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Ting-Lei Gu
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Journal Articles

Abstract 961: 6-phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumor growth by inhibiting LKB1-AMPK signaling

Changliang Shan, Shannon E. Elf, Ting-Lei Gu, Hanna J. Khoury, Titus Boggon, Sumin Kang, Jing Chen
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 961.
https://doi.org/10.1158/1538-7445.AM2014-961
Published: 01 October 2014
View article titled, Abstract 961: 6-phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumor growth by inhibiting LKB1-AMPK signaling
Journal Articles

Abstract 3362: Tyr-phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate pyruvate dehydrogenase complex and promote the Warburg effect

Jun Fan, Ting-Lei Gu, Titus Boggon, Sumin Kang, Jing Chen
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3362.
https://doi.org/10.1158/1538-7445.AM2014-3362
Published: 01 October 2014
View article titled, Abstract 3362: Tyr-phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate pyruvate dehydrogenase complex and promote the Warburg effect
Journal Articles

Abstract 2925: p90RSK2 coordinates pro-apoptotic and anti-apoptotic signaling pathways to protect cancer cells from anoikis.

Lingtao Jin, Dan Li, Jongseok Lee, Gina N. Alesi, Jun Fan, Hee-Bum Kang, Dongsheng Wang, Haian Fu, Jack Taunton, Titus J. Boggon, Meghan Tucker, Ting-Lei Gu, Zhuo G. Chen, Dong M. Shin, Fadlo R. Khuri, Sumin Kang
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2925.
https://doi.org/10.1158/1538-7445.AM2013-2925
Published: 15 April 2013
View article titled, Abstract 2925: p90RSK2 coordinates pro-apoptotic and anti-apoptotic signaling pathways to protect cancer cells from anoikis.
Journal Articles

Identification of Anaplastic Lymphoma Kinase as a Potential Therapeutic Target in Ovarian Cancer

Hong Ren, Zhi-Ping Tan, Xin Zhu, Katherine Crosby, Herbert Haack, Jian-Min Ren, Sean Beausoleil, Albrecht Moritz, Gregory Innocenti, John Rush, Yi Zhang, Xin-Min Zhou, Ting-Lei Gu, Yi-Feng Yang, Michael J. Comb
Journal: Cancer Research
Cancer Res (2012) 72 (13): 3312–3323.
https://doi.org/10.1158/0008-5472.CAN-11-3931
Published: 01 July 2012
View article titled, Identification of Anaplastic Lymphoma Kinase as a Potential Therapeutic Target in Ovarian Cancer
Open the PDF for Identification of Anaplastic Lymphoma Kinase as a Potential Therapeutic Target in Ovarian Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 997: Oncogenic tyrosine kinases are localized to mitochondria and regulate cancer metabolism by phosphorylating key components of pyruvate dehydrogenase kinase complex

Jing Chen, Taro Hitosugi, Jun Fan, Sumin Kang, Ting-Lei Gu, Titus Boggon
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 997.
https://doi.org/10.1158/1538-7445.AM2012-997
Published: 15 April 2012
View article titled, Abstract 997: Oncogenic tyrosine kinases are localized to mitochondria and regulate cancer metabolism by phosphorylating key components of pyruvate dehydrogenase kinase complex
Journal Articles

Abstract 2798: Tyrosine phosphorylation of LDH-A is important for cancer cell redox homeostasis and tumor growth

Jun Fan, Taro Hitosugi, Tae-Wook Chung, Xu Wang, Ting-Lei Gu, Johannes L. Roesel, Zhuo (Georgia) Chen, Titus Boggon, Fadlo R. Khuri, Sumin Kang, Jing Chen
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2798.
https://doi.org/10.1158/1538-7445.AM2011-2798
Published: 15 April 2011
View article titled, Abstract 2798: Tyrosine phosphorylation of LDH-A is important for cancer cell redox homeostasis and tumor growth
Journal Articles

Abstract 1257: Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism

Tae-Wook Chung, Taro Hitosugi, Jun Fan, Xu Wang, Ting-Lei Gu, Johannes L. Roesel, Titus Boggon, Zhuo (Georgia) Chen, Fadlo R. Khuri, Sumin Kang, Jing Chen
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 1257.
https://doi.org/10.1158/1538-7445.AM2011-1257
Published: 15 April 2011
View article titled, Abstract 1257: Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism
Journal Articles

Abstract LB-399: Chronic inhibition of mutant EGFR in NSCLC leads to EGFR TKI resistance by TGF-β1 mediated epithelial to mesenchymal transition

Takeshi Shimamura, Julian Carretero, Chunxiao Xu, Marzia Capelletti, Klarisa Rikova, Ting-Lei Gu, Susumu Kobayashi, Andrew Rogers, Pasi A. Janne, Kwok-Kin Wong, Geoffrey I. Shapiro
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): LB-399.
https://doi.org/10.1158/1538-7445.AM2011-LB-399
Published: 15 April 2011
View article titled, Abstract LB-399: Chronic inhibition of mutant EGFR in NSCLC leads to EGFR TKI resistance by TGF-β1 mediated epithelial to mesenchymal transition
Journal Articles

Abstract 34: Oncogenic tyrosine kinases phosphorylate and inhibit PKM2 to provide a metabolic advantage to tumor growth

Taro Hitosugi, Sumin Kang, Matthew G. Vander Heiden, Tae-Wook Chung, Sagar Lonial, Xu Wang, Georgia Z. Chen, Jianxin Xie, Ting-Lei Gu, Roberto D. Polakiewicz, Johannes L. Roesel, Titus Boggon, Fadlo Khuri, D. Gary Gilliland, Lewis C. Cantley, Jonathan Kaufman, Jing Chen
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 34.
https://doi.org/10.1158/1538-7445.AM10-34
Published: 15 April 2010
View article titled, Abstract 34: Oncogenic tyrosine kinases phosphorylate and inhibit PKM2 to provide a metabolic advantage to tumor growth
Journal Articles

Abstract LB-309: EML4-ALK signaling is required for the maintenance of neoplastic phenotype of non-small cell lung cancer cells: Novel strategy for lung cancer-tailored therapies

Claudia Voena, Elena Panizza, Lucia D'Amico, Chiara Ambrogio, Martinengo Cinzia, Francesco Boccalatte, Ludovica Riera, Lisa Bonello, Roberta Pulito, Jorg Hamm, Mangeng Cheng, Bruce Ruggeri, Ting-Lei Gu, Roberto D. Polakiewicz, Enzo Medico, Roberto Chiarle, Giorgio Inghirami
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): LB-309.
https://doi.org/10.1158/1538-7445.AM10-LB-309
Published: 15 April 2010
View article titled, Abstract LB-309: EML4-ALK signaling is required for the maintenance of neoplastic phenotype of non-small cell lung cancer cells: Novel strategy for lung cancer-tailored therapies
Journal Articles

EGF stimulates RSK2 activation through activation of the MEK/ERK pathway and Src-dependent tyrosine phosphorylation of RSK2 at Y529

Sumin Kang, Shaozhong Dong, Ailan Guo, Hong Ruan, Sagar Lonial, Hanna Khoury, Ting-Lei Gu, Jing Chen
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 3486.
Published: 01 May 2008
View article titled, EGF stimulates RSK2 activation through activation of the MEK/ERK pathway and Src-dependent tyrosine phosphorylation of RSK2 at Y529
Journal Articles

Phosphoproteome of activated FLT3 in leukemia

Ting-Lei Gu, Julie Nardone, Marc Loriaux, Kim Lee, Judit Villen, Steven Gygi, John Rush, Michael Comb, Brian Druker, Michael Heinrich, Roberto Polakiewicz
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 3134.
Published: 01 May 2007
View article titled, Phosphoproteome of activated FLT3 in leukemia
Journal Articles

PhosphoScan® analysis reveals insights into the mechanisms responsible for disruption of cell-cell adhesion mediated by activation of the CSF-1R in mammary epithelial cells

Melodie Knowlton, Carolyn Wrobel, Ting-Lei Gu, Bryan Ballif, Steven Gygi, Roberto Polakiewicz, Joan Brugge
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 408.
Published: 01 May 2007
View article titled, PhosphoScan<sup>® </sup>analysis reveals insights into the mechanisms responsible for disruption of cell-cell adhesion mediated by activation of the CSF-1R in mammary epithelial cells
Journal Articles

Core-Binding Factor: A Central Player in Hematopoiesis and Leukemia

Nancy A. Speck, Terry Stacy, Qing Wang, Trista North, Ting-Lei Gu, Janelle Miller, Michael Binder, Miguel Marín-Padilla
Journal: Cancer Research
Cancer Res (1999) 59 (7_Supplement): 1789s–1793s.
Published: 01 April 1999
View article titled, Core-Binding Factor: A Central Player in Hematopoiesis and Leukemia
Open the PDF for Core-Binding Factor: A Central Player in Hematopoiesis and Leukemia in another window