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Journal Articles

Abstract 5922: Clinical validation of a spectroscopic liquid biopsy for early detection of brain cancer

James M. Cameron, Paul M. Brennan, Georgios Antoniou, Holly J. Butler, Loren Christie, Justin J.A. Conn, Tom Curran, Ewan Gray, Mark G. Hegarty, Michael Jenkinson, Daniel Orringer, David S. Palmer, Alexandra Sala, Benjamin R. Smith, Matthew J. Baker
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5922.
https://doi.org/10.1158/1538-7445.AM2022-5922
Published: 15 June 2022
View article titled, Abstract 5922: Clinical validation of a spectroscopic liquid biopsy for early detection of brain cancer
Journal Articles

Astrocytes Promote Medulloblastoma Progression through Hedgehog Secretion

Yongqiang Liu, Larra W. Yuelling, Yuan Wang, Fang Du, Renata E. Gordon, Jenny A. O'Brien, Jessica M.Y. Ng, Shannon Robins, Eric H. Lee, Hailong Liu, Tom Curran, Zeng-Jie Yang
Journal: Cancer Research
Cancer Res (2017) 77 (23): 6692–6703.
https://doi.org/10.1158/0008-5472.CAN-17-1463
Published: 30 November 2017
View article titled, Astrocytes Promote Medulloblastoma Progression through Hedgehog Secretion
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Includes: Supplementary data
Journal Articles

Nestin Mediates Hedgehog Pathway Tumorigenesis

Peng Li, Eric H. Lee, Fang Du, Renata E. Gordon, Larra W. Yuelling, Yongqiang Liu, Jessica M.Y. Ng, Hao Zhang, Jinhua Wu, Andrey Korshunov, Stefan M. Pfister, Tom Curran, Zeng-jie Yang
Journal: Cancer Research
Series: Author Choice
Cancer Res (2016) 76 (18): 5573–5583.
https://doi.org/10.1158/0008-5472.CAN-16-1547
Published: 15 September 2016
View article titled, Nestin Mediates Hedgehog Pathway Tumorigenesis
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Includes: Supplementary data
Journal Articles

Generation of a Mouse Model of Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System through Combined Deletion of Snf5 and p53

Jessica M.Y. Ng, Daniel Martinez, Eric D. Marsh, Zhe Zhang, Eric Rappaport, Mariarita Santi, Tom Curran
Journal: Cancer Research
Cancer Res (2015) 75 (21): 4629–4639.
https://doi.org/10.1158/0008-5472.CAN-15-0874
Published: 01 November 2015
View article titled, Generation of a Mouse Model of Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System through Combined Deletion of Snf5 and p53
Open the PDF for Generation of a Mouse Model of Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System through Combined Deletion of Snf5 and p53 in another window
Includes: Supplementary data
Journal Articles

Abstract 5423: Identification of immunotargets in Hedgehog medulloblastoma for immunotherapy

Grace S. Tan, Tom Curran
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 5423.
https://doi.org/10.1158/1538-7445.AM2015-5423
Published: 01 August 2015
View article titled, Abstract 5423: Identification of immunotargets in Hedgehog medulloblastoma for immunotherapy
Journal Articles

Menin Epigenetically Represses Hedgehog Signaling in MEN1 Tumor Syndrome

Buddha Gurung, Zijie Feng, Daniel V. Iwamoto, Austin Thiel, Guanghui Jin, Chen-Min Fan, Jessica M.Y. Ng, Tom Curran, Xianxin Hua
Journal: Cancer Research
Cancer Res (2013) 73 (8): 2650–2658.
https://doi.org/10.1158/0008-5472.CAN-12-3158
Published: 15 April 2013
View article titled, Menin Epigenetically Represses Hedgehog Signaling in MEN1 Tumor Syndrome
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Includes: Supplementary data
Journal Articles

SNPs and Chips: SNP and gene expression arrays of the pediatric CNS tumors Atypical Teratoid Rhabdoid Tumor and Choroid Plexus Carcinoma

Jessica Mei Ng, Tom Curran
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): LB-238.
Published: 01 May 2007
View article titled, SNPs and Chips: SNP and gene expression arrays of the pediatric CNS tumors Atypical Teratoid Rhabdoid Tumor and Choroid Plexus Carcinoma
Journal Articles

Functional imaging of targeted therapies in mice: experience with a Shh pathway antagonist

Hiromichi Kimura, Tom Curran
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 5502.
Published: 01 May 2007
View article titled, Functional imaging of targeted therapies in mice: experience with a Shh pathway antagonist
Journal Articles

Medulloblastomas Derived from Cxcr6 Mutant Mice Respond to Treatment with a Smoothened Inhibitor

Ken Sasai, Justyna T. Romer, Hiromichi Kimura, Derek E. Eberhart, Dennis S. Rice, Tom Curran
Journal: Cancer Research
Cancer Res (2007) 67 (8): 3871–3877.
https://doi.org/10.1158/0008-5472.CAN-07-0493
Published: 17 April 2007
View article titled, Medulloblastomas Derived from <em>Cxcr6</em> Mutant Mice Respond to Treatment with a Smoothened Inhibitor
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Includes: Supplementary data
Journal Articles

Patched2 Modulates Tumorigenesis in Patched1 Heterozygous Mice

Youngsoo Lee, Heather L. Miller, Helen R. Russell, Kelli Boyd, Tom Curran, Peter J. McKinnon
Journal: Cancer Research
Cancer Res (2006) 66 (14): 6964–6971.
https://doi.org/10.1158/0008-5472.CAN-06-0505
Published: 18 July 2006
View article titled, Patched2 Modulates Tumorigenesis in Patched1 Heterozygous Mice
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Journal Articles

Shh Pathway Activity Is Down-Regulated in Cultured Medulloblastoma Cells: Implications for Preclinical Studies

Ken Sasai, Justyna T. Romer, Youngsoo Lee, David Finkelstein, Christine Fuller, Peter J. McKinnon, Tom Curran
Journal: Cancer Research
Cancer Res (2006) 66 (8): 4215–4222.
https://doi.org/10.1158/0008-5472.CAN-05-4505
Published: 17 April 2006
View article titled, Shh Pathway Activity Is Down-Regulated in Cultured Medulloblastoma Cells: Implications for Preclinical Studies
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Includes: Supplementary data
Journal Articles

Shh pathway activity is maintained in direct allografts of medulloblastoma cells whereas it is irreversibly lost in cell culture: Implications for preclinical studies of smoothened antagonists

Ken Sasai, Justyna T. Romer, Tom Curran
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1138.
Published: 15 April 2006
View article titled, Shh pathway activity is maintained in direct allografts of medulloblastoma cells whereas it is irreversibly lost in cell culture: Implications for preclinical studies of smoothened antagonists
Journal Articles

Targeting Medulloblastoma: Small-Molecule Inhibitors of the Sonic Hedgehog Pathway as Potential Cancer Therapeutics

Justyna Romer, Tom Curran
Journal: Cancer Research
Cancer Res (2005) 65 (12): 4975–4978.
https://doi.org/10.1158/0008-5472.CAN-05-0481
Published: 15 June 2005
View article titled, Targeting Medulloblastoma: Small-Molecule Inhibitors of the Sonic Hedgehog Pathway as Potential Cancer Therapeutics
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Journal Articles

A Molecular Fingerprint for Medulloblastoma

Youngsoo Lee, Heather L. Miller, Patricia Jensen, Roberto Hernan, Michele Connelly, Cynthia Wetmore, Frederique Zindy, Martine F. Roussel, Tom Curran, Richard J. Gilbertson, Peter J. McKinnon
Journal: Cancer Research
Cancer Res (2003) 63 (17): 5428–5437.
Published: 18 September 2003
View article titled, A Molecular Fingerprint for Medulloblastoma
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Includes: Supplementary data
Journal Articles

Reovirus Prolongs Survival and Reduces the Frequency of Spinal and Leptomeningeal Metastases from Medulloblastoma

Wen Qing Yang, Donna Senger, Huong Muzik, Zhong Qiao Shi, Denise Johnson, Penny M. A. Brasher, N. Barry Rewcastle, Mark Hamilton, Jim Rutka, Johannes Wolff, Cynthia Wetmore, Tom Curran, Patrick W. K. Lee, Peter A. Forsyth
Journal: Cancer Research
Cancer Res (2003) 63 (12): 3162–3172.
Published: 15 June 2003
View article titled, Reovirus Prolongs Survival and Reduces the Frequency of Spinal and Leptomeningeal Metastases from Medulloblastoma
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Journal Articles

Mouse Embryos Cloned from Brain Tumors

Leyi Li, Michele C. Connelly, Cynthia Wetmore, Tom Curran, James I. Morgan
Journal: Cancer Research
Cancer Res (2003) 63 (11): 2733–2736.
Published: 01 June 2003
View article titled, Mouse Embryos Cloned from Brain Tumors
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Journal Articles

Loss of p53 but not ARF Accelerates Medulloblastoma in Mice Heterozygous for patched

Cynthia Wetmore, Derek E. Eberhart, Tom Curran
Journal: Cancer Research
Cancer Res (2001) 61 (2): 513–516.
Published: 01 January 2001
View article titled, Loss of <em>p53</em> but not <em>ARF</em> Accelerates Medulloblastoma in Mice Heterozygous for <em>patched</em>
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Journal Articles

The Normal patched Allele Is Expressed in Medulloblastomas from Mice with Heterozygous Germ-Line Mutation of patched

Cynthia Wetmore, Derek E. Eberhart, Tom Curran
Journal: Cancer Research
Cancer Res (2000) 60 (8): 2239–2246.
Published: 01 April 2000
View article titled, The Normal <em>patched</em> Allele Is Expressed in Medulloblastomas from Mice with Heterozygous Germ-Line Mutation of <em>patched</em>
Open the PDF for The Normal <em>patched</em> Allele Is Expressed in Medulloblastomas from Mice with Heterozygous Germ-Line Mutation of <em>patched</em> in another window