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Timothy Hoey
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Journal Articles

Abstract 1733: Wnt antagonists synergize with immune checkpoint inhibitors to enhance anti-tumor responses

Jenny Ross, Timothy Hoey, Ann Kapoun, John Lewicki, Austin Gurney, Christopher L. Murriel
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1733.
DOI: https://doi.org/10.1158/1538-7445.AM2018-1733
Published: 01 July 2018
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Journal Articles

Abstract 1911: R-SPONDIN3 antagonism sensitizes colorectal cancer to taxane treatment

Marcus M. Fischer, V. Pete Yeung, Fiore Cattaruzza, Christopher Murriel, James W. Evans, Gilbert O'Young, Alayne Brunner, Min Wang, Belinda Cancilla, Ann Kapoun, Timothy Hoey
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1911.
DOI: https://doi.org/10.1158/1538-7445.AM2017-1911
Published: 01 July 2017
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Journal Articles

Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates β-Catenin Signaling and Tumorigenesis in Multiple Cancer Types

Cecile Chartier, Janak Raval, Fumiko Axelrod, Chris Bond, Jennifer Cain, Cristina Dee-Hoskins, Shirley Ma, Marcus M. Fischer, Jalpa Shah, Jie Wei, May Ji, Andrew Lam, Michelle Stroud, Wan-Ching Yen, Pete Yeung, Belinda Cancilla, Gilbert O'Young, Min Wang, Ann M. Kapoun, John Lewicki, Timothy Hoey, Austin Gurney
Journal: Cancer Research
Series: Author Choice
Cancer Res (2016) 76 (3): 713–723.
DOI: https://doi.org/10.1158/0008-5472.CAN-15-0561
Published: 31 January 2016
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Includes: Supplementary data
Journal Articles

Abstract 2323: Tarextumab (Anti-NOTCH2/3) reverses NOTCH2 and NOTCH3-dependent tumorigenicity and metastases in small cell lung cancer

Jalpa Shah, Gilbert O'Young, Jie Wei, Marcus Fischer, Wan-Ching Yen, Belinda Cancilla, Ann Kapoun, John Lewicki, Jennifer Cain, Timothy Hoey
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2323.
DOI: https://doi.org/10.1158/1538-7445.AM2015-2323
Published: 01 August 2015
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Journal Articles

Abstract 2576: Enhanced antitumor efficacy by sequential application of Wnt pathway antagonists in combination with taxanes

Wan-Ching Yen, Marcus Fischer, Belinda Cancilla, Fiore Cattaruzza, Tracy Tang, Pete Yeung, John Lewicki, Austin Gurney, Timothy Hoey
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2576.
DOI: https://doi.org/10.1158/1538-7445.AM2015-2576
Published: 01 August 2015
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Abstract 4233: Wnt pathway antagonist ipafricept (FZD8-Fc, OMP-54F28) inhibits tumor growth and reduces tumor-initiating cell frequency in ovarian patient-derived xenograft models

Marcus M. Fischer, Wan-Ching Yen, Chun Zheng, Randall Henner, Fiore Cattaruzza, Tracy Tang, Pete Yeung, Tanuka Biswas, John Lewicki, Austin Gurney, Ann M. Kapoun, Timothy Hoey
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4233.
DOI: https://doi.org/10.1158/1538-7445.AM2015-4233
Published: 01 August 2015
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Journal Articles

Abstract 2830: Predictive biomarker identification for response to vantictumab (OMP-18R5; anti-Frizzled) by mining gene expression data of human breast cancer xenografts

Chun Zhang, Pete Yeung, Lucia Beviglia, Belinda Cancilla, Tracy Tang, Wan-Ching Yen, Austin Gurney, John Lewicki, Timothy Hoey, Ann M. Kapoun
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2830.
DOI: https://doi.org/10.1158/1538-7445.AM2014-2830
Published: 01 October 2014
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Journal Articles

Abstract 1907: Wnt pathway antagonist OMP-54F28 (FZD8-Fc) inhibits tumor growth and reduces tumor-initiating cell frequency in patient-derived hepatocellular carcinoma and ovarian cancer xenograft models

Pete Yeung, Lucia Beviglia, Belinda Cancilla, Cristina Dee-Hoskins, James W. Evans, Marcus M. Fischer, Wan-Ching Yen, Austin Gurney, John Lewicki, Timothy Hoey, Ann M. Kapoun
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1907.
DOI: https://doi.org/10.1158/1538-7445.AM2014-1907
Published: 01 October 2014
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Journal Articles

Abstract 1898: The combination of gemcitabine/nab-paclitaxel and anti-DLL4 (demcizumab) produces synergistic growth inhibition, delays tumor recurrence and reduces tumor initiating cells in pancreatic cancer

Wan-Ching Yen, Marcus Fischer, John Lewicki, Austin Gurney, Timothy Hoey
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1898.
DOI: https://doi.org/10.1158/1538-7445.AM2014-1898
Published: 01 October 2014
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Journal Articles

Abstract 207: Dual targeting of DLL4 and VEGF signaling by a novel bispecific antibody inhibits tumor growth and reduces cancer stem cell frequency

Wan-Ching Yen, Fumiko Axelrod, Chris Bond, Jennifer Cain, Cecile Chartier, Marcus Fischer, Shirley Ma, Rene Meisner, Janak Raval, Jalpa Shah, Austin Gurney, John Lewicki, Timothy Hoey
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 207.
DOI: https://doi.org/10.1158/1538-7445.AM2014-207
Published: 01 October 2014
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Journal Articles

Abstract 3048: OMP-59R5 (Anti-Notch2/3) inhibits tumor growth and reduces cancer stem cell frequency in patient derived SCLC xenografts

Marcus M. Fischer, Jalpa Shah, Jennifer Cain, Belinda Cancilla, James W. Evans, Christopher L. Murriel, Tracy Tang, Jie Wei, Wan-Ching Yen, Chun Zhang, Austin Gurney, John Lewicki, Ann M. Kapoun, Timothy Hoey
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3048.
DOI: https://doi.org/10.1158/1538-7445.AM2014-3048
Published: 01 October 2014
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Journal Articles

Abstract 4547: Enhanced anti-tumor effect of WNT pathway antagonists in combination with taxanes

Wan-Ching Yen, Marcus M. Fischer, John Lewicki, Austin Gurney, Timothy Hoey
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4547.
DOI: https://doi.org/10.1158/1538-7445.AM2014-4547
Published: 01 October 2014
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Journal Articles

Abstract 1764: Inhibition of R-spondin (RSPO) signaling reduces the growth of multiple human tumors

Austin Gurney, Fumiko Axelrod, Chris Bond, Jennifer Cain, Cecile Chartier, Marcus Fischer, May Ji, Chris Murriel, Janak Raval, Jalpa Shah, Min Wang, Wan-Ching Yen, Ann Kapoun, John Lewicki, Timothy Hoey
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1764.
DOI: https://doi.org/10.1158/1538-7445.AM2014-1764
Published: 01 October 2014
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Journal Articles

Abstract 910: NOTCH3 expression is predictive of efficacy in pancreas tumor models treated with OMP-59R5, a monoclonal antibody targeting the NOTCH2 and NOTCH3 receptors

Belinda Cancilla, Wan-Ching Yen, Chun Zhang, Marcus M. Fischer, May Ji, Tracy Tang, Yu-Wang Liu, Raymond S. Tam, Min Wang, Austin Gurney, Timothy Hoey, John Lewicki, Ann M. Kapoun
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 910.
DOI: https://doi.org/10.1158/1538-7445.AM2014-910
Published: 01 October 2014
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Abstract B44: Targeting Notch signaling with a dual Notch 2/3 antagonist, OMP-59R5, inhibits tumor growth and decreases cancer stem cell frequency in pancreatic cancer.

Wan-Ching Yen, Marcus Fischer, Aaron Sato, Min Wang, Ann M. Kapoun, John Lewicki, Austin Gurney, Timothy Hoey
Journal: Cancer Research
Cancer Res (2012) 72 (14_Supplement): B44.
DOI: https://doi.org/10.1158/1538-7445.PANCA2012-B44
Published: 03 April 2014
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Journal Articles

NOTCH3 Signaling Regulates MUSASHI-1 Expression in Metastatic Colorectal Cancer Cells

Anna Pastò, Valentina Serafin, Giorgia Pilotto, Claudia Lago, Chiara Bellio, Livio Trusolino, Andrea Bertotti, Timothy Hoey, Michelina Plateroti, Giovanni Esposito, Marica Pinazza, Marco Agostini, Donato Nitti, Alberto Amadori, Stefano Indraccolo
Journal: Cancer Research
Cancer Res (2014) 74 (7): 2106–2118.
DOI: https://doi.org/10.1158/0008-5472.CAN-13-2022
Published: 31 March 2014
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Includes: Supplementary data
Journal Articles

Canonical Wnt Signaling Is Required for Pancreatic Carcinogenesis

Yaqing Zhang, John P. Morris, IV, Wei Yan, Heather K. Schofield, Austin Gurney, Diane M. Simeone, Sarah E. Millar, Timothy Hoey, Matthias Hebrok, Marina Pasca di Magliano
Journal: Cancer Research
Cancer Res (2013) 73 (15): 4909–4922.
DOI: https://doi.org/10.1158/0008-5472.CAN-12-4384
Published: 31 July 2013
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Includes: Supplementary data
Journal Articles

Abstract 3725: Anti-DLL4 (demcizumab) inhibits tumor growth and reduces cancer stem cell frequency in patient-derived ovarian cancer xenografts.

Wan-Ching Yen, Marcus M. Fischer, Jalpa Shah, Jie Wei, Jennifer Cain, Pete Yeung, Lucia Beviglia, Belinda Cancilla, Ann Kapoun, John Lewicki, Austin Gurney, Timothy Hoey
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3725.
DOI: https://doi.org/10.1158/1538-7445.AM2013-3725
Published: 15 April 2013
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Journal Articles

Abstract 218: R-Spondin (RSPO) signaling drives the growth of multiple human tumor types.

Austin Gurney, Cecile Chartier, Fumiko Axelrod, Jennifer Cain, Wan-Ching Yen, Christopher Murriel, Janak Raval, Marcus Fischer, Jalpa Shah, May Ji, Christopher Bond, Ann Kapoun, John Lewicki, Timothy Hoey
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 218.
DOI: https://doi.org/10.1158/1538-7445.AM2013-218
Published: 15 April 2013
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Abstract 4330: In vivo evaluation of anti-tumor activity by an anti-VEGF and anti-DLL4 bispecific antibody in a humanized model of skin graft.

Lucia Beviglia, Pete Yeung, Wang-Ching Yen, Belinda Cancilla, Sato Aaron, Chris Bond, Janak Raval, Fumiko Axelrod, Cecile Chartier, Shirley Ma, Austin Gurney, John Lewicki, Ann M. Kapoun, Timothy Hoey
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4330.
DOI: https://doi.org/10.1158/1538-7445.AM2013-4330
Published: 15 April 2013
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