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Tomasz Skorski
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Journal Articles

R-Loop Accumulation in Spliceosome Mutant Leukemias Confers Sensitivity to PARP1 Inhibition by Triggering Transcription–Replication Conflicts

Zhiyan Silvia Liu, Sayantani Sinha, Maxwell Bannister, Axia Song, Erica Arriaga-Gomez, Alexander J. McKeeken, Elizabeth A. Bonner, Benjamin K. Hanson, Martina Sarchi, Kouhei Takashima, Dawei Zong, Victor M. Corral, Evan Nguyen, Jennifer Yoo, Wannasiri Chiraphapphaiboon, Cassandra Leibson, Matthew C. McMahon, Sumit Rai, Elizabeth M. Swisher, Zohar Sachs, Srinivas Chatla, Derek L. Stirewalt, H. Joachim Deeg, Tomasz Skorski, Eirini P. Papapetrou, Matthew J. Walter, Timothy A. Graubert, Sergei Doulatov, Stanley C. Lee, Hai Dang Nguyen
Journal: Cancer Research
Cancer Res (2024) 84 (4): 577–597.
https://doi.org/10.1158/0008-5472.CAN-23-3239
Published: 15 February 2024
View article titled, R-Loop Accumulation in Spliceosome Mutant Leukemias Confers Sensitivity to PARP1 Inhibition by Triggering Transcription–Replication Conflicts
Open the PDF for R-Loop Accumulation in Spliceosome Mutant Leukemias Confers Sensitivity to PARP1 Inhibition by Triggering Transcription–Replication Conflicts in another window
Includes: Supplementary data
Journal Articles

Abstract A022: Poly (ADP-Ribose) glycohydrolase (PARG) removes repressive Poly-ADP Ribose marks from DNA polymerase theta (polq) to stimulate DNA double-strand breaks repair in myeloid malignancies

Umeshkumar Vekariya, Leonid Minakhin, Mrityunjay Tyagi, Tatiana Kent, Gurushankar Chandramouly, Katherine Sullivan-Reed, Jessica Atkins, Margaret Nieborowska-Skorska, Anna-Mariya Kukuyan, Richard Pomerantz, Tomasz Skorski
Journal: Cancer Research
Cancer Res (2024) 84 (1_Supplement): A022.
https://doi.org/10.1158/1538-7445.DNAREPAIR24-A022
Published: 09 January 2024
View article titled, Abstract A022: Poly (ADP-Ribose) glycohydrolase (PARG) removes repressive Poly-ADP Ribose marks from DNA polymerase theta (polq) to stimulate DNA double-strand breaks repair in myeloid malignancies
Journal Articles

Abstract 1694: Loss ofZNF251stimulates NHEJ resulting in PARP inhibitor resistance inBRCA1-mutated cancer cells

Jian Huang, Tomasz Skorski
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1694.
https://doi.org/10.1158/1538-7445.AM2023-1694
Published: 04 April 2023
View article titled, Abstract 1694: Loss of<em>ZNF251</em>stimulates NHEJ resulting in PARP inhibitor resistance in<em>BRCA1</em>-mutated cancer cells
Journal Articles

Abstract 823: ABL1 kinase regulates leukemia phenotype and response to therapy

Konstantin Golovine, Zhaorui Lian, Kumaraswamy Naidu Chitrala, Gleb Ablakov, Margaret Nieborowska-Skorska, Jian Huang, Tomasz Skorski
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 823.
https://doi.org/10.1158/1538-7445.AM2022-823
Published: 15 June 2022
View article titled, Abstract 823: ABL1 kinase regulates leukemia phenotype and response to therapy
Journal Articles

TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors

Silvia Maifrede, Bac Viet Le, Margaret Nieborowska-Skorska, Konstantin Golovine, Katherine Sullivan-Reed, Wangisa M.B. Dunuwille, Joseph Nacson, Michael Hulse, Kelsey Keith, Jozef Madzo, Lisa Beatrice Caruso, Zachary Gazze, Zhaorui Lian, Antonella Padella, Kumaraswamy N. Chitrala, Boris A. Bartholdy, Ksenia Matlawska-Wasowska, Daniela Di Marcantonio, Giorgia Simonetti, Georg Greiner, Stephen M. Sykes, Peter Valent, Elisabeth M. Paietta, Martin S. Tallman, Hugo F. Fernandez, Mark R. Litzow, Mark D. Minden, Jian Huang, Giovanni Martinelli, George S. Vassiliou, Italo Tempera, Katarzyna Piwocka, Neil Johnson, Grant A. Challen, Tomasz Skorski
Journal: Cancer Research
Cancer Res (2021) 81 (19): 5089–5101.
https://doi.org/10.1158/0008-5472.CAN-20-3761
Published: 01 October 2021
View article titled, <em>TET2</em> and <em>DNMT3A</em> Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors
Open the PDF for <em>TET2</em> and <em>DNMT3A</em> Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors in another window
Includes: Supplementary data
Journal Articles

Imatinib Sensitivity in BCR-ABL1–Positive Chronic Myeloid Leukemia Cells Is Regulated by the Remaining Normal ABL1 Allele

Anna Virgili, Mateusz Koptyra, Yashodhara Dasgupta, Eliza Glodkowska-Mrowka, Tomasz Stoklosa, Elisabeth P. Nacheva, Tomasz Skorski
Journal: Cancer Research
Cancer Res (2011) 71 (16): 5381–5386.
https://doi.org/10.1158/0008-5472.CAN-11-0068
Published: 11 August 2011
View article titled, Imatinib Sensitivity in BCR-ABL1–Positive Chronic Myeloid Leukemia Cells Is Regulated by the Remaining Normal <em>ABL1</em> Allele
Open the PDF for Imatinib Sensitivity in BCR-ABL1–Positive Chronic Myeloid Leukemia Cells Is Regulated by the Remaining Normal <em>ABL1</em> Allele in another window
Includes: Supplementary data
Journal Articles

BCR/ABL Stimulates WRN to Promote Survival and Genomic Instability

Artur Slupianek, Tomasz Poplawski, Stanislaw K. Jozwiakowski, Kimberly Cramer, Dariusz Pytel, Ewelina Stoczynska, Michal O. Nowicki, Janusz Blasiak, Tomasz Skorski
Journal: Cancer Research
Cancer Res (2011) 71 (3): 842–851.
https://doi.org/10.1158/0008-5472.CAN-10-1066
Published: 01 February 2011
View article titled, BCR/ABL Stimulates WRN to Promote Survival and Genomic Instability
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Includes: Supplementary data
Journal Articles

BCR/ABL and Other Kinases from Chronic Myeloproliferative Disorders Stimulate Single-Strand Annealing, an Unfaithful DNA Double-Strand Break Repair

Kimberly Cramer, Margaret Nieborowska-Skorska, Mateusz Koptyra, Artur Slupianek, Emir Tyrone P. Penserga, Connie J. Eaves, Walter Aulitzky, Tomasz Skorski
Journal: Cancer Research
Cancer Res (2008) 68 (17): 6884–6888.
https://doi.org/10.1158/0008-5472.CAN-08-1101
Published: 28 August 2008
View article titled, BCR/ABL and Other Kinases from Chronic Myeloproliferative Disorders Stimulate Single-Strand Annealing, an Unfaithful DNA Double-Strand Break Repair
Open the PDF for BCR/ABL and Other Kinases from Chronic Myeloproliferative Disorders Stimulate Single-Strand Annealing, an Unfaithful DNA Double-Strand Break Repair in another window
Includes: Supplementary data
Journal Articles

BCR/ABL Inhibits Mismatch Repair to Protect from Apoptosis and Induce Point Mutations

Tomasz Stoklosa, Tomasz Poplawski, Mateusz Koptyra, Margaret Nieborowska-Skorska, Grzegorz Basak, Artur Slupianek, Marina Rayevskaya, Ilona Seferynska, Larry Herrera, Janusz Blasiak, Tomasz Skorski
Journal: Cancer Research
Cancer Res (2008) 68 (8): 2576–2580.
https://doi.org/10.1158/0008-5472.CAN-07-6858
Published: 15 April 2008
View article titled, BCR/ABL Inhibits Mismatch Repair to Protect from Apoptosis and Induce Point Mutations
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Includes: Supplementary data
Journal Articles

Id1 Transcription Inhibitor–Matrix Metalloproteinase 9 Axis Enhances Invasiveness of the Breakpoint Cluster Region/Abelson Tyrosine Kinase–Transformed Leukemia Cells

Margaret Nieborowska-Skorska, Grazyna Hoser, Lori Rink, Maciej Malecki, Plamen Kossev, Mariusz A. Wasik, Tomasz Skorski
Journal: Cancer Research
Cancer Res (2006) 66 (8): 4108–4116.
https://doi.org/10.1158/0008-5472.CAN-05-1584
Published: 17 April 2006
View article titled, Id1 Transcription Inhibitor–Matrix Metalloproteinase 9 Axis Enhances Invasiveness of the Breakpoint Cluster Region/Abelson Tyrosine Kinase–Transformed Leukemia Cells
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Journal Articles

Role of Signal Transducer and Activator of Transcription 5 in Nucleophosmin/ Anaplastic Lymphoma Kinase-mediated Malignant Transformation of Lymphoid Cells

Malgorzata Nieborowska-Skorska, Artur Slupianek, Liquan Xue, Qian Zhang, Puthiyaveettil N. Raghunath, Grazyna Hoser, Mariusz A. Wasik, Stephan W. Morris, Tomasz Skorski
Journal: Cancer Research
Cancer Res (2001) 61 (17): 6517–6523.
Published: 01 September 2001
View article titled, Role of Signal Transducer and Activator of Transcription 5 in Nucleophosmin/ Anaplastic Lymphoma Kinase-mediated Malignant Transformation of Lymphoid Cells
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Journal Articles

Role of Phosphatidylinositol 3-Kinase-Akt Pathway in Nucleophosmin/Anaplastic Lymphoma Kinase-mediated Lymphomagenesis

Artur Slupianek, Margaret Nieborowska-Skorska, Grazyna Hoser, Andrea Morrione, Miroslaw Majewski, Liquan Xue, Stephan W. Morris, Mariusz A. Wasik, Tomasz Skorski
Journal: Cancer Research
Cancer Res (2001) 61 (5): 2194–2199.
Published: 01 March 2001
View article titled, Role of Phosphatidylinositol 3-Kinase-Akt Pathway in Nucleophosmin/Anaplastic Lymphoma Kinase-mediated Lymphomagenesis
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Journal Articles

Activation of Mitochondrial Raf-1 Is Involved in the Antiapoptotic Effects of Akt

Miroslaw Majewski, Malgorzata Nieborowska-Skorska, Paolo Salomoni, Artur Slupianek, Krzysztof Reiss, Rossana Trotta, Bruno Calabretta, Tomasz Skorski
Journal: Cancer Research
Cancer Res (1999) 59 (12): 2815–2819.
Published: 15 June 1999
View article titled, Activation of Mitochondrial Raf-1 Is Involved in the Antiapoptotic Effects of Akt
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Journal Articles

c-RAF-1 Serine/Threonine Kinase Is Required in BCR/ABL-dependent and Normal Hematopoiesis

Tomasz Skorski, Malgorzata Nieborowska-Skorska, Cezary Szczylik, Palanisamy Kanakaraj, Danilo Perrotti, Gerald Zon, Alan Gewirtz, Bice Perussia, Bruno Calabretta
Journal: Cancer Research
Cancer Res (1995) 55 (11): 2275–2278.
Published: 01 June 1995
View article titled, c-RAF-1 Serine/Threonine Kinase Is Required in BCR/ABL-dependent and Normal Hematopoiesis
Open the PDF for c-RAF-1 Serine/Threonine Kinase Is Required in BCR/ABL-dependent and Normal Hematopoiesis in another window
Journal Articles

Inhibition of Proliferation by c-myb Antisense RNA and Oligodeoxynucleotides in Transformed Neuroectodermal Cell Lines

Giuseppe Raschellà, Anna Negroni, Tomasz Skorski, Sabina Pucci, Malgorzata Nieborowska-Skorska, Antonino Romeo, Bruno Calabretta
Journal: Cancer Research
Cancer Res (1992) 52 (15): 4221–4226.
Published: 01 August 1992
View article titled, Inhibition of Proliferation by c-<em>myb</em> Antisense RNA and Oligodeoxynucleotides in Transformed Neuroectodermal Cell Lines
Open the PDF for Inhibition of Proliferation by c-<em>myb</em> Antisense RNA and Oligodeoxynucleotides in Transformed Neuroectodermal Cell Lines in another window