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Tomoaki Takakura
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Journal Articles

Physicochemical and Pharmacokinetic Characterization of Highly Potent Recombinant l-Methionine γ-Lyase Conjugated with Polyethylene Glycol as an Antitumor Agent

Tomoaki Takakura, Akio Takimoto, Yoshihide Notsu, Hiroshi Yoshida, Takaomi Ito, Hirofumi Nagatome, Masahiro Ohno, Yoshinao Kobayashi, Takayuki Yoshioka, Kenji Inagaki, Shigeo Yagi, Robert M. Hoffman, Nobuyoshi Esaki
Journal: Cancer Research
Cancer Res (2006) 66 (5): 2807–2814.
https://doi.org/10.1158/0008-5472.CAN-05-3910
Published: 01 March 2006
View article titled, Physicochemical and Pharmacokinetic Characterization of Highly Potent Recombinant <sc>l</sc>-Methionine γ-Lyase Conjugated with Polyethylene Glycol as an Antitumor Agent
Open the PDF for Physicochemical and Pharmacokinetic Characterization of Highly Potent Recombinant <sc>l</sc>-Methionine γ-Lyase Conjugated with Polyethylene Glycol as an Antitumor Agent in another window
Journal Articles

PEGylation confers greatly extended half-life and attenuated immunogenicity to recombinant methioninase in primates

Zhijian Yang, Junhua Wang, Quan Lu, Jinbao Xu, Yoshinao Kobayashi, Tomoaki Takakura, Akio Takimoto, Takayuki Yoshioka, Changgen Lian, Chunmei Chen, Dongdong Zhang, Ying Zhang, Shukuan Li, Xinghua Sun, Yuying Tan, Shigeo Yagi, Eugene P. Frenkel, Robert M. Hoffman
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 329.
Published: 01 May 2005
View article titled, PEGylation confers greatly extended half-life and attenuated immunogenicity to recombinant methioninase in primates
Journal Articles

PEGylation Confers Greatly Extended Half-Life and Attenuated Immunogenicity to Recombinant Methioninase in Primates

Zhijian Yang, Junhua Wang, Quan Lu, Jinbao Xu, Yoshinao Kobayashi, Tomoaki Takakura, Akio Takimoto, Takayuji Yoshioka, Changgen Lian, Chunmei Chen, Dongdong Zhang, Ying Zhang, Shukuan Li, Xinghua Sun, Yuying Tan, Shigeo Yagi, Eugene P. Frenkel, Robert M. Hoffman
Journal: Cancer Research
Cancer Res (2004) 64 (18): 6673–6678.
https://doi.org/10.1158/0008-5472.CAN-04-1822
Published: 16 September 2004
View article titled, PEGylation Confers Greatly Extended Half-Life and Attenuated Immunogenicity to Recombinant Methioninase in Primates
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Journal Articles

Circulating Half-Life of PEGylated Recombinant Methioninase Holoenzyme Is Highly Dose Dependent on Cofactor Pyridoxal-5′-Phosphate

Zhijian Yang, Xinghua Sun, Shukuan Li, Yuying Tan, Xiaoen Wang, Nan Zhang, Shigeo Yagi, Tomoaki Takakura, Yoshinao Kobayashi, Akio Takimoto, Takayuki Yoshioka, Akinori Suginaka, Eugene P. Frenkel, Robert M. Hoffman
Journal: Cancer Research
Cancer Res (2004) 64 (16): 5775–5778.
https://doi.org/10.1158/0008-5472.CAN-04-1406
Published: 16 August 2004
View article titled, Circulating Half-Life of PEGylated Recombinant Methioninase Holoenzyme Is Highly Dose Dependent on Cofactor Pyridoxal-5′-Phosphate
Open the PDF for Circulating Half-Life of PEGylated Recombinant Methioninase Holoenzyme Is Highly Dose Dependent on Cofactor Pyridoxal-5′-Phosphate in another window