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Timothy Cloughesy
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Journal Articles

Abstract CT062: GBM AGILE: A global, phase 2/3 adaptive platform trial to evaluate multiple regimens in newly diagnosed and recurrent glioblastoma

Ingo K. Mellinghoff, Brian Alexander, Donald Berry, Nicholas Blondin, Meredith Buxton, Webster Cavenee, Howard Colman, John de Groot, Macarena I. de la Fuente, Benjamin Ellingson, Gary Gordon, Emma M.V. Hyddmark, Mustafa Khasraw, Andrew Lassman, Eudocia Lee, Wenbin Li, Michael Lim, Tom Mikkelsen, Apoorva Nelli, James Perry, Erik Sulman, Kirk Tanner, Michael Weller, Patrick Y. Wen, Timothy Cloughesy
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT062.
https://doi.org/10.1158/1538-7445.AM2023-CT062
Published: 14 April 2023
View articletitled, Abstract CT062: GBM AGILE: A global, phase 2/3 adaptive platform trial to evaluate multiple regimens in newly diagnosed and recurrent glioblastoma
Journal Articles

Abstract LB125: Pharmacokinetics of paxalisib in phase 2 clinical study in glioblastoma (GBM) with unmethylated O6-methylguanine-methyltransferase (MGMT) promotor status

Patrick Y. Wen, John de Groot, James D. Battiste, Samuel A. Goldlust, Denise Damek, James S. Garner, Jeremy A. Simpson, Alan Olivero, Timothy Cloughesy
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB125.
https://doi.org/10.1158/1538-7445.AM2021-LB125
Published: 01 July 2021
View articletitled, Abstract LB125: Pharmacokinetics of paxalisib in phase 2 clinical study in glioblastoma (GBM) with unmethylated O6-methylguanine-methyltransferase (MGMT) promotor status
Journal Articles

Abstract CT205: Phase 2 study to evaluate the safety, pharmacokinetics, and clinical activity of the PI3K / mTOR inhibitor paxalisib (GDC-0084) in glioblastoma (GBM) with unmethylated O6-methylguanine-methyltransferase (MGMT) promotor status

Patrick Y. Wen, John de Groot, James D. Battiste, Samuel A. Goldlust, James S. Garner, Jeremy A. Simpson, Jelle Kijlstra, Alan Olivero, Timothy Cloughesy
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): CT205.
https://doi.org/10.1158/1538-7445.AM2020-CT205
Published: 15 August 2020
View articletitled, Abstract CT205: Phase 2 study to evaluate the safety, pharmacokinetics, and clinical activity of the PI3K / mTOR inhibitor paxalisib (GDC-0084) in glioblastoma (GBM) with unmethylated O6-methylguanine-methyltransferase (MGMT) promotor status
Journal Articles

Abstract 3594: Adaptively randomized seamless-phase multiarm platform trial: Glioblastoma Multiforme Adaptive Global Innovative Learning Environment (GBM AGILE)

Donald A. Berry, Todd Graves, Jason Connor, Brian Alexander, Timothy Cloughesy, Anna Barker, Scott M. Berry, for the GBM AGILE Global Alliance
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3594.
https://doi.org/10.1158/1538-7445.AM2017-3594
Published: 01 July 2017
View articletitled, Abstract 3594: Adaptively randomized seamless-phase multiarm platform trial: Glioblastoma Multiforme Adaptive Global Innovative Learning Environment (GBM AGILE)
Journal Articles

Abstract 447: The IDH1 mutation in human glioblastoma and its effects on epigenetic modification and cell fate selection

Matthew C. Garrett, Jack Mottahedeh, Jantzen Sperry, Ascia Eskin, Giovanni Coppola, Ya-shin Shih, Albert Lai, Arthur Chou, Linda Liau, Rob Prins, Timothy Cloughesy, Hong Wu, Stanley Nelson, Harley Kornblum
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 447.
https://doi.org/10.1158/1538-7445.AM2014-447
Published: 01 October 2014
View articletitled, Abstract 447: The IDH1 mutation in human glioblastoma and its effects on epigenetic modification and cell fate selection
Journal Articles

Prognostic Significance of Growth Kinetics in Newly Diagnosed Glioblastomas Revealed by Combining Serial Imaging with a Novel Biomathematical Model

Christina H. Wang, Jason K. Rockhill, Maciej Mrugala, Danielle L. Peacock, Albert Lai, Katy Jusenius, Joanna M. Wardlaw, Timothy Cloughesy, Alexander M. Spence, Russ Rockne, Ellsworth C. Alvord, Jr., Kristin R. Swanson
Journal: Cancer Research
Cancer Res (2009) 69 (23): 9133–9140.
https://doi.org/10.1158/0008-5472.CAN-08-3863
Published: 30 November 2009
View articletitled, Prognostic Significance of Growth Kinetics in Newly Diagnosed Glioblastomas Revealed by Combining Serial Imaging with a Novel Biomathematical Model
Open the PDF for Prognostic Significance of Growth Kinetics in Newly Diagnosed Glioblastomas Revealed by Combining Serial Imaging with a Novel Biomathematical Model in another window
Includes: Supplementary data
Journal Articles

Abstract #1985: EGFR signaling through the PI3K pathway promotes tumor survival via SREBP1-mediated lipogenesis in glioblastoma patients

Deliang Guo, Robert Prins, Isabel Hildebrandt, Julie Dang, Daisuke Kuga, Kelly Lin, Tiffany Huang, Ava Kofman, Horacio Soto, Mary Mazzotta, Johannes Czernin, John Shyy, William Yong, Harry Vinters, Steve Horvath, Andrew Watson, Caius Radu, Timothy Cloughesy, Paul Mischel
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 1985.
Published: 01 May 2009
View articletitled, Abstract #1985: EGFR signaling through the PI3K pathway promotes tumor survival via SREBP1-mediated lipogenesis in glioblastoma patients
Journal Articles

AMPK suppressed glioma growth by synergistically regulating protein translation and inhibiting lipogenesis

Deliang Guo, Timothy Cloughesy, Paul Mischel
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 4350.
Published: 01 May 2008
View articletitled, AMPK suppressed glioma growth by synergistically regulating protein translation and inhibiting lipogenesis
Journal Articles

Robustness of gene expression profiling in glioma specimen samplings and derived cell lines.

Ruty Mehrian-Shai, Juergen Reichardt, Thomas Kremen, Linda Liau, Timothy Cloughesy, Paul Mischel, Stanley Nelson
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 102.
Published: 01 May 2005
View articletitled, Robustness of gene expression profiling in glioma specimen samplings and derived cell lines.
Journal Articles

Gene Expression Profiling of Gliomas Strongly Predicts Survival

William A. Freije, F. Edmundo Castro-Vargas, Zixing Fang, Steve Horvath, Timothy Cloughesy, Linda M. Liau, Paul S. Mischel, Stanley F. Nelson
Journal: Cancer Research
Cancer Res (2004) 64 (18): 6503–6510.
https://doi.org/10.1158/0008-5472.CAN-04-0452
Published: 16 September 2004
View articletitled, Gene Expression Profiling of Gliomas Strongly Predicts Survival
Open the PDF for Gene Expression Profiling of Gliomas Strongly Predicts Survival in another window
Includes: Supplementary data
Journal Articles

A Pharmacokinetic (PK) study of SU-5416 in patients on enzyme-inducing anti-epileptic drugs (EIAED), by the North American Brain Tumor Consortium

Tanyifor M. Tohnya, Alex Sparreboom, Howard A. Fine, Alfred Yung, Patrick Wen, Timothy Cloughesy, Larry Junck, Frank Lieberman, Michael Prados, William D. Figg
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 91.
Published: 01 April 2004
View articletitled, A Pharmacokinetic (PK) study of SU-5416 in patients on enzyme-inducing anti-epileptic drugs (EIAED), by the North American Brain Tumor Consortium