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Journal Articles

Abstract 1967: Plexin-B2 mediates tumor cell clustering with monocyte interactions in breast cancer metastasis

Free
Emma Schuster, Nurmaa Dashzeveg, Fangjia Tong, Yuzhi Jia, Lamiaa El-Shennawy, Tong Zhang, Andrew Hoffmann, Kibria Golam, Youbin Zhang, Joshua Squires, Erika Ramos, Rokana Taftaf, David Scholten, Hannah Almubarak, Valery Adorno-Cruz, David Sullivan, Carolina Reduzzi, Allegra Minor, William Purev-Ochir, Rong Xu, Kalliopi Siziopikou, Leonidas Plantanias, Ami Shah, William Muller, William Gradishar, Chia-Feng Tsai, Tujin Shi, Huiping Liu
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 1967.
https://doi.org/10.1158/1538-7445.AM2025-1967
Published: 21 April 2025
View article titled, Abstract 1967: Plexin-B2 mediates tumor cell clustering with monocyte interactions in breast cancer metastasis
Journal Articles

Abstract 2371: BGB-B167, a first-in-class 4-1BB/CEACAM5 bispecific antibody, exhibits potent in vitro and < for vivo antitumor activity and < for superior safety profile in preclinical models

Free
Zhuo Li, Liang Qu, Xin Chen, Liu Xue, Jie Li, Qi Liu, Jian Sun, Hanzi Sun, Yun Chen, Yuanyuan Xie, Wanyi Wang, Lin Zhu, Penghao Wang, Xiaosui Zhou, Hongjia Hou, Jie Chen, Xinyi Liu, Yilu Zhang, Ning Liu, Xinyi Liang, Shuo Zhang, Xiaoyan Tang, Jing Song, Tong Zhang, Xiaomin Song, Xuesong Liu, Kang Li, Chichi Huang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2371.
https://doi.org/10.1158/1538-7445.AM2024-2371
Published: 22 March 2024
View article titled, Abstract 2371: BGB-B167, a first-in-class 4-1BB/CEACAM5 bispecific antibody, exhibits potent in vitro and &amp;lt; for vivo antitumor activity and &amp;lt; for superior safety profile in preclinical models
Journal Articles

Abstract CT206: A phase I study of binimetinib, a MEK inhibitor, in combination with pembrolizumab in patients with advanced non-small cell lung cancer (NSCLC)

Free
Christopher F. Theriau, Jamie Feng, Lawson Eng, Frances A. Shepherd, Mary DeCarolis, Vivian Glenns, Swati Kulkarni, Rachel VanderMeer, Urszula Zurawska-Fortin, Desiree Hao, Lisa Le, Isabel Wozniczka, Aida Al-Kindy, Danny Xie, Tong Zhang, Vasanth Subramanian, Tracy Stockley, Penelope A. Bradbury, Geoffrey Liu, Natasha B. Leighl
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT206.
https://doi.org/10.1158/1538-7445.AM2023-CT206
Published: 14 April 2023
View article titled, Abstract CT206: A phase I study of binimetinib, a MEK inhibitor, in combination with pembrolizumab in patients with advanced non-small cell lung cancer (NSCLC)
Journal Articles

Abstract 4434: A PD-1-targeted, receptor-masked IL-2 immunocytokine with maintained potential to engage endogenous IL-2Ra drives selective stimulation of PD-1+ T cells and robust anti-tumor efficacy

Free
Jiaxi Wu, Nicolin Bloch, Aaron Chang, Ramandeep Bhavsar, Supriya Patel, Qingqing Wang, Hassan Shakil Ahmed, Vidur Garg, Michael Amatulli, Yuetian Yan, Shunhai Wang, Drew Dudgeon, Willy Ramos, Pamela Krueger, Ashique Rafique, Tammy Huang, Erica Ullman, Aynur Hermann, William Olson, John Lin, Eric Smith, Tong Zhang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4434.
https://doi.org/10.1158/1538-7445.AM2023-4434
Published: 04 April 2023
View article titled, Abstract 4434: A PD-1-targeted, receptor-masked IL-2 immunocytokine with maintained potential to engage endogenous IL-2Ra drives selective stimulation of PD-1+ T cells and robust anti-tumor efficacy
Journal Articles

Cyclocreatine Suppresses Creatine Metabolism and Impairs Prostate Cancer Progression

Open Access
Rachana Patel, Catriona A. Ford, Lisa Rodgers, Linda K. Rushworth, Janis Fleming, Ernest Mui, Tong Zhang, David Watson, Victoria Lynch, Gillian Mackay, David Sumpton, Owen J. Sansom, Johan Vande Voorde, Hing Y. Leung
Journal: Cancer Research
Cancer Res (2022) 82 (14): 2565–2575.
https://doi.org/10.1158/0008-5472.CAN-21-1301
Published: 18 July 2022
View article titled, Cyclocreatine Suppresses Creatine Metabolism and Impairs Prostate Cancer Progression
Open the PDF for Cyclocreatine Suppresses Creatine Metabolism and Impairs Prostate Cancer Progression in another window
Includes: Supplementary data
Journal Articles

Assessment of Tumor Redox Status through (S)-4-(3-[18F]fluoropropyl)-L-Glutamic Acid PET Imaging of System xc− Activity

Available to Purchase
Patrick N. McCormick, Hannah E. Greenwood, Matthias Glaser, Oliver D.K. Maddocks, Thibault Gendron, Kerstin Sander, Gayatri Gowrishankar, Aileen Hoehne, Tong Zhang, Adam J. Shuhendler, David Y. Lewis, Mathias Berndt, Norman Koglin, Mark F. Lythgoe, Sanjiv S. Gambhir, Erik Årstad, Timothy H. Witney
Journal: Cancer Research
Cancer Res (2019) 79 (4): 853–863.
https://doi.org/10.1158/0008-5472.CAN-18-2634
Published: 15 February 2022
View article titled, Assessment of Tumor Redox Status through (S)-4-(3-[18F]fluoropropyl)-L-Glutamic Acid PET Imaging of System xc− Activity
Open the PDF for Assessment of Tumor Redox Status through (S)-4-(3-[18F]fluoropropyl)-L-Glutamic Acid PET Imaging of System xc− Activity in another window
Includes: Multimedia, Supplementary data
Journal Articles

Abstract 1854: A Fc-competent anti-human TIGIT blocking antibody BGB-A1217 elicits strong immune responses and potent anti-tumor efficacy in pre-clinical models

Free
Xin Chen, Liu Xue, Xiao Ding, Qi Liu, Jing Zhang, Lei Jiang, Sha Liu, Hongjia Hou, Qing Zhu, Bin Jiang, Lijie Zhang, Xiaosui Zhou, Jie Ma, Yucheng Li, Wei Jin, Min Wei, Zhirong Shen, Mike Liu, Kang Li, Tong Zhang
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1854.
https://doi.org/10.1158/1538-7445.AM2021-1854
Published: 01 July 2021
View article titled, Abstract 1854: A Fc-competent anti-human TIGIT blocking antibody BGB-A1217 elicits strong immune responses and potent anti-tumor efficacy in pre-clinical models
Journal Articles

Hypoxia-Induced Suppression of Alternative Splicing of MBD2 Promotes Breast Cancer Metastasis via Activation of FZD1

Available to Purchase
Zhaoji Liu, Linchong Sun, Yongping Cai, Shengqi Shen, Tong Zhang, Nana Wang, Gongwei Wu, Wenhao Ma, Shi-Ting Li, Caixia Suo, Yijie Hao, Wei-Dong Jia, Gregg L. Semenza, Ping Gao, Huafeng Zhang
Journal: Cancer Research
Cancer Res (2021) 81 (5): 1265–1278.
https://doi.org/10.1158/0008-5472.CAN-20-2876
Published: 01 March 2021
View article titled, Hypoxia-Induced Suppression of Alternative Splicing of MBD2 Promotes Breast Cancer Metastasis via Activation of FZD1
Open the PDF for Hypoxia-Induced Suppression of Alternative Splicing of MBD2 Promotes Breast Cancer Metastasis via Activation of FZD1 in another window
Includes: Supplementary data
Journal Articles

Abstract 5626: Investigation of T cell activation by anti-human PD-1 antibodies Nivolumab, Pembrolizumab and BGB-A317 using tumor-infiltrating lymphocytes (TILs) from colorectal cancer and colorectal liver metastasis patients

Free
Lusong Luo, Xiaoran Wu, Tong Zhang, Chunyan Fu, Yanjuan Zhang, Amy Guo, Dongping Zhou, Lianhai Zhang, Kun Wang, Baocai Xing, Jiafu Ji, Lai Wang, Kang Li
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5626.
https://doi.org/10.1158/1538-7445.AM2017-5626
Published: 01 July 2017
View article titled, Abstract 5626: Investigation of T cell activation by anti-human PD-1 antibodies Nivolumab, Pembrolizumab and BGB-A317 using tumor-infiltrating lymphocytes (TILs) from colorectal cancer and colorectal liver metastasis patients
Journal Articles

Abstract 2628: BGB-A425: a humanized anti-human Tim-3 antibody that exhibits strong immune cell activation

Free
Tong Zhang, Liu Xue, Jing Zhang, Qi Liu, Jie Ma, Yi Zhang, Yingdi Shi, Hongjia Hou, Hao Peng, Ning Liu, Yilu Zhang, Xiaomin Song, Yucheng Li, Jing Song, Lai Wang, Min Wei, Kang Li
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2628.
https://doi.org/10.1158/1538-7445.AM2017-2628
Published: 01 July 2017
View article titled, Abstract 2628: BGB-A425: a humanized anti-human Tim-3 antibody that exhibits strong immune cell activation
Journal Articles

Abstract 2226: Anti-human PD-1 antibody BGB-A317 exhibits potent immune cell activation

Free
Tong Zhang, Jing Song, Yucheng Li, Jie Ma, Yingdi Shi, Xiaoran Wu, Lanlan Xu, Qi Liu, Yanping Cao, Yali Wang, Hao Peng, Hongjia Hou, Xu Zhao, Xiaomin Song, Lai Wang, Min Wei, Lusong Luo, Kang Li
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2226.
https://doi.org/10.1158/1538-7445.AM2016-2226
Published: 15 July 2016
View article titled, Abstract 2226: Anti-human PD-1 antibody BGB-A317 exhibits potent immune cell activation
Journal Articles

Abstract 5002: Anti-tumor activity of a novel anti-human PD-1 antibody BGB-A317 in mouse models

Free
Xiaomin Song, Zhiyu Tang, Tong Zhang, Mingming Guo, Wenfeng Gong, Yong Liu, Ningning Zhang, Yilu Zhang, Yanjuan Zhang, Jie Ma, Jing Song, Kang Li, Lai Wang
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 5002.
https://doi.org/10.1158/1538-7445.AM2016-5002
Published: 15 July 2016
View article titled, Abstract 5002: Anti-tumor activity of a novel anti-human PD-1 antibody BGB-A317 in mouse models
Journal Articles

Abstract 4765: Impact of TP53 status and functional classification on molecular profiles in breast cancer subtypes

Free
Swati Garg, Mahadeo A. Sukhai, Maksym Misyura, Mariam Thomas, Tong Zhang, Lillian L. Siu, Philippe L. Bedard, Tracy L. Stockley, Suzanne Kamel-Reid
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4765.
https://doi.org/10.1158/1538-7445.AM2016-4765
Published: 15 July 2016
View article titled, Abstract 4765: Impact of TP53 status and functional classification on molecular profiles in breast cancer subtypes
Journal Articles

Abstract A2-38: Interpretation and classification system for somatic variants identified in solid tumor molecular profiling

Free
Mahadeo A. Sukhai, Mariam Thomas, Kenneth J. Craddock, Tong Zhang, Tracy L. Stockley, Suzanne Kamel-Reid
Journal: Cancer Research
Cancer Res (2015) 75 (22_Supplement_1): A2-38.
https://doi.org/10.1158/1538-7445.TRANSCAGEN-A2-38
Published: 15 November 2015
View article titled, Abstract A2-38: Interpretation and classification system for somatic variants identified in solid tumor molecular profiling
Journal Articles

Abstract A1-25: Intratumor heterogeneity in never-smoker Asian EGFR mutant lung adenocarcinoma

Free
Rahul Nahar, Weiwei Zhai, Angela Takano, Alexis Jiaying Khng, Xingliang Liu, Chong Hee Lim, Audrey S.M. Teo, Cheryl Xueli Chan, Apoorva Gogna, Kiat-Hon Lim, Tina Koh, Huay Mei Poh, Yin Yeng Lee, Liang He Chen, Tong Zhang, Vidhya Gomathi Krishnan, N Gopalakrishna Iyer, Pauline Ng, Wan Teck Lim, Bing Lim, Eng-Huat Tan, Daniel S.W. Tan, Axel M. Hillmer
Journal: Cancer Research
Cancer Res (2015) 75 (22_Supplement_1): A1-25.
https://doi.org/10.1158/1538-7445.TRANSCAGEN-A1-25
Published: 15 November 2015
View article titled, Abstract A1-25: Intratumor heterogeneity in never-smoker Asian EGFR mutant lung adenocarcinoma
Journal Articles

Abstract B2-54: Intratumor heterogeneity in never-smoker Asian EGFR mutant lung adenocarcinoma

Free
Rahul Nahar, Weiwei Zhai, Angela Takano, Alexis Jiaying Khng, Xingliang Liu, Chong Hee Lim, Audrey S.M. Teo, Cheryl Xueli Chan, Apoorva Gogna, Kiat-Hon Lim, Tina Koh, Huay Mei Poh, Yin Yeng Lee, Liang He Chen, Tong Zhang, Vidhya Gomathi Krishnan, N Gopalakrishna Iyer, Pauline Ng, Wan Teck Lim, Bing Lim, Eng-Huat Tan, Daniel S.W. Tan, Axel M. Hillmer
Journal: Cancer Research
Cancer Res (2015) 75 (22_Supplement_2): B2-54.
https://doi.org/10.1158/1538-7445.COMPSYSBIO-B2-54
Published: 15 November 2015
View article titled, Abstract B2-54: Intratumor heterogeneity in never-smoker Asian EGFR mutant lung adenocarcinoma
Journal Articles

Abstract 4260: Clinical testing and implementation of the TruSight Myeloid Next Generation Sequencing (NGS) panel for identification of clinically relevant variants in hematological malignancies

Free
Mariam Thomas, Mahadeo Sukhai, Tong Zhang, Djamel Harbi, Justin De Souza, Katherine MacDonald, Trevor Pugh, Mark Minden, Andre Schuh, Tracy L. Stockley, Suzanne Kamel-Reid
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4260.
https://doi.org/10.1158/1538-7445.AM2015-4260
Published: 01 August 2015
View article titled, Abstract 4260: Clinical testing and implementation of the TruSight Myeloid Next Generation Sequencing (NGS) panel for identification of clinically relevant variants in hematological malignancies
Journal Articles

Abstract 615: Noninvasive diagnosis of actionable mutations by deep sequencing of circulating tumor DNA in multiple myeloma

Free
Rayan Kaedbey, Olena Kis, Arnavaz Danesh, Mark Dowar, Tiantian Li, Zhihua Li, Jessica Liu, Mark Mansour, Mahadeo Sukhai, Tong Zhang, Suzanne Kamel-Reid, Trevor J. Pugh, Suzanne Trudel
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 615.
https://doi.org/10.1158/1538-7445.AM2015-615
Published: 01 August 2015
View article titled, Abstract 615: Noninvasive diagnosis of actionable mutations by deep sequencing of circulating tumor DNA in multiple myeloma
Journal Articles

Abstract 628: Determinants of quality of next-generation sequencing output from the strand-specific TruSight Tumor Sequencing Panel in a clinical diagnostic setting

Free
Swati Garg, Mahadeo A. Sukhai, Mariam Thomas, Michelle Mah, Tong Zhang, Trevor Pugh, Suzanne Kamel-Reid, Tracey L. Stockley
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 628.
https://doi.org/10.1158/1538-7445.AM2015-628
Published: 01 August 2015
View article titled, Abstract 628: Determinants of quality of next-generation sequencing output from the strand-specific TruSight Tumor Sequencing Panel in a clinical diagnostic setting
Journal Articles

Abstract 4713: High-throughput multiplex Sequenom MassARRAY clinical diagnostic assay for the identification of actionable genetic variants in hematologic malignancies

Free
Mahadeo A. Sukhai, Mariam Thomas, Tong Zhang, Cuihong Wei, Suzanne Trudel, Karen Yee, Mark D. Minden, Andre Schuh, Tracy Stockley, Suzanne Kamel-Reid
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4713.
https://doi.org/10.1158/1538-7445.AM2014-4713
Published: 01 October 2014
View article titled, Abstract 4713: High-throughput multiplex Sequenom MassARRAY clinical diagnostic assay for the identification of actionable genetic variants in hematologic malignancies