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Abstract 29: Design of a phase I chemoprevention study of metformin and Li-Fraumeni syndrome (LFS)

Farzana L. Walcott, Paul M. Hwang, Ping-yuan Wang, Sharon A. Savage, Phuong Mai, Seth M. Steinberg, Michael N. Pollak, Philip A. Dennis, Antonio Tito Fojo

Cancer Res (2014) 74 (23_Supplement): 29.

DOI: https://doi.org/10.1158/1538-7445.CANSUSC14-29

Published: 12 December 2014

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Journal Articles

Abstract LB-106: Microtubule-targeting agents (MTAs) disrupt intracellular trafficking of DNA repair proteins and augment the toxicity of DNA damaging agents (DDAs)

Marianne S. Poruchynsky, Edina Komlodi-Pasztor, Julia Wilkerson, Shana Trostel, Mauricio Burroto-Pichun, Tito Fojo

Cancer Res (2014) 74 (19_Supplement): LB-106.

DOI: https://doi.org/10.1158/1538-7445.AM2014-LB-106

Published: 01 October 2014

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Journal Articles

Therapies with Diverse Mechanisms of Action Kill Cells by a Similar Exponential Process in Advanced Cancers

Krastan B. Blagoev, Julia Wilkerson, Wilfred D. Stein, James Yang, Susan E. Bates, Tito Fojo

Cancer Res (2014) 74 (17): 4653–4662.

DOI: https://doi.org/10.1158/0008-5472.CAN-14-0420

Published: 01 September 2014

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Journal Articles

Abstract 5152: Estimating the fraction of a tumor that is killed by a drug.

Wilfred D. Stein, Julia Wilkerson, Elisabet Manasanch, Sen H. Zhuang, Susan E. Bates, Tito Fojo

Cancer Res (2013) 73 (8_Supplement): 5152.

DOI: https://doi.org/10.1158/1538-7445.AM2013-5152

Published: 15 April 2013

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Journal Articles

Abstract 765: Growth rates of tumors with numerous histologies remain constant while patients are on therapy

Wilfred D. Stein, Julia Wilkerson, Bamidele Adesunloye, Ravi Madan, Susan E. Bates, Samuel Wells, William Dahut, Yang-min Ning, Sen Hong Zhuang, Robert J. Motzer, Tito Fojo

Cancer Res (2012) 72 (8_Supplement): 765.

DOI: https://doi.org/10.1158/1538-7445.AM2012-765

Published: 15 April 2012

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Journal Articles

Abstract 4547: Treatment of human medullary thyroid carcinoma (MTC) with either proteasome (Pr) or histone deacetylase (HDAC) inhibitors leads to a fall in RET mRNA levels and, in turn, a decrease in RET protein expression providing alternate strategies to reduce RET expression in a tyrosine-kinase driven disease

Marianne S. Poruchynsky, Ann W. Gramza, Samuel A. Wells, Tito Fojo

Cancer Res (2011) 71 (8_Supplement): 4547.

DOI: https://doi.org/10.1158/1538-7445.AM2011-4547

Published: 15 April 2011

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Journal Articles

Microtubule-Disrupting Chemotherapeutics Result in Enhanced Proteasome-Mediated Degradation and Disappearance of Tubulin in Neural Cells

Lyn M. Huff, Dan L. Sackett, Marianne S. Poruchynsky, Tito Fojo

Cancer Res (2010) 70 (14): 5870–5879.

DOI: https://doi.org/10.1158/0008-5472.CAN-09-4281

Published: 14 July 2010

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Includes: Supplementary data

Journal Articles

Abstract 2554: Copper transporter 2 (CTR2) is able to transport cisplatin and/or oxaliplatin in drug-resistant cell lines

Edina M. Komlodi-Pasztor, Robert Murphy, Julia Wilkerson, Tito Fojo

Cancer Res (2010) 70 (8_Supplement): 2554.

DOI: https://doi.org/10.1158/1538-7445.AM10-2554

Published: 15 April 2010

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Journal Articles

Abstract 3527: A pharmacodynamic study of docetaxel in combination with the p-glycoprotein antagonist, tariquidar (XR9576) in patients with lung, ovarian, and cervical cancer

Ronan J. Kelly, Robert Robey, Deborah Draper, Clara Chen, Aradhana M. Venkatesan, William D. Figg, Erin Gardner, Richard Piekarz, Frank Balis, Tito Fojo, Susan E. Bates

Cancer Res (2010) 70 (8_Supplement): 3527.

DOI: https://doi.org/10.1158/1538-7445.AM10-3527

Published: 15 April 2010

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Journal Articles

Abstract #3870: Tubulin homeostasis in neural cells but not in cancer cells leads to rapid proteasome-mediated tubulin degradation following drug-induced microtubule depolymerization

Lyn Huff, Dan Sackett, Marianne Poruchynsky, Tito Fojo

Cancer Res (2009) 69 (9_Supplement): 3870.

Published: 01 May 2009

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Journal Articles

Abstract #599: Impaired p53 binding to importin: A novel mechanism of cytoplasmic sequestration identified in oxaliplatin-resistant cells

Edina Komlodi-Pasztor, Shana Trostel, Dan Sackett, Marianne Poruchynsky, Tito Fojo

Cancer Res (2009) 69 (9_Supplement): 599.

Published: 01 May 2009

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Journal Articles

The novel epothilone ixabepilone reduces the growth rate constants of renal carcinoma tumors in comparison with a placebo: Description of a novel algorithm to assess therapeutic efficacy

wilfred stein, Maureen Edgerly, Hui Huang, Michael Menefee, Susan Bates, Tito Fojo

Cancer Res (2008) 68 (9_Supplement): 5829.

Published: 01 May 2008

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Journal Articles

Proteasome inhibitors increase tubulin polymerization and stabilization in tissue culture cells. A possible mechanism contributing to peripheral neuropathy and cellular toxicity following proteasome inhibition.

Marianne Poruchynsky, Dan Sackett, Robert Robey, Yvona Ward, Christina Annunziata, Tito Fojo

Cancer Res (2008) 68 (9_Supplement): 3268.

Published: 01 May 2008

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Journal Articles

Oxaliplatin resistant cells possess a mutant p53 that is confined to the cytoplasm

Edina Komlodi-Pasztor, Shana Trostel, Bob Murphy, Tito Fojo

Cancer Res (2008) 68 (9_Supplement): 2785.

Published: 01 May 2008

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Journal Articles

Cisplatin markedly enhances microtubule depolymerization in A549 cell line compared with oxaliplatin

Young Joo Min, Marianne S. Poruchynsky, Dan L. Sackett, Bob Murphy, Tito Fojo

Cancer Res (2008) 68 (9_Supplement): 3335.

Published: 01 May 2008

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Journal Articles

A new approach for the treatment of adrenal cancer: Testing an adrenal-specific adenovirus suicide gene therapy vector in an adrenal cancer xenograft model system

Merrill Goldsmith, William Waud, Tito Fojo

Cancer Res (2007) 67 (9_Supplement): 3312.

Published: 01 May 2007

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Journal Articles

Tumor growth rate constants derived from data gathered while patients are on clinical trial correlate strongly with patient survival: a novel strategy for evaluation of clinical trial data

wilfred stein, Susan Bates, William Figg, William Dahut, Tito Fojo

Cancer Res (2007) 67 (9_Supplement): 2662.

Published: 01 May 2007

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Journal Articles

Expression of VEGF and N-cadherin in adrenal cortical cancers and a mouse xenograft model to assess possible new therapeutic targets

Irina Veytsman, John Yu, Sherry Yang, Dat Nguyen, Merrill Goldsmith, William Waud, Tito Fojo

Cancer Res (2007) 67 (9_Supplement): 5274.

Published: 01 May 2007

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Journal Articles

Aberrant Transcription from an Unrelated Promoter Can Result in MDR-1 Expression following Drug Selection In vitro and in Relapsed Lymphoma Samples

Lyn Mickley Huff, Zheng Wang, Angel Iglesias, Tito Fojo, Jong-Seok Lee

Cancer Res (2005) 65 (24): 11694–11703.

DOI: https://doi.org/10.1158/0008-5472.CAN-04-1349

Published: 15 December 2005

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Journal Articles

Genetic and Epigenetic Modeling of the Origins of Multidrug-Resistant Cells in a Human Sarcoma Cell Line

Kevin G. Chen, Yan C. Wang, Marci E. Schaner, Brian Francisco, George E. Durán, Dejan Juric, Lyn M. Huff, Hesed Padilla-Nash, Thomas Ried, Tito Fojo, Branimir I. Sikic

Cancer Res (2005) 65 (20): 9388–9397.

DOI: https://doi.org/10.1158/0008-5472.CAN-04-4133

Published: 17 October 2005

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Includes: Supplementary data

NARROW

Abstract 29: Design of a phase I chemoprevention study of metformin and Li-Fraumeni syndrome (LFS)

Abstract LB-106: Microtubule-targeting agents (MTAs) disrupt intracellular trafficking of DNA repair proteins and augment the toxicity of DNA damaging agents (DDAs)

Therapies with Diverse Mechanisms of Action Kill Cells by a Similar Exponential Process in Advanced Cancers

Abstract 5152: Estimating the fraction of a tumor that is killed by a drug.

Abstract 765: Growth rates of tumors with numerous histologies remain constant while patients are on therapy

Microtubule-Disrupting Chemotherapeutics Result in Enhanced Proteasome-Mediated Degradation and Disappearance of Tubulin in Neural Cells

Abstract 2554: Copper transporter 2 (CTR2) is able to transport cisplatin and/or oxaliplatin in drug-resistant cell lines

Abstract 3527: A pharmacodynamic study of docetaxel in combination with the p-glycoprotein antagonist, tariquidar (XR9576) in patients with lung, ovarian, and cervical cancer

Abstract #3870: Tubulin homeostasis in neural cells but not in cancer cells leads to rapid proteasome-mediated tubulin degradation following drug-induced microtubule depolymerization

Abstract #599: Impaired p53 binding to importin: A novel mechanism of cytoplasmic sequestration identified in oxaliplatin-resistant cells

The novel epothilone ixabepilone reduces the growth rate constants of renal carcinoma tumors in comparison with a placebo: Description of a novel algorithm to assess therapeutic efficacy

Proteasome inhibitors increase tubulin polymerization and stabilization in tissue culture cells. A possible mechanism contributing to peripheral neuropathy and cellular toxicity following proteasome inhibition.

Oxaliplatin resistant cells possess a mutant p53 that is confined to the cytoplasm

Cisplatin markedly enhances microtubule depolymerization in A549 cell line compared with oxaliplatin

A new approach for the treatment of adrenal cancer: Testing an adrenal-specific adenovirus suicide gene therapy vector in an adrenal cancer xenograft model system

Tumor growth rate constants derived from data gathered while patients are on clinical trial correlate strongly with patient survival: a novel strategy for evaluation of clinical trial data

Expression of VEGF and N-cadherin in adrenal cortical cancers and a mouse xenograft model to assess possible new therapeutic targets

Aberrant Transcription from an Unrelated Promoter Can Result in MDR-1 Expression following Drug Selection In vitro and in Relapsed Lymphoma Samples

Genetic and Epigenetic Modeling of the Origins of Multidrug-Resistant Cells in a Human Sarcoma Cell Line

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