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Todd W. Miller
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Journal Articles

Abstract 5098: Targeting fatty acid dependency in hormone receptor positive HER2 negative drug tolerant persister bone metastases

Free
Abigail E. Goen, Jonathan D. Marotti, Todd W. Miller
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5098.
https://doi.org/10.1158/1538-7445.AM2025-5098
Published: 21 April 2025
View articletitled, Abstract 5098: Targeting fatty acid dependency in hormone receptor positive HER2 negative drug tolerant persister bone metastases
Journal Articles

Abstract 4227: Chromatin remodeling enhances the anti-cancer effects of estrogen therapy in ER+ breast cancer

Free
Anneka L. Johnson, Alexa Warren, Nicole Traphagen, Alyssa Roberts, Patricia Muskus, Barbara Karakyriakou, Eugene Demidenko, Fred W. Kolling, Owen Wilkins, Kimberly Birmingham, Brock Christensen, Todd W. Miller
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4227.
https://doi.org/10.1158/1538-7445.AM2025-4227
Published: 21 April 2025
View articletitled, Abstract 4227: Chromatin remodeling enhances the anti-cancer effects of estrogen therapy in ER+ breast cancer
Journal Articles

Abstract 5130: DNA methylation profiling reveals epigenetic dynamics across epithelial-mesenchymal transition states in the triple-negative breast tumor microenvironment

Free
Hanxu Lu, Fred W. Kolling, Lucas A. Salas, Diwakar R. Pattabiraman, Todd W. Miller, Brock C. Christensen
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5130.
https://doi.org/10.1158/1538-7445.AM2025-5130
Published: 21 April 2025
View articletitled, Abstract 5130: DNA methylation profiling reveals epigenetic dynamics across epithelial-mesenchymal transition states in the triple-negative breast tumor microenvironment
Journal Articles

Abstract 4206: Investigation into the mechanisms and therapeutic potential of R-loop-induced DNA damage in ER+ breast cancer

Free
Alyssa Roberts, Nicole Traphagen, Anneka Johnson, Eugene Demidenko, Patricia Muskus, Xiaofeng Wang, Todd W. Miller
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4206.
https://doi.org/10.1158/1538-7445.AM2025-4206
Published: 21 April 2025
View articletitled, Abstract 4206: Investigation into the mechanisms and therapeutic potential of R-loop-induced DNA damage in ER+ breast cancer
Journal Articles

Abstract 4685: Targeting fatty acid oxidation improves radiation sensitivity in glioblastoma

Free
Tingting Huang, Kenneth Austin, Todd W. Miller, Kelli B. Pointer
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4685.
https://doi.org/10.1158/1538-7445.AM2025-4685
Published: 21 April 2025
View articletitled, Abstract 4685: Targeting fatty acid oxidation improves radiation sensitivity in glioblastoma
Journal Articles

Oxidative Phosphorylation Is a Metabolic Vulnerability of Endocrine Therapy–Tolerant Persister Cells in ER+ Breast Cancer

Available to Purchase
Steven Tau, Mary D. Chamberlin, Huijuan Yang, Jonathan D. Marotti, Patricia C. Muskus, Alyssa M. Roberts, Melissa M. Carmichael, Lauren Cressey, Christo Philip C. Dragnev, Eugene Demidenko, Riley A. Hampsch, Shannon M. Soucy, Fred W. Kolling, Kimberley S. Samkoe, James V. Alvarez, Arminja N. Kettenbach, Todd W. Miller
Journal: Cancer Research
Cancer Res (2025) 85 (6): 1145–1161.
https://doi.org/10.1158/0008-5472.CAN-24-1204
Published: 14 March 2025
View articletitled, Oxidative Phosphorylation Is a Metabolic Vulnerability of Endocrine Therapy–Tolerant Persister Cells in ER+ Breast Cancer
Open the PDF for Oxidative Phosphorylation Is a Metabolic Vulnerability of Endocrine Therapy–Tolerant Persister Cells in ER+ Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract P4-02-12: Oxidative phosphorylation and NRF2 activation mediate resistance to estrogen deprivation in ER+ breast cancer

Free
Steven Tau, Todd W. Miller
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P4-02-12.
https://doi.org/10.1158/1538-7445.SABCS21-P4-02-12
Published: 15 February 2022
View articletitled, Abstract P4-02-12: Oxidative phosphorylation and NRF2 activation mediate resistance to estrogen deprivation in ER+ breast cancer
Journal Articles

Abstract 4359: Rational development of novel treatment regimens to improve the efficacy of estrogen therapy in anti-estrogen-resistant ER+ breast cancer

Free
Nicole A. Traphagen, Amanda Jiang, Sarah R. Hosford, Todd W. Miller
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4359.
https://doi.org/10.1158/1538-7445.AM2020-4359
Published: 15 August 2020
View articletitled, Abstract 4359: Rational development of novel treatment regimens to improve the efficacy of estrogen therapy in anti-estrogen-resistant ER+ breast cancer
Journal Articles

Abstract P3-08-15: Immunologic correlates of long-term outcome in the residual disease of triple-negative breast cancer after neoadjuvant chemotherapy

Free
Justin M Balko, Mellissa Nixon, Paula I Gonzalez-Ericsson, Mark A Pilkinton, Wyatt J McDonnell, Violeta Sanchez, Susan R Opalenik, Sherene Loi, Brent Rexer, Vandana Abramson, Valerie Jansen, Simon Mallal, Jonathan D Marotti, Kevin Shee, Todd W Miller, Melinda E Sanders, Ingrid A Mayer, Roberto Salgado
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P3-08-15.
https://doi.org/10.1158/1538-7445.SABCS19-P3-08-15
Published: 15 February 2020
View articletitled, Abstract P3-08-15: Immunologic correlates of long-term outcome in the residual disease of triple-negative breast cancer after neoadjuvant chemotherapy
Journal Articles

Abstract 4239: Development of pan-cancer transcriptional signatures that predict chemosensitivity

Free
Jason D. Wells, Todd W. Miller
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4239.
https://doi.org/10.1158/1538-7445.AM2019-4239
Published: 01 July 2019
View articletitled, Abstract 4239: Development of pan-cancer transcriptional signatures that predict chemosensitivity
Journal Articles

Abstract OT1-2-01: Circulating tumor DNA in plasma as a surrogate for tumor biopsy to identify tumor genetic alterations in patients with multi-focal metastatic breast cancer

Free
Mary D Chamberlin, Todd W Miller, Jennifer R Bean, Richard J Barth, Kari M Rosenkranz, Jonathan D Marotti, John M Gemery, Jiang Gui
Journal: Cancer Research
Cancer Res (2015) 75 (9_Supplement): OT1-2-01.
https://doi.org/10.1158/1538-7445.SABCS14-OT1-2-01
Published: 01 May 2015
View articletitled, Abstract OT1-2-01: Circulating tumor DNA in plasma as a surrogate for tumor biopsy to identify tumor genetic alterations in patients with multi-focal metastatic breast cancer
Journal Articles

Abstract P5-20-04: Autophagy promotes escape from PI3K inhibition in ER+ breast cancer

Free
Wei Yang, Todd W Miller
Journal: Cancer Research
Cancer Res (2015) 75 (9_Supplement): P5-20-04.
https://doi.org/10.1158/1538-7445.SABCS14-P5-20-04
Published: 01 May 2015
View articletitled, Abstract P5-20-04: Autophagy promotes escape from PI3K inhibition in ER+ breast cancer
Journal Articles

Abstract P5-20-03: Understanding pharmacodynamics and consequences of PI3K inhibition in ER+ breast tumors

Free
Wei Yang, Jennifer R Bean, Lloye Dillon, Laurent Salphati, Jodie Pang, Xiaolin Zhang, Michelle Nannini Pepe, Todd W Miller
Journal: Cancer Research
Cancer Res (2015) 75 (9_Supplement): P5-20-03.
https://doi.org/10.1158/1538-7445.SABCS14-P5-20-03
Published: 01 May 2015
View articletitled, Abstract P5-20-03: Understanding pharmacodynamics and consequences of PI3K inhibition in ER+ breast tumors
Journal Articles

Abstract P5-20-02: PTEN status dictates the roles of PI3K isoforms p110α and p110β in modulation of AKT/mTOR and response to growth factor signaling in ER+ breast cancer

Free
Lloye M Dillon, Stephanie J Bouley, Todd W Miller
Journal: Cancer Research
Cancer Res (2015) 75 (9_Supplement): P5-20-02.
https://doi.org/10.1158/1538-7445.SABCS14-P5-20-02
Published: 01 May 2015
View articletitled, Abstract P5-20-02: PTEN status dictates the roles of PI3K isoforms p110α and p110β in modulation of AKT/mTOR and response to growth factor signaling in ER+ breast cancer
Journal Articles

Abstract P3-05-17: Haddow's paradox revisited: Anti-estrogen withdrawal induces ER-driven apoptosis in anti-estrogen-resistant cells

Free
Sarah R Hosford, Todd W Miller
Journal: Cancer Research
Cancer Res (2015) 75 (9_Supplement): P3-05-17.
https://doi.org/10.1158/1538-7445.SABCS14-P3-05-17
Published: 01 May 2015
View articletitled, Abstract P3-05-17: Haddow's paradox revisited: Anti-estrogen withdrawal induces ER-driven apoptosis in anti-estrogen-resistant cells
Journal Articles

Abstract 5512: Pharmacodynamic analysis of PI3K inhibition in breast tumors: A model to improve early clinical investigation of novel agents

Free
Wei Yang, Jennifer R. Bean, Lloye Dillon, Laurent Salphati, Michelle Nannini, Todd W. Miller
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 5512.
https://doi.org/10.1158/1538-7445.AM2014-5512
Published: 01 October 2014
View articletitled, Abstract 5512: Pharmacodynamic analysis of PI3K inhibition in breast tumors: A model to improve early clinical investigation of novel agents
Journal Articles

Abstract 3342: The p110β isoform of PI3K modulates response to growth factor receptor signaling in breast cancer cells irrespective of PTEN status

Free
Stephanie J. Bouley, Lloye M. Dillon, Todd W. Miller
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3342.
https://doi.org/10.1158/1538-7445.AM2014-3342
Published: 01 October 2014
View articletitled, Abstract 3342: The p110β isoform of PI3K modulates response to growth factor receptor signaling in breast cancer cells irrespective of PTEN status
Journal Articles

Activation of MAPK Pathways due to DUSP4 Loss Promotes Cancer Stem Cell-like Phenotypes in Basal-like Breast Cancer

Free
Justin M. Balko, Luis J. Schwarz, Neil E. Bhola, Richard Kurupi, Phillip Owens, Todd W. Miller, Henry Gómez, Rebecca S. Cook, Carlos L. Arteaga
Journal: Cancer Research
Cancer Res (2013) 73 (20): 6346–6358.
https://doi.org/10.1158/0008-5472.CAN-13-1385
Published: 14 October 2013
View articletitled, Activation of MAPK Pathways due to DUSP4 Loss Promotes Cancer Stem Cell-like Phenotypes in Basal-like Breast Cancer
Open the PDF for Activation of MAPK Pathways due to DUSP4 Loss Promotes Cancer Stem Cell-like Phenotypes in Basal-like Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract LB-37: P-REX1 is a novel PTEN-interacting protein that activates PI3K signaling in breast cancer.

Free
Lloye M. Dillon, Jennifer R. Bean, Justin M. Balko, W. Hayes McDonald, David B. Friedman, Ana M. Gonzalez-Angulo, Gordon B. Mills, Carlos L. Arteaga, Todd W. Miller
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): LB-37.
https://doi.org/10.1158/1538-7445.AM2013-LB-37
Published: 15 April 2013
View articletitled, Abstract LB-37: P-REX1 is a novel PTEN-interacting protein that activates PI3K signaling in breast cancer.
Journal Articles

A Kinome-Wide Screen Identifies the Insulin/IGF-I Receptor Pathway as a Mechanism of Escape from Hormone Dependence in Breast Cancer

Free
Emily M. Fox, Todd W. Miller, Justin M. Balko, Maria G. Kuba, Violeta Sánchez, R. Adam Smith, Shuying Liu, Ana María González-Angulo, Gordon B. Mills, Fei Ye, Yu Shyr, H. Charles Manning, Elizabeth Buck, Carlos L. Arteaga
Journal: Cancer Research
Cancer Res (2011) 71 (21): 6773–6784.
https://doi.org/10.1158/0008-5472.CAN-11-1295
Published: 30 October 2011
View articletitled, A Kinome-Wide Screen Identifies the Insulin/IGF-I Receptor Pathway as a Mechanism of Escape from Hormone Dependence in Breast Cancer
Open the PDF for A Kinome-Wide Screen Identifies the Insulin/IGF-I Receptor Pathway as a Mechanism of Escape from Hormone Dependence in Breast Cancer in another window
Includes: Supplementary data