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Tona M. Gilmer
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Journal Articles

Abstract LB181: First disclosure of XRD-0394, a novel dual ATM/DNA-PK inhibitor, that potently radiosensitizes and potentiates PARP and topoisomerase inhibitors

Tona M. Gilmer, Chun-Hsiang Lai, Kexiao Guo, Katherine Deland, Kathleen A. Ashcraft, Amy E. Stewart, Yaode Wang, Jianmin Fu, Kris C. Wood, Deborah A. Smith, Jonathan T. Yang, Christopher T. Chen, Michael F. Gensheimer, Paul B. Romesser, Steven H. Lin, David G. Kirsch, Michael B. Kastan
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB181.
https://doi.org/10.1158/1538-7445.AM2024-LB181
Published: 05 April 2024
View articletitled, Abstract LB181: First disclosure of XRD-0394, a novel dual ATM/DNA-PK inhibitor, that potently radiosensitizes and potentiates PARP and topoisomerase inhibitors
Journal Articles

Abstract 976: BRAF inhibitor GSK2118436 - single agent and combination activity with other targeted agents in BRAF V600 mutant melanoma

James G. Greger, Stephen D. Eastman, Hong Shi, Vivian Zhang, Ashley Hughes, Li Liu, Tona M. Gilmer
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 976.
https://doi.org/10.1158/1538-7445.AM2012-976
Published: 15 April 2012
View articletitled, Abstract 976: BRAF inhibitor GSK2118436 - single agent and combination activity with other targeted agents in BRAF V600 mutant melanoma
Journal Articles

Abstract 4834: Basement membrane localized tumor cells are protected from HER2-targeted therapy in vivo

Jason J. Zoeller, Roderick T. Bronson, Tona M. Gilmer, Laura M. Selfors, Yiling Lu, Gordon B. Mills, Joan S. Brugge
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4834.
https://doi.org/10.1158/1538-7445.AM2012-4834
Published: 15 April 2012
View articletitled, Abstract 4834: Basement membrane localized tumor cells are protected from HER2-targeted therapy in vivo
Journal Articles

Abstract 1592: Targeting proliferative signals in patient-derived pancreatic cancers propagated orthotopically in immunocompromised mice

Dustin M. Walters, Catharine R. Cowan, Sara J. Adair, Cheryl A. Borgman, Jayme B. Stokes, Edward B. Stelow, Bryce T. Lowrey, Tona M. Gilmer, J. Thomas Parsons, Todd W. Bauer
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 1592.
https://doi.org/10.1158/1538-7445.AM2011-1592
Published: 15 April 2011
View articletitled, Abstract 1592: Targeting proliferative signals in patient-derived pancreatic cancers propagated orthotopically in immunocompromised mice
Journal Articles

Abstract 673: Novel anti-tumor activity of lapatinib derives from off-target up-regulation of TRAIL death receptors

Nathan G. Dolloff, Lori S. Hart, Patrick A. Mayes, David T. Dicker, Robin C. Humphreys, Tona M. Gilmer, Wafik S. El-Deiry
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 673.
https://doi.org/10.1158/1538-7445.AM10-673
Published: 15 April 2010
View articletitled, Abstract 673: Novel anti-tumor activity of lapatinib derives from off-target up-regulation of TRAIL death receptors
Journal Articles

Abstract 1565: Pazopanib reveals B-Raf regulation of anti-angiogenesis pathways and prevents brain metastatic colonization of HER2+ breast cancer cells

Brunilde Gril, Diane Palmieri, Yong Qian, Eleazar Vega-Valle, David J. Liewehr, Seth M. Steinberg, Tona M. Gilmer, Rakesh Kumar, Stephen D. Rubin, Patricia S. Steeg
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1565.
https://doi.org/10.1158/1538-7445.AM10-1565
Published: 15 April 2010
View articletitled, Abstract 1565: Pazopanib reveals B-Raf regulation of anti-angiogenesis pathways and prevents brain metastatic colonization of HER2+ breast cancer cells
Journal Articles

Abstract 3627: Inhibition of HER family kinase signaling and tumor cell proliferation in non-EGFR and non-HER2 positive cell lines by lapatinib

James G. Greger, Hong Shi, Li Liu, Tona M. Gilmer
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3627.
https://doi.org/10.1158/1538-7445.AM10-3627
Published: 15 April 2010
View articletitled, Abstract 3627: Inhibition of HER family kinase signaling and tumor cell proliferation in non-EGFR and non-HER2 positive cell lines by lapatinib
Journal Articles

Novel Mechanism of Lapatinib Resistance in HER2-Positive Breast Tumor Cells: Activation of AXL

Li Liu, James Greger, Hong Shi, Yuan Liu, Joel Greshock, Roland Annan, Wendy Halsey, Ganesh M. Sathe, Anne-Marie Martin, Tona M. Gilmer
Journal: Cancer Research
Cancer Res (2009) 69 (17): 6871–6878.
https://doi.org/10.1158/0008-5472.CAN-08-4490
Published: 31 August 2009
View articletitled, Novel Mechanism of Lapatinib Resistance in HER2-Positive Breast Tumor Cells: Activation of AXL
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Includes: Supplementary data
Journal Articles

Characterization of an Akt Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity

Nelson Rhodes, Dirk A. Heerding, Derek R. Duckett, Derek J. Eberwein, Victoria B. Knick, Timothy J. Lansing, Randy T. McConnell, Tona M. Gilmer, Shu-Yun Zhang, Kimberly Robell, Jason A. Kahana, Robert S. Geske, Elena V. Kleymenova, Anthony E. Choudhry, Zhihong Lai, Jack D. Leber, Elisabeth A. Minthorn, Susan L. Strum, Edgar R. Wood, Pearl S. Huang, Robert A. Copeland, Rakesh Kumar
Journal: Cancer Research
Cancer Res (2008) 68 (7): 2366–2374.
https://doi.org/10.1158/0008-5472.CAN-07-5783
Published: 01 April 2008
View articletitled, Characterization of an Akt Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity
Open the PDF for Characterization of an Akt Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity in another window
Includes: Supplementary data
Journal Articles

Impact of Common Epidermal Growth Factor Receptor and HER2 Variants on Receptor Activity and Inhibition by Lapatinib

Tona M. Gilmer, Louann Cable, Krystal Alligood, David Rusnak, Glenn Spehar, Kathleen T. Gallagher, Ermias Woldu, H. Luke Carter, Anne T. Truesdale, Lisa Shewchuk, Edgar R. Wood
Journal: Cancer Research
Cancer Res (2008) 68 (2): 571–579.
https://doi.org/10.1158/0008-5472.CAN-07-2404
Published: 15 January 2008
View articletitled, Impact of Common Epidermal Growth Factor Receptor and HER2 Variants on Receptor Activity and Inhibition by Lapatinib
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Includes: Supplementary data
Journal Articles

Activity of the Dual Kinase Inhibitor Lapatinib (GW572016) against HER-2-Overexpressing and Trastuzumab-Treated Breast Cancer Cells

Gottfried E. Konecny, Mark D. Pegram, Natarajan Venkatesan, Richard Finn, Guorong Yang, Martina Rahmeh, Michael Untch, David W. Rusnak, Glenn Spehar, Robert J. Mullin, Barry R. Keith, Tona M. Gilmer, Mark Berger, Karl C. Podratz, Dennis J. Slamon
Journal: Cancer Research
Cancer Res (2006) 66 (3): 1630–1639.
https://doi.org/10.1158/0008-5472.CAN-05-1182
Published: 01 February 2006
View articletitled, Activity of the Dual Kinase Inhibitor Lapatinib (GW572016) against HER-2-Overexpressing and Trastuzumab-Treated Breast Cancer Cells
Open the PDF for Activity of the Dual Kinase Inhibitor Lapatinib (GW572016) against HER-2-Overexpressing and Trastuzumab-Treated Breast Cancer Cells in another window
Journal Articles

A Unique Structure for Epidermal Growth Factor Receptor Bound to GW572016 (Lapatinib): Relationships among Protein Conformation, Inhibitor Off-Rate, and Receptor Activity in Tumor Cells

Edgar R. Wood, Anne T. Truesdale, Octerloney B. McDonald, Derek Yuan, Anne Hassell, Scott H. Dickerson, Byron Ellis, Christopher Pennisi, Earnest Horne, Karen Lackey, Krystal J. Alligood, David W. Rusnak, Tona M. Gilmer, Lisa Shewchuk
Journal: Cancer Research
Cancer Res (2004) 64 (18): 6652–6659.
https://doi.org/10.1158/0008-5472.CAN-04-1168
Published: 16 September 2004
View articletitled, A Unique Structure for Epidermal Growth Factor Receptor Bound to GW572016 (Lapatinib): Relationships among Protein Conformation, Inhibitor Off-Rate, and Receptor Activity in Tumor Cells
Open the PDF for A Unique Structure for Epidermal Growth Factor Receptor Bound to GW572016 (Lapatinib): Relationships among Protein Conformation, Inhibitor Off-Rate, and Receptor Activity in Tumor Cells in another window
Journal Articles

Synergistic induction of apoptosis between GW572016 and inhibitors of phosphatidylinositol 3-kinase/AKT pathway

Robert L. Tansik, Sara C. Singer, Steven L. Knapp, Nelson Rhodes, Tona M. Gilmer, Inderjit K. Dev
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 1076.
Published: 01 April 2004
View articletitled, Synergistic induction of apoptosis between GW572016 and inhibitors of phosphatidylinositol 3-kinase/AKT pathway
Journal Articles

The Characterization of Novel, Dual ErbB-2/EGFR, Tyrosine Kinase Inhibitors: Potential Therapy for Cancer

David W. Rusnak, Karen Affleck, Stuart G. Cockerill, Colin Stubberfield, Robert Harris, Martin Page, Kathryn J. Smith, Stephen B. Guntrip, Malcolm C. Carter, Robert J. Shaw, Amanda Jowett, Jeremy Stables, Peter Topley, Edgar R. Wood, Perry S. Brignola, Sue H. Kadwell, Bryan R. Reep, Robert J. Mullin, Krystal J. Alligood, Barry R. Keith, Renae M. Crosby, Doris M. Murray, W. Blaine Knight, Tona M. Gilmer, Karen Lackey
Journal: Cancer Research
Cancer Res (2001) 61 (19): 7196–7203.
Published: 01 October 2001
View articletitled, The Characterization of Novel, Dual ErbB-2/EGFR, Tyrosine Kinase Inhibitors: Potential Therapy for Cancer
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Journal Articles

Mutational Activation of pp60c-src Leads to a Tumorigenic Phenotype in a Preneoplastic Syrian Hamster Embryo Cell Line

Timothy J. Lansing, Bartel F. Turk, Steven B. Kanner, Tona M. Gilmer
Journal: Cancer Research
Cancer Res (1997) 57 (10): 1962–1969.
Published: 01 May 1997
View articletitled, Mutational Activation of pp60c-src Leads to a Tumorigenic Phenotype in a Preneoplastic Syrian Hamster Embryo Cell Line
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Journal Articles

Separate Pathways for p53 Induction by Ionizing Radiation and N-(Phosphonoacetyl)-l-aspartate1

Chaw-Yuan M. Chen, Ingrid Hall, Timothy J. Lansing, Tona M. Gilmer, Thea D. Tlsty, Michael B. Kastan
Journal: Cancer Research
Cancer Res (1996) 56 (16): 3659–3662.
Published: 01 August 1996
View articletitled, Separate Pathways for p53 Induction by Ionizing Radiation and N-(Phosphonoacetyl)-l-aspartate1
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Journal Articles

Correlation of V-src Gene Amplification with the Tumorigenic Phenotype in a Syrian Hamster Embryo Cell Line

Tona M. Gilmer, Pattie W. Lamb, Mitsuo Oshimura, J. Carl Barrett
Journal: Cancer Research
Cancer Res (1987) 47 (17): 4663–4666.
Published: 01 September 1987
View articletitled, Correlation of V-src Gene Amplification with the Tumorigenic Phenotype in a Syrian Hamster Embryo Cell Line
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Journal Articles

Evidence for Multiple Steps in Neoplastic Transformation of Normal and Preneoplastic Syrian Hamster Embryo Cells following Transfection with Harvey Murine Sarcoma Virus Oncogene (v-Ha-ras)

David G. Thomassen, Tona M. Gilmer, Lois A. Annab, J. Carl Barrett
Journal: Cancer Research
Cancer Res (1985) 45 (2): 726–732.
Published: 01 February 1985
View articletitled, Evidence for Multiple Steps in Neoplastic Transformation of Normal and Preneoplastic Syrian Hamster Embryo Cells following Transfection with Harvey Murine Sarcoma Virus Oncogene (v-Ha-ras)
Open the PDF for Evidence for Multiple Steps in Neoplastic Transformation of Normal and Preneoplastic Syrian Hamster Embryo Cells following Transfection with Harvey Murine Sarcoma Virus Oncogene (v-Ha-ras) in another window