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Toshiyuki Sakai
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Journal Articles

Abstract 5847: A histone deacetylase inhibitor OBP-801 and eribulin synergistically inhibit the growth with apoptosis in triple-negative breast cancer cells

Hisako Ono, Yoshihiro Sowa, Yosuke Iizumi, Mano Horinaka, Tetsuya Taguchi, Toshiyuki Sakai
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5847.
https://doi.org/10.1158/1538-7445.AM2018-5847
Published: 01 July 2018
View article titled, Abstract 5847: A histone deacetylase inhibitor OBP-801 and eribulin synergistically inhibit the growth with apoptosis in triple-negative breast cancer cells
Journal Articles

Abstract 2279: Adenine nucleotide translocase-2 is a key molecule in the enhancement of TRAIL sensitivity by flavonoids

Masakatsu Oishi, Yosuke Iizumi, Takashi Ueda, Saya Ito, Terukazu Nakamura, Fumiya Hongo, Yoshio Naya, Tsuneharu Miki, Toshiyuki Sakai
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2279.
https://doi.org/10.1158/1538-7445.AM2014-2279
Published: 01 October 2014
View article titled, Abstract 2279: Adenine nucleotide translocase-2 is a key molecule in the enhancement of TRAIL sensitivity by flavonoids
Journal Articles

Enhanced Inhibition of ERK Signaling by a Novel Allosteric MEK Inhibitor, CH5126766, That Suppresses Feedback Reactivation of RAF Activity

Nobuya Ishii, Naoki Harada, Eric W. Joseph, Kazuhiro Ohara, Takaaki Miura, Hiroshi Sakamoto, Yutaka Matsuda, Yasushi Tomii, Yukako Tachibana-Kondo, Hitoshi Iikura, Toshihiro Aoki, Nobuo Shimma, Mikio Arisawa, Yoshihiro Sowa, Poulikos I. Poulikakos, Neal Rosen, Yuko Aoki, Toshiyuki Sakai
Journal: Cancer Research
Series: Author Choice
Cancer Res (2013) 73 (13): 4050–4060.
https://doi.org/10.1158/0008-5472.CAN-12-3937
Published: 30 June 2013
View article titled, Enhanced Inhibition of ERK Signaling by a Novel Allosteric MEK Inhibitor, CH5126766, That Suppresses Feedback Reactivation of RAF Activity
Open the PDF for Enhanced Inhibition of ERK Signaling by a Novel Allosteric MEK Inhibitor, CH5126766, That Suppresses Feedback Reactivation of RAF Activity in another window
Includes: Supplementary data
Journal Articles

Abstract 242: Anti-obesity drugorlistat enhances sensitivity toTRAIL by two different pathways inhormone-refractory prostate cancer cells

Jun Fujiwara, Yoshihiro Sowa, Mano Horinaka, Makoto Koyama, Miki Wakada, Tsuneharu Miki, Toshiyuki Sakai
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 242.
https://doi.org/10.1158/1538-7445.AM2012-242
Published: 15 April 2012
View article titled, Abstract 242: Anti-obesity drugorlistat enhances sensitivity toTRAIL by two different pathways inhormone-refractory prostate cancer cells
Journal Articles

Abstract 299: CDK1 and CDK2 activity is a strong predictor of renal cell cancer recurrence

Fumiya Hongo, Natsuki Takaha, Yasunori Kimura, Terukazu Nakamura, Kazuya Mikami, Satoshi Nakayama, Tomoko Matsushima, Hideki Ishihara, Toshiyuki Sakai, Tsuneharu Miki
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 299.
https://doi.org/10.1158/1538-7445.AM2011-299
Published: 15 April 2011
View article titled, Abstract 299: CDK1 and CDK2 activity is a strong predictor of renal cell cancer recurrence
Journal Articles

Abstract 3585: Antitumor activities of JTP-74057 (GSK1120212), a novel MEK1/2 inhibitor, on colorectal cancer cell lines in vitro and in vivo

Takayuki Yamaguchi, Reina Kakefuda, Nobuyuki Tajima, Yoshihiro Sowa, Toshiyuki Sakai
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 3585.
https://doi.org/10.1158/1538-7445.AM2011-3585
Published: 15 April 2011
View article titled, Abstract 3585: Antitumor activities of JTP-74057 (GSK1120212), a novel MEK1/2 inhibitor, on colorectal cancer cell lines in vitro and in vivo
Journal Articles

Abstract 3606: CH5126766 is a novel allosteric inhibitor of MEK that prevents its phosphorylation by RAF

Nobuya Ishii, Naoki Harada, Hiroshi Sakamoto, Yutaka Matsuda, Yasushi Tomii, Yukako Tachibana-Kondo, Takaaki Miura, Kazuhiro Ohara, Hitoshi Iikura, Toshihiro Aoki, Nobuo Shimma, Mikio Arisawa, Eric Joseph, Poulikos Poulikakos, Yoshihiro Sowa, Neal Rosen, Yuko Aoki, Toshiyuki Sakai
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 3606.
https://doi.org/10.1158/1538-7445.AM2011-3606
Published: 15 April 2011
View article titled, Abstract 3606: CH5126766 is a novel allosteric inhibitor of MEK that prevents its phosphorylation by RAF
Journal Articles

Abstract 2695: Lactobacillus plantarum induces TRAIL production and facilitates natural killer activity against cancer cells

Mano Horinaka, Tatsushi Yoshida, Atsuko Kishi, Kaoru Akatani, Takashi Yasuda, Junji Kouhara, Miki Wakada, Toshiyuki Sakai
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2695.
https://doi.org/10.1158/1538-7445.AM2011-2695
Published: 15 April 2011
View article titled, Abstract 2695: Lactobacillus plantarum induces TRAIL production and facilitates natural killer activity against cancer cells
Journal Articles

Abstract 2560: Cyclin-dependent kinase inhibitor SU9516 enhances sensitivity to methotrexate in human T-cell Jurkat cells

Hitoji Uchiyama, Yoshihiro Sowa, Miki Wakada, Mayumi Yogosawa, Ryoko Nakanishi, Mano Horinaka, Chihiro Shimazaki, Masafumi Taniwaki, Toshiyuki Sakai
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2560.
https://doi.org/10.1158/1538-7445.AM10-2560
Published: 15 April 2010
View article titled, Abstract 2560: Cyclin-dependent kinase inhibitor SU9516 enhances sensitivity to methotrexate in human T-cell Jurkat cells
Journal Articles

Abstract 5415: Histone deacetylase inhibitors and 15-deoxy-Δ12,14-prostaglandin J2 synergistically induce apoptosis

Makoto Koyama, Yasuyuki Izutani, Ahmed E. Goda, Taka-aki Matsui, Mano Horinaka, Mitsuhiro Tomosugi, Jun Fujiwara, Yoshitaka Nakamura, Miki Wakada, Shingo Yogosawa, Yoshihiro Sowa, Toshiyuki Sakai
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 5415.
https://doi.org/10.1158/1538-7445.AM10-5415
Published: 15 April 2010
View article titled, Abstract 5415: Histone deacetylase inhibitors and 15-deoxy-Δ<sup>12,14</sup>-prostaglandin J<sub>2</sub> synergistically induce apoptosis
Journal Articles

Abstract #5499: Overcoming TRAIL resistance by dipyridamole: A new role for an old drug

Ahmed Goda, Tatsushi Yoshida, Mano Horinaka, Takashi Yasuda, Takumi Shiraishi, Miki Wakada, Toshiyuki Sakai
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 5499.
Published: 01 May 2009
View article titled, Abstract #5499: Overcoming TRAIL resistance by dipyridamole: A new role for an old drug
Journal Articles

Baicalein Overcomes Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Resistance via Two Different Cell-Specific Pathways in Cancer Cells but not in Normal Cells

Hiroya Taniguchi, Tatsushi Yoshida, Mano Horinaka, Takashi Yasuda, Ahmed E. Goda, Masako Konishi, Miki Wakada, Keisho Kataoka, Toshikazu Yoshikawa, Toshiyuki Sakai
Journal: Cancer Research
Cancer Res (2008) 68 (21): 8918–8927.
https://doi.org/10.1158/0008-5472.CAN-08-1120
Published: 30 October 2008
View article titled, Baicalein Overcomes Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Resistance via Two Different Cell-Specific Pathways in Cancer Cells but not in Normal Cells
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Includes: Supplementary data
Journal Articles

Gefitinib induces p15INK4b and causes G1 arrest by inhibiting the MAPK/ERK pathway

Makoto Koyama, Youichirou Matsuzaki, Shingo Yogosawa, Toshiaki Hitomi, Mayumi Kawanaka, Toshiyuki Sakai
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 4850.
Published: 01 May 2008
View article titled, Gefitinib induces p15<sup>INK4b</sup> and causes G1 arrest by inhibiting the MAPK/ERK pathway
Journal Articles

p53 inactivation upregulates p73 expression through E2F mediated transcriptional regulation

Chaitali Tophkhane, Shihe Yang, Toshiyuki Sakai, Wanguo Liu, XiaoHe Yang
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2784.
Published: 01 May 2008
View article titled, p53 inactivation upregulates p73 expression through E2F mediated transcriptional regulation
Journal Articles

Dietary flavonoid apigenin sensitizes malignant tumor cells to tumor necrosis factor-related apoptosis-inducing ligand

Mano Horinaka, Tatsushi Yoshida, Takumi Shiraishi, Susumu Nakata, Miki Wakada, Toshiyuki Sakai
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 5134.
Published: 01 May 2007
View article titled, Dietary flavonoid apigenin sensitizes malignant tumor cells to tumor necrosis factor-related apoptosis-inducing ligand
Journal Articles

Proteasome inhibitor MG132 induces Death Receptor 5 through CHOP in prostate cancer cell

Tatsushi Yoshida, Takumi Shiraishi, Susumu Nakata, Miki Wakada, Yoichi Mizutani, Tsuneharu Miki, Toshiyuki Sakai
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 564.
Published: 15 April 2006
View article titled, Proteasome inhibitor MG132 induces Death Receptor 5 through CHOP in prostate cancer cell
Journal Articles

Luteolin induces death receptor 5 up-regulation and the combination of TRAIL and luteolin enhances apoptosis in human cervical cancer HeLa cells

Mano Horinaka, Tatsushi Yoshida, Takumi Shiraishi, Susumu Nakata, Miki Wakada, Ryoko Nakanishi, Hoyoku Nishino, Toshiyuki Sakai
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 177.
Published: 15 April 2006
View article titled, Luteolin induces death receptor 5 up-regulation and the combination of TRAIL and luteolin enhances apoptosis in human cervical cancer HeLa cells
Journal Articles

Mechanism of sensitization of PC3 cells to TRAIL-mediated apoptosis by 2-methoxyestradiol (2ME2): Regulation of DR5 expression by the transcription repressor Yin Yang 1 (YY1)

Mehran S. Neshat, Sarah Huerta-Yepez, Toshiyuki Sakai, Theresa La Vallee, Benjamin Bonavida
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 176.
Published: 15 April 2006
View article titled, Mechanism of sensitization of PC3 cells to TRAIL-mediated apoptosis by 2-methoxyestradiol (2ME<sub>2</sub>): Regulation of DR5 expression by the transcription repressor Yin Yang 1 (YY1)
Journal Articles

Tunicamycin Enhances Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Induced Apoptosis in Human Prostate Cancer Cells

Takumi Shiraishi, Tatsushi Yoshida, Susumu Nakata, Mano Horinaka, Miki Wakada, Yoichi Mizutani, Tsuneharu Miki, Toshiyuki Sakai
Journal: Cancer Research
Cancer Res (2005) 65 (14): 6364–6370.
https://doi.org/10.1158/0008-5472.CAN-05-0312
Published: 15 July 2005
View article titled, Tunicamycin Enhances Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Induced Apoptosis in Human Prostate Cancer Cells
Open the PDF for Tunicamycin Enhances Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Induced Apoptosis in Human Prostate Cancer Cells in another window
Journal Articles

Proteasome Inhibitor MG132 Induces Death Receptor 5 through CCAAT/Enhancer-Binding Protein Homologous Protein

Tatsushi Yoshida, Takumi Shiraishi, Susumu Nakata, Mano Horinaka, Miki Wakada, Yoichi Mizutani, Tsuneharu Miki, Toshiyuki Sakai
Journal: Cancer Research
Cancer Res (2005) 65 (13): 5662–5667.
https://doi.org/10.1158/0008-5472.CAN-05-0693
Published: 01 July 2005
View article titled, Proteasome Inhibitor MG132 Induces Death Receptor 5 through CCAAT/Enhancer-Binding Protein Homologous Protein
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