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Tom Mikkelsen
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Journal Articles

Abstract CT062: GBM AGILE: A global, phase 2/3 adaptive platform trial to evaluate multiple regimens in newly diagnosed and recurrent glioblastoma

Ingo K. Mellinghoff, Brian Alexander, Donald Berry, Nicholas Blondin, Meredith Buxton, Webster Cavenee, Howard Colman, John de Groot, Macarena I. de la Fuente, Benjamin Ellingson, Gary Gordon, Emma M.V. Hyddmark, Mustafa Khasraw, Andrew Lassman, Eudocia Lee, Wenbin Li, Michael Lim, Tom Mikkelsen, Apoorva Nelli, James Perry, Erik Sulman, Kirk Tanner, Michael Weller, Patrick Y. Wen, Timothy Cloughesy
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT062.
https://doi.org/10.1158/1538-7445.AM2023-CT062
Published: 14 April 2023
View article titled, Abstract CT062: GBM AGILE: A global, phase 2/3 adaptive platform trial to evaluate multiple regimens in newly diagnosed and recurrent glioblastoma
Journal Articles

Abstract LB013: Subclonal evolution and expansion of spatially distinct THY1-positive cells is associated with recurrence in glioblastoma

Wajd N. Al-Holou, Hanxiao Wang, Visweswaran Ravikumar, Morgan Oneka, Roel G. Verhaak, Hoon Kim, Drew Pratt, Sandra Camelo-Piragua, Corey Speers, Daniel Wahl, Sunita Shankar, Todd Hollon, Oren Sagher, Jason Heth, Karin M. Muraszko, Theodore S. Lawrence, Ana C. deCarvalho, Tom Mikkelsen, Arvind Rao, Alnawaz Rehemtulla
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB013.
https://doi.org/10.1158/1538-7445.AM2022-LB013
Published: 15 June 2022
View article titled, Abstract LB013: Subclonal evolution and expansion of spatially distinct THY1-positive cells is associated with recurrence in glioblastoma
Journal Articles

Abstract 1505: Platelet derived growth factor receptor alpha oncogene dependency in glioblastoma

Artem D. Berezovsky, Susan M. Irtenkauf, Andrea D. Transou, Laura A. Hasselbach, Tom Mikkelsen, Ana C. deCarvalho
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1505.
https://doi.org/10.1158/1538-7445.AM2020-1505
Published: 15 August 2020
View article titled, Abstract 1505: Platelet derived growth factor receptor alpha oncogene dependency in glioblastoma
Journal Articles

Abstract LB-234: Pre-surgical identification of diagnostic, prognostic and predictive DNA methylation-based markers in serum (liquid biopsy) of patients harboring gliomas

Houtan Noushmehr, Thais S. Sabedot, Tathiane M. Malta, Kevin K. Nelson, James Snyder, Michael Wells, Maritza S. Mosella, Ana C. deCarvalho, Karam Asmaro, Lisa Scarpace, Adam M. Robin, Mark L. Rosenblum, Tom Mikkelsen, Jack Rock, Tobias Walbert, Ian Lee, Laila M. Poisson, Steven N. Kalkanis, Ana V. Castro
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-234.
https://doi.org/10.1158/1538-7445.AM2019-LB-234
Published: 01 July 2019
View article titled, Abstract LB-234: Pre-surgical identification of diagnostic, prognostic and predictive DNA methylation-based markers in serum (liquid biopsy) of patients harboring gliomas
Journal Articles

Abstract 3491: Heterogeneous extrachromosomal amplification of mutant PDGFRA is associated with an aggressive phenotype in glioblastoma

Artem D. Berezovsky, Andrea D. Transou, Susan M. Irtenkauf, Laura A. Hasselbach, Julie Koeman, Hoon Kim, Roel G. Verhaak, Tom Mikkelsen, Laila M. Poisson, Ana C. deCarvalho
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3491.
https://doi.org/10.1158/1538-7445.AM2018-3491
Published: 01 July 2018
View article titled, Abstract 3491: Heterogeneous extrachromosomal amplification of mutant PDGFRA is associated with an aggressive phenotype in glioblastoma
Journal Articles

Abstract 3860: Magnetization transfer and T2-weighted MRI studies are useful for visualizing phenotypic presentations of orthotopic, patient-derived xenograft mouse models of glioblastoma

Tavarekere N. Nagaraja, Rasha Elmghirbi, Susan Irtenkauf, Laura Hasselbach, Baruch Tawil, Stephen L. Brown, Swayamprava Panda, Glauber Cabral, Tom Mikkelsen, James R. Ewing, Ana deCarvalho
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3860.
https://doi.org/10.1158/1538-7445.AM2017-3860
Published: 01 July 2017
View article titled, Abstract 3860: Magnetization transfer and T<sub>2</sub>-weighted MRI studies are useful for visualizing phenotypic presentations of orthotopic, patient-derived xenograft mouse models of glioblastoma
Journal Articles

Abstract 2710: Model evolution technique as a novel concept for characterization of tumor heterogeneity in dynamic contrast enhanced MRI studies

Hassan Bagher-Ebadian, Azimeh NV Dehkordi, Rasha Alamgharibi, David Nathanson, Hamid Soltanian-Zadeh, Arbab S. Ali, Stephen Brown, Meser M. Ali, Tom Mikkelsen, James R. Ewing
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2710.
https://doi.org/10.1158/1538-7445.AM2016-2710
Published: 15 July 2016
View article titled, Abstract 2710: Model evolution technique as a novel concept for characterization of tumor heterogeneity in dynamic contrast enhanced MRI studies
Journal Articles

Abstract 3380: Direct contact with perivascular tumor cells enhances integrin αvβ3 signaling and migration of endothelial cells

Monica Burgett, Justin Lathia, Patrick Roth, Amy Nowacki, Elena Pugacheva, Ping Huang, Amit Vasanji, Li Meizhang, Tatiana Byzova, Tom Mikkelsen, Shideng Bao, Jeremy Rich, Michael Weller, Candece Gladson
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3380.
https://doi.org/10.1158/1538-7445.AM2016-3380
Published: 15 July 2016
View article titled, Abstract 3380: Direct contact with perivascular tumor cells enhances integrin αvβ3 signaling and migration of endothelial cells
Journal Articles

Abstract 628: A method to examine spatial relationships between tumor cells and vasculature using a mouse orthotopic PDX glioblastoma model

Tavarekere N. Nagaraja, Kelly Keenan, Susan Irtenkauf, Laura Hasselbach, Swayamprava Panda, Glauber Cabral, James R. Ewing, Tom Mikkelsen, Ana deCarvalho.
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 628.
https://doi.org/10.1158/1538-7445.AM2016-628
Published: 15 July 2016
View article titled, Abstract 628: A method to examine spatial relationships between tumor cells and vasculature using a mouse orthotopic PDX glioblastoma model
Journal Articles

Abstract 3881: In vivo and in vitro characterization of genomic diversity and clonal evolution in glioblastoma

Ana C. deCarvalho, Hoon Kim, Laila Poisson, Roel Verhaak, Tom Mikkelsen
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3881.
https://doi.org/10.1158/1538-7445.AM2015-3881
Published: 01 August 2015
View article titled, Abstract 3881: <em>In vivo</em> and <em>in vitro</em> characterization of genomic diversity and clonal evolution in glioblastoma
Journal Articles

Abstract 4178: L1CAM and integrin αvβ3 mediate direct cell contact between cancer stem cells and endothelial cells: Promotion of endothelial cell migration and survival

Monica E. Burgett, Justin D. Lathia, Patrick Roth, Amy S. Nowacki, Ping Huang, Amit Vasanji, Meizhang Li, Tatiana Byzova, Tom Mikkelsen, Shideng Bao, Jeremy Rich, Michael Weller, Candece L. Gladson
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4178.
https://doi.org/10.1158/1538-7445.AM2015-4178
Published: 01 August 2015
View article titled, Abstract 4178: L1CAM and integrin αvβ3 mediate direct cell contact between cancer stem cells and endothelial cells: Promotion of endothelial cell migration and survival
Journal Articles

Abstract 3195: STAT3 inhibition using shRNA inhibits GBM proliferation, cell migration, anchorage-independent growth of mouse, rat, and human stem-like cells in vitro; and it induces long term survival and anti-GBM immunity in vivo

Nathan T. VanderVeen, Nicholas Raja, Elizabeth Yi, James Curtin, Peter Chockley, Hikmat Assi, Jonathan Savakus, Tom Mikkelsen, Samuel Rabkin, Pedro R. Lowenstein, Maria G. Castro
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3195.
https://doi.org/10.1158/1538-7445.AM2015-3195
Published: 01 August 2015
View article titled, Abstract 3195: STAT3 inhibition using shRNA inhibits GBM proliferation, cell migration, anchorage-independent growth of mouse, rat, and human stem-like cells in vitro; and it induces long term survival and anti-GBM immunity in vivo
Journal Articles

Abstract 1755: TORK/DNA-PK inhibitor CC-115 is effective as a single agent in a subset of glioblastoma patient-derived cancer stem cells and xenografts and potentiates temozolomide therapy

Kimberly Bergman, Susan M. Irtenkauf, Laura A. Hasselbach, Claudius Mueller, Emanuel Petricoin, Heather Raymon, Tom Mikkelsen, Ana C. Decarvalho
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1755.
https://doi.org/10.1158/1538-7445.AM2015-1755
Published: 01 August 2015
View article titled, Abstract 1755: TORK/DNA-PK inhibitor CC-115 is effective as a single agent in a subset of glioblastoma patient-derived cancer stem cells and xenografts and potentiates temozolomide therapy
Journal Articles

Abstract P4-02-09: RUNX3 hypermethylation in circulating tumor DNA is a biomarker of breast cancer distant metastasis

Bodour Salhia, Gerald C Gooden, Kyle N Johnson, Waibhav Tembe, Garrick Wallstrom, Winnie Liang, Manmeet Ahluwalia, Steven N Kalkanis, Tom Mikkelsen, Steven A Toms
Journal: Cancer Research
Cancer Res (2015) 75 (9_Supplement): P4-02-09.
https://doi.org/10.1158/1538-7445.SABCS14-P4-02-09
Published: 01 May 2015
View article titled, Abstract P4-02-09: RUNX3 hypermethylation in circulating tumor DNA is a biomarker of breast cancer distant metastasis
Journal Articles

Abstract B55: Glioblastoma xenografts obtained from patient derived cancer stem cells preserve the heterogeneous response to targeted therapy

Ana C. deCarvalho, Laura Hasselbach, Kevin Nelson, Tom Mikkelsen
Journal: Cancer Research
Cancer Res (2011) 71 (18_Supplement): B55.
https://doi.org/10.1158/1538-7445.FBCR11-B55
Published: 28 October 2014
View article titled, Abstract B55: Glioblastoma xenografts obtained from patient derived cancer stem cells preserve the heterogeneous response to targeted therapy
Journal Articles

Abstract 984: Alteration of the p53 pathway is associated with subclonal tumor progression in glioblastoma

Hoon Kim, Siyuan Zheng, Seyed S. Amini, Selene M. Virk, Tom Mikkelsen, Daniel J. Brat, Jonna Grimsby, Carrie Sougnez, Andrew E. Sloan, Mark L. Cohen, Erwin G. Van Meir, Lisa Scarpace, The Cancer Genome Research Network, Peter W. Laird, John N. Weinstein, Eric Lander, Stacey Gabriel, Gad Getz, Matthew Meyerson, Lynda Chin, Jill S. Barnholtz-Sloan, Roel G.w. Verhaak
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 984.
https://doi.org/10.1158/1538-7445.AM2014-984
Published: 01 October 2014
View article titled, Abstract 984: Alteration of the p53 pathway is associated with subclonal tumor progression in glioblastoma
Journal Articles

Abstract 2061: Extended adjuvant temozolomide improves survival in a glioblastoma mouse model

Hanxiao Wang, Wajd Al-Holou, Kevin Heist, Craig J. Galbán, Ana C. deCarvalho, Tom Mikkelsen, Brian D. Ross, Alnawaz Rehemtulla
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2061.
https://doi.org/10.1158/1538-7445.AM2014-2061
Published: 01 October 2014
View article titled, Abstract 2061: Extended adjuvant temozolomide improves survival in a glioblastoma mouse model
Journal Articles

Abstract 1213: Comparing protein pathway activation mapping portraits between gliobastoma patient-matched primary tumor, xenografts and neurospheres: implications for precision medicine

Claudius Mueller, Ana C. deCarvalho, Tom Mikkelsen, Laila Poisson, Valerie Calvert, Andrew Borgman, David M. Cherba, Mary E. Winn, Emanuel F. Petricoin
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1213.
https://doi.org/10.1158/1538-7445.AM2014-1213
Published: 01 October 2014
View article titled, Abstract 1213: Comparing protein pathway activation mapping portraits between gliobastoma patient-matched primary tumor, xenografts and neurospheres: implications for precision medicine
Journal Articles

Abstract 3385: Sox2 is necessary for glioblastoma cell plasticity

Artem D. Berezovsky, Laila M. Poisson, Xin Hong, Tom Mikkelsen, Ana C. deCarvalho
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3385.
https://doi.org/10.1158/1538-7445.AM2014-3385
Published: 01 October 2014
View article titled, Abstract 3385: Sox2 is necessary for glioblastoma cell plasticity
Journal Articles

Abstract 3795: Cabozantinib affects multiple signaling pathways in glioblastoma and is effective in a subset of xenograft tumors

Ana C. deCarvalho, Kimberly Arnold, Claudius Mueller, Emanuel F. Petricoin, Laila M. Poisson, Tom Mikkelsen
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3795.
https://doi.org/10.1158/1538-7445.AM2014-3795
Published: 01 October 2014
View article titled, Abstract 3795: Cabozantinib affects multiple signaling pathways in glioblastoma and is effective in a subset of xenograft tumors