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Tin-Lok Wong
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Journal Articles

Abstract 1755: ADAR1-mediated RNA editing of SCD1 links lipid metabolism to gastric cancer drug resistance and self-renewal

Jia Jian Loh, Tin Lok Wong, Shixun Lu, Helen HN Yan, Hoi Cheong Siu, Ren Xi, Dessy Chan, Max JF Kam, Lei Zhou, Man Tong, John A. Copland, Leilei Chen, Jingping Yun, Suet Yi Leung, Stephanie Ma
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1755.
https://doi.org/10.1158/1538-7445.AM2023-1755
Published: 04 April 2023
View article titled, Abstract 1755: ADAR1-mediated RNA editing of SCD1 links lipid metabolism to gastric cancer drug resistance and self-renewal
Journal Articles

Abstract 2449: p38β promotes cancer stemness and chemoresistance in hepatocellular carcinoma

Ianto Bosheng Huang, Yunong Xie, Tin Lok Wong, Terence Kin Wah Lee, Jing-Ping Yun, Stephanie Kwai Yee Ma, Man Tong
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2449.
https://doi.org/10.1158/1538-7445.AM2023-2449
Published: 04 April 2023
View article titled, Abstract 2449: p38β promotes cancer stemness and chemoresistance in hepatocellular carcinoma
Journal Articles

Abstract 2433: SERPINA12 promotes the tumorigenic capacity of hepatocellular carcinoma stem cells through hyperactivation of AKT/β-catenin signaling

Huajian Yu, Lei Zhou, Jane Ho-Chun Loong, Ka-Hei Lam, Tin-Lok Wong, Kai-Yu Ng, Man Tong, Victor WS Ma, Yanyan Wang, Xiang Zhang, Terence K Lee, Jing-Ping Yun, Jun Yu, Stephanie Ma
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2433.
https://doi.org/10.1158/1538-7445.AM2023-2433
Published: 04 April 2023
View article titled, Abstract 2433: SERPINA12 promotes the tumorigenic capacity of hepatocellular carcinoma stem cells through hyperactivation of AKT/β-catenin signaling
Journal Articles

Abstract 2429: AGPAT4 as a novel metabolic driver of oncogenic stemness and dedifferentiation in hepatocellular carcinoma

Kai Yu Ng, Tsz-Lok Fong, Ya Gao, Tin-Lok Wong, Yuan Gao, Jing-Ping Yun, Xin-Yuan Guan, Ming Liu, Clive YS Chung, Stephanie Ma
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2429.
https://doi.org/10.1158/1538-7445.AM2023-2429
Published: 04 April 2023
View article titled, Abstract 2429: AGPAT4 as a novel metabolic driver of oncogenic stemness and dedifferentiation in hepatocellular carcinoma
Journal Articles

Caspase-3–Induced Activation of SREBP2 Drives Drug Resistance via Promotion of Cholesterol Biosynthesis in Hepatocellular Carcinoma

Etienne Ho Kit Mok, Carmen Oi Ning Leung, Lei Zhou, Martina Mang Leng Lei, Hoi Wing Leung, Man Tong, Tin Lok Wong, Eunice Yuen Ting Lau, Irene Oi Lin Ng, Jin Ding, Jing Ping Yun, Jun Yu, Hui Lian Zhu, Chi Ho Lin, Dan Lindholm, Kit Sum Leung, Jonathan D. Cybulski, David M. Baker, Stephanie Ma, Terence Kin Wah Lee
Journal: Cancer Research
Cancer Res (2022) 82 (17): 3102–3115.
https://doi.org/10.1158/0008-5472.CAN-21-2934
Published: 02 September 2022
View article titled, Caspase-3–Induced Activation of SREBP2 Drives Drug Resistance via Promotion of Cholesterol Biosynthesis in Hepatocellular Carcinoma
Open the PDF for Caspase-3–Induced Activation of SREBP2 Drives Drug Resistance via Promotion of Cholesterol Biosynthesis in Hepatocellular Carcinoma in another window
Includes: Supplementary data
Journal Articles

A Combinatorial CRISPR–Cas9 Screen Identifies Ifenprodil as an Adjunct to Sorafenib for Liver Cancer Treatment

Feng Xu, Man Tong, Cindy S.W. Tong, Becky K.C. Chan, Hoi Yee Chu, Tin Lok Wong, John H.C. Fong, Maggie S.H. Cheung, Kylie Hin-Man Mak, Lakhansing Pardeshi, Yuanhua Huang, Koon Ho Wong, Gigi C.G. Choi, Stephanie Ma, Alan S.L. Wong
Journal: Cancer Research
Cancer Res (2021) 81 (24): 6219–6232.
https://doi.org/10.1158/0008-5472.CAN-21-1017
Published: 15 December 2021
View article titled, A Combinatorial CRISPR–Cas9 Screen Identifies Ifenprodil as an Adjunct to Sorafenib for Liver Cancer Treatment
Open the PDF for A Combinatorial CRISPR–Cas9 Screen Identifies Ifenprodil as an Adjunct to Sorafenib for Liver Cancer Treatment in another window
Includes: Supplementary data
Journal Articles

FSTL1 Secreted by Activated Fibroblasts Promotes Hepatocellular Carcinoma Metastasis and Stemness

Jia-Jian Loh, Tsz-Wai Li, Lei Zhou, Tin-Lok Wong, Xue Liu, Victor W.S. Ma, Chung-Mau Lo, Kwan Man, Terence K. Lee, Wen Ning, Man Tong, Stephanie Ma
Journal: Cancer Research
Cancer Res (2021) 81 (22): 5692–5705.
https://doi.org/10.1158/0008-5472.CAN-20-4226
Published: 15 November 2021
View article titled, FSTL1 Secreted by Activated Fibroblasts Promotes Hepatocellular Carcinoma Metastasis and Stemness
Open the PDF for FSTL1 Secreted by Activated Fibroblasts Promotes Hepatocellular Carcinoma Metastasis and Stemness in another window
Includes: Supplementary data
Journal Articles

Abstract 1852: Down-regulation of PRMT6 drives Warburg effect through ERK induced relocalization of PKM2 to promote tumorigenicity and sorafenib resistance in hepatocellular carcinoma

Tin-Lok Wong, Lok-Hei Chan, Stephanie Ma
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1852.
https://doi.org/10.1158/1538-7445.AM2019-1852
Published: 01 July 2019
View article titled, Abstract 1852: Down-regulation of PRMT6 drives Warburg effect through ERK induced relocalization of PKM2 to promote tumorigenicity and sorafenib resistance in hepatocellular carcinoma
Journal Articles

Abstract 1432: Deranged tyrosine metabolism drives tumorigenesis in liver cancer

Man Tong, Tin Lok Wong, Steve Tin-Chi Luk, Noelia Che, Xin Yuan Guan, Yun Fei Yuan, Terence Kin-Wah Lee, Stephanie Ma
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1432.
https://doi.org/10.1158/1538-7445.AM2018-1432
Published: 01 July 2018
View article titled, Abstract 1432: Deranged tyrosine metabolism drives tumorigenesis in liver cancer
Journal Articles

FSTL1 Promotes Metastasis and Chemoresistance in Esophageal Squamous Cell Carcinoma through NFκB–BMP Signaling Cross-talk

Marco Chi-Chung Lau, Kai Yu Ng, Tin Lok Wong, Man Tong, Terence K. Lee, Xiao-Yan Ming, Simon Law, Nikki P. Lee, Annie L. Cheung, Yan-Ru Qin, Kwok Wah Chan, Wen Ning, Xin-Yuan Guan, Stephanie Ma
Journal: Cancer Research
Cancer Res (2017) 77 (21): 5886–5899.
https://doi.org/10.1158/0008-5472.CAN-17-1411
Published: 31 October 2017
View article titled, FSTL1 Promotes Metastasis and Chemoresistance in Esophageal Squamous Cell Carcinoma through NFκB–BMP Signaling Cross-talk
Open the PDF for FSTL1 Promotes Metastasis and Chemoresistance in Esophageal Squamous Cell Carcinoma through NFκB–BMP Signaling Cross-talk in another window
Includes: Supplementary data
Journal Articles

Abstract LB-139: PRMT6-dependent CRAF/ERK signaling regulates cancer stem cell plasticity in liver cancer

Lok Hei Chan, Lei Zhou, Kai Yu Ng, Tin Lok Wong, Stella Chai, Terence K Lee, Xin Yuan Guan, Yick Pang Ching, Chung Mau Lo, Kwan Man, Benedetta Artegiani, Hans Clevers, Helen H Yan, Suet Yi Leung, Stèphane Richard, Michael SY Huen, Stephanie Ma
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): LB-139.
https://doi.org/10.1158/1538-7445.AM2017-LB-139
Published: 01 July 2017
View article titled, Abstract LB-139: PRMT6-dependent CRAF/ERK signaling regulates cancer stem cell plasticity in liver cancer
Journal Articles

Abstract 5416: Downregulation of PRMT6 promotes the Warburg effect in hepatocellular carcinoma via PKM2

Tin Lok Wong, Lok Hei Chan, Stephanie Ma
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5416.
https://doi.org/10.1158/1538-7445.AM2017-5416
Published: 01 July 2017
View article titled, Abstract 5416: Downregulation of PRMT6 promotes the Warburg effect in hepatocellular carcinoma via PKM2
Journal Articles

Abstract 1548: Down-regulation of 4-hydroxyphenylpyruvate dioxygenate (HPD) contributes to the pathogenesis of hepatocellular carcinoma (HCC) through ERK / BCL-2 signalling activation

Man Tong, Tin Lok Wong, Steve Tin-Chi Luk, Noélia Che, Kai Yau Wong, Tsun Ming Fung, Xin-Yuan Guan, Nikki P Lee, Yun-Fei Yuan, Terence K Lee, Stephanie Ma
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1548.
https://doi.org/10.1158/1538-7445.AM2017-1548
Published: 01 July 2017
View article titled, Abstract 1548: Down-regulation of 4-hydroxyphenylpyruvate dioxygenate (HPD) contributes to the pathogenesis of hepatocellular carcinoma (HCC) through ERK / BCL-2 signalling activation