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Journal Articles

Abstract 5340: The methylation burden is determined by the duration of exposure to carcinogenic factors

Harumi Yamada, Hideyuki Takeshima, Tohru Niwa, Takeshi Toyoda, Satoshi Yamashita, Toshikazu Ushijima
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5340.
https://doi.org/10.1158/1538-7445.AM2018-5340
Published: 01 July 2018
View article titled, Abstract 5340: The methylation burden is determined by the duration of exposure to carcinogenic factors
Journal Articles

Abstract 5331: Repression of TET genes and enhancement of DNA methyltransferase activity are critical for induction of aberrant DNA methylation

Hideyuki Takeshima, Tohru Niwa, Harumi Yamada, Satoshi Yamashita, Mika Wakabayashi, Toshikazu Ushijima
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5331.
https://doi.org/10.1158/1538-7445.AM2018-5331
Published: 01 July 2018
View article titled, Abstract 5331: Repression of <em>TET</em> genes and enhancement of DNA methyltransferase activity are critical for induction of aberrant DNA methylation
Journal Articles

Abstract 1048: Chromatin remodelers are frequently disrupted by epigenetic and genetic alterations at an early stage of carcinogenesis

Hideyuki Takeshima, Tohru Niwa, Takamasa Takahashi, Takayuki Ando, Hirokazu Taniguchi, Hitoshi Katai, Toshiro Sugiyama, Toshikazu Ushijima
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1048.
https://doi.org/10.1158/1538-7445.AM2015-1048
Published: 01 August 2015
View article titled, Abstract 1048: Chromatin remodelers are frequently disrupted by epigenetic and genetic alterations at an early stage of carcinogenesis
Journal Articles

Abstract LB-284: Toward clinical sequencing: analysis of FFPE samples of 121 gastric cancer by a benchtop sequencer

Satoshi Yamashita, Yasutoshi Kuboki, Tohru Niwa, Akiko Nagatsuma, Kohei Shitara, Nozomu Fuse, Toshihiko Doi, Atsushi Ochiai, Atsushi Ohtsu, Toshikazu Ushijima
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): LB-284.
https://doi.org/10.1158/1538-7445.AM2014-LB-284
Published: 01 October 2014
View article titled, Abstract LB-284: Toward clinical sequencing: analysis of FFPE samples of 121 gastric cancer by a benchtop sequencer
Journal Articles

Abstract 4264: Whole exome and targeted sequencing identified the MAPK and PI3K pathways as the main targets in intracranial and testicular germ cell tumors

Koichi Ichimura, Shintaro Fukushima, Yasushi Totoki, Yuko Matsushita, Ayaka Otsuka, Arata Tomiyama, Tohru Niwa, Ryuichi Sakai, Toshikazu Ushijima, Taishi Nakamura, Tomonari Suzuki, Kouhei Fukuoka, Takaaki Yanagisawa, Kazuhiko Mishima, Yoichi Nakazato, Fumie Hosoda, Yoshitaka Narita, Soichiro Shibui, Akihiko Yoshida, Hirokazu Takami, Akitake Mukasa, Koki Aihara, Nobuhito Saito, Toshihiro Kumabe, Masayuki Kanamori, Teiji Tominaga, Keiichi Kobayashi, Saki Shimizu, Motoo Nagane, Toshihiko Iuchi, Masahiro Mizoguchi, Koji Yoshimoto, Kaoru Tamura, Taketoshi Maehara, Kazuhiko Sugiyama, Mitsutoshi Nakada, Keiichi Sakai, Yonehiro Kanemura, Masahiro Nonaka, Kiyotaka Yokogami, Hideo Takeshima, Nobutaka Kawahara, Tatsuya Takayama, Masahiro Yao, Hiromi Nakamura, Natsuko Hama, Masao Matsutani, Tatsuhiro Shibata, Ryo Nishikawa
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4264.
https://doi.org/10.1158/1538-7445.AM2014-4264
Published: 01 October 2014
View article titled, Abstract 4264: Whole exome and targeted sequencing identified the MAPK and PI3K pathways as the main targets in intracranial and testicular germ cell tumors
Journal Articles

Abstract 5349: Aberrant trimethylation of histone H3 lysine 27 is induced by chronic inflammation in mouse colonic epithelial cells, and is involved in the formation of a field for cancerization.

Hideyuki Takeshima, Daigo Ikegami, Mika Wakabayashi, Tohru Niwa, Young-Joon Kim, Toshikazu Ushijima
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5349.
https://doi.org/10.1158/1538-7445.AM2013-5349
Published: 15 April 2013
View article titled, Abstract 5349: Aberrant trimethylation of histone H3 lysine 27 is induced by chronic inflammation in mouse colonic epithelial cells, and is involved in the formation of a field for cancerization.
Journal Articles

Abstract 4089: Identification of a DNA methylation marker to detect the presence of lymph node metastases of gastric cancers

Yasuyuki Shigematsu, Tohru Niwa, Satoshi Yamashita, Hirokazu Taniguchi, Ryoji Kushima, Hitoshi Katai, Masao Ichinose, Toshikazu Ushijima
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4089.
https://doi.org/10.1158/1538-7445.AM2012-4089
Published: 15 April 2012
View article titled, Abstract 4089: Identification of a DNA methylation marker to detect the presence of lymph node metastases of gastric cancers
Journal Articles

Abstract 2002: Prevention of gastric cancers induced by Helicobacter pylori infection with a DNA demethylating reagent, 5-aza-2′-deoxycytidine

Tohru Niwa, Takeshi Toyoda, Tetsuya Tsukamoto, Akiko Mori, Masae Tatematsu, Toshikazu Ushijima
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2002.
https://doi.org/10.1158/1538-7445.AM2011-2002
Published: 15 April 2011
View article titled, Abstract 2002: Prevention of gastric cancers induced by <em>Helicobacter pylori</em> infection with a DNA demethylating reagent, 5-aza-2′-deoxycytidine
Journal Articles

Abstract 176: The presence of RNA polymerase II, active or stalled, predicts epigenetic fate of promoter CpG islands

Hideyuki Takeshima, Satoshi Yamashita, Taichi Shimazu, Tohru Niwa, Toshikazu Ushijima
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 176.
https://doi.org/10.1158/1538-7445.AM10-176
Published: 15 April 2010
View article titled, Abstract 176: The presence of RNA polymerase II, active or stalled, predicts epigenetic fate of promoter CpG islands
Journal Articles

Inflammatory Processes Triggered by Helicobacter pylori Infection Cause Aberrant DNA Methylation in Gastric Epithelial Cells

Tohru Niwa, Tetsuya Tsukamoto, Takeshi Toyoda, Akiko Mori, Harunari Tanaka, Takao Maekita, Masao Ichinose, Masae Tatematsu, Toshikazu Ushijima
Journal: Cancer Research
Cancer Res (2010) 70 (4): 1430–1440.
https://doi.org/10.1158/0008-5472.CAN-09-2755
Published: 14 February 2010
View article titled, Inflammatory Processes Triggered by <em>Helicobacter pylori</em> Infection Cause Aberrant DNA Methylation in Gastric Epithelial Cells
Open the PDF for Inflammatory Processes Triggered by <em>Helicobacter pylori</em> Infection Cause Aberrant DNA Methylation in Gastric Epithelial Cells in another window
Includes: Supplementary data
Journal Articles

Abstract #3380: Causal role of Helicobacter pylori infection in the induction of aberrant DNA methylation in gastric epithelial cells, and its critical role in inflammation

Tohru Niwa, Tetsuya Tsukamoto, Akiko Mori, Takeshi Toyoda, Masao Ichinose, Masae Tatematsu, Toshikazu Ushijima
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 3380.
Published: 01 May 2009
View article titled, Abstract #3380: Causal role of Helicobacter pylori infection in the induction of aberrant DNA methylation in gastric epithelial cells, and its critical role in inflammation
Journal Articles

Methylation Silencing of Transforming Growth Factor-β Receptor Type II in Rat Prostate Cancers

Satoshi Yamashita, Satoru Takahashi, Nathalie McDonell, Naoko Watanabe, Tohru Niwa, Kosuke Hosoya, Yoshimi Tsujino, Tomoyuki Shirai, Toshikazu Ushijima
Journal: Cancer Research
Cancer Res (2008) 68 (7): 2112–2121.
https://doi.org/10.1158/0008-5472.CAN-07-5282
Published: 01 April 2008
View article titled, Methylation Silencing of Transforming Growth Factor-β Receptor Type II in Rat Prostate Cancers
Open the PDF for Methylation Silencing of Transforming Growth Factor-β Receptor Type II in Rat Prostate Cancers in another window
Includes: Supplementary data
Journal Articles

Identification of genomic regions aberrantly methylated by Helicobacter pylori infection in Mongolian gerbils and humans

Tohru Niwa, Tetsuya Tsukamoto, Harunari Tanaka, Masae Tatematsu, Masao Ichinose, Toshikazu Ushijima
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 1040.
Published: 01 May 2007
View article titled, Identification of genomic regions aberrantly methylated by <em>Helicobacter pylori</em> infection in Mongolian gerbils and humans