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Toshiyoshi Fujiwara
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Journal Articles

Abstract CT024: Early safety from an open label Phase I study to evaluate the safety and efficacy of a telomerase-specific oncolytic adenovirus (OBP-301) with pembrolizumab in patients with advanced solid tumors. (EPOC1505)

Takashi Kojima, Toshiyoshi Fujiwara, Yasuhiro Shirakawa, Keisuke Hori, Hiromi Ono, Masako Nakamoto, Nami Hirano, Masashi Wakabayashi, Shogo Nomura, Yosuke Togashi, Hiroyoshi Nishikawa, Akihiro Sato, Atushi Ohtsu, Toshihiko Doi
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): CT024.
DOI: https://doi.org/10.1158/1538-7445.AM2019-CT024
Published: 01 July 2019
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Journal Articles

Abstract CT185: Phase I dose-escalation study of endoscopic intratumoral injection of OBP-301 (telomelysin) with radiotherapy in esophageal cancer patients unfit for standard treatments

Toshiyoshi Fujiwara, Shunsuke Tanabe, Hiroshi Tazawa, Nobuhiko Kanaya, Kazuhiro Noma, Shunsuke Kagawa, Shinji Kuroda, Yasuo Urata, Yasuhiro Shirakawa
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): CT185.
DOI: https://doi.org/10.1158/1538-7445.AM2019-CT185
Published: 01 July 2019
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Journal Articles

Abstract LB-310: Overcoming resistance of conventional therapies by targeting cancer-associated fibroblasts (CAFs) with near-infrared photoimmunotherapy (NIR-PIT)

Satoshi Komoto, Kazuhiro Noma, Ryoichi Katsube, Takuya Kato, Toshiaki Ohara, Hiroaki Sato, Toru Narusaka, Noriyuki Nisiwaki, Hiroshi Tazawa, Yasuhiro Shirakawa, Toshiyoshi Fujiwara
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-310.
DOI: https://doi.org/10.1158/1538-7445.AM2019-LB-310
Published: 01 July 2019
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Journal Articles

Abstract 4852: Boosting immunity against pancreatic cancer by OBP-702 (Pfifteloxin), telomerase-specific replicative adenovirus armed with wild-type p53 gene

Hiroyuki Araki, Hiroshi Tazawa, Takuro Fushimi, Takeyoshi Nishiyama, Satotu Kikuchi, Shinji Kuroda, Ryuichi Yoshida, Hiroyuki Kishimoto, Masahiko Nishizaki, Yasuo Urata, Shunsuke Kagawa, Toshiyoshi Fujiwara
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4852.
DOI: https://doi.org/10.1158/1538-7445.AM2019-4852
Published: 01 July 2019
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Journal Articles

Abstract 4823: Elimination of invasive pancreatic cancer cells by p53-activating oncolytic virotherapy as novel precision medicine

Takuro Fushimi, Hiroshi Tazawa, Takeshi Koujima, Hiroyuki Araki, Takeyoshi Nishiyama, Satoru Kikuchi, Shinji Kuroda, Ryuichi Yoshida, Hiroyuki Kishimoto, Masahiko Nishizaki, Yasuo Urata, Shunsuke Kagawa, Toshiyoshi Fujiwara
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4823.
DOI: https://doi.org/10.1158/1538-7445.AM2019-4823
Published: 01 July 2019
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Journal Articles

Abstract 4851: Involvement of extracellular vesicles in the abscopal effect induced by oncolytic adenovirotherapy

Yoshihiko Kakiuchi, Shinji Kuroda, Nobuhiko Kanaya, Kento Kumon, Tomoko Tsumura, Satoru Kikuchi, Masahiko Nishizaki, Shunsuke Kagawa, Hiroshi Tazawa, Yasuo Urata, Toshiyoshi Fujiwara
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4851.
DOI: https://doi.org/10.1158/1538-7445.AM2019-4851
Published: 01 July 2019
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Journal Articles

Abstract 4330: Activation of AZIN1 RNA editing facilitates and promotes invasive potential of cancer associated fibroblasts in colorectal cancer

Sho Takeda, Kunitoshi Shigeyasu, Yoshinaga Okugawa, Kazuhiro Yoshida, Yoshiko Mori, Shuya Yano, Kazuhiro Noma, Yuzo Umeda, Yoshitaka Kondo, Hiroyuki Kishimoto, Fuminori Teraishi, Hiroshi Tazawa, Shunsuke Kagawa, Ajay Goel, Toshiyoshi Fujiwara
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4330.
DOI: https://doi.org/10.1158/1538-7445.AM2019-4330
Published: 01 July 2019
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Journal Articles

Abstract 3231: Oncolytic immunotherapy with PD-1 blockade and telomerase-specific oncolytic adenovirus in osteosarcoma

Koji Demiya, Hiroshi Tazawa, Yusuke Mochizuki, Miho Kure, Joe Hasei, Toshiyuki Kunisada, Yasuo Urata, Toshifumi Ozaki, Toshiyoshi Fujiwara
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3231.
DOI: https://doi.org/10.1158/1538-7445.AM2019-3231
Published: 01 July 2019
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Journal Articles

Abstract 2979: Boosting replication and penetration of telomerase-specific replicative virus by paclitaxel induces synthetic lethality in peritoneal metastasis of gastric cancer

Toshihiro Ogawa, Satoru Kikuchi, Wataru Ishikawa, Hiroshi Tazawa, Motoyasu Tabuchi, Shinji Kuroda, Kazuhiro Noma, Masahiko Nishizaki, Shunsuke Kagawa, Yasuo Urata, Toshiyoshi Fujiwara
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2979.
DOI: https://doi.org/10.1158/1538-7445.AM2019-2979
Published: 01 July 2019
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Journal Articles

Abstract 3617: Trastuzumab-conjugated gold nanoparticles as novel HER2-targeted therapeutics against trastuzumab-resistant gastric cancer

Kento Kumon, Tetsushi Kubota, Shinji Kuroda, Nobuhiko Kanaya, Yoshihiko Kakiuchi, Tomoko Tsumura, Satoru Kikuchi, Shunsuke Kagawa, Hiroshi Tazawa, Toshiyoshi Fujiwara
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3617.
DOI: https://doi.org/10.1158/1538-7445.AM2019-3617
Published: 01 July 2019
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Journal Articles

Abstract 1155: Stemness control by iron chelator is a novel therapeutic strategy for esophageal cancer

Toru Narusaka, Toshiaki Ohara, Kazuhiro Noma, Yuki Katsura, Noriyuki Nishiwaki, Motoyasu Tabuchi, Takuro Fushimi, Toshihiro Ogawa, Sho Takeda, Satoshi Komoto, Hiroaki Sato, Satoru Kikuchi, Yasuko Tomono, Hiroshi Tazawa, Shunsuke Kagawa, Yasuhiro Shirakawa, Toshiyoshi Fujiwara
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1155.
DOI: https://doi.org/10.1158/1538-7445.AM2019-1155
Published: 01 July 2019
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Journal Articles

Abstract 2873: Elimination of MYCN-amplified neuroblastoma cells by telomerase-targeted oncolytic virotherapy as novel precision medicine

Morimichi Tani, Hiroshi Tazawa, Terutaka Tanimoto, Hiroshi Nouso, Yasuo Urata, Shunsuke Kagawa, Takuo Noda, Toshiyoshi Fujiwara
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2873.
DOI: https://doi.org/10.1158/1538-7445.AM2019-2873
Published: 01 July 2019
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Journal Articles

Abstract 4519: The reciprocal interaction between neutrophil extracellular traps and cancer cells impacts on their malignant potentials

Hiroki Kajioka, Shunsuke Kagawa, Atene Ito, Kazuya Kuwada, Satoru Kikuchi, Shinji Kuroda, Ryuichi Yoshida, Hiroshi Tazawa, Toshiyoshi Fujiwara
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4519.
DOI: https://doi.org/10.1158/1538-7445.AM2019-4519
Published: 01 July 2019
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Journal Articles

Abstract 5066: Dual-targeting photoimmunotherapy (NIR-PIT) for esophageal cancer cells and cancer-associated fibroblasts (CAFs)

Hiroaki Sato, Kazuhiro Noma, Toru Narusaka, Satoshi Komoto, Yuki Katsura, Takuya Kato, Takayuki Ninomiya, Toshiaki Ohara, Hiroshi Tazawa, Yasuhiro Shirakawa, Hisataka Kobayashi, Toshiyoshi Fujiwara
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5066.
DOI: https://doi.org/10.1158/1538-7445.AM2018-5066
Published: 01 July 2018
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Journal Articles

Abstract 5200: Extracellular vesicles in the ascites from gastric cancer patients play critical roles to promote peritoneal dissemination in the intraperitoneal cancer microenvironment

Atene Ito, shunsuke kagawa, Shuichi Sakamoto, Kazuya Kuwada, Satoru Kikuchi, Shinji Kuroda, Ryuichi Yoshida, Hiroshi Tazawa, Toshiyoshi Fujiwara
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5200.
DOI: https://doi.org/10.1158/1538-7445.AM2018-5200
Published: 01 July 2018
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Journal Articles

Abstract 4776: Antitumor activity of pan-HER inhibitors in HER2-positive gastric cancer

Takahiro Yoshioka, Kazuhiko Shien, Yuta Takahashi, Eisuke Kurihara, Kei Namba, Yusuke Ogoshi, Hidejiro Torigoe, Hiroki Sato, Hiromasa Yamamoto, Junichi Soh, Toshiyoshi Fujiwara, Shinichi Toyooka
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4776.
DOI: https://doi.org/10.1158/1538-7445.AM2018-4776
Published: 01 July 2018
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Journal Articles

Abstract 4807: Novel theranostic strategy against peritoneal metastasis of scirrhous gastric cancer: Combination with fluorescence oncolytic adenovirus and chemotherapy

Wataru Ishikawa, Satoru Kikuchi, Hiroshi Tazawa, Toshiaki Ohara, Shinji Kuroda, Kazuhiro Noma, Hiroyuki Kishimoto, Masahiko Nishizaki, Yasuo Urata, Shunsuke Kagawa, Toshiyoshi Fujiwara
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4807.
DOI: https://doi.org/10.1158/1538-7445.AM2018-4807
Published: 01 July 2018
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Journal Articles

Abstract LB-045: Iron depletion suppress the stemness markers and functions of cancer stem cells

Toshiaki Ohara, Yuki Katsura, Kazuhiro Noma, Toru Narusaka, Takuya Kato, Hiroaki Sato, Satoshi Komoto, Yasuko Tomono, Takayuki Ninomiya, Hiroshi Tazawa, Shunsuke Kagawa, Yasuhiro Shirakawa, Toshiyoshi Fujiwara
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-045.
DOI: https://doi.org/10.1158/1538-7445.AM2018-LB-045
Published: 01 July 2018
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Abstract 5915: Overexpression of tumor suppressor p53 gene by oncolytic adenovirus boosts immune responses in human pancreatic ductal adenocarcinoma cells

Hiroyuki Araki, Hiroshi Tazawa, Takeshi Ieda, Takuro Fushimi, Shinji Kuroda, Ryuichi Yoshida, Hiroyuki Kishimoto, Masahiko Nishizaki, Yasuo Urata, Shunsuke Kagawa, Toshiyoshi Fujiwara
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5915.
DOI: https://doi.org/10.1158/1538-7445.AM2018-5915
Published: 01 July 2018
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Abstract 4570: Telomerase-specific oncolytic virotherapy promotes therapeuticefficacy of PD-1 blockade in murine osteosarcoma

Yusuke Mochizuki, Hiroshi Tazawa, Koji Demiya, Tadashi Komatsubara, Kazuhisa Sugiu, Joe Hasei, Toshiyuki Kunisada, Yasuo Urata, Toshifumi Ozaki, Toshiyoshi Fujiwara
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4570.
DOI: https://doi.org/10.1158/1538-7445.AM2018-4570
Published: 01 July 2018
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