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Journal Articles

Abstract B029: Tumor immune microenvironment determinants of response to lenvatinib and a PD-1 blockade in clear cell renal cell carcinoma

Lynda Vuong, Fengshen Kuo, Hui Jiang, Eduardo A. Mascareno, Phillip Rappold, Erich Sabio, Kate Weiss, Andrew Cornish, Stephen Reese, Mojca Adlesic, David Solit, Ian Frew, Oguz Akin, Yingbei Chen, Ming O. Li, Timothy A. Chan, Ari A. Hakimi

Cancer Res (2023) 83 (16_Supplement): B029.

https://doi.org/10.1158/1538-7445.KIDNEY23-B029

Published: 15 August 2023

View articletitled, Abstract B029: Tumor immune microenvironment determinants of response to lenvatinib and a PD-1 blockade in clear cell renal cell carcinoma

Journal Articles

KDM6A Loss Triggers an Epigenetic Switch That Disrupts Urothelial Differentiation and Drives Cell Proliferation in Bladder Cancer

Hong Qiu, Vladimir Makarov, Jennifer K. Bolzenius, Angela Halstead, Yvonne Parker, Allen Wang, Gopakumar V. Iyer, Hannah Wise, Daniel Kim, Varna Thayaparan, Daniel J. Lindner, Georges-Pascal Haber, Angela H. Ting, Bing Ren, Timothy A. Chan, Vivek Arora, David B. Solit, Byron H. Lee

Cancer Res (2023) 83 (6): 814–829.

https://doi.org/10.1158/0008-5472.CAN-22-1444

Published: 15 March 2023

View articletitled, KDM6A Loss Triggers an Epigenetic Switch That Disrupts Urothelial Differentiation and Drives Cell Proliferation in Bladder Cancer

Includes: Supplementary data

Journal Articles

Abstract A019: Epigenetic regulation by H3K9 methylation enables resistance to anti-androgen therapy in prostate cancer

Ritika Tiwari, Mehdi Baratchian, Michael Berk, Jianneng Li, Amy Guerinot, Vladimir Makarov, Timothy A. Chan, Abhishek A. Chakraborty, Nima Sharifi

Cancer Res (2022) 82 (23_Supplement_2): A019.

https://doi.org/10.1158/1538-7445.CancEpi22-A019

Published: 01 December 2022

View articletitled, Abstract A019: Epigenetic regulation by H3K9 methylation enables resistance to anti-androgen therapy in prostate cancer

Journal Articles

Colorectal Cancer Develops Inherent Radiosensitivity That Can Be Predicted Using Patient-Derived Organoids

Kuo-Shun Hsu, Mohammad Adileh, Maria Laura Martin, Vladimir Makarov, Jiapeng Chen, Chao Wu, Sahra Bodo, Stefan Klingler, Charles-Etienne Gabriel Sauvé, Bryan C. Szeglin, J. Joshua Smith, Zvi Fuks, Nadeem Riaz, Timothy A. Chan, Makoto Nishimura, Philip B. Paty, Richard Kolesnick

Cancer Res (2022) 82 (12): 2298–2312.

https://doi.org/10.1158/0008-5472.CAN-21-4128

Published: 15 June 2022

View articletitled, Colorectal Cancer Develops Inherent Radiosensitivity That Can Be Predicted Using Patient-Derived Organoids

Includes: Supplementary data

Journal Articles

Immune Determinants of the Association between Tumor Mutational Burden and Immunotherapy Response across Cancer Types

Neelam Sinha, Sanju Sinha, Cristina Valero, Alejandro A. Schäffer, Kenneth Aldape, Kevin Litchfield, Timothy A. Chan, Luc G.T. Morris, Eytan Ruppin

Cancer Res (2022) 82 (11): 2076–2083.

https://doi.org/10.1158/0008-5472.CAN-21-2542

Published: 06 June 2022

View articletitled, Immune Determinants of the Association between Tumor Mutational Burden and Immunotherapy Response across Cancer Types

Includes: Supplementary data

Journal Articles

Abstract 2047: Association of retinoblastoma function with response to immuno-oncology treatment in patients with small cell lung cancer

David Balli, Xuya Wang, Naiyer A. Rizvi, Timothy A. Chan, Afshin Dowlati, Parul Doshi, Han Chang

Cancer Res (2020) 80 (16_Supplement): 2047.

https://doi.org/10.1158/1538-7445.AM2020-2047

Published: 15 August 2020

View articletitled, Abstract 2047: Association of retinoblastoma function with response to immuno-oncology treatment in patients with small cell lung cancer

Journal Articles

Abstract 345: Characterizing and therapeutically targeting G-quadruplex DNA in ATRX-mutant glioma

Yuxiang Wang, Carla Danussi, Kasthuri Kannan, Timothy A. Chan, Jason T. Huse

Cancer Res (2018) 78 (13_Supplement): 345.

https://doi.org/10.1158/1538-7445.AM2018-345

Published: 01 July 2018

View articletitled, Abstract 345: Characterizing and therapeutically targeting G-quadruplex DNA in ATRX-mutant glioma

Journal Articles

Abstract 4322: Atrx inactivation drives motility and dysregulates differentiation in glioma cells of origin through global epigenomic remodeling

Carla Danussi, Promita Bose, Pedro Silberman, John S. Van Arnam, Mark Vitucci, Oliver Tang, Adriana Heguy, Timothy A. Chan, Erik P. Sulman, Frederick Lang, Chad J. Creighton, Benjamin Deneen, C Ryan Miller, David J. Picketts, Kasthuri Kannan, Jason T. Huse

Cancer Res (2018) 78 (13_Supplement): 4322.

https://doi.org/10.1158/1538-7445.AM2018-4322

Published: 01 July 2018

View articletitled, Abstract 4322: Atrx inactivation drives motility and dysregulates differentiation in glioma cells of origin through global epigenomic remodeling

Journal Articles

Abstract 2988: Immunogenomic analyses of tumor cells and microenvironment in patients with advanced melanoma before and after treatment with nivolumab

Cancer Res (2017) 77 (13_Supplement): 2988.

https://doi.org/10.1158/1538-7445.AM2017-2988

Published: 01 July 2017

View articletitled, Abstract 2988: Immunogenomic analyses of tumor cells and microenvironment in patients with advanced melanoma before and after treatment with nivolumab

Journal Articles

Abstract 976: ImmunoMap: a novel bioinformatics tool for immune cell repertoire analysis

John-William Sidhom, Catherine A. Bessell, Jonathan J. Havel, Timothy A. Chan, Jonathan P. Schneck

Cancer Res (2017) 77 (13_Supplement): 976.

https://doi.org/10.1158/1538-7445.AM2017-976

Published: 01 July 2017

View articletitled, Abstract 976: ImmunoMap: a novel bioinformatics tool for immune cell repertoire analysis

Journal Articles

Spatial Proximity to Fibroblasts Impacts Molecular Features and Therapeutic Sensitivity of Breast Cancer Cells Influencing Clinical Outcomes

Cancer Res (2016) 76 (22): 6495–6506.

https://doi.org/10.1158/0008-5472.CAN-16-1457

Published: 14 November 2016

View articletitled, Spatial Proximity to Fibroblasts Impacts Molecular Features and Therapeutic Sensitivity of Breast Cancer Cells Influencing Clinical Outcomes

Includes: Supplementary data

Journal Articles

Abstract B32: Inhibiting DNA methylation causes an interferon response in cancer via dsRNA including endogenous retroviruses

Katherine B. Chiappinelli, Pamela L. Strissel, Alexis Desrichard, Huili Li, Christine Henke, Benjamin Akman, Alexander Hein, Neal S. Rote, Leslie M. Cope, Alexandra Snyder, Vladimir Makarov, Sadna Budhu, Jedd Wolchok, Cynthia A. Zahnow, Taha Mergoub, Timothy A. Chan, Reiner Strick, Stephen B. Baylin

Cancer Res (2016) 76 (2_Supplement): B32.

https://doi.org/10.1158/1538-7445.CHROMEPI15-B32

Published: 14 January 2016

View articletitled, Abstract B32: Inhibiting DNA methylation causes an interferon response in cancer via dsRNA including endogenous retroviruses

Journal Articles

Abstract LB-169: Multidimensional genomic dissection of chromosome 9p in glioma

David M. Roy, Logan A. Walsh, Alexis Desrichard, Jianjiong Gao, Promita Bose, Jason T. Huse, William Lee, Timothy A. Chan

Cancer Res (2015) 75 (15_Supplement): LB-169.

https://doi.org/10.1158/1538-7445.AM2015-LB-169

Published: 01 August 2015

View articletitled, Abstract LB-169: Multidimensional genomic dissection of chromosome 9p in glioma

Journal Articles

Abstract 521: Glioma-associated IDH mutation induces miR-34a repression and stem cell-like physiology through enhanced PDGF signaling

Joachim Silber, Girish Harinath, Prasanna Tamarapu Parthasarathy, Armida W.M. Fabius, Sevin Turcan, Timothy A. Chan, Jason T. Huse

Cancer Res (2014) 74 (19_Supplement): 521.

https://doi.org/10.1158/1538-7445.AM2014-521

Published: 01 October 2014

View articletitled, Abstract 521: Glioma-associated IDH mutation induces miR-34a repression and stem cell-like physiology through enhanced PDGF signaling

Journal Articles

Abstract 2797: Breast cancer methylomes establish an epigenomic foundation for metastasis

Timothy A. Chan, Fang Fang, Sevin Turcan, Andreas Rimner

Cancer Res (2011) 71 (8_Supplement): 2797.

https://doi.org/10.1158/1538-7445.AM2011-2797

Published: 15 April 2011

View articletitled, Abstract 2797: Breast cancer methylomes establish an epigenomic foundation for metastasis

Journal Articles

Abstract 3911: Functional copy number alterations (CNAS) in oral cancer

Luc G. Morris, Ian Ganly, Barry Taylor, Bhuvanesh Singh, Agnes Viale, Adriana Heguy, Timothy A. Chan

Cancer Res (2011) 71 (8_Supplement): 3911.

https://doi.org/10.1158/1538-7445.AM2011-3911

Published: 15 April 2011

View articletitled, Abstract 3911: Functional copy number alterations (CNAS) in oral cancer

Journal Articles

Abstract 4924: Gene-specific hyper and hypomethylation in follicular lymphoma progression

Matilde Saggese, Venkata Thodima, Adriana Heguy, Timothy A. Chan, Raju S. K. Chaganti

Cancer Res (2010) 70 (8_Supplement): 4924.

https://doi.org/10.1158/1538-7445.AM10-4924

Published: 15 April 2010

View articletitled, Abstract 4924: Gene-specific hyper and hypomethylation in follicular lymphoma progression

Journal Articles

Abstract 2222: Mutational and copy number analysis of the PI3K/Akt/mTOR pathway in oral cavity squamous cell carcinoma

Luc GT Morris, Ian Ganly, Adriana Heguy, Timothy A. Chan

Cancer Res (2010) 70 (8_Supplement): 2222.

https://doi.org/10.1158/1538-7445.AM10-2222

Published: 15 April 2010

View articletitled, Abstract 2222: Mutational and copy number analysis of the PI3K/Akt/mTOR pathway in oral cavity squamous cell carcinoma

Journal Articles

Methylation of TFPI2 in Stool DNA: A Potential Novel Biomarker for the Detection of Colorectal Cancer

Cancer Res (2009) 69 (11): 4691–4699.

https://doi.org/10.1158/0008-5472.CAN-08-0142

Published: 01 June 2009

View articletitled, Methylation of TFPI2 in Stool DNA: A Potential Novel Biomarker for the Detection of Colorectal Cancer

Includes: Supplementary data

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Abstract B029: Tumor immune microenvironment determinants of response to lenvatinib and a PD-1 blockade in clear cell renal cell carcinoma

KDM6A Loss Triggers an Epigenetic Switch That Disrupts Urothelial Differentiation and Drives Cell Proliferation in Bladder Cancer

Abstract A019: Epigenetic regulation by H3K9 methylation enables resistance to anti-androgen therapy in prostate cancer

Colorectal Cancer Develops Inherent Radiosensitivity That Can Be Predicted Using Patient-Derived Organoids

Immune Determinants of the Association between Tumor Mutational Burden and Immunotherapy Response across Cancer Types

Abstract 2047: Association of retinoblastoma function with response to immuno-oncology treatment in patients with small cell lung cancer

Abstract 345: Characterizing and therapeutically targeting G-quadruplex DNA in ATRX-mutant glioma

Abstract 4322: Atrx inactivation drives motility and dysregulates differentiation in glioma cells of origin through global epigenomic remodeling

Abstract 2988: Immunogenomic analyses of tumor cells and microenvironment in patients with advanced melanoma before and after treatment with nivolumab

Abstract 976: ImmunoMap: a novel bioinformatics tool for immune cell repertoire analysis

Spatial Proximity to Fibroblasts Impacts Molecular Features and Therapeutic Sensitivity of Breast Cancer Cells Influencing Clinical Outcomes

Abstract B32: Inhibiting DNA methylation causes an interferon response in cancer via dsRNA including endogenous retroviruses

Abstract LB-169: Multidimensional genomic dissection of chromosome 9p in glioma

Abstract 521: Glioma-associated IDH mutation induces miR-34a repression and stem cell-like physiology through enhanced PDGF signaling

Abstract 2797: Breast cancer methylomes establish an epigenomic foundation for metastasis

Abstract 3911: Functional copy number alterations (CNAS) in oral cancer

Abstract 4924: Gene-specific hyper and hypomethylation in follicular lymphoma progression

Abstract 2222: Mutational and copy number analysis of the PI3K/Akt/mTOR pathway in oral cavity squamous cell carcinoma

Methylation of TFPI2 in Stool DNA: A Potential Novel Biomarker for the Detection of Colorectal Cancer

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