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Tim H-M. Huang
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Journal Articles

Abstract 6284: Multimoics reveal aberrant pathways and regulation of castration resistant and metastatic prostate cancer

Aaron M. Horning, Chia-Nung Hung, Brandon Liebermann, Chih-Wei Chou, Che-Kuang Lin, Yao Vickie Wang, Victor X. Jin, Michael A. Liss, Chiou-Miin Wang, Chun- Lin, Meizhen Chen, Tim H-M Huang, Chun-Liang Chen
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6284.
https://doi.org/10.1158/1538-7445.AM2024-6284
Published: 22 March 2024
View articletitled, Abstract 6284: Multimoics reveal aberrant pathways and regulation of castration resistant and metastatic prostate cancer
Journal Articles

PRC2-Mediated Epigenetic Suppression of Type I IFN-STAT2 Signaling Impairs Antitumor Immunity in Luminal Breast Cancer

Juyeong Hong, Ji Hoon Lee, Zhao Zhang, Yanming Wu, Mei Yang, Yiji Liao, Richard de la Rosa, Jessica Scheirer, Douglas Pechacek, Nu Zhang, Zhenming Xu, Tyler Curiel, Xi Tan, Tim H.-M. Huang, Kexin Xu
Journal: Cancer Research
Cancer Res (2022) 82 (24): 4624–4640.
https://doi.org/10.1158/0008-5472.CAN-22-0736
Published: 16 December 2022
View articletitled, PRC2-Mediated Epigenetic Suppression of Type I IFN-STAT2 Signaling Impairs Antitumor Immunity in Luminal Breast Cancer
Open the PDF for PRC2-Mediated Epigenetic Suppression of Type I IFN-STAT2 Signaling Impairs Antitumor Immunity in Luminal Breast Cancer in another window
Includes: Supplementary data
Journal Articles

A First-in-Class Inhibitor of ER Coregulator PELP1 Targets ER+ Breast Cancer

Kristin A. Altwegg, Suryavathi Viswanadhapalli, Monica Mann, Dimple Chakravarty, Samaya Krishnan, Zexuan Liu, Junhao Liu, Uday P. Pratap, Behnam Ebrahimi, John R. Sanchez, Xiaonan Li, Shihong Ma, Ben H. Park, Bindu Santhamma, Yidong Chen, Zhao Lai, Ganesh V. Raj, Yaxia Yuan, Daohong Zhou, Gangadhara R. Sareddy, Rajeshwar R. Tekmal, Stan McHardy, Tim H.-M. Huang, Manjeet K. Rao, Hariprasad Vankayalapati, Ratna K. Vadlamudi
Journal: Cancer Research
Cancer Res (2022) 82 (20): 3830–3844.
https://doi.org/10.1158/0008-5472.CAN-22-0698
Published: 17 October 2022
View articletitled, A First-in-Class Inhibitor of ER Coregulator PELP1 Targets ER+ Breast Cancer
Open the PDF for A First-in-Class Inhibitor of ER Coregulator PELP1 Targets ER+ Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Contacts with Macrophages Promote an Aggressive Nanomechanical Phenotype of Circulating Tumor Cells in Prostate Cancer

Pawel A. Osmulski, Alessandra Cunsolo, Meizhen Chen, Yusheng Qian, Chun-Lin Lin, Chia-Nung Hung, Devalingam Mahalingam, Nameer B. Kirma, Chun-Liang Chen, Josephine A. Taverna, Michael A. Liss, Ian M. Thompson, Tim H.-M. Huang, Maria E. Gaczynska
Journal: Cancer Research
Cancer Res (2021) 81 (15): 4110–4123.
https://doi.org/10.1158/0008-5472.CAN-20-3595
Published: 01 August 2021
View articletitled, Contacts with Macrophages Promote an Aggressive Nanomechanical Phenotype of Circulating Tumor Cells in Prostate Cancer
Open the PDF for Contacts with Macrophages Promote an Aggressive Nanomechanical Phenotype of Circulating Tumor Cells in Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Single-Cell Proteomic Profiling Identifies Combined AXL and JAK1 Inhibition as a Novel Therapeutic Strategy for Lung Cancer

Josephine A. Taverna, Chia-Nung Hung, Daniel T. DeArmond, Meizhen Chen, Chun-Lin Lin, Pawel A. Osmulski, Maria E. Gaczynska, Chiou-Miin Wang, Nicholas D. Lucio, Chih-Wei Chou, Chun-Liang Chen, Alia Nazarullah, Shellye R. Lampkin, Lianqun Qiu, David J. Bearss, Steven Warner, Clifford J. Whatcott, Lars Mouritsen, Mark Wade, Steven Weitman, Ruben A. Mesa, Nameer B. Kirma, Wei-Ting Chao, Tim H.-M. Huang
Journal: Cancer Research
Cancer Res (2020) 80 (7): 1551–1563.
https://doi.org/10.1158/0008-5472.CAN-19-3183
Published: 02 April 2020
View articletitled, Single-Cell Proteomic Profiling Identifies Combined AXL and JAK1 Inhibition as a Novel Therapeutic Strategy for Lung Cancer
Open the PDF for Single-Cell Proteomic Profiling Identifies Combined AXL and JAK1 Inhibition as a Novel Therapeutic Strategy for Lung Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 2766: Amplification-associated upregulation of genes involved in oxidative phosphorylation for disseminated prostate cancer cells

Chun-Lin Lin, Tan Xi, Chia-Nung Hung, Pawel A. Osmulski, Chih-Wei Chou, Meizhen Chen, Chiou-Miin Wang, Kohzoh Mitsuya, Nameer Kirma, Maria E. Gaczynska, Chun-Liang Chen, Tim H.-M. Huang
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2766.
https://doi.org/10.1158/1538-7445.AM2019-2766
Published: 01 July 2019
View articletitled, Abstract 2766: Amplification-associated upregulation of genes involved in oxidative phosphorylation for disseminated prostate cancer cells
Journal Articles

Abstract 173: Upregulated EPHB2 and SRC pathways modulate spatial EGFR dynamics and malignant phenotypes and predict poor prognosis in prostate cancer

Yen-Liang Liu, Aaron M. Horning, Che-Kuang Lin, Brandon Lieberman, Chia-Nung Hung, Chih-Wei Chou, Chiou-Miin Wang, Michael A. Liss, Mirae Kim, Rohan Vasisht, Evan P. Perillo, Katherine Blocher, Hannah Horng, Xi Tian, Chun-Lin Lin, Andrew K. Dunn, Tim H.-M. Huang, Hsin-Chih Yeh, Chun-Liang Chen
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 173.
https://doi.org/10.1158/1538-7445.AM2019-173
Published: 01 July 2019
View articletitled, Abstract 173: Upregulated EPHB2 and SRC pathways modulate spatial EGFR dynamics and malignant phenotypes and predict poor prognosis in prostate cancer
Journal Articles

Adipokines Deregulate Cellular Communication via Epigenetic Repression of Gap Junction Loci in Obese Endometrial Cancer

Srikanth R. Polusani, Yi-Wen Huang, Guangcun Huang, Chun-Wei Chen, Chiou-Miin Wang, Li-Ling Lin, Pawel Osmulski, Nicholas D. Lucio, Lu Liu, Ya-Ting Hsu, Yufan Zhou, Chun-Lin Lin, Irene Aguilera-Barrantes, Philip T. Valente, Edward R. Kost, Chun-Liang Chen, Eun Yong Shim, Sang Eun Lee, Jianhua Ruan, Maria E. Gaczynska, Pearlly Yan, Paul J. Goodfellow, David G. Mutch, Victor X. Jin, Bruce J. Nicholson, Tim H.-M. Huang, Nameer B. Kirma
Journal: Cancer Research
Cancer Res (2019) 79 (1): 196–208.
https://doi.org/10.1158/0008-5472.CAN-18-1615
Published: 02 January 2019
View articletitled, Adipokines Deregulate Cellular Communication via Epigenetic Repression of Gap Junction Loci in Obese Endometrial Cancer
Open the PDF for Adipokines Deregulate Cellular Communication via Epigenetic Repression of Gap Junction Loci in Obese Endometrial Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 3402: Castration resistance transcriptome in prostate cancer revealed by single-cell RNA-seq

Aaron M. Horning, Che-Kuang Lin, Yao Wang, Brandon Lieberman, Devalingam Mahalingam, Ming Gao, Pei Wang, Chiou-Miin Wang, Zhijie Liu, Jianhua Ruan, Michael A. Liss, Victor X. Jin, Tim H-M Huang, Chun-Liang Chen
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3402.
https://doi.org/10.1158/1538-7445.AM2018-3402
Published: 01 July 2018
View articletitled, Abstract 3402: Castration resistance transcriptome in prostate cancer revealed by single-cell RNA-seq
Journal Articles

Single-Cell RNA-seq Reveals a Subpopulation of Prostate Cancer Cells with Enhanced Cell-Cycle–Related Transcription and Attenuated Androgen Response

Aaron M. Horning, Yao Wang, Che-Kuang Lin, Anna D. Louie, Rohit R. Jadhav, Chia-Nung Hung, Chiou-Miin Wang, Chun-Lin Lin, Nameer B. Kirma, Michael A. Liss, Addanki P. Kumar, LuZhe Sun, Zhijie Liu, Wei-Ting Chao, Qianben Wang, Victor X. Jin, Chun-Liang Chen, Tim H.-M. Huang
Journal: Cancer Research
Cancer Res (2018) 78 (4): 853–864.
https://doi.org/10.1158/0008-5472.CAN-17-1924
Published: 14 February 2018
View articletitled, Single-Cell RNA-seq Reveals a Subpopulation of Prostate Cancer Cells with Enhanced Cell-Cycle–Related Transcription and Attenuated Androgen Response
Open the PDF for Single-Cell RNA-seq Reveals a Subpopulation of Prostate Cancer Cells with Enhanced Cell-Cycle–Related Transcription and Attenuated Androgen Response in another window
Includes: Supplementary data
Journal Articles

Abstract 4778: HP1-mediated spatiotemporal control of estrogen-responsive transcription in breast cancer cells

Pei-Yin Hsu, Hang-Kai Hsu, Victor X. Jin, Zelton D. Sharp, Tim H.-M. Huang
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4778.
https://doi.org/10.1158/1538-7445.AM2015-4778
Published: 01 August 2015
View articletitled, Abstract 4778: HP1-mediated spatiotemporal control of estrogen-responsive transcription in breast cancer cells
Journal Articles

Abstract P6-07-02: Amplified DERE-mediated epigenetic repression in ERα-mediated breast tumorigenesis

Pei-Yin Hsu, Hang-Kai Hsu, Yi-dong Chen, Victor X Jin, Zelton D Sharp, Tim H-M Huang
Journal: Cancer Research
Cancer Res (2015) 75 (9_Supplement): P6-07-02.
https://doi.org/10.1158/1538-7445.SABCS14-P6-07-02
Published: 01 May 2015
View articletitled, Abstract P6-07-02: Amplified DERE-mediated epigenetic repression in ERα-mediated breast tumorigenesis
Journal Articles

Abstract C22: Next-generation sequencing reveals CpG island shore methylation regulates caveolin-1 expression in breast cancer

Xi Rao, Jared Evans, Heejoon Chae, Je-Keun Rhee, Sun Kim, Tim H-M Huang, Kenneth P. Nephew
Journal: Cancer Research
Cancer Res (2011) 71 (18_Supplement): C22.
https://doi.org/10.1158/1538-7445.FBCR11-C22
Published: 28 October 2014
View articletitled, Abstract C22: Next-generation sequencing reveals CpG island shore methylation regulates caveolin-1 expression in breast cancer
Journal Articles

Abstract 5588: Epithelial-to-mesenchymal markers of circulating tumor cells for detection of castration-resistant prostate cancer

Chun-Liang Chen, Pawel Osmulski, Devalingam Mahalingam, Aaron M. Horning, Rohit R. Jadhav, Anna D. Louie, Chiou-Miin Wang, Tim H.-M. Huang
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 5588.
https://doi.org/10.1158/1538-7445.AM2014-5588
Published: 01 October 2014
View articletitled, Abstract 5588: Epithelial-to-mesenchymal markers of circulating tumor cells for detection of castration-resistant prostate cancer
Journal Articles

Abstract 4783: Amplification of distant estrogen response elements epigenetically deregulates target genes in ERα-mediated breast tumorigenesis

PEI-YIN HSU, HANG-KAI HSU, Victor X. Jin, Zelton D. Sharp, Tim H.-M. Huang
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4783.
https://doi.org/10.1158/1538-7445.AM2014-4783
Published: 01 October 2014
View articletitled, Abstract 4783: Amplification of distant estrogen response elements epigenetically deregulates target genes in ERα-mediated breast tumorigenesis
Journal Articles

Abstract 2318: The role of EZH2 as an epigenetic switch of the TGF-β/SMAD4 targets in regulating EMT in ovarian cancer

Jora Meng-Ju Lin, Jacqueline Shay, Jian-Liang Chou, Pearlly S. Yan, Tim H.-M. Huang, Hung Cheng Lai, Michael W.y. Chan
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2318.
https://doi.org/10.1158/1538-7445.AM2014-2318
Published: 01 October 2014
View articletitled, Abstract 2318: The role of EZH2 as an epigenetic switch of the TGF-β/SMAD4 targets in regulating EMT in ovarian cancer
Journal Articles

Abstract 3326: Parallel EMT pathways mediated by epidermal growth factor, EpCAM and mesenchymal cadherins in benign endometriotic lesions and endometrial cancer

Ya-Ting Hsu, Joseph Liu, Peter A. Binkley, Robert S. Schenken, Rajshwar R. Tekmal, Tim H.-M. Huang, Nameer B. Kirma
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3326.
https://doi.org/10.1158/1538-7445.AM2014-3326
Published: 01 October 2014
View articletitled, Abstract 3326: Parallel EMT pathways mediated by epidermal growth factor, EpCAM and mesenchymal cadherins in benign endometriotic lesions and endometrial cancer
Journal Articles

Abstract 3341: Cross-talk between PI3K/AKT and ERα signaling leads to STAT3/6-modulated epigenetic transcription in aggressive breast cancer

Hang-Kai Hsu, Pei-Yin Hsu, Yao Wang, Zelton D. Sharp, Tim H.-M. Huang, Victor X. Jin
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3341.
https://doi.org/10.1158/1538-7445.AM2014-3341
Published: 01 October 2014
View articletitled, Abstract 3341: Cross-talk between PI3K/AKT and ERα signaling leads to STAT3/6-modulated epigenetic transcription in aggressive breast cancer
Journal Articles

Abstract 2889: Identification of estrogen receptor modulated gene methylation network in breast cancer.

Yu-Chiao Chiu, Tzu-Hung Hsiao, Fei Gu, Yidong Chen, Tim H-M Huang, Eric Y. Chuang
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2889.
https://doi.org/10.1158/1538-7445.AM2013-2889
Published: 15 April 2013
View articletitled, Abstract 2889: Identification of estrogen receptor modulated gene methylation network in breast cancer.
Journal Articles

Abstract 603: Targeted Casp8AP2 methylation increased drug resistance in mesenchymal stem cell and cancer cells

Yu-Wei Leu, Mei-Yu Pai, Chia-Chen Hsu, Kuan-Der Lee, Chih-Cheng Chen, Yao-Li Chen, Tim H.-M. Huang, Shu-Huei Hsiao
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 603.
https://doi.org/10.1158/1538-7445.AM2012-603
Published: 15 April 2012
View articletitled, Abstract 603: Targeted Casp8AP2 methylation increased drug resistance in mesenchymal stem cell and cancer cells