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Timothy C. Chambers
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Journal Articles

Abstract PS18-46: Inhibition of breast cancer stem cells in 2- and 3-dimensional culture by novel salinomycin analogs

Alicja Joanna Urbaniak, Megan R. Reed, Michał Antoszczak, Michał Sulik, Adam Huczyński, Robert L. Eoff, Melanie C. MacNicol, Timothy C. Chambers, Angus M. MacNicol
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PS18-46.
https://doi.org/10.1158/1538-7445.SABCS20-PS18-46
Published: 15 February 2021
View article titled, Abstract PS18-46: Inhibition of breast cancer stem cells in 2- and 3-dimensional culture by novel salinomycin analogs
Journal Articles

Cell Cycle–Dependent Mechanisms Underlie Vincristine-Induced Death of Primary Acute Lymphoblastic Leukemia Cells

Anisha Kothari, Walter N. Hittelman, Timothy C. Chambers
Journal: Cancer Research
Cancer Res (2016) 76 (12): 3553–3561.
https://doi.org/10.1158/0008-5472.CAN-15-2104
Published: 14 June 2016
View article titled, Cell Cycle–Dependent Mechanisms Underlie Vincristine-Induced Death of Primary Acute Lymphoblastic Leukemia Cells
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Includes: Supplementary data
Journal Articles

BH3 Inhibitor Sensitivity and Bcl-2 Dependence in Primary Acute Lymphoblastic Leukemia Cells

Sarah E. Alford, Anisha Kothari, Floris C. Loeff, Joshua M. Eichhorn, Nandini Sakurikar, Henriette M. Goselink, Robert L. Saylors, Inge Jedema, J.H. Frederik Falkenburg, Timothy C. Chambers
Journal: Cancer Research
Cancer Res (2015) 75 (7): 1366–1375.
https://doi.org/10.1158/0008-5472.CAN-14-1849
Published: 31 March 2015
View article titled, BH3 Inhibitor Sensitivity and Bcl-2 Dependence in Primary Acute Lymphoblastic Leukemia Cells
Open the PDF for BH3 Inhibitor Sensitivity and Bcl-2 Dependence in Primary Acute Lymphoblastic Leukemia Cells in another window
Includes: Supplementary data
Journal Articles

Abstract 1739: Unexpected complexity in Mcl-1 phosphorylation in response to microtubule inhibitors.

Rong Chu, Timothy C. Chambers
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1739.
https://doi.org/10.1158/1538-7445.AM2013-1739
Published: 15 April 2013
View article titled, Abstract 1739: Unexpected complexity in Mcl-1 phosphorylation in response to microtubule inhibitors.
Journal Articles

Abstract 14: Role of Cdk1 and Bcl-2 proteins in mitotic cell death

Nandini Sakurikar, Stephen S. Taylor, Timothy C. Chambers
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 14.
https://doi.org/10.1158/1538-7445.AM2011-14
Published: 15 April 2011
View article titled, Abstract 14: Role of Cdk1 and Bcl-2 proteins in mitotic cell death
Journal Articles

Effect of siRNA blockage on c-Jun function in vinblastine-induced apoptosis

Sergey N. Kolomeichuk, Anca Bene, Christopher S. Lyle, Maheswari Rajasekaran, Meenakshi Upreti, Richard A. Dennis, Timothy C. Chambers
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 328.
Published: 15 April 2006
View article titled, Effect of siRNA blockage on c-Jun function in vinblastine-induced apoptosis
Journal Articles

Role of Bax oligomerization and Bax activation in vinblastine-induced apoptosis

Meenakshi Upreti, Christopher S. Lyle, Kanaga Sabapathy, Timothy C. Chambers
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 119.
Published: 15 April 2006
View article titled, Role of Bax oligomerization and Bax activation in vinblastine-induced apoptosis
Journal Articles

Comparison of methods to block c-Jun function in order to determine its role in vinblastine-induced apoptosis

Anca Bene, Timothy C. Chambers
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 542.
Published: 01 May 2005
View article titled, Comparison of methods to block c-Jun function in order to determine its role in vinblastine-induced apoptosis
Journal Articles

The microtubule inhibitor vinblastine promotes subcellular redistribution, posttranslational modifications, and protein-protein interactions of Bcl-2 family proteins

Christopher S. Lyle, Brian Skaug, Meenakshi Upreti, Timothy C. Chambers
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 824.
Published: 01 May 2005
View article titled, The microtubule inhibitor vinblastine promotes subcellular redistribution, posttranslational modifications, and protein-protein interactions of Bcl-2 family proteins
Journal Articles

Characterization of vinblastine-induced Bcl-xL and Bcl-2 phosphorylation

Lihua Du, Christopher S. Lyle, Timothy C. Chambers
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 1192–1193.
Published: 01 April 2004
View article titled, Characterization of vinblastine-induced Bcl-xL and Bcl-2 phosphorylation
Journal Articles

The role of c-Jun in vinblastine sensitivity.

Toria B. Obey, Timothy C. Chambers
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 521.
Published: 01 April 2004
View article titled, The role of c-Jun in vinblastine sensitivity.
Journal Articles

The c-Jun NH2-terminal Protein Kinase/AP-1 Pathway Is Required for Efficient Apoptosis Induced by Vinblastine

Meiyun Fan, Mary E. Goodwin, Michael J. Birrer, Timothy C. Chambers
Journal: Cancer Research
Cancer Res (2001) 61 (11): 4450–4458.
Published: 01 June 2001
View article titled, The c-Jun NH<sub>2</sub>-terminal Protein Kinase/AP-1 Pathway Is Required for Efficient Apoptosis Induced by Vinblastine
Open the PDF for The c-Jun NH<sub>2</sub>-terminal Protein Kinase/AP-1 Pathway Is Required for Efficient Apoptosis Induced by Vinblastine in another window
Journal Articles

Modulation of Mitogen-activated Protein Kinases and Phosphorylation of Bcl-2 by Vinblastine Represent Persistent Forms of Normal Fluctuations at G2-M

Meiyun Fan, Lihua Du, Albert A. Stone, Kathleen M. Gilbert, Timothy C. Chambers
Journal: Cancer Research
Cancer Res (2000) 60 (22): 6403–6407.
Published: 15 November 2000
View article titled, Modulation of Mitogen-activated Protein Kinases and Phosphorylation of Bcl-2 by Vinblastine Represent Persistent Forms of Normal Fluctuations at G<sub>2</sub>-M
Open the PDF for Modulation of Mitogen-activated Protein Kinases and Phosphorylation of Bcl-2 by Vinblastine Represent Persistent Forms of Normal Fluctuations at G<sub>2</sub>-M in another window