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Journal Articles

Abstract C054: Hypoxia promotes a durable epithelial-mesenchymal transition in pancreas cancer through a histone methylation-MAPK signaling axis

Brooke A. Brown, Paul J. Myers, Sara J. Adair, Jason R. Pitarresi, Shiv Sah Teli, Peppi Karppinen, Ben Z. Stanger, Todd W. Bauer, Matthew J. Lazzara

Cancer Res (2022) 82 (22_Supplement): C054.

DOI: https://doi.org/10.1158/1538-7445.PANCA22-C054

Published: 15 November 2022

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Journal Articles

Abstract PO-007: PRMT5 inhibition sensitizes pancreatic cancer to gemcitabine in orthotopic and metastatic murine models

William J. Kane, Sara J. Adair, Sarbajeet Nagdas, Denis Liu, Xiaolong Wei, Mazhar Adli, Todd W. Bauer

Cancer Res (2020) 80 (22_Supplement): PO-007.

DOI: https://doi.org/10.1158/1538-7445.PANCA20-PO-007

Published: 13 November 2020

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Journal Articles

Abstract C19: The role of resident liver macrophages in suppressing the progression of hepatic micrometastases from pancreatic ductal adenocarcinoma

Alex D. Michaels, Timothy E. Newhook, James M. Lindberg, Sara J. Adair, Sarbajeet Nagdas, Matthew G. Mullen, Edward B. Stelow, J. Thomas Parsons, Todd W. Bauer

Cancer Res (2016) 76 (15_Supplement): C19.

DOI: https://doi.org/10.1158/1538-7445.TME16-C19

Published: 28 July 2016

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Journal Articles

Abstract A47: A patient-derived xenograft model of pancreatic cancer in mice to develop novel adjuvant therapies

Matthew G. Mullen, Timothy E. Newhook, James M. Lindberg, Sara J. Adair, Edik M. Blais, Alex D. Michaels, Edward B. Stelow, Jason A. Papin, J. Thomas Parsons, Todd W. Bauer

Cancer Res (2016) 76 (7_Supplement): A47.

DOI: https://doi.org/10.1158/1538-7445.TUMMET15-A47

Published: 26 May 2016

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Journal Articles

Abstract CT220: A randomized multicenter phase Ib/II study to assess the safety and the immunological effect of chemoradiation therapy (CRT) in combination with Pembrolizumab (anti-PD1) to CRT alone in patients with resectable or borderline resectable pancreatic canc

Matthew H.G Katz, Todd W. Bauer, Gauri Rajani Varadhachary, Reid B. Adams, Amy R. Lankford, Gina Petroni, Timothy N. Bullock, Craig L. Slingluff, Osama E. Rahma

Cancer Res (2015) 75 (15_Supplement): CT220.

DOI: https://doi.org/10.1158/1538-7445.AM2015-CT220

Published: 01 August 2015

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Journal Articles

Abstract 4040: The MEK inhibitor trametinib delays tumor outgrowth and prolongs survival in a patient-derived mouse model of occult hepatic metastatic pancreatic cancer

Timothy Eric Newhook, James M. Lindberg, Sara J. Adair, J. Thomas Parsons, Todd W. Bauer

Cancer Res (2014) 74 (19_Supplement): 4040.

DOI: https://doi.org/10.1158/1538-7445.AM2014-4040

Published: 01 October 2014

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Journal Articles

Abstract 808: Combination therapy with a MEK inhibitor plus T-type calcium channel inhibitor is highly effective in patient-derived pancreatic ductal adenocarcinomas

Timothy Eric Newhook, James M. Lindberg, Sara J. Adair, Edik Blais, Jason Papin, Lloyd Gray, J. Thomas Parsons, Todd W. Bauer

Cancer Res (2014) 74 (19_Supplement): 808.

DOI: https://doi.org/10.1158/1538-7445.AM2014-808

Published: 01 October 2014

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Journal Articles

Abstract 935: Inhibition of pancreatic cancer growth via MEK-targeted therapy is significantly enhanced by concomitant inhibition of EGFR and Her2.

James M. Lindberg, Timothy E. Newhook, Sara J. Adair, Clifford A. Cutchins, Alison Kim, J. Thomas Parsons, Todd W. Bauer

Cancer Res (2013) 73 (8_Supplement): 935.

DOI: https://doi.org/10.1158/1538-7445.AM2013-935

Published: 15 April 2013

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Journal Articles

Abstract 5600: Acquired resistance of pancreatic cancers to combination therapy with lapatinib plus the MEK 1/2 inhibitor GSK1120212: Using a murine orthotopic xenograft model to identify resistance pathways

James M. Lindberg, Dustin M. Walters, Sara J. Adair, Wenjun Xin, Blais Edik, Jayme B. Stokes, Cheryl A. Borgman, Edward B. Stelow, Hanna K. Sanoff, Jae K. Lee, Jason A. Papin, J. Thomas Parsons, Todd W. Bauer

Cancer Res (2012) 72 (8_Supplement): 5600.

DOI: https://doi.org/10.1158/1538-7445.AM2012-5600

Published: 15 April 2012

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Journal Articles

Abstract 1592: Targeting proliferative signals in patient-derived pancreatic cancers propagated orthotopically in immunocompromised mice

Dustin M. Walters, Catharine R. Cowan, Sara J. Adair, Cheryl A. Borgman, Jayme B. Stokes, Edward B. Stelow, Bryce T. Lowrey, Tona M. Gilmer, J. Thomas Parsons, Todd W. Bauer

Cancer Res (2011) 71 (8_Supplement): 1592.

DOI: https://doi.org/10.1158/1538-7445.AM2011-1592

Published: 15 April 2011

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Journal Articles

Abstract LB-241: Cancer-associated fibroblasts modulate growth- and metastasis-promoting pathways in human pancreatic cancer cells and augment orthotopic tumor growth in mice

Dustin M. Walters, Sara J. Adair, Jayme B. Stokes, Bryce Lowrey, J. Thomas Parsons, Todd W. Bauer

Cancer Res (2010) 70 (8_Supplement): LB-241.

DOI: https://doi.org/10.1158/1538-7445.AM10-LB-241

Published: 15 April 2010

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Journal Articles

Abstract LB-158: A human xenograft model for developing personalized targeted therapy for pancreatic cancer

Dustin M. Walters, Sara J. Adair, Jayme B. Stokes, Cheryl Borgman, Bryce Lowrey, Reid B. Adams, Jay W. Fox, Jason A. Papin, J. Thomas Parsons, Todd W. Bauer

Cancer Res (2010) 70 (8_Supplement): LB-158.

DOI: https://doi.org/10.1158/1538-7445.AM10-LB-158

Published: 15 April 2010

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Journal Articles

Vascular Endothelial Growth Factor Receptor-1 Activation Mediates Epithelial to Mesenchymal Transition in Human Pancreatic Carcinoma Cells

Anthony D. Yang, E. Ramsay Camp, Fan Fan, Lanlan Shen, Michael J. Gray, Wenbiao Liu, Ray Somcio, Todd W. Bauer, Yan Wu, Daniel J. Hicklin, Lee M. Ellis

Cancer Res (2006) 66 (1): 46–51.

DOI: https://doi.org/10.1158/0008-5472.CAN-05-3086

Published: 05 January 2006

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Journal Articles

Targeting of Urokinase Plasminogen Activator Receptor in Human Pancreatic Carcinoma Cells Inhibits c-Met– and Insulin-like Growth Factor-I Receptor–Mediated Migration and Invasion and Orthotopic Tumor Growth in Mice

Todd W. Bauer, Wenbiao Liu, Fan Fan, Ernest R. Camp, Anthony Yang, Ray J. Somcio, Corazon D. Bucana, Jennifer Callahan, Graham C. Parry, Douglas B. Evans, Douglas D. Boyd, Andrew P. Mazar, Lee M. Ellis

Cancer Res (2005) 65 (17): 7775–7781.

DOI: https://doi.org/10.1158/0008-5472.CAN-05-0946

Published: 01 September 2005

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Journal Articles

Effect of Hsp90 inhibition on Rac activation, cell migration, tumor growth and liver metastasis of human pancreatic carcinoma

Todd W. Bauer, Ray J. Somcio, Anthony D. Yang, Ernest R. Camp, Wenbiao Liu, Fan Fan, Meghan E. Minard, Gary E. Gallick, Lee M. Ellis

Cancer Res (2005) 65 (9_Supplement): 358.

Published: 01 May 2005

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Journal Articles

In vitro and in vivo characterization of a monoclonal antibody, ATN-658, targeting the uPA system

Jennifer A. Callahan, Ivy Beck, Todd W. Bauer, Lee M. Ellis, Andrew P. Mazar, Graham C. Parry

Cancer Res (2005) 65 (9_Supplement): 1454–1455.

Published: 01 May 2005

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Journal Articles

Cross-talk between insulin-like growth factor-I (IGF-I) and Hepatocyte Growth Factor (HGF) pathways increases cell invasion and migration in human colon carcinoma cells.

Todd W. Bauer, Fan Fan, Wen B. Liu, Gary E. Gallick, Lee M. Ellis

Cancer Res (2004) 64 (7_Supplement): 562–563.

Published: 01 April 2004

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NARROW

Abstract C054: Hypoxia promotes a durable epithelial-mesenchymal transition in pancreas cancer through a histone methylation-MAPK signaling axis

Abstract PO-007: PRMT5 inhibition sensitizes pancreatic cancer to gemcitabine in orthotopic and metastatic murine models

Abstract C19: The role of resident liver macrophages in suppressing the progression of hepatic micrometastases from pancreatic ductal adenocarcinoma

Abstract A47: A patient-derived xenograft model of pancreatic cancer in mice to develop novel adjuvant therapies

Abstract CT220: A randomized multicenter phase Ib/II study to assess the safety and the immunological effect of chemoradiation therapy (CRT) in combination with Pembrolizumab (anti-PD1) to CRT alone in patients with resectable or borderline resectable pancreatic canc

Abstract 4040: The MEK inhibitor trametinib delays tumor outgrowth and prolongs survival in a patient-derived mouse model of occult hepatic metastatic pancreatic cancer

Abstract 808: Combination therapy with a MEK inhibitor plus T-type calcium channel inhibitor is highly effective in patient-derived pancreatic ductal adenocarcinomas

Abstract 935: Inhibition of pancreatic cancer growth via MEK-targeted therapy is significantly enhanced by concomitant inhibition of EGFR and Her2.

Abstract 5600: Acquired resistance of pancreatic cancers to combination therapy with lapatinib plus the MEK 1/2 inhibitor GSK1120212: Using a murine orthotopic xenograft model to identify resistance pathways

Abstract 1592: Targeting proliferative signals in patient-derived pancreatic cancers propagated orthotopically in immunocompromised mice

Abstract LB-241: Cancer-associated fibroblasts modulate growth- and metastasis-promoting pathways in human pancreatic cancer cells and augment orthotopic tumor growth in mice

Abstract LB-158: A human xenograft model for developing personalized targeted therapy for pancreatic cancer

Vascular Endothelial Growth Factor Receptor-1 Activation Mediates Epithelial to Mesenchymal Transition in Human Pancreatic Carcinoma Cells

Targeting of Urokinase Plasminogen Activator Receptor in Human Pancreatic Carcinoma Cells Inhibits c-Met– and Insulin-like Growth Factor-I Receptor–Mediated Migration and Invasion and Orthotopic Tumor Growth in Mice

Effect of Hsp90 inhibition on Rac activation, cell migration, tumor growth and liver metastasis of human pancreatic carcinoma

In vitro and in vivo characterization of a monoclonal antibody, ATN-658, targeting the uPA system

Cross-talk between insulin-like growth factor-I (IGF-I) and Hepatocyte Growth Factor (HGF) pathways increases cell invasion and migration in human colon carcinoma cells.

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