon Forbes, Matthew Gorton, Kristian Gray, Kelly Halliday, Rachel Harrison, Katy Hills, Jonathon Hinton, Andy Jenkinson, David Jones, Vivienne Kosmidou, Ross Laman, Richard Lugg, Andrew Menzies, Janet Perry, Robert Petty, Keiran Raine, David Richardson, Rebecca Shepherd, Alexandra Small, Helen Solomon, Calli Tofts, Jennifer Varian, Sofie West, Sara Widaa, Andy Yates, Douglas F. Easton, Gregory Riggins, Jennifer E. Roy, Kymberly K. Levine, Wolf Mueller, Tracy T. Batchelor, David N. Louis, Michael R. Stratton, P. Andrew Futreal, Richard Wooster
Journal: Cancer Research
Cancer Res (2006) 66 (8): 3987–3991.
https://doi.org/10.1158/0008-5472.CAN-06-0127
Published: 17 April 2006
View article titled, A Hypermutation Phenotype and Somatic <em>MSH6</em> Mutations in Recurrent Human Malignant Gliomas after Alkylator Chemotherapy
Open the PDF for A Hypermutation Phenotype and Somatic <em>MSH6</em> Mutations in Recurrent Human Malignant Gliomas after Alkylator Chemotherapy in another window
Includes: Supplementary data