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Journal Articles

Abstract B014: The number analysis of digital data in Nature’s ecosystem: The unified general dynamics theory of “Unity of One” and its fractional distribution, action and interaction principle, and algorithms for computerized translational informatics

Ting-Chao Chou

Cancer Res (2024) 84 (3_Supplement_2): B014.

https://doi.org/10.1158/1538-7445.CANEVOL23-B014

Published: 01 February 2024

View articletitled, Abstract B014: The number analysis of digital data in Nature’s ecosystem: The unified general dynamics theory of “Unity of One” and its fractional distribution, action and interaction principle, and algorithms for computerized translational informatics

Journal Articles

Abstract LB021: Pharmacodynamics algorithm integrated assessments-and-ranking of multiple candidate drugs in preclinical and clinical protocol design and quantitative computerized simulation

Ting-Chao Chou

Cancer Res (2021) 81 (13_Supplement): LB021.

https://doi.org/10.1158/1538-7445.AM2021-LB021

Published: 01 July 2021

View articletitled, Abstract LB021: Pharmacodynamics algorithm integrated assessments-and-ranking of multiple candidate drugs in preclinical and clinical protocol design and quantitative computerized simulation

Journal Articles

Abstract 5510: Mass-action law based general pharmacodynamics theory and algorithm for quantitative computer simulation of drug-evaluations in cells, in animals and in clinical trials

Ting-Chao Chou

Cancer Res (2020) 80 (16_Supplement): 5510.

https://doi.org/10.1158/1538-7445.AM2020-5510

Published: 15 August 2020

View articletitled, Abstract 5510: Mass-action law based general pharmacodynamics theory and algorithm for quantitative computer simulation of drug-evaluations in cells, in animals and in clinical trials

Journal Articles

Abstract CT155: General pharmacodynamics algorithm-based clinical protocol design with two to three dose-data points for single-drug, and ten data points for two-drug-combination synergy quantification, using computer simulation for digitalized data analysis and conclusions

Ting-Chao Chou

Cancer Res (2020) 80 (16_Supplement): CT155.

https://doi.org/10.1158/1538-7445.AM2020-CT155

Published: 15 August 2020

View articletitled, Abstract CT155: General pharmacodynamics algorithm-based clinical protocol design with two to three dose-data points for single-drug, and ten data points for two-drug-combination synergy quantification, using computer simulation for digitalized data analysis and conclusions

Journal Articles

Abstract 4554: Unified theoretical algorithms for graphics dynamic multiple transformations of dose-effect relationships with computer simulation

Ting-Chao Chou

Cancer Res (2017) 77 (13_Supplement): 4554.

https://doi.org/10.1158/1538-7445.AM2017-4554

Published: 01 July 2017

View articletitled, Abstract 4554: Unified theoretical algorithms for graphics dynamic multiple transformations of dose-effect relationships with computer simulation

Journal Articles

Abstract 4554A: Simple, efficient, and quantitative approach for determination of synergism, additive effect, and antagonism of drugs in vivo using combination index method: a proposition for clinical protocol design and regulatory synergy claims

Jianing Fu, Ting-Chao Chou

Cancer Res (2017) 77 (13_Supplement): 4554A.

https://doi.org/10.1158/1538-7445.AM2017-4554A

Published: 01 July 2017

View articletitled, Abstract 4554A: Simple, efficient, and quantitative approach for determination of synergism, additive effect, and antagonism of drugs in vivo using combination index method: a proposition for clinical protocol design and regulatory synergy claims

Journal Articles

Abstract 3276: Computerized quantification of synergism or antagonism in anticancer drug combination with different mechanisms and/or modes of actions.

Ting-Chao Chou

Cancer Res (2013) 73 (8_Supplement): 3276.

https://doi.org/10.1158/1538-7445.AM2013-3276

Published: 15 April 2013

View articletitled, Abstract 3276: Computerized quantification of synergism or antagonism in anticancer drug combination with different mechanisms and/or modes of actions.

Journal Articles

Abstract 5526: Mass-action law algorithm-based computer simulation for efficient and econo-green cancer drug discovery and development.

Ting-Chao Chou

Cancer Res (2013) 73 (8_Supplement): 5526.

https://doi.org/10.1158/1538-7445.AM2013-5526

Published: 15 April 2013

View articletitled, Abstract 5526: Mass-action law algorithm-based computer simulation for efficient and econo-green cancer drug discovery and development.

Journal Articles

Abstract 1765: Potent antitumor BO-1922, derivative of indolizino[6,7-b]indole, against human colon, lung, and pancreatic cancers in xenograft model

Tsann-Long Su, Satishkumar Tala, Ravi Chaniyara, Chi-Wei Chen, Te-Chang Lee, Ting-Chao Chou

Cancer Res (2012) 72 (8_Supplement): 1765.

https://doi.org/10.1158/1538-7445.AM2012-1765

Published: 15 April 2012

View articletitled, Abstract 1765: Potent antitumor BO-1922, derivative of indolizino[6,7-b]indole, against human colon, lung, and pancreatic cancers in xenograft model

Journal Articles

Abstract 3521: Alleviation of cancer chemotherapeutic agent-induced toxicity by the synthetic panaxytriol analogues of Panax Ginseng

Ting-Chao Chou, Huajin Dong, Xiuguo Zhang, Xiaoguang Lei, Samuel J. Danishefsky

Cancer Res (2011) 71 (8_Supplement): 3521.

https://doi.org/10.1158/1538-7445.AM2011-3521

Published: 15 April 2011

View articletitled, Abstract 3521: Alleviation of cancer chemotherapeutic agent-induced toxicity by the synthetic panaxytriol analogues of Panax Ginseng

Journal Articles

Abstract 3527: Therapeutic cure against five human xenograft tumors and strongly suppressed drug-resistant and refractory xenograft tumors in nude mice by the third generation epothilone: Iso-oxazole fludelone

Ting-Chao Chou, Xiuguo Zhang, Huajin Dong, Samuel J. Danishefsky

Cancer Res (2011) 71 (8_Supplement): 3527.

https://doi.org/10.1158/1538-7445.AM2011-3527

Published: 15 April 2011

View articletitled, Abstract 3527: Therapeutic cure against five human xenograft tumors and strongly suppressed drug-resistant and refractory xenograft tumors in nude mice by the third generation epothilone: Iso-oxazole fludelone

Journal Articles

Abstract 2534: Novel and stable water-soluble N-mustards with potent therapeutic efficacy against human tumor xenografts in nude mice

Tsann-Long Su, Rajesh Kakadiya, Huajin Dong, Yi-Ren Chen, Pei-Chih Lee, Ting-Chao Chou, Pei-Wen Hsiao, Te-Chang Lee, Bhavin Marvania

Cancer Res (2011) 71 (8_Supplement): 2534.

https://doi.org/10.1158/1538-7445.AM2011-2534

Published: 15 April 2011

View articletitled, Abstract 2534: Novel and stable water-soluble N-mustards with potent therapeutic efficacy against human tumor xenografts in nude mice

Journal Articles

Rebuttal to the Response of Lee and Kong

Ting-Chao Chou

Cancer Res (2011) 71 (7): 2796–2797.

https://doi.org/10.1158/0008-5472.CAN-11-0381

Published: 31 March 2011

View articletitled, Rebuttal to the Response of Lee and Kong

Journal Articles

Combined Treatment of Pancreatic Cancer with Mithramycin A and Tolfenamic Acid Promotes Sp1 Degradation and Synergistic Antitumor Activity—Letter

Ting-Chao Chou

Cancer Res (2011) 71 (7): 2793.

https://doi.org/10.1158/0008-5472.CAN-11-0379

Published: 31 March 2011

View articletitled, Combined Treatment of Pancreatic Cancer with Mithramycin A and Tolfenamic Acid Promotes Sp1 Degradation and Synergistic Antitumor Activity—Letter

Journal Articles

Abstract 5398: Drug combination synergy quantification in animals and clinics using computerized combination index method

Ting-Chao Chou

Cancer Res (2010) 70 (8_Supplement): 5398.

https://doi.org/10.1158/1538-7445.AM10-5398

Published: 15 April 2010

View articletitled, Abstract 5398: Drug combination synergy quantification in animals and clinics using computerized combination index method

Journal Articles

Abstract 3517: Complete remission of xenograft tumor in nude mice induced by N-mustard-quinoline conjugates bearing hydrazinecarboxamide linker

Tsann-Long Su, Rajesh Kakadiya, Huajin Dong, Amit Kumar, Te-Chang Lee, Tung-Hu Tsai, Ting-Chao Chou

Cancer Res (2010) 70 (8_Supplement): 3517.

https://doi.org/10.1158/1538-7445.AM10-3517

Published: 15 April 2010

View articletitled, Abstract 3517: Complete remission of xenograft tumor in nude mice induced by N-mustard-quinoline conjugates bearing hydrazinecarboxamide linker

Journal Articles

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

Ting-Chao Chou

Cancer Res (2010) 70 (2): 440–446.

https://doi.org/10.1158/0008-5472.CAN-09-1947

Published: 13 January 2010

View articletitled, Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

Journal Articles

Abstract #4577: Synergistic interaction between microtubule targeting epothilone, Fludelone, and the main active ingredient in red ginseng, Panaxytriol: Synergism determination based on combination index via computer simulation

Ting-Chao Chou, Xiaoguang Lei, Huajin Dong, Xiu-Guo Zhang, Samuel Danishefsky

Cancer Res (2009) 69 (9_Supplement): 4577.

Published: 01 May 2009

View articletitled, Abstract #4577: Synergistic interaction between microtubule targeting epothilone, Fludelone, and the main active ingredient in red ginseng, Panaxytriol: Synergism determination based on combination index via computer simulation

Journal Articles

Abstract #4572: Comparison of drug combinations in vitro, in animals, and in clinics by using the combination index method via computer simulation

Ting-Chao Chou

Cancer Res (2009) 69 (9_Supplement): 4572.

Published: 01 May 2009

View articletitled, Abstract #4572: Comparison of drug combinations in vitro, in animals, and in clinics by using the combination index method via computer simulation

Journal Articles

Abstract #4518: Complete xenograft tumor remission by N-mustard-9-anilinoacridine conjugates having a carbamate or carbonate linker

Tsann-Long Su, Naval Kapuriya, Huajin Dong, Ting-Chao Chou, Yu-Ting Chen, Te-Chang Lee, Tung-Hu Tsai

Cancer Res (2009) 69 (9_Supplement): 4518.

Published: 01 May 2009

View articletitled, Abstract #4518: Complete xenograft tumor remission by N-mustard-9-anilinoacridine conjugates having a carbamate or carbonate linker

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Abstract B014: The number analysis of digital data in Nature’s ecosystem: The unified general dynamics theory of “Unity of One” and its fractional distribution, action and interaction principle, and algorithms for computerized translational informatics

Abstract LB021: Pharmacodynamics algorithm integrated assessments-and-ranking of multiple candidate drugs in preclinical and clinical protocol design and quantitative computerized simulation

Abstract 5510: Mass-action law based general pharmacodynamics theory and algorithm for quantitative computer simulation of drug-evaluations in cells, in animals and in clinical trials

Abstract CT155: General pharmacodynamics algorithm-based clinical protocol design with two to three dose-data points for single-drug, and ten data points for two-drug-combination synergy quantification, using computer simulation for digitalized data analysis and conclusions

Abstract 4554: Unified theoretical algorithms for graphics dynamic multiple transformations of dose-effect relationships with computer simulation

Abstract 4554A: Simple, efficient, and quantitative approach for determination of synergism, additive effect, and antagonism of drugs in vivo using combination index method: a proposition for clinical protocol design and regulatory synergy claims

Abstract 3276: Computerized quantification of synergism or antagonism in anticancer drug combination with different mechanisms and/or modes of actions.

Abstract 5526: Mass-action law algorithm-based computer simulation for efficient and econo-green cancer drug discovery and development.

Abstract 1765: Potent antitumor BO-1922, derivative of indolizino[6,7-b]indole, against human colon, lung, and pancreatic cancers in xenograft model

Abstract 3521: Alleviation of cancer chemotherapeutic agent-induced toxicity by the synthetic panaxytriol analogues of Panax Ginseng

Abstract 3527: Therapeutic cure against five human xenograft tumors and strongly suppressed drug-resistant and refractory xenograft tumors in nude mice by the third generation epothilone: Iso-oxazole fludelone

Abstract 2534: Novel and stable water-soluble N-mustards with potent therapeutic efficacy against human tumor xenografts in nude mice

Rebuttal to the Response of Lee and Kong

Combined Treatment of Pancreatic Cancer with Mithramycin A and Tolfenamic Acid Promotes Sp1 Degradation and Synergistic Antitumor Activity—Letter

Abstract 5398: Drug combination synergy quantification in animals and clinics using computerized combination index method

Abstract 3517: Complete remission of xenograft tumor in nude mice induced by N-mustard-quinoline conjugates bearing hydrazinecarboxamide linker

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

Abstract #4577: Synergistic interaction between microtubule targeting epothilone, Fludelone, and the main active ingredient in red ginseng, Panaxytriol: Synergism determination based on combination index via computer simulation

Abstract #4572: Comparison of drug combinations in vitro, in animals, and in clinics by using the combination index method via computer simulation

Abstract #4518: Complete xenograft tumor remission by N-mustard-9-anilinoacridine conjugates having a carbamate or carbonate linker

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