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Tomasz Cierpicki
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Journal Articles

Abstract 6286: Targeting Polycomb Repressive Complex 1 with small-molecule inhibitors as a potential therapeutic approach to combat leukemia

Miranda L. Simes, Yiwu Yao, Se Ra Park, Trupta Purohit, Hongzhi Miao, Xiaotian Zhang, Weijiang Ying, Felicia Gray, Shirish Shukla, Qingjie Zhao, Caroline Nikolaidis, Alyssa Winkler, Jolanta Grembecka, Tomasz Cierpicki
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6286.
https://doi.org/10.1158/1538-7445.AM2023-6286
Published: 04 April 2023
View article titled, Abstract 6286: Targeting Polycomb Repressive Complex 1 with small-molecule inhibitors as a potential therapeutic approach to combat leukemia
Journal Articles

Abstract PR001: Mutant NPM1 hijacks transcriptional hub to maintain pathogenic gene programs and block differentiation in acute myeloid leukemia

Xue Qing Wang, Dandan Fan, Yiman Liu, Qinyu Han, Jolanta Grembecka, Tomasz Cierpicki, Jianzhong Su, Shasha Chong, Liling Wan, Xiaotian Zhang
Journal: Cancer Research
Cancer Res (2022) 82 (23_Supplement_2): PR001.
https://doi.org/10.1158/1538-7445.CancEpi22-PR001
Published: 01 December 2022
View article titled, Abstract PR001: Mutant NPM1 hijacks transcriptional hub to maintain pathogenic gene programs and block differentiation in acute myeloid leukemia
Journal Articles

Abstract 3274: Targeting NSD family histone methyltransferase activity with irreversible inhibitors

Christina Howard, Sergei Zari, Shuangjiang Li, Huang Huang, EunGi Kim, Se Ra Park, Trupta Purohit, Hongzhi Miao, Xiaotian Zhang, Caroline Nikolaidis, Hao Li, Juliano Ndoj, HyoJe Cho, Jolanta Grembecka, Tomasz Cierpicki
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3274.
https://doi.org/10.1158/1538-7445.AM2022-3274
Published: 15 June 2022
View article titled, Abstract 3274: Targeting NSD family histone methyltransferase activity with irreversible inhibitors
Journal Articles

Abstract 1373: The role of the ASH1L SET domain in leukemogenesis

David Rogawski, Hongzhi Miao, Katarzyna Kempinska, Lili Chen, Jen Chase, Ann Friedman, Xiaomei Yan, Kenichi Nishioka, Gang Huang, Patricia Ernst, Andy Muntean, Ivan Maillard, Tomasz Cierpicki, Jolanta Grembecka
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1373.
https://doi.org/10.1158/1538-7445.AM2017-1373
Published: 01 July 2017
View article titled, Abstract 1373: The role of the ASH1L SET domain in leukemogenesis
Journal Articles

Abstract 5835: Oncogenic activation of the serine synthesis pathway by the scaffolding protein menin

Laurie Kathleen Svoboda, Selina Shiqing Teh, Sudha Sud, Armand Bankhead, Brian Magnuson, Mats Ljungman, Costas Lyssiotis, Tomasz Cierpicki, Jolanta Grembecka, Elizabeth R. Lawlor
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5835.
https://doi.org/10.1158/1538-7445.AM2017-5835
Published: 01 July 2017
View article titled, Abstract 5835: Oncogenic activation of the serine synthesis pathway by the scaffolding protein menin
Journal Articles

Abstract 5077: A novel small molecule menin-MLL inhibitor for potential treatment of MLL-rearranged leukemias

Tao Wu, Linda Kessler, Shuangwei Li, Trupta Purohit, Shisheng Li, Hongzhi Miao, Brian Linhares, Rasmus Hansen, Jeff Kucharski, Yi Wang, Ke Yu, Katarzyna Kempinska, Tess Ely, Szymon Klossowski, Ata Zarieh, Ulf Peters, Jun Feng, Yvonne Yao, Yuan Liu, Bo Wen, Francis Burrows, Duxin Sun, Jingchuan Zhang, Levan Darjania, Dana Hu-Lowe, Patrick Zarrinkar, Liansheng Li, Tomasz Cierpicki, Jolanta Grembecka, Pingda Ren, Yi Liu
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5077.
https://doi.org/10.1158/1538-7445.AM2017-5077
Published: 01 July 2017
View article titled, Abstract 5077: A novel small molecule menin-MLL inhibitor for potential treatment of MLL-rearranged leukemias
Journal Articles

Abstract SY27-02: Targeting leukemia stem cells with small molecule inhibitors of PRC1

Tomasz Cierpicki
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): SY27-02.
https://doi.org/10.1158/1538-7445.AM2016-SY27-02
Published: 15 July 2016
View article titled, Abstract SY27-02: Targeting leukemia stem cells with small molecule inhibitors of PRC1
Journal Articles

Abstract 3898: Structure-based optimization of small molecule inhibitors of the protein-protein interaction between menin and mixed lineage leukemia (MLL)

Jonathan Pollock, Dmitry Borkin, Katarzyna Kempinska, Trupta Purohit, Xiaoqin Li, Bo Wen, Ting Zhao, Hongzhi Miao, Shirish Shukla, Miao He, Duxin Sun, Tomasz Cierpicki, Jolanta Grembecka
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3898.
https://doi.org/10.1158/1538-7445.AM2016-3898
Published: 15 July 2016
View article titled, Abstract 3898: Structure-based optimization of small molecule inhibitors of the protein-protein interaction between menin and mixed lineage leukemia (MLL)
Journal Articles

Abstract 4690: Novel Ring1B-Bmi1 small molecule inhibitors target leukemia stem cells

Shirish Shukla, Felicia Gray, Weijang Ying, Hyoje Cho, Qingjie Zhao, Hongzhi Miao, Trupta Purohit, Jolanta Grembecka, Tomasz Cierpicki
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4690.
https://doi.org/10.1158/1538-7445.AM2016-4690
Published: 15 July 2016
View article titled, Abstract 4690: Novel Ring1B-Bmi1 small molecule inhibitors target leukemia stem cells
Journal Articles

Abstract 3520: Small molecule inhibitors of ring1B-Bmi1 E3 ligase target polycomb repressive complex 1 activity and regulate cell proliferation

Shirish Shukla, Qingjie Zhao, Weijang Ying, Felicia Gray, Kelly Vandenberg, George Lund, Bohdan Boytsov, Shihan He, Jolanta Grembecka, Tomasz Cierpicki
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3520.
https://doi.org/10.1158/1538-7445.AM2015-3520
Published: 01 August 2015
View article titled, Abstract 3520: Small molecule inhibitors of ring1B-Bmi1 E3 ligase target polycomb repressive complex 1 activity and regulate cell proliferation
Journal Articles

Abstract 3636: Targeting the MLL complex in castration resistant prostate cancer

Rohit Malik, Amjad P. Khan, Irfan A. Asangani, Marcin Cieślik, John R. Prensner, Xiaoju Wang, Matthew K. Iyer, Xia Jiang, Dmitry Borkin, June Escara-Wilke, Rachell Stender, Yi-Mi Wu, Xuhong Cao, Felix Y. Feng, Jolanta Grembecka, Tomasz Cierpicki, Arul M. Chinnaiyan
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3636.
https://doi.org/10.1158/1538-7445.AM2015-3636
Published: 01 August 2015
View article titled, Abstract 3636: Targeting the MLL complex in castration resistant prostate cancer
Journal Articles

Abstract 1398: Targeting novel co-activators of androgen receptor in castration resistant prostate cancer

Rohit Malik, Amjad P. Khan, John R. Prensner, Matthew K. Iyer, Dmitry Borkin, Xiaoju Wang, Xia Jiang, Shruthi Subramaniam, Yang Shi, Rachell Stender, Yi-Mi Wu, Xuhong Cao, Jolanta Grembecka, Tomasz Cierpicki, Arul Chinnaiyan
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1398.
https://doi.org/10.1158/1538-7445.AM2014-1398
Published: 01 October 2014
View article titled, Abstract 1398: Targeting novel co-activators of androgen receptor in castration resistant prostate cancer
Journal Articles

Abstract 2534: High-affinity small molecule inhibitors of the menin-MLL interaction reverse oncogenic transformation mediated by MLL fusion proteins in leukemia

Jolanta E. Grembecka, Shihan He, Timothy J. Senter, Dmitry Borkin, Jonathan Pollock, Changho Han, Sunil Kumar Upadhyay, Trupta Purohit, Hongzhi Miao, Rocco D. Gogliotti D. Gogliotti, Craig W. Lindsley, Tomasz Cierpicki, Shaun R. Stauffer
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2534.
https://doi.org/10.1158/1538-7445.AM2014-2534
Published: 01 October 2014
View article titled, Abstract 2534: High-affinity small molecule inhibitors of the menin-MLL interaction reverse oncogenic transformation mediated by MLL fusion proteins in leukemia
Journal Articles

Abstract 3225: LEDGF IBD domain represents therapeutic target for MLL leukemia and HIV

Tomasz Cierpicki, Marcelo J. Murai, Jonathan Pollock, Trupta Purohit, Shihan He, Adam Yokom, Jay L. Hess, Andrew G. Muntean, Jolanta Grembecka
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3225.
https://doi.org/10.1158/1538-7445.AM2014-3225
Published: 01 October 2014
View article titled, Abstract 3225: LEDGF IBD domain represents therapeutic target for MLL leukemia and HIV
Journal Articles

Dysregulated Hematopoiesis Caused by Mammary Cancer Is Associated with Epigenetic Changes and Hox Gene Expression in Hematopoietic Cells

Alexander Sio, Manreet K. Chehal, Kevin Tsai, Xueling Fan, Morgan E. Roberts, Brad H. Nelson, Jolanta Grembecka, Tomasz Cierpicki, Danielle L. Krebs, Kenneth W. Harder
Journal: Cancer Research
Cancer Res (2013) 73 (19): 5892–5904.
https://doi.org/10.1158/0008-5472.CAN-13-0842
Published: 01 October 2013
View article titled, Dysregulated Hematopoiesis Caused by Mammary Cancer Is Associated with Epigenetic Changes and <em>Hox</em> Gene Expression in Hematopoietic Cells
Open the PDF for Dysregulated Hematopoiesis Caused by Mammary Cancer Is Associated with Epigenetic Changes and <em>Hox</em> Gene Expression in Hematopoietic Cells in another window
Includes: Supplementary data
Journal Articles

Convergence of the ZMIZ1 and NOTCH1 Pathways at C-MYC in Acute T Lymphoblastic Leukemias

Lesley A. Rakowski, Derek D. Garagiola, Choi M. Li, Margaret Decker, Sarah Caruso, Morgan Jones, Rork Kuick, Tomasz Cierpicki, Ivan Maillard, Mark Y. Chiang
Journal: Cancer Research
Cancer Res (2013) 73 (2): 930–941.
https://doi.org/10.1158/0008-5472.CAN-12-1389
Published: 16 January 2013
View article titled, Convergence of the ZMIZ1 and NOTCH1 Pathways at C-MYC in Acute T Lymphoblastic Leukemias
Open the PDF for Convergence of the ZMIZ1 and NOTCH1 Pathways at C-MYC in Acute T Lymphoblastic Leukemias in another window
Includes: Supplementary data